S V Kotenko

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression
    Pasi Kaukinen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    Virol J 3:66. 2006
  2. pmc IFN-λs
    Sergei V Kotenko
    Department of Biochemistry and Molecular Biology, University Hospital Cancer Center, New Jersey Medical School, University of Medicine and Dentistry, USA
    Curr Opin Immunol 23:583-90. 2011
  3. ncbi The family of IL-10-related cytokines and their receptors: related, but to what extent?
    Sergei V Kotenko
    Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry, 185 South Orange Avenue, MSB E 631, Newark, NJ 07103, USA
    Cytokine Growth Factor Rev 13:223-40. 2002
  4. ncbi IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex
    Sergei V Kotenko
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Nat Immunol 4:69-77. 2003
  5. ncbi Full house: 12 receptors for 27 cytokines
    Sergei V Kotenko
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry New Jersey Medical School, 185 South Orange Avenue, MSB E 631, Newark, NJ 07103, USA
    Int Immunopharmacol 4:593-608. 2004
  6. ncbi Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity
    S V Kotenko
    Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Immunol 166:7096-103. 2001
  7. ncbi Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes
    S V Kotenko
    Department of Molecular Genetics and Microbiology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
    J Biol Chem 276:2725-32. 2001
  8. pmc Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)
    S V Kotenko
    Department of Molecular Genetics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854 5635, USA
    Proc Natl Acad Sci U S A 97:1695-700. 2000
  9. ncbi Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma
    Ahmed Lasfar
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey 07103, USA
    Cancer Res 66:4468-77. 2006
  10. ncbi hTid-1, a human DnaJ protein, modulates the interferon signaling pathway
    S Sarkar
    Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
    J Biol Chem 276:49034-42. 2001

Research Grants

  1. Characterization of the IL-TIF Receptor Complex
    Sergei Kotenko; Fiscal Year: 2005
  2. Role of Interferon-lambda in Antiviral Response
    Sergei Kotenko; Fiscal Year: 2009

