Research Topics
Genomes and Genes
| Juan J LafailleSummaryAffiliation: New York University Country: USA Publications
| Collaborators
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Detail Information
Publications
Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?Maria A Curotto de Lafaille
Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, and Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Immunity 30:626-35. 2009....
Control of homeostatic proliferation by regulatory T cellsShiqian Shen
Molecular Pathogenesis Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
J Clin Invest 115:3517-26. 2005..The presence of Tregs resulted in a lower accumulation of T cells, enhanced apoptosis, and impaired differentiation to a cytokine-producing state. We conclude that Tregs play a major role in the control of homeostatic proliferation...
Swift entry of myelin-specific T lymphocytes into the central nervous system in spontaneous autoimmune encephalomyelitisGlaucia C Furtado
Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
J Immunol 181:4648-55. 2008..Taken together, our results suggest that peripheral activation of T cells in draining lymph nodes is an early event in the development of EAE, which paves the way for the initial burst of IFN-gamma-producing CD4(+) T cell into the CNS...- Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammationMaria A Curotto de Lafaille
Program of Molecular Pathogenesis, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
Immunity 29:114-26. 2008..Thus, whereas adaptive Foxp3(+) Treg cells regulate sensitization to allergens and the severity of chronic inflammation, IFN-gamma-producing cells can play a beneficial role in inflammatory conditions involving eosinophils... - TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizesMonica W L Leung
Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 206:2121-30. 2009..Our results indicate that although the TCR has an instructive role in determining Foxp3 expression, selection of Foxp3(+) individual clones in the thymus is limited by a very small niche... - The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsIvaylo I Ivanov
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Cell 126:1121-33. 2006..Together, these studies suggest that RORgammat is a key regulator of immune homeostasis and highlight its potential as a therapeutic target in inflammatory diseases... - Oral tolerance in the absence of naturally occurring TregsDaniel Mucida
Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
J Clin Invest 115:1923-33. 2005..However, unlike oral administration of antigen, which induced Tregs but not effector T cells, i.p. immunization led to the simultaneous induction of Tregs and effector Th2 cells displaying the same antigen specificity... - Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cellsJonathan M Weiss
Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 209:1723-42, S1. 2012..In the same animals, iT reg cells in secondary lymphoid organs remain Nrp1(low). We also determined that, in spontaneous EAE, iT reg cells help to establish a chronic phase of the disease... - Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivoCarlos E Tadokoro
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 203:505-11. 2006..Thus, T reg cells can exert an early effect on immune responses by attenuating the establishment of stable contacts during priming of naive T cells by DCs... - Unique maturation program of the IgE response in vivoAgustin Erazo
Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Immunity 26:191-203. 2007..Our results have implications for the understanding of IgE memory responses in allergy... - Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cellsYi Ding
Molecular Pathogenesis Program and Skirball Institute for Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
Nat Med 14:162-9. 2008..Thus, through enhanced survival of existing regulatory T cells, and through induction of unresponsiveness in precursors of T effector cells, beta-catenin stabilization has a powerful effect on the prevention of inflammatory disease... - CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansionMaria A Curotto de Lafaille
Molecular Pathogenesis Program, Skirball Institute, and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
J Immunol 173:7259-68. 2004..The maintenance of CD25 expression by CD4(+)CD25(+) cells depends on IL-2 secreted by cotransferred CD4(+)CD25(-) or by Ag-stimulated T cells in peripheral lymphoid organs... - Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell functionAlexandra Zanin-Zhorov
Molecular Pathogenesis Program, Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Proc Natl Acad Sci U S A 109:1625-30. 2012..Dlgh1 operates independently of the negative feedback pathway mediated by the related adapter protein Carma1 and thus presents an array of unique targets to selectively manipulate Treg function... - Latent TGF-beta1-transduced CD4+ T cells suppress the progression of allergic encephalomyelitisMitsuyuki Murano
Department of Pathology, NYU Cancer Institute, School of Medicine, New York, NY, USA
J Leukoc Biol 79:140-6. 2006..PL mice. Furthermore, the GFP+ TGF-beta1-producing Th2 cells were detectable in the spinal cords of the injected mice... - Sequential class switching is required for the generation of high affinity IgE antibodiesHuizhong Xiong
