Hannah L Klein

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc The consequences of Rad51 overexpression for normal and tumor cells
    Hannah L Klein
    Department of Biochemistry, New York University School of Medicine, NYU Medical Center, 550 First Avenue, New York, NY 10016, United States
    DNA Repair (Amst) 7:686-93. 2008
  2. ncbi request reprint Reversal of fortune: Rad5 to the rescue
    Hannah L Klein
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 28:181-3. 2007
  3. ncbi request reprint A SUMOry of DNA replication: synthesis, damage, and repair
    Hannah L Klein
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Cell 127:455-7. 2006
  4. pmc Spontaneous chromosome loss in Saccharomyces cerevisiae is suppressed by DNA damage checkpoint functions
    H L Klein
    Department of Biochemistry and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Genetics 159:1501-9. 2001
  5. pmc Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Delta with other DNA repair genes in Saccharomyces cerevisiae
    H L Klein
    Department of Biochemistry and Kaplan Cancer Center, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    Genetics 157:557-65. 2001
  6. ncbi request reprint Effects of tumor-associated mutations on Rad54 functions
    Marina Smirnova
    Department of Biochemistry and Kaplan Comprehensive Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 279:24081-8. 2004
  7. pmc Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants
    F Palladino
    Department of Biochemistry and Kaplan Cancer Center, New York University Medical Center, New York 10016
    Genetics 132:23-37. 1992
  8. pmc Role of transcription in plasmid maintenance in the hpr1Delta mutant of Saccharomyces cerevisiae
    Robert J Merker
    Department of Biochemistry and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 22:8763-73. 2002
  9. pmc hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae
    Robert J Merker
    Department of Biochemistry and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 22:421-9. 2002
  10. ncbi request reprint Role of the error-free damage bypass postreplication repair pathway in the maintenance of genomic stability
    Marina Smirnova
    Department of Biochemistry, Kaplan Comprehensive Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mutat Res 532:117-35. 2003

