Research Topics
Genomes and Genes
| S V KotenkoSummaryAffiliation: New Jersey Country: USA Publications
Research Grants
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Detail Information
Publications
Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expressionPasi Kaukinen
Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
Virol J 3:66. 2006..Previously, the serine protease NS3/4A was shown to inhibit IFN-beta gene expression by blocking dsRNA-activated retinoic acid-inducible gene I (RIG-I) and Toll-like receptor 3 (TLR3)-mediated signaling pathways...
IFN-λsSergei V Kotenko
Department of Biochemistry and Molecular Biology, University Hospital Cancer Center, New Jersey Medical School, University of Medicine and Dentistry, USA
Curr Opin Immunol 23:583-90. 2011..Recent studies have started to reveal unique biological activities of IFN-λs in and beyond innate antiviral immunity...
The family of IL-10-related cytokines and their receptors: related, but to what extent?Sergei V Kotenko
Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry, 185 South Orange Avenue, MSB E 631, Newark, NJ 07103, USA
Cytokine Growth Factor Rev 13:223-40. 2002..Although data indicate that these cytokines are involved in regulation of inflammatory and immune responses, their major functions remain to be discovered...- IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complexSergei V Kotenko
Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
Nat Immunol 4:69-77. 2003..This receptor-ligand system may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs... - Full house: 12 receptors for 27 cytokinesSergei V Kotenko
Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry New Jersey Medical School, 185 South Orange Avenue, MSB E 631, Newark, NJ 07103, USA
Int Immunopharmacol 4:593-608. 2004..Nevertheless, signaling events induced through various combinations of CRF2 subunits partially overlap, leading to the induction of overlapping but cytokine-specific biological activities... - Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activityS V Kotenko
Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
J Immunol 166:7096-103. 2001..Thus, the soluble receptor designated IL-22BP inhibits IL-22 activity by binding IL-22 and blocking its interaction with the cell surface IL-22R complex... - Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexesS V Kotenko
Department of Molecular Genetics and Microbiology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
J Biol Chem 276:2725-32. 2001.... - Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)S V Kotenko
Department of Molecular Genetics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854 5635, USA
Proc Natl Acad Sci U S A 97:1695-700. 2000..We demonstrated that cmvIL-10 is expressed in CMV-infected cells. Thus, expression of cmvIL-10 extends the range of counter measures developed by CMV to circumvent detection and destruction by the host immune system... - Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanomaAhmed Lasfar
Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey 07103, USA
Cancer Res 66:4468-77. 2006..IFN-lambda2 cells, suggesting that IFN-lambdas engage host mechanisms to inhibit melanoma growth. These in vivo experiments show the antitumor activities of IFN-lambdas and suggest their strong therapeutic potential... - hTid-1, a human DnaJ protein, modulates the interferon signaling pathwayS Sarkar
Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
J Biol Chem 276:49034-42. 2001..Furthermore, both hTid-1(S) and hTid-1(L) can modulate IFN-gamma-mediated transcriptional activity... - The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activityB P Pollack
Department of Molecular Genetics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
J Biol Chem 274:31531-42. 1999..This report provides a clue to the biochemical function for this conserved protein and suggests that protein methyltransferases may have a role in cellular signaling... - Other kinases can substitute for Jak2 in signal transduction by interferon-gammaS V Kotenko
Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
J Biol Chem 271:17174-82. 1996..The results may suggest that the Jaks do not contribute to the specificity of signal transduction in the Jak-Stat pathway to the same degree as Stats... - Identification and functional characterization of a second chain of the interleukin-10 receptor complexS V Kotenko
Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854 5635, USA
EMBO J 16:5894-903. 1997..Thus, the CRFB4 chain, which we designate as the IL-10R2 or IL-10Rbeta chain, serves as an accessory chain essential for the active IL-10 receptor complex and to initiate IL-10-induced signal transduction events... 