Collaborators

Detail Information

Publications30

  1. pmc Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression
    Pasi Kaukinen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    Virol J 3:66. 2006
    ..Previously, the serine protease NS3/4A was shown to inhibit IFN-beta gene expression by blocking dsRNA-activated retinoic acid-inducible gene I (RIG-I) and Toll-like receptor 3 (TLR3)-mediated signaling pathways...
  2. pmc IFN-λs
    Sergei V Kotenko
    Department of Biochemistry and Molecular Biology, University Hospital Cancer Center, New Jersey Medical School, University of Medicine and Dentistry, USA
    Curr Opin Immunol 23:583-90. 2011
    ..Recent studies have started to reveal unique biological activities of IFN-λs in and beyond innate antiviral immunity...
  3. ncbi The family of IL-10-related cytokines and their receptors: related, but to what extent?
    Sergei V Kotenko
    Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry, 185 South Orange Avenue, MSB E 631, Newark, NJ 07103, USA
    Cytokine Growth Factor Rev 13:223-40. 2002
    ..Although data indicate that these cytokines are involved in regulation of inflammatory and immune responses, their major functions remain to be discovered...
  4. ncbi IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex
    Sergei V Kotenko
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Nat Immunol 4:69-77. 2003
    ..This receptor-ligand system may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs...
  5. ncbi Full house: 12 receptors for 27 cytokines
    Sergei V Kotenko
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry New Jersey Medical School, 185 South Orange Avenue, MSB E 631, Newark, NJ 07103, USA
    Int Immunopharmacol 4:593-608. 2004
    ..Nevertheless, signaling events induced through various combinations of CRF2 subunits partially overlap, leading to the induction of overlapping but cytokine-specific biological activities...
  6. ncbi Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity
    S V Kotenko
    Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Immunol 166:7096-103. 2001
    ..Thus, the soluble receptor designated IL-22BP inhibits IL-22 activity by binding IL-22 and blocking its interaction with the cell surface IL-22R complex...
  7. ncbi Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes
    S V Kotenko
    Department of Molecular Genetics and Microbiology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
    J Biol Chem 276:2725-32. 2001
    ....
  8. pmc Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)
    S V Kotenko
    Department of Molecular Genetics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854 5635, USA
    Proc Natl Acad Sci U S A 97:1695-700. 2000
    ..We demonstrated that cmvIL-10 is expressed in CMV-infected cells. Thus, expression of cmvIL-10 extends the range of counter measures developed by CMV to circumvent detection and destruction by the host immune system...
  9. ncbi Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma
    Ahmed Lasfar
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey 07103, USA
    Cancer Res 66:4468-77. 2006
    ..IFN-lambda2 cells, suggesting that IFN-lambdas engage host mechanisms to inhibit melanoma growth. These in vivo experiments show the antitumor activities of IFN-lambdas and suggest their strong therapeutic potential...
  10. ncbi hTid-1, a human DnaJ protein, modulates the interferon signaling pathway
    S Sarkar
    Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
    J Biol Chem 276:49034-42. 2001
    ..Furthermore, both hTid-1(S) and hTid-1(L) can modulate IFN-gamma-mediated transcriptional activity...
  11. ncbi The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity
    B P Pollack
    Department of Molecular Genetics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
    J Biol Chem 274:31531-42. 1999
    ..This report provides a clue to the biochemical function for this conserved protein and suggests that protein methyltransferases may have a role in cellular signaling...
  12. ncbi Other kinases can substitute for Jak2 in signal transduction by interferon-gamma
    S V Kotenko
    Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
    J Biol Chem 271:17174-82. 1996
    ..The results may suggest that the Jaks do not contribute to the specificity of signal transduction in the Jak-Stat pathway to the same degree as Stats...
  13. pmc Identification and functional characterization of a second chain of the interleukin-10 receptor complex
    S V Kotenko
    Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854 5635, USA
    EMBO J 16:5894-903. 1997
    ..Thus, the CRFB4 chain, which we designate as the IL-10R2 or IL-10Rbeta chain, serves as an accessory chain essential for the active IL-10 receptor complex and to initiate IL-10-induced signal transduction events...
  14. doi Regulation of apoptosis by type III interferons
    W Li
    Department of Biochemistry and Molecular Biology, New Jersey Medical School University Hospital Cancer Center, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    Cell Prolif 41:960-79. 2008
    ..However, ability of type III IFNs to regulate cell population growth remains largely uncharacterized...
  15. pmc Inhibition of type I and type III interferons by a secreted glycoprotein from Yaba-like disease virus
    Jiaying Huang
    Department of Biochemistry and Molecular Biology, University Hospital Cancer Center, New Jersey Medical School, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 104:9822-7. 2007
    ..These results suggest that type III IFNs may be an effective treatment for some poxviral infections...
  16. doi Antitumor activity of type I and type III interferons in BNL hepatoma model
    Walid Abushahba
