H L Klein

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc RDH54, a RAD54 homologue in Saccharomyces cerevisiae, is required for mitotic diploid-specific recombination and repair and for meiosis
    H L Klein
    Department of Biochemistry and Kaplan Cancer Center, New York University Medical Center, New York 10016, USA
    Genetics 147:1533-43. 1997
  2. pmc Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Delta with other DNA repair genes in Saccharomyces cerevisiae
    H L Klein
    Department of Biochemistry and Kaplan Cancer Center, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    Genetics 157:557-65. 2001
  3. pmc Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae
    H Y Fan
    Department of Biochemistry, New York University Medical Center, New York 10016
    Genetics 137:945-56. 1994
  4. pmc Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae
    H Y Fan
    Department of Biochemistry, New York University Medical Center, New York 10016, USA
    Genetics 142:749-59. 1996
  5. pmc The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene
    L Rong
    Department of Biochemistry, New York University Medical Center, New York 10016
    Genetics 127:75-85. 1991
  6. pmc HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene
    A Aguilera
    Department of Biochemistry, New York University Medical Center, New York 10016
    Mol Cell Biol 10:1439-51. 1990
  7. pmc Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants
    F Palladino
    Department of Biochemistry and Kaplan Cancer Center, New York University Medical Center, New York 10016
    Genetics 132:23-37. 1992
  8. ncbi request reprint Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae
    L Rong
    Department of Biochemistry, New York University Medical Center, New York 10016
    J Biol Chem 268:1252-9. 1993
  9. pmc High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability
    H Y Fan
    Department of Biochemistry and Kaplan Cancer Center, New York University Medical Center, New York, New York 10016, USA
    Mol Cell Biol 21:5459-70. 2001
  10. pmc Spontaneous chromosome loss in Saccharomyces cerevisiae is suppressed by DNA damage checkpoint functions
    H L Klein
    Department of Biochemistry and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Genetics 159:1501-9. 2001

Collaborators

Detail Information

Publications15

  1. pmc RDH54, a RAD54 homologue in Saccharomyces cerevisiae, is required for mitotic diploid-specific recombination and repair and for meiosis
    H L Klein
    Department of Biochemistry and Kaplan Cancer Center, New York University Medical Center, New York 10016, USA
    Genetics 147:1533-43. 1997
    ..The RDH54 gene is also required for meiosis as homozygous mutant diploids show very poor sporulation and reduced spore viability. The role of the RDH54 gene in mitotic repair and in meiosis and the pathway in which it acts are discussed...
  2. pmc Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Delta with other DNA repair genes in Saccharomyces cerevisiae
    H L Klein
    Department of Biochemistry and Kaplan Cancer Center, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    Genetics 157:557-65. 2001
    ..However, cells do not achieve wild-type growth rates, suggesting that unrepaired damage is still present and may lead to chromosome loss...
  3. pmc Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae
    H Y Fan
    Department of Biochemistry, New York University Medical Center, New York 10016
    Genetics 137:945-56. 1994
    ..The SOH1 gene has been cloned and sequenced. The null allele is 10-fold increased for recombination as measured by deletion of a leu2 direct repeat...
  4. pmc Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae
    H Y Fan
    Department of Biochemistry, New York University Medical Center, New York 10016, USA
    Genetics 142:749-59. 1996
    ..Because mutations in SOH1, RPB2 and SUA7 suppress the hyperrecombination phenotype of hpr1 mutants, this suggests a link between recombination in direct repeats and transcription...
  5. pmc The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene
    L Rong
    Department of Biochemistry, New York University Medical Center, New York 10016
    Genetics 127:75-85. 1991
    ..We propose that the HPR5 gene functions in the RAD6 repair pathway...
  6. pmc HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene
    A Aguilera
    Department of Biochemistry, New York University Medical Center, New York 10016
    Mol Cell Biol 10:1439-51. 1990
    ..We conclude that Hpr1 is a novel eucaryotic protein, mutation of which causes an increase in mitotic intrachromosomal excision recombination, and that it may be functionally related to an activity of the topoisomerase I protein...
  7. pmc Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants
    F Palladino
    Department of Biochemistry and Kaplan Cancer Center, New York University Medical Center, New York 10016
    Genetics 132:23-37. 1992
    ....
  8. ncbi request reprint Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae
    L Rong
    Department of Biochemistry, New York University Medical Center, New York 10016
    J Biol Chem 268:1252-9. 1993
    ..The carboxyl-terminal region of the protein is shown to contain a sequence for nuclear localization. Expression of the SRS2 in yeast was examined and found to be extremely low...
  9. pmc High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability
    H Y Fan
    Department of Biochemistry and Kaplan Cancer Center, New York University Medical Center, New York, New York 10016, USA
    Mol Cell Biol 21:5459-70. 2001
    ..The ability of a pre-mRNA splicing factor to suppress the hyperrecombination phenotype of a defective PolII complex raises the possibility of integrating transcription, RNA processing, and genome stability or a second role for SUB2...
  10. pmc Spontaneous chromosome loss in Saccharomyces cerevisiae is suppressed by DNA damage checkpoint functions
    H L Klein
    Department of Biochemistry and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Genetics 159:1501-9. 2001
    ..The mec1 checkpoint function mutant, defective in the yeast ATR homolog, results in increased recombination through a process that is distinct from that operative in wild-type cells...
  11. ncbi request reprint Role of Ser-53 phosphorylation in the activity of human translation initiation factor eIF-4E in mammalian and yeast cells
    Y Zhang
    Department of Biochemistry, New York University Medical Center, NY 10016, USA
    Gene 163:283-8. 1995
    ..These data demonstrate that Ser53 is not a requisite activating site for phosphorylation of mammalian eIF-4E in human or yeast cells, under conditions in which it participates in protein synthesis...
  12. ncbi request reprint Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin
    I E Vainberg
    Department of Biochemistry, New York University Medical Center, New York 10016, USA
    Cell 93:863-73. 1998
    ..We show that by directing target proteins to chaperonin, prefoldin promotes folding in an environment in which there are many competing pathways for nonnative proteins...
  13. ncbi request reprint Genetic control of intrachromosomal recombination
    H L Klein
    Department of Biochemistry, New York University Medical Center, NY 10016
    Bioessays 17:147-59. 1995
    ..RAD52-dependent events encompass all events that involve the initial steps of a recombination reaction, which include strand invasion to form a heteroduplex intermediate...
  14. pmc The Saccharomyces cerevisiae hyperrecombination mutant hpr1Delta is synthetically lethal with two conditional alleles of the acetyl coenzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA
    R Schneiter
    Institut fur Biochemie und Lebensmittelchemie, Technische Universitat Graz, A 8010 Graz, Austria
    Mol Cell Biol 19:3415-22. 1999
    ....
  15. pmc Genetic control of intrachromosomal recombination in Saccharomyces cerevisiae. I. Isolation and genetic characterization of hyper-recombination mutations
    A Aguilera
    Department of Biochemistry, New York University, New York 10016
    Genetics 119:779-90. 1988
    ..Further studies are required to show whether different recombination pathways or different outcomes of the same recombination pathway are controlled by the genes identified in this study...