Regulation of apoptosis by type III interferonsW Li
Department of Biochemistry and Molecular Biology, New Jersey Medical School University Hospital Cancer Center, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
Cell Prolif 41:960-79. 2008..However, ability of type III IFNs to regulate cell population growth remains largely uncharacterized...- Inhibition of type I and type III interferons by a secreted glycoprotein from Yaba-like disease virusJiaying Huang
Department of Biochemistry and Molecular Biology, University Hospital Cancer Center, New Jersey Medical School, Newark, NJ 07103, USA
Proc Natl Acad Sci U S A 104:9822-7. 2007..These results suggest that type III IFNs may be an effective treatment for some poxviral infections... - Antitumor activity of type I and type III interferons in BNL hepatoma modelWalid Abushahba
Department of Biochemistry and Molecular Biology and University Hospital Cancer Center, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
Cancer Immunol Immunother 59:1059-71. 2010.... - Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2Faruk Sheikh
Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
J Immunol 172:2006-10. 2004..IL-10, IL-19, IL-20, IL-22, and IL-24 fail to signal through the combination of IL-10R2 and IL-20R1 proteins, demonstrating that this receptor combination is unique and specific for IL-26... - Effect of interferon-lambda on replication of hepatitis B virus in human hepatoma cellsSeung Ho Hong
Department of Microbiology, Ajou University School of Medicine, Youngtongku Wonchondong San 5, Suwon 442 749, Republic of Korea
Virus Res 126:245-9. 2007..Our results suggest that the antiviral activity of IFN-lambda against HBV may be limited in human cells... - Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kineticsTobias Marcello
Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10021, USA
Gastroenterology 131:1887-98. 2006..CONCLUSIONS: These results demonstrate distinct differences in IFN-lambda- and IFN-alpha-induced antiviral states. Understanding these differences may prove useful for developing new HCV treatment strategies... - Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signalingLaure Dumoutier
Ludwig Institute for Cancer Research, Brussels Branch and the Experimental Medicine Unit, Universite de Louvain, B 1200 Brussels, Belgium
J Biol Chem 279:32269-74. 2004..Taken together, these observations extend the functional similarities between IFN-lambdas and type I IFNs and shed some new light on the mechanisms of activation of STAT2 and STAT4 by these cytokines... - Alpha and lambda interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virusBo Chi
Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA
J Virol 80:5032-40. 2006..Defining the mechanism of RSV-induced suppression may guide vaccine design and provide insight into previously uncharacterized human T-cell responses and activities of interferons... - Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2Mai Wang
Vanderbilt Ingram Cancer Center, Department of Cancer Biology, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA
J Biol Chem 277:7341-7. 2002..Taken together, these results provide compelling evidence for IL-24 being the fourth member of IL-10 family of cytokines to which their specific receptors have been identified... - Murine interferon lambdas (type III interferons) exhibit potent antiviral activity in vivo in a poxvirus infection modelNathan W Bartlett
Department of Virology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK
J Gen Virol 86:1589-96. 2005..Thus, by characterizing murine IFN-lambdas within a mouse infection model, the potent antiviral and immunostimulatory activity of IFN-lambdas in response to poxvirus infection has been demonstrated... - The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chainRaymond P Donnelly
Division of Therapeutic Proteins, HFM 538, 1401 Rockville Pike, Rockville, MD 20852, USA
J Leukoc Biol 76:314-21. 2004..Consequently, the receptors for these cytokines may provide novel targets for inhibiting the growth of certain types of cancer... - Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20Sergei Pletnev
Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Maryland 21702 1201, USA
Biochemistry 42:12617-24. 2003.... - Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26Haluk B Oral
Department of Microbiology and Infectious Diseases, Immunology Unit, Uludag University School of Medicine, 16059 Bursa, Turkey
Eur J Immunol 36:380-8. 2006..These data demonstrate that IL-19, IL-20 and IL-22 may participate in T cell-mediated diseases by distinct regulation of T cell cytokine profiles... - A new member of the interleukin 10-related cytokine family encoded by a poxvirusNathan W Bartlett
Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK
J Gen Virol 85:1401-12. 2004..These results demonstrate that Y134R is a new viral member of the IL-10-related cytokine family and that its activity in vivo affects virus virulence... - Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activationAnna Usacheva
Department of Pharmacology, University of Illinois, Chicago 60612, USA
J Biol Chem 277:48220-6. 2002..Interestingly, Box 2B localizes close to the membrane region (8-10 amino acids from the membrane) similar to Box 1, whereas Box 2A is more distal (38-58 amino acids from the membrane)... - IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genesPamela I Osterlund
Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
J Immunol 179:3434-42. 2007.... - Role of deficient type III interferon-lambda production in asthma exacerbationsMarco Contoli
Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK
Nat Med 12:1023-6. 2006..These results identify previously unknown mechanisms of susceptibility to infection in asthma and suggest new approaches to prevention and/or treatment of asthma exacerbations...
Research Grants
- Characterization of the IL-TIF Receptor ComplexSergei Kotenko; Fiscal Year: 2005..The long-term goal of this project is to obtain new knowledge that will improve our understanding of mechanisms that regulate proper functioning of the immune system. ..
- Role of Interferon-lambda in Antiviral ResponseSergei Kotenko; Fiscal Year: 2009..abstract_text> ..