Xiang Peng Kong
Affiliation: New York University
Kumar R, Pan R, Upadhyay C, Mayr L, Cohen S, Wang X, et al
. Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody 2424 with Neutralizing Activity against HIV-1 JRFL. J Virol. 2015;89:9090-102 pubmed publisher
..Hence, the epitope of 2424 is in one of the vulnerable sites on the virus that may be exploited in designing HIV vaccine immunogens. ..
Pan R, Gorny M, Zolla Pazner S, Kong X. The V1V2 Region of HIV-1 gp120 Forms a Five-Stranded Beta Barrel. J Virol. 2015;89:8003-10 pubmed publisher
..We also showed that V1V2 forms a 5-stranded beta barrel, an elegant structure allowing sequence variations in the strand-connecting loops while preserving a conserved core. ..
Chukwu J, Pedersen J, Pedersen L, Volbracht C, Sigurdsson E, Kong X. Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau Protein. Sci Rep. 2018;8:6209 pubmed publisher
..Overall, the structure of the antibody-antigen complex clarifies why certain phosphorylation sites in tau are more closely linked to neurodegeneration than others. ..
Jia M, Lu H, Kong X, Cheng Mayer C, Wu X. Gp120 V5 Is Targeted by the First Wave of Sequential Neutralizing Antibodies in SHIVSF162P3N-Infected Rhesus Macaques. Viruses. 2018;10: pubmed publisher
..Longitudinal plasmas revealed 2⁻3 sequential waves of neutralizing antibodies in macaques with breadth, implicating that 3 sequential envelope variants, if not more, may be required for the broadening of HIV-1 neutralizing antibodies. ..
Chan K, Pan R, Costa M, Gorny M, Wang S, Lu S, et al
. Structural Comparison of Human Anti-HIV-1 gp120 V3 Monoclonal Antibodies of the Same Gene Usage Induced by Vaccination and Chronic Infection. J Virol. 2018;92: pubmed publisher
Wu X, Kong X. Antigenic landscape of the HIV-1 envelope and new immunological concepts defined by HIV-1 broadly neutralizing antibodies. Curr Opin Immunol. 2016;42:56-64 pubmed publisher
..We also summarize new immunological concepts implicated in bnAb sequences and their lineage studies. ..
Jiang X, Totrov M, Li W, Sampson J, Williams C, Lu H, et al
. Rationally Designed Immunogens Targeting HIV-1 gp120 V1V2 Induce Distinct Conformation-Specific Antibody Responses in Rabbits. J Virol. 2016;90:11007-11019 pubmed
..We show here that such immunogens can be designed and that they induced conformation-specific antibody responses in rabbits. Our immunogens are therefore prototypes of vaccine candidates targeting the V1V2 region of HIV-1 Env. ..
Pan R, Qin Y, Banasik M, Lees W, Shepherd A, Cho M, et al
. Increased Epitope Complexity Correlated with Antibody Affinity Maturation and a Novel Binding Mode Revealed by Structures of Rabbit Antibodies against the Third Variable Loop (V3) of HIV-1 gp120. J Virol. 2018;92: pubmed publisher
..Our study provides novel insights about neutralization-susceptible V3 epitope structures and demonstrates that rabbits can serve as a useful animal model to evaluate human vaccine candidates. ..