Skirball Institute of Biomolecular Medicine, The Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 209:353-64. 2012..We demonstrate that a small amount of high affinity IgE can cause anaphylaxis and is pathogenic. Low affinity IgE competes with high affinity IgE for binding to Fcε receptors and prevents anaphylaxis and is thus beneficial... - Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sitesJiyun V Kim
Helen L and Martin S Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
J Immunol Methods 352:89-100. 2010..Interestingly, infiltration of the cerebral cortex by GFP(+) cells in these mice required three conditions: EAE induction, cortical injury and expression of CXCR6 on immune cells... - Immune regulatory mechanisms influence early pathology in spinal cord injury and in spontaneous autoimmune encephalomyelitisMaria Cecilia G Marcondes
Program of Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, USA
Am J Pathol 166:1749-60. 2005..Overall, our results suggest that common mechanisms regulate T-cell accumulation in CNS lesions of different causes, such as mechanic lesion or autoimmune-mediated damage... - Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cellsAntonio Maraver
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 1st Avenue, New York, NY 10016, USA
Blood 110:3218-25. 2007.... - Protein kinase C-theta mediates negative feedback on regulatory T cell functionAlexandra Zanin-Zhorov
Molecular Pathogenesis Program, Helen and Martin Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
Science 328:372-6. 2010..Treg freed of PKC-theta-mediated inhibition can function in the presence of inflammatory cytokines and thus have therapeutic potential in control of inflammatory diseases... - IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitisAllen K Wensky
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
J Immunol 174:1416-23. 2005.... - The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphateAlejandra Mendoza
Program in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Cell Rep 2:1104-10. 2012..Spns2 is needed in endothelial cells to supply lymph S1P and support lymphocyte circulation. As a differential requirement for lymph and blood S1P, Spns2 may be an attractive target for immune suppressive drugs... - Do regulatory T cells play a role in the control of homeostatic proliferation?Maria A Curotto de Lafaille
Molecular Pathogenesis Progam, Skirball Institute of Biomolecular Medicine, and Department of Pathology, New York University School of Medicine, New York 10016, USA
Int Rev Immunol 24:269-84. 2005..One of these relates to the stage at which regulatory T cells could play a role (i.e., T-cell proliferation vs. survival)... - Induced CD4+Foxp3+ regulatory T cells in immune toleranceAngelina M Bilate
Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
Annu Rev Immunol 30:733-58. 2012..Here we review how iTreg cells develop and how they participate in immunological tolerance, contrasting, when possible, iTreg cells with nTreg cells... - T-cell receptor transgenic mice in the study of autoimmune diseasesJuan J Lafaille
Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
J Autoimmun 22:95-106. 2004.... - Lipid phosphate phosphatase 3 enables efficient thymic egressBeatrice Breart
Program in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 208:1267-78. 2011..These results suggest that S1P generation and destruction are tightly regulated and that LPP3 is essential to establish the balance... - Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activityJun R Huh
Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
Nature 472:486-90. 2011..These data indicate that derivatives of digoxin can be used as chemical templates for the development of RORγt-targeted therapeutic agents that attenuate inflammatory lymphocyte function and autoimmune disease... - The role of regulatory T cells in allergyMaria A Curotto de Lafaille
Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University School of Medicine, NY 10016, USA
Springer Semin Immunopathol 25:295-310. 2004..This article reviews the recent progress on thymic-derived as well as peripherally induced regulatory T cells as they relate to atopy. The latter discussion also includes regulatory T cells that arise through immunotherapy... - What is unique about the IgE response?Huizhong Xiong
Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, USA
Adv Immunol 116:113-41. 2012.... - Early self-regulatory mechanisms control the magnitude of CD8+ T cell responses against liver stages of murine malariaJulius C R Hafalla
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY 10010, USA
J Immunol 171:964-70. 2003.... - CD4(+) regulatory T cells in autoimmunity and allergyMaria A Curotto de Lafaille
Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, and Department of Pathology New York University School of Medicine, New York, NY 10016, USA
Curr Opin Immunol 14:771-8. 2002.... - Maternal-fetal immune tolerance, block by blockMichael Gobert
Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
Cell 150:7-9. 2012..Samstein et al. reveal a role for inducible regulatory T cells in the enforcement of maternal-fetal immune tolerance... - Interleukin 2 signaling is required for CD4(+) regulatory T cell functionGlaucia C Furtado
Program of Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 196:851-7. 2002..However, IL-2 signaling in regulatory T cells is essential for their protective function. Altogether, our results favor a model whereby IL-2 induces regulatory T cell activity...