Collaborators

Detail Information

Publications32

  1. pmc The consequences of Rad51 overexpression for normal and tumor cells
    Hannah L Klein
    Department of Biochemistry, New York University School of Medicine, NYU Medical Center, 550 First Avenue, New York, NY 10016, United States
    DNA Repair (Amst) 7:686-93. 2008
    ..While increased Rad51 can provide drug resistance, it also leads to increased genomic instability and may contribute to carcinogenesis...
  2. ncbi request reprint Reversal of fortune: Rad5 to the rescue
    Hannah L Klein
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 28:181-3. 2007
    ..2007) show that the yeast Rad5 protein can promote error-free template switching and replication past a DNA lesion via a novel DNA unwinding reaction that also pairs nascent and parental strands...
  3. ncbi request reprint A SUMOry of DNA replication: synthesis, damage, and repair
    Hannah L Klein
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Cell 127:455-7. 2006
    ..Recombination at stalled replication forks is regulated at an early stage by sumoylation. In this issue of Cell, Branzei et al. show that the Ubc9/SUMO modification pathway controls the accumulation of cruciform structures at stalled forks...
  4. pmc Spontaneous chromosome loss in Saccharomyces cerevisiae is suppressed by DNA damage checkpoint functions
    H L Klein
    Department of Biochemistry and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Genetics 159:1501-9. 2001
    ..The mec1 checkpoint function mutant, defective in the yeast ATR homolog, results in increased recombination through a process that is distinct from that operative in wild-type cells...
  5. pmc Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Delta with other DNA repair genes in Saccharomyces cerevisiae
    H L Klein
    Department of Biochemistry and Kaplan Cancer Center, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    Genetics 157:557-65. 2001
    ..However, cells do not achieve wild-type growth rates, suggesting that unrepaired damage is still present and may lead to chromosome loss...
  6. ncbi request reprint Effects of tumor-associated mutations on Rad54 functions
    Marina Smirnova
    Department of Biochemistry and Kaplan Comprehensive Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 279:24081-8. 2004
    ....
  7. pmc Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants
    F Palladino
    Department of Biochemistry and Kaplan Cancer Center, New York University Medical Center, New York 10016
    Genetics 132:23-37. 1992
    ....
  8. pmc Role of transcription in plasmid maintenance in the hpr1Delta mutant of Saccharomyces cerevisiae
    Robert J Merker
    Department of Biochemistry and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 22:8763-73. 2002
    ..Models for the role of Hpr1p in mature mRNA formation and the cause of plasmid instability in the absence of the Hpr1 protein are discussed...
  9. pmc hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae
    Robert J Merker
    Department of Biochemistry and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 22:421-9. 2002
    ..The hpr1Delta mutant acts in a pathway distinct from previously described mutants that reduce life span...
  10. ncbi request reprint Role of the error-free damage bypass postreplication repair pathway in the maintenance of genomic stability
    Marina Smirnova
    Department of Biochemistry, Kaplan Comprehensive Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mutat Res 532:117-35. 2003
    ..In diploid strains, the most dramatic increase is in the abnormality of chromosome loss when a repair or damage detection pathway is defective...
  11. pmc The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene
    L Rong
    Department of Biochemistry, New York University Medical Center, New York 10016
    Genetics 127:75-85. 1991
    ..We propose that the HPR5 gene functions in the RAD6 repair pathway...
  12. pmc The role of Candida albicans homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity
    Samantha J Hoot
    Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    BMC Microbiol 11:214. 2011
    ..This study addresses the role of the homologous recombination factors Rad54 and Rdh54 in cell growth, DNA damage and FLC resistance in Candida albicans...
  13. pmc Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae
    H Y Fan
    Department of Biochemistry, New York University Medical Center, New York 10016, USA
    Genetics 142:749-59. 1996
    ..Because mutations in SOH1, RPB2 and SUA7 suppress the hyperrecombination phenotype of hpr1 mutants, this suggests a link between recombination in direct repeats and transcription...
  14. pmc HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene
    A Aguilera
    Department of Biochemistry, New York University Medical Center, New York 10016
    Mol Cell Biol 10:1439-51. 1990
    ..We conclude that Hpr1 is a novel eucaryotic protein, mutation of which causes an increase in mitotic intrachromosomal excision recombination, and that it may be functionally related to an activity of the topoisomerase I protein...
  15. pmc Genetic control of intrachromosomal recombination in Saccharomyces cerevisiae. I. Isolation and genetic characterization of hyper-recombination mutations
    A Aguilera
    Department of Biochemistry, New York University, New York 10016
    Genetics 119:779-90. 1988
    ..Further studies are required to show whether different recombination pathways or different outcomes of the same recombination pathway are controlled by the genes identified in this study...
  16. pmc Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae
    H Y Fan
    Department of Biochemistry, New York University Medical Center, New York 10016
    Genetics 137:945-56. 1994
    ..The SOH1 gene has been cloned and sequenced. The null allele is 10-fold increased for recombination as measured by deletion of a leu2 direct repeat...
  17. pmc RDH54, a RAD54 homologue in Saccharomyces cerevisiae, is required for mitotic diploid-specific recombination and repair and for meiosis