    Department of Biochemistry and Molecular Biology and University Hospital Cancer Center, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Cancer Immunol Immunother 59:1059-71. 2010
    ....
  17. ncbi Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2
    Faruk Sheikh
    Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 172:2006-10. 2004
    ..IL-10, IL-19, IL-20, IL-22, and IL-24 fail to signal through the combination of IL-10R2 and IL-20R1 proteins, demonstrating that this receptor combination is unique and specific for IL-26...
  18. ncbi Effect of interferon-lambda on replication of hepatitis B virus in human hepatoma cells
    Seung Ho Hong
    Department of Microbiology, Ajou University School of Medicine, Youngtongku Wonchondong San 5, Suwon 442 749, Republic of Korea
    Virus Res 126:245-9. 2007
    ..Our results suggest that the antiviral activity of IFN-lambda against HBV may be limited in human cells...
  19. ncbi Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics
    Tobias Marcello
    Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10021, USA
    Gastroenterology 131:1887-98. 2006
    ..We aimed to determine whether IFN-lambda exhibits antiviral activity toward HCV and to compare the signal transduction and effector gene pathways with those of IFN-alpha...
  20. ncbi Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling
    Laure Dumoutier
    Ludwig Institute for Cancer Research, Brussels Branch and the Experimental Medicine Unit, Universite de Louvain, B 1200 Brussels, Belgium
    J Biol Chem 279:32269-74. 2004
    ..Taken together, these observations extend the functional similarities between IFN-lambdas and type I IFNs and shed some new light on the mechanisms of activation of STAT2 and STAT4 by these cytokines...
  21. pmc Alpha and lambda interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virus
    Bo Chi
    Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA
    J Virol 80:5032-40. 2006
    ..Defining the mechanism of RSV-induced suppression may guide vaccine design and provide insight into previously uncharacterized human T-cell responses and activities of interferons...
  22. ncbi Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2
    Mai Wang
    Vanderbilt Ingram Cancer Center, Department of Cancer Biology, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    J Biol Chem 277:7341-7. 2002
    ..Taken together, these results provide compelling evidence for IL-24 being the fourth member of IL-10 family of cytokines to which their specific receptors have been identified...
  23. ncbi Murine interferon lambdas (type III interferons) exhibit potent antiviral activity in vivo in a poxvirus infection model
    Nathan W Bartlett
    Department of Virology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK
    J Gen Virol 86:1589-96. 2005
    ..Thus, by characterizing murine IFN-lambdas within a mouse infection model, the potent antiviral and immunostimulatory activity of IFN-lambdas in response to poxvirus infection has been demonstrated...
  24. ncbi The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain
    Raymond P Donnelly
    Division of Therapeutic Proteins, HFM 538, 1401 Rockville Pike, Rockville, MD 20852, USA
    J Leukoc Biol 76:314-21. 2004
    ..Consequently, the receptors for these cytokines may provide novel targets for inhibiting the growth of certain types of cancer...
  25. ncbi Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20
    Sergei Pletnev
    Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Maryland 21702 1201, USA
    Biochemistry 42:12617-24. 2003
    ....
  26. ncbi Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26
    Haluk B Oral
    Department of Microbiology and Infectious Diseases, Immunology Unit, Uludag University School of Medicine, 16059 Bursa, Turkey
    Eur J Immunol 36:380-8. 2006
    ..These data demonstrate that IL-19, IL-20 and IL-22 may participate in T cell-mediated diseases by distinct regulation of T cell cytokine profiles...
  27. ncbi A new member of the interleukin 10-related cytokine family encoded by a poxvirus
    Nathan W Bartlett
    Department of Virology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    J Gen Virol 85:1401-12. 2004
    ..These results demonstrate that Y134R is a new viral member of the IL-10-related cytokine family and that its activity in vivo affects virus virulence...
  28. ncbi Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation
    Anna Usacheva
    Department of Pharmacology, University of Illinois, Chicago 60612, USA
    J Biol Chem 277:48220-6. 2002
    ..Interestingly, Box 2B localizes close to the membrane region (8-10 amino acids from the membrane) similar to Box 1, whereas Box 2A is more distal (38-58 amino acids from the membrane)...
  29. ncbi IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes
    Pamela I Osterlund
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Immunol 179:3434-42. 2007
    ....
  30. ncbi Role of deficient type III interferon-lambda production in asthma exacerbations
    Marco Contoli
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK
    Nat Med 12:1023-6. 2006
    ..These results identify previously unknown mechanisms of susceptibility to infection in asthma and suggest new approaches to prevention and/or treatment of asthma exacerbations...

Research Grants10

  1. Characterization of the IL-TIF Receptor Complex
    Sergei Kotenko; Fiscal Year: 2005
    ..The long-term goal of this project is to obtain new knowledge that will improve our understanding of mechanisms that regulate proper functioning of the immune system. ..
  2. Role of Interferon-lambda in Antiviral Response
    Sergei Kotenko; Fiscal Year: 2009
    ..abstract_text> ..