Jian Kang

Summary

Affiliation: New York Medical College
Country: USA

Publications

  1. pmc Enteroaggregative Escherichia coli flagellin-induced interleukin-8 secretion requires Toll-like receptor 5-dependent p38 MAP kinase activation
    Mohammed A S Khan
    Division of Infectious Diseases, University of British Columbia, Vancouver Hospital and Health Sciences Centre, 2733 Heather Street, Vancouver, BC V5Z 3J5 Canada
    Immunology 112:651-60. 2004
  2. ncbi request reprint Astrocyte-mediated potentiation of inhibitory synaptic transmission
    J Kang
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla 10595, USA
    Nat Neurosci 1:683-92. 1998
  3. pmc Sulforhodamine 101 induces long-term potentiation of intrinsic excitability and synaptic efficacy in hippocampal CA1 pyramidal neurons
    J Kang
    Department of Cell Biology and Anatomy, New York Medical College, Basic Science Building, Valhalla, NY 10595, USA
    Neuroscience 169:1601-9. 2010
  4. pmc Connexin 43 hemichannels are permeable to ATP
    Jian Kang
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 28:4702-11. 2008
  5. ncbi request reprint Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons
    Ning Kang
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, 10595, USA
    J Neurophysiol 94:4121-30. 2005
  6. doi request reprint A central role of connexin 43 in hypoxic preconditioning
    Jane H C Lin
    Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 28:681-95. 2008
  7. pmc Intercellular calcium signaling mediated by point-source burst release of ATP
    Gregory Arcuino
    Department of Cell Biology, Anatomy, and Pathology, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 99:9840-5. 2002
  8. ncbi request reprint Presynaptic inactivation of action potentials and postsynaptic inhibition of GABAA currents contribute to KA-induced disinhibition in CA1 pyramidal neurons
    Ning Kang
    Dept of Cell Biology and Anatomy, New York Medical College, Basic Science Bldg, Rm 220, Valhalla, NY 10595, USA
    J Neurophysiol 92:873-82. 2004
  9. pmc Astrocyte-mediated activation of neuronal kainate receptors
    Qing Song Liu
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 101:3172-7. 2004
  10. ncbi request reprint Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons
    Jun Xu
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 25:1750-60. 2005

