Juan J Lafaille

Summary

Affiliation: New York University
Country: USA

Publications

  1. doi request reprint Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?
    Maria A Curotto de Lafaille
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, and Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 30:626-35. 2009
  2. doi request reprint Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation
    Maria A Curotto de Lafaille
    Program of Molecular Pathogenesis, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Immunity 29:114-26. 2008
  3. ncbi request reprint Swift entry of myelin-specific T lymphocytes into the central nervous system in spontaneous autoimmune encephalomyelitis
    Glaucia C Furtado
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 181:4648-55. 2008
  4. pmc Control of homeostatic proliferation by regulatory T cells
    Shiqian Shen
    Molecular Pathogenesis Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Clin Invest 115:3517-26. 2005
  5. pmc Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
    Jonathan M Weiss
    Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 209:1723-42, S1. 2012
  6. pmc The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate
    Alejandra Mendoza
    Program in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Cell Rep 2:1104-10. 2012
  7. ncbi request reprint The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    Ivaylo I Ivanov
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 126:1121-33. 2006
  8. pmc TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes
    Monica W L Leung
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 206:2121-30. 2009
  9. pmc Oral tolerance in the absence of naturally occurring Tregs
    Daniel Mucida
    Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Clin Invest 115:1923-33. 2005
  10. pmc Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo
    Carlos E Tadokoro
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 203:505-11. 2006