    H L Klein
    Department of Biochemistry and Kaplan Cancer Center, New York University Medical Center, New York 10016, USA
    Genetics 147:1533-43. 1997
    ..The RDH54 gene is also required for meiosis as homozygous mutant diploids show very poor sporulation and reduced spore viability. The role of the RDH54 gene in mitotic repair and in meiosis and the pathway in which it acts are discussed...
  18. doi request reprint Methods to study mitotic homologous recombination and genome stability
    Xiuzhong Zheng
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Methods Mol Biol 745:3-13. 2011
    ..The assays, while not inclusive of all genome instability assays, give a broad assessment of general genome damage or inability to repair damage in various genetic backgrounds...
  19. doi request reprint Breaking up just got easier to do
    Hannah L Klein
    Department of Biochemistry, New York University Langone Medical Center, 550 First Avenue, New York, NY 10016, USA
    Cell 138:20-2. 2009
    ..2009) and in Molecular Cell (Andersen et al., 2009; Muñoz et al., 2009) now identify the human SLX4 and show that in association with the SLX1 endonuclease it directs the symmetric cleavage and resolution of Holliday junctions...
  20. ncbi request reprint Replication, recombination, and repair: going for the gold
    Hannah L Klein
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 9:471-80. 2002
    ..The signals and controls that permit cells to transition between replication and recombination modes are now being identified...
  21. ncbi request reprint Genetic control of intrachromosomal recombination
    H L Klein
    Department of Biochemistry, New York University Medical Center, NY 10016
    Bioessays 17:147-59. 1995
    ..RAD52-dependent events encompass all events that involve the initial steps of a recombination reaction, which include strand invasion to form a heteroduplex intermediate...
  22. pmc High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability
    H Y Fan
    Department of Biochemistry and Kaplan Cancer Center, New York University Medical Center, New York, New York 10016, USA
    Mol Cell Biol 21:5459-70. 2001
    ..The ability of a pre-mRNA splicing factor to suppress the hyperrecombination phenotype of a defective PolII complex raises the possibility of integrating transcription, RNA processing, and genome stability or a second role for SUB2...
  23. ncbi request reprint Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae
    L Rong
    Department of Biochemistry, New York University Medical Center, New York 10016
    J Biol Chem 268:1252-9. 1993
    ..The carboxyl-terminal region of the protein is shown to contain a sequence for nuclear localization. Expression of the SRS2 in yeast was examined and found to be extremely low...
  24. pmc Characterization of the Interaction between the Saccharomyces cerevisiae Rad51 Recombinase and the DNA Translocase Rdh54
    Sergio R Santa Maria
    From the Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York 10016 and
    J Biol Chem 288:21999-2005. 2013
    ..Altogether, these results reveal a distinction between damage sensitivity and Rad51 removal with regard to Rdh54 interaction with Rad51. ..
  25. ncbi request reprint Sgs1-the maestro of recombination
    Hannah L Klein
    Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY 10016, USA
    Cell 149:257-9. 2012
    ..Zakharyevich et al. and De Muyt et al. now uncover a key role for Sgs1 in meiotic crossover regulation, which in turn reveals a joint molecule resolution pathway that produces the majority of crossovers in budding yeast...
  26. ncbi request reprint R we there yet? R-loop hazards to finishing the journey
    Catherine J Potenski
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 44:848-50. 2011
    ..2011) and Wahba et al. (2011), provide insight into how RNA:DNA hybrids lead to genetic instability...
  27. ncbi request reprint Role of Ser-53 phosphorylation in the activity of human translation initiation factor eIF-4E in mammalian and yeast cells
    Y Zhang
    Department of Biochemistry, New York University Medical Center, NY 10016, USA
    Gene 163:283-8. 1995
    ..These data demonstrate that Ser53 is not a requisite activating site for phosphorylation of mammalian eIF-4E in human or yeast cells, under conditions in which it participates in protein synthesis...
  28. ncbi request reprint Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin
    I E Vainberg
    Department of Biochemistry, New York University Medical Center, New York 10016, USA
    Cell 93:863-73. 1998
    ..We show that by directing target proteins to chaperonin, prefoldin promotes folding in an environment in which there are many competing pathways for nonnative proteins...
  29. ncbi request reprint Yeast recombination factor Rdh54 functionally interacts with the Rad51 recombinase and catalyzes Rad51 removal from DNA
    Peter Chi
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 281:26268-79. 2006
    ..Rad51 complex formation. The Rdh54 expression and purification procedures described here should facilitate the functional dissection of this DNA recombination/repair factor...
  30. doi request reprint Molecular biology: DNA endgames
    Hannah L Klein
    Nature 455:740-1. 2008
  31. pmc Mrc1 is required for sister chromatid cohesion to aid in recombination repair of spontaneous damage
    Hong Xu
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Mol Cell Biol 24:7082-90. 2004
    ....
  32. ncbi request reprint Biochemical and genetic characterization of Hmi1p, a yeast DNA helicase involved in the maintenance of mitochondrial DNA
    Danny S Monroe
    Department of Biology, University of North Carolina at Chapel Hill, NC 27599 2380, USA
    Yeast 22:1269-86. 2005
    ..The helicase activity, however, is not essential. Point mutants that lack ATPase/helicase activity partially complement a strain lacking Hmi1p. We suggest several possible roles for Hmi1p in mtDNA metabolism...