Collaborators

Detail Information

Publications34

  1. pmc Enteroaggregative Escherichia coli flagellin-induced interleukin-8 secretion requires Toll-like receptor 5-dependent p38 MAP kinase activation
    Mohammed A S Khan
    Division of Infectious Diseases, University of British Columbia, Vancouver Hospital and Health Sciences Centre, 2733 Heather Street, Vancouver, BC V5Z 3J5 Canada
    Immunology 112:651-60. 2004
    ....
  2. ncbi request reprint Astrocyte-mediated potentiation of inhibitory synaptic transmission
    J Kang
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla 10595, USA
    Nat Neurosci 1:683-92. 1998
    ..Astrocytes may therefore be a necessary intermediary in activity-dependent modulation of inhibitory synapses in the hippocampus...
  3. pmc Sulforhodamine 101 induces long-term potentiation of intrinsic excitability and synaptic efficacy in hippocampal CA1 pyramidal neurons
    J Kang
    Department of Cell Biology and Anatomy, New York Medical College, Basic Science Building, Valhalla, NY 10595, USA
    Neuroscience 169:1601-9. 2010
    ..As such, SR101 can be used as an experimental tool to induce epileptic seizures...
  4. pmc Connexin 43 hemichannels are permeable to ATP
    Jian Kang
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 28:4702-11. 2008
    ..Furthermore, a putative Cx43 hemichannel with characteristics identical to the Cx43 hemichannel in C6 cells was identified in the membrane of hippocampal astrocytes in acutely prepared slices...
  5. ncbi request reprint Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons
    Ning Kang
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, 10595, USA
    J Neurophysiol 94:4121-30. 2005
    ..Our study provides a novel mechanism, astrocytic release of glutamate, for seizure initiation...
  6. doi request reprint A central role of connexin 43 in hypoxic preconditioning
    Jane H C Lin
    Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 28:681-95. 2008
    ..Thus, adaptive modulation of Cx43 can offset environmental stress by adenosine-mediated elevation of cellular resistance...
  7. pmc Intercellular calcium signaling mediated by point-source burst release of ATP
    Gregory Arcuino
    Department of Cell Biology, Anatomy, and Pathology, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 99:9840-5. 2002
    ....
  8. ncbi request reprint Presynaptic inactivation of action potentials and postsynaptic inhibition of GABAA currents contribute to KA-induced disinhibition in CA1 pyramidal neurons
    Ning Kang
    Dept of Cell Biology and Anatomy, New York Medical College, Basic Science Bldg, Rm 220, Valhalla, NY 10595, USA
    J Neurophysiol 92:873-82. 2004
    ..Thus the postsynaptic KAR-mediated inhibition of GABA(A) currents may contribute to the KAR agonist-induced decrease in the potency of uIPSCs and KA-induced disinhibition...
  9. pmc Astrocyte-mediated activation of neuronal kainate receptors
    Qing Song Liu
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 101:3172-7. 2004
    ..By modulating the activity of interneurons, astrocytes may play a critical role in circuit function of hippocampus...
  10. ncbi request reprint Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons
    Jun Xu
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 25:1750-60. 2005
    ..This new form of hippocampal neuronal plasticity could be a cellular correlate of learning and memory besides synaptic LTP...
  11. ncbi request reprint The mechanisms and functions of activity-dependent long-term potentiation of intrinsic excitability
    Jun Xu
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    Rev Neurosci 16:311-23. 2005
    ..These intrinsic plasticities and their cooperation enrich the functions fulfilled by neurons, and may serve as a supplementary mechanism for learning and memory...
  12. pmc Two distinct modes of exocytotic fusion pore expansion in large astrocytic vesicles
    Hong Peng
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    J Biol Chem 288:16872-81. 2013
    ..Two modes of fusion pore formation demonstrate a novel mechanism underlying fusion pore expansion and provide a new explanation for full and partial collapses of large secretory vesicles...
  13. ncbi request reprint Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells
    Jane H C Lin
    Departments of Pathology and Anatomy and Cell Biology, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 22:4302-11. 2002
    ....
  14. ncbi request reprint A kainate receptor increases the efficacy of GABAergic synapses
    L Jiang
    Department of Cell Biology and Anatomy, New York Medical College, Basic Science Building, Room 220, Valhalla, NY 10595, USA
    Neuron 30:503-13. 2001
    ..The results suggest that glutamate released from excitatory synapses may also function as an intermediary between excitatory and inhibitory synapses to protect overexcitation of local circuits...
  15. pmc Receptor-mediated glutamate release from volume sensitive channels in astrocytes
    Takahiro Takano
    Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 102:16466-71. 2005
    ..Our observations indicate that volume-sensitive channel may constitute a previously uncharacterized target for modulation of astrocyte-neuronal interactions...
  16. ncbi request reprint Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells
    Neeta Singh Roy
    Department of Neurology, Cornell University Medical College, NYC, NY 10021, USA
    Exp Neurol 196:224-34. 2005
    ..These results suggest the utility of promoter/enhancer-based FACS for the isolation of specific phenotypes from hES cell populations as a means of purifying clinically appropriate vectors for cell therapy...
  17. pmc Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair
    Jian Kang
    Section of Molecular Biology, Division of Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0322, USA
    EMBO J 21:1447-55. 2002
    ..Thus, NBS1 and ATM have overlapping and distinct functions in animal development and DNA repair...
  18. doi request reprint Surgical embryo transfer resulted in birth of live offspring in farmed blue fox
    Guo Shi Liu
    Laboratory of Animal Embryonic Biotechnology, College of Animal Science and Technology, China Agricultural University, Beijing, PR China
    Anim Reprod Sci 105:424-9. 2008
    ..Two of the recipients littered 46-49 days after embryo transfer; one gave birth to 7 pups and the other 1 pup. This report describes the first successful embryo transfer in the farmed blue fox in China...
  19. doi request reprint Adenovirus-mediated intra-arterial delivery of cellular repressor of E1A-stimulated genes inhibits neointima formation in rabbits after balloon injury