Collaborators

Detail Information

Publications34

  1. doi request reprint Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?
    Maria A Curotto de Lafaille
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, and Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 30:626-35. 2009
    ....
  2. doi request reprint Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation
    Maria A Curotto de Lafaille
    Program of Molecular Pathogenesis, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Immunity 29:114-26. 2008
    ..Thus, whereas adaptive Foxp3(+) Treg cells regulate sensitization to allergens and the severity of chronic inflammation, IFN-gamma-producing cells can play a beneficial role in inflammatory conditions involving eosinophils...
  3. ncbi request reprint Swift entry of myelin-specific T lymphocytes into the central nervous system in spontaneous autoimmune encephalomyelitis
    Glaucia C Furtado
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 181:4648-55. 2008
    ..Taken together, our results suggest that peripheral activation of T cells in draining lymph nodes is an early event in the development of EAE, which paves the way for the initial burst of IFN-gamma-producing CD4(+) T cell into the CNS...
  4. pmc Control of homeostatic proliferation by regulatory T cells
    Shiqian Shen
    Molecular Pathogenesis Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Clin Invest 115:3517-26. 2005
    ..The presence of Tregs resulted in a lower accumulation of T cells, enhanced apoptosis, and impaired differentiation to a cytokine-producing state. We conclude that Tregs play a major role in the control of homeostatic proliferation...
  5. pmc Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
    Jonathan M Weiss
    Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 209:1723-42, S1. 2012
    ..In the same animals, iT reg cells in secondary lymphoid organs remain Nrp1(low). We also determined that, in spontaneous EAE, iT reg cells help to establish a chronic phase of the disease...
  6. pmc The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate
    Alejandra Mendoza
    Program in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Cell Rep 2:1104-10. 2012
    ..Spns2 is needed in endothelial cells to supply lymph S1P and support lymphocyte circulation. As a differential requirement for lymph and blood S1P, Spns2 may be an attractive target for immune suppressive drugs...
  7. ncbi request reprint The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    Ivaylo I Ivanov
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 126:1121-33. 2006
    ..Together, these studies suggest that RORgammat is a key regulator of immune homeostasis and highlight its potential as a therapeutic target in inflammatory diseases...
  8. pmc TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes
    Monica W L Leung
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 206:2121-30. 2009
    ..Our results indicate that although the TCR has an instructive role in determining Foxp3 expression, selection of Foxp3(+) individual clones in the thymus is limited by a very small niche...
  9. pmc Oral tolerance in the absence of naturally occurring Tregs
    Daniel Mucida
    Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Clin Invest 115:1923-33. 2005
    ..However, unlike oral administration of antigen, which induced Tregs but not effector T cells, i.p. immunization led to the simultaneous induction of Tregs and effector Th2 cells displaying the same antigen specificity...
  10. pmc Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo
    Carlos E Tadokoro
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 203:505-11. 2006
    ..Thus, T reg cells can exert an early effect on immune responses by attenuating the establishment of stable contacts during priming of naive T cells by DCs...
  11. ncbi request reprint CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion
    Maria A Curotto de Lafaille
    Molecular Pathogenesis Program, Skirball Institute, and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 173:7259-68. 2004
    ..The maintenance of CD25 expression by CD4(+)CD25(+) cells depends on IL-2 secreted by cotransferred CD4(+)CD25(-) or by Ag-stimulated T cells in peripheral lymphoid organs...
  12. pmc Unique maturation program of the IgE response in vivo
    Agustin Erazo
    Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Immunity 26:191-203. 2007
    ..Our results have implications for the understanding of IgE memory responses in allergy...
  13. doi request reprint Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells
    Yi Ding
    Molecular Pathogenesis Program and Skirball Institute for Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Med 14:162-9. 2008
    ..Thus, through enhanced survival of existing regulatory T cells, and through induction of unresponsiveness in precursors of T effector cells, beta-catenin stabilization has a powerful effect on the prevention of inflammatory disease...
  14. doi request reprint What is unique about the IgE response?
    Huizhong Xiong
    Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, USA
    Adv Immunol 116:113-41. 2012
    ....
  15. pmc Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function
    Alexandra Zanin-Zhorov
    Molecular Pathogenesis Program, Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 109:1625-30. 2012
    ..Dlgh1 operates independently of the negative feedback pathway mediated by the related adapter protein Carma1 and thus presents an array of unique targets to selectively manipulate Treg function...
  16. ncbi request reprint Latent TGF-beta1-transduced CD4+ T cells suppress the progression of allergic encephalomyelitis
    Mitsuyuki Murano
    Department of Pathology, NYU Cancer Institute, School of Medicine, New York, NY, USA
    J Leukoc Biol 79:140-6. 2006
    ..PL mice. Furthermore, the GFP+ TGF-beta1-producing Th2 cells were detectable in the spinal cords of the injected mice...
  17. pmc Sequential class switching is required for the generation of high affinity IgE antibodies
    Huizhong Xiong
    Skirball Institute of Biomolecular Medicine, The Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 209:353-64. 2012
