Affiliation: New York University
- Measuring cell identity in noisy biological systemsKENNETH D BIRNBAUM
Center for Genomics and Systems Biology, Department of Biology, New York University, NY 10003, USA
Nucleic Acids Res 39:9093-107. 2011..The approach provides a unifying theoretical framework for quantifying specificity in the presence of noise, which is widely applicable across diverse biological systems...
- Stochastic de-repression of Rhodopsins in single photoreceptors of the fly retinaPranidhi Sood
Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York, USA
PLoS Comput Biol 8:e1002357. 2012..Our results indicate that even in the absence of Dve, the Rhodopsin regulatory network can maintain highly stable states. We propose that the role of Dve in outer PRs is to buffer against rare fluctuations in this network...
- Evolution in microbesEdo Kussell
Center for Genomics and Systems Biology, Department of Biology, Department of Physics, New York University, New York, New York 10003, USA
Annu Rev Biophys 42:493-514. 2013..Second, populations are viewed from a physiological perspective, and their nongenetic heterogeneity is examined. Bringing together these two viewpoints remains a major challenge for the future...
- Polymer-population mapping and localization in the space of phenotypesEdo Kussell
Laboratory of Living Matter and Center for Studies in Physics and Biology, The Rockefeller University, 1230 York Avenue, Box 34, New York, New York 10021, USA
Phys Rev Lett 97:068101. 2006..Using this mapping, we develop a path integral formulation for populations and predict the existence of a biological counterpart for the well-known heteropolymer localization phase transition...
- Interlocked feedforward loops control cell-type-specific Rhodopsin expression in the Drosophila eyeRobert J Johnston
Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
Cell 145:956-68. 2011..Furthermore, Dve levels are finely tuned to yield cell-type- and region-specific repression or activation outcomes. This interlocked FFL motif may be a general mechanism to control terminal cell-fate specification...
- Phenotypic diversity, population growth, and information in fluctuating environmentsEdo Kussell
Laboratory of Living Matter and Center for Studies in Physics and Biology, Rockefeller University, 1230 York Avenue, Box 34, New York, NY 10021 6399, USA
Science 309:2075-8. 2005..The optimal switching rates then mimic the statistics of environmental changes. We derive a relation between the long-term growth rate of the organism and the information available about its fluctuating environment...
- Individual histories and selection in heterogeneous populationsStanislas Leibler
Center for Studies in Physics and Biology, and Laboratory of Living Matter, The Rockefeller University, 1230 York Avenue, Box 34, New York, NY 10021, USA
Proc Natl Acad Sci U S A 107:13183-8. 2010....
- Bacterial persistence: a model of survival in changing environmentsEdo Kussell
Rockefeller University, New York, New York 10021 6399, USA
Genetics 169:1807-14. 2005..In contrast to typical examples of adaptations to features of a single environment, persistence appears to constitute an adaptation that is tuned to the distribution of environmental change...