    Yaling Han
    Cardiovascular Research Institute and Department of Cardiology, Shenyang Northern Hospital, Shenyang, China
    J Vasc Surg 48:201-9. 2008
    ..This study examined the effect on neointimal hyperplasia of adenovirus-mediated delivery of cellular repressor of E1A-stimulated genes (CREG) to the artery after balloon injury...
  20. ncbi request reprint Extracellular matrix secreted by senescent fibroblasts induced by UVB promotes cell proliferation in HaCaT cells through PI3K/AKT and ERK signaling pathways
    Jian Kang
    Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, P R China
    Int J Mol Med 21:777-84. 2008
    ..Pharmacological manipulation of those signaling components may lead to the prevention and treatment of skin cancer induced by chronic solar exposure...
  21. ncbi request reprint Association of connexin 37 gene polymorphisms with risk of coronary artery disease in northern Han Chinese
    Yaling Han
    Department of Cardiology, Cardiovascular Research Institute, Northern Hospital, Shenyang, China
    Cardiology 110:260-5. 2008
    ..The aim of our study is to investigate the association between 3 GJA4 gene polymorphisms (-1930C/T, C1019T and I1297D) and the susceptibility to CAD in northern Han Chinese...
  22. ncbi request reprint Estrogen-eluting stent implantation inhibits neointimal formation and extracellular signal-regulated kinase activation
    Yaling Han
    Department of Cardiology, Cardiovascular Research Institute, Shenyang Northern Hospital, Shenyang, China
    Catheter Cardiovasc Interv 70:647-53. 2007
    ..Preliminary trial of estrogen-eluting stent implantation in patients with coronary disease also suggests a reduction in restenosis...
  23. ncbi request reprint Glutamate-induced exocytosis of glutamate from astrocytes
    Jun Xu
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institutes, University of Texas Southwestern Medical Center, Dallas Texas 75390, USA
    J Biol Chem 282:24185-97. 2007
    ..These large vesicles could play important roles in the feedback control of neuronal circuits and epileptic seizures...
  24. ncbi request reprint [Association of C1019T polymorphism in the connexin 37 gene and coronary artery disease in Chinese Han population]
    Ya Ling Han
    Department of Cardiology, Shenyang General Hospital, Cardiovascular Research Institute of PLA, Shenyang 110016, China
    Zhonghua Yi Xue Za Zhi 87:100-4. 2007
    ..To investigate the association between the connexin 37 (CX37) C1019T polymorphism and the susceptibility to coronary artery disease (CAD) in northern Han population of China...
  25. ncbi request reprint [Cardioprotective effects of sodium ferulate mediated by nitric oxide on ischemia-reperfusion injured myocardium: experiment with isolated rat hearts]
    Ji chun Liu
    Department of Cardiothoracic Surgery, First Affiliated Hospital, Nanchang University, Nanchang 330006, China
    Zhonghua Yi Xue Za Zhi 86:987-91. 2006
    ..To investigate the cardioprotective effects of sodium ferulate (SF) mediated by nitric oxide on ischemia-reperfusion injured myocardium...
  26. pmc Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression
    Jian Kang
    Division of Biological Sciences, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0322, USA
    Mol Cell Biol 25:661-70. 2005
    ..Therefore, NBS1, H2AX, and p53 play synergistic roles in ATM-dependent DNA damage responses and tumor suppression...
  27. ncbi request reprint Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord
    Neeta S Roy
    Department of Neurology and Neuroscience, Cornell University Medical Center, New York, New York 10021, USA
    Nat Biotechnol 22:297-305. 2004
    ..The cells have survived >168 doublings in vitro, with karyotypic normalcy and without replicative senescence. hTERT overexpression thus permits the generation of progenitor lines able to give rise to phenotypically restricted neurons...
  28. ncbi request reprint [Cell apoptosis and the change of Fas/FasL gene in experimental pulmonary fibrosis]
    Jin Zhao Li
    Institute of Respiratory Disease, First Affiliated Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Jie He He Hu Xi Za Zhi 28:184-7. 2005
    ..To investigate the changes and significance of cell apoptosis and Fas/FasL gene in pulmonary fibrosis...
  29. pmc An astrocytic basis of epilepsy
    Guo Feng Tian
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Med 11:973-81. 2005
    ..Our results show an unanticipated key role for astrocytes in seizure activity. As such, these findings identify astrocytes as a proximal target for the treatment of epileptic disorders...
  30. ncbi request reprint Experimental treatment of human neuroblastoma using live-attenuated poliovirus
    Hidemi Toyoda
    Department of Pediatrics, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Oncol 24:49-58. 2004
    ....
  31. ncbi request reprint Expression of short-form caspase 8 correlates with decreased sensitivity to Fas-mediated apoptosis in neuroblastoma cells
    Rodrick R Kisenge
    Department of Pediatrics, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Cancer Sci 94:598-605. 2003
    ..These results indicate that the profile of caspase 8 expression is an important determinant of the response of neuroblastoma cells to Fas-mediated cell death...
  32. ncbi request reprint Lenalidomide inhibits proliferation of Namalwa CSN.70 cells and interferes with Gab1 phosphorylation and adaptor protein complex assembly
    Anita K Gandhi
    Celgene Corporation, 86 Morris Avenue, Summit, NJ 07901, United States
    Leuk Res 30:849-58. 2006
    ..These studies provide evidence for the mechanism of action of lenalidomide in chromosome 5 deleted hematopoietic tumors in vitro, and may provide a better understanding of the drug's activity in clinical applications...
  33. ncbi request reprint [The effect of TNP-470 on the proliferation and apoptosis of lung adenocarcinoma cells]
    Xiaochun Ma
    Institute of Respiratory Disease, The First Clinical College, China Medical University, Shenyang 110001, China
    Zhonghua Nei Ke Za Zhi 41:244-7. 2002
    ..To investigate the effect of TNP-470 on the proliferation and apoptosis of lung adenocarcinoma cells and to explore the mechanism of the effect...
  34. ncbi request reprint Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo
    Xiaohai Wang
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:816-23. 2006
    ..These findings indicate that astrocytes respond to synaptic input, by means of spillover or ectopic release of glutamate, and that increases in astrocytic Ca(2+) occur independently of postsynaptic excitatory activity...