    ..We demonstrate that a small amount of high affinity IgE can cause anaphylaxis and is pathogenic. Low affinity IgE competes with high affinity IgE for binding to Fcε receptors and prevents anaphylaxis and is thus beneficial...
  18. pmc Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites
    Jiyun V Kim
    Helen L and Martin S Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    J Immunol Methods 352:89-100. 2010
    ..Interestingly, infiltration of the cerebral cortex by GFP(+) cells in these mice required three conditions: EAE induction, cortical injury and expression of CXCR6 on immune cells...
  19. pmc Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells
    Antonio Maraver
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 1st Avenue, New York, NY 10016, USA
    Blood 110:3218-25. 2007
    ....
  20. pmc Immune regulatory mechanisms influence early pathology in spinal cord injury and in spontaneous autoimmune encephalomyelitis
    Maria Cecilia G Marcondes
    Program of Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, USA
    Am J Pathol 166:1749-60. 2005
    ..Overall, our results suggest that common mechanisms regulate T-cell accumulation in CNS lesions of different causes, such as mechanic lesion or autoimmune-mediated damage...
  21. pmc Protein kinase C-theta mediates negative feedback on regulatory T cell function
    Alexandra Zanin-Zhorov
    Molecular Pathogenesis Program, Helen and Martin Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Science 328:372-6. 2010
    ..Treg freed of PKC-theta-mediated inhibition can function in the presence of inflammatory cytokines and thus have therapeutic potential in control of inflammatory diseases...
  22. pmc Characterization of Two Distinct Lymphoproliferative Diseases Caused by Ectopic Expression of the Notch Ligand DLL4 on T Cells
    Huizhong Xiong
    Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, New York, United States of America The Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 8:e84841. 2013
    ..These observations resolved the discrepancy of previous papers on DLL4 driven hematological diseases in mice, and show the critical importance of the timing and duration of Notch activity. ..
  23. ncbi request reprint IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis
    Allen K Wensky
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    J Immunol 174:1416-23. 2005
    ....
  24. ncbi request reprint Do regulatory T cells play a role in the control of homeostatic proliferation?
    Maria A Curotto de Lafaille
    Molecular Pathogenesis Progam, Skirball Institute of Biomolecular Medicine, and Department of Pathology, New York University School of Medicine, New York 10016, USA
    Int Rev Immunol 24:269-84. 2005
    ..One of these relates to the stage at which regulatory T cells could play a role (i.e., T-cell proliferation vs. survival)...
  25. doi request reprint Induced CD4+Foxp3+ regulatory T cells in immune tolerance
    Angelina M Bilate
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Annu Rev Immunol 30:733-58. 2012
    ..Here we review how iTreg cells develop and how they participate in immunological tolerance, contrasting, when possible, iTreg cells with nTreg cells...
  26. ncbi request reprint T-cell receptor transgenic mice in the study of autoimmune diseases
    Juan J Lafaille
    Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    J Autoimmun 22:95-106. 2004
    ....
  27. ncbi request reprint The role of regulatory T cells in allergy
    Maria A Curotto de Lafaille
    Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University School of Medicine, NY 10016, USA
    Springer Semin Immunopathol 25:295-310. 2004
    ..This article reviews the recent progress on thymic-derived as well as peripherally induced regulatory T cells as they relate to atopy. The latter discussion also includes regulatory T cells that arise through immunotherapy...
  28. pmc Lipid phosphate phosphatase 3 enables efficient thymic egress
    Beatrice Breart
    Program in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 208:1267-78. 2011
    ..These results suggest that S1P generation and destruction are tightly regulated and that LPP3 is essential to establish the balance...
  29. pmc Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity
    Jun R Huh
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 472:486-90. 2011
    ..These data indicate that derivatives of digoxin can be used as chemical templates for the development of RORγt-targeted therapeutic agents that attenuate inflammatory lymphocyte function and autoimmune disease...
  30. doi request reprint Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor
    Christopher N Parkhurst
    Molecular Neurobiology Program, The Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA
    Cell 155:1596-609. 2013
    ..Together, our findings reveal that microglia serve important physiological functions in learning and memory by promoting learning-related synapse formation through BDNF signaling. ..
  31. ncbi request reprint Early self-regulatory mechanisms control the magnitude of CD8+ T cell responses against liver stages of murine malaria
    Julius C R Hafalla
    Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY 10010, USA
    J Immunol 171:964-70. 2003
    ....
  32. ncbi request reprint CD4(+) regulatory T cells in autoimmunity and allergy
    Maria A Curotto de Lafaille
    Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, and Department of Pathology New York University School of Medicine, New York, NY 10016, USA
    Curr Opin Immunol 14:771-8. 2002
    ....
  33. ncbi request reprint Maternal-fetal immune tolerance, block by block
    Michael Gobert
    Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Cell 150:7-9. 2012
    ..Samstein et al. reveal a role for inducible regulatory T cells in the enforcement of maternal-fetal immune tolerance...
  34. pmc Interleukin 2 signaling is required for CD4(+) regulatory T cell function
    Glaucia C Furtado
    Program of Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 196:851-7. 2002
    ..However, IL-2 signaling in regulatory T cells is essential for their protective function. Altogether, our results favor a model whereby IL-2 induces regulatory T cell activity...