Research Grants6

  1. DIFFERENTIAL MODULATION OF GABAERGIC SYNAPSES BY KARS
    Jian Kang; Fiscal Year: 2001
    ..The KAR-mediated modulation of GABAergic synapses provides a fundamental new mechanism for glutamate-mediated interaction between excitatory and inhibitory synapses. ..
  2. DIFFERENTIAL MODULATION OF GABAERGIC SYNAPSES BY KARS
    Jian Kang; Fiscal Year: 2002
    ..The KAR-mediated modulation of GABAergic synapses provides a fundamental new mechanism for glutamate-mediated interaction between excitatory and inhibitory synapses. ..
  3. ASTROCYTE MEDIATED LTP
    Jian Kang; Fiscal Year: 2002
    ....
  4. DIFFERENTIAL MODULATION OF GABAERGIC SYNAPSES BY KARS
    Jian Kang; Fiscal Year: 2003
    ..The KAR-mediated modulation of GABAergic synapses provides a fundamental new mechanism for glutamate-mediated interaction between excitatory and inhibitory synapses. ..
  5. DIFFERENTIAL MODULATION OF GABAERGIC SYNAPSES BY KARS
    Jian Kang; Fiscal Year: 2004
    ..The KAR-mediated modulation of GABAergic synapses provides a fundamental new mechanism for glutamate-mediated interaction between excitatory and inhibitory synapses. ..
  6. DIFFERENTIAL MODULATION OF GABAERGIC SYNAPSES BY KARS
    Jian Kang; Fiscal Year: 2005
    ..The KAR-mediated modulation of GABAergic synapses provides a fundamental new mechanism for glutamate-mediated interaction between excitatory and inhibitory synapses. ..