Research Topics
Species | Jian KangSummaryAffiliation: New York Medical College Country: USA Publications
Research Grants
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Detail Information
Publications
Enteroaggregative Escherichia coli flagellin-induced interleukin-8 secretion requires Toll-like receptor 5-dependent p38 MAP kinase activationMohammed A S Khan
Division of Infectious Diseases, University of British Columbia, Vancouver Hospital and Health Sciences Centre, 2733 Heather Street, Vancouver, BC V5Z 3J5 Canada
Immunology 112:651-60. 2004....
Astrocyte-mediated potentiation of inhibitory synaptic transmissionJ Kang
Department of Cell Biology and Anatomy, New York Medical College, Valhalla 10595, USA
Nat Neurosci 1:683-92. 1998..Astrocytes may therefore be a necessary intermediary in activity-dependent modulation of inhibitory synapses in the hippocampus...
Connexin 43 hemichannels are permeable to ATPJian Kang
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 28:4702-11. 2008..Furthermore, a putative Cx43 hemichannel with characteristics identical to the Cx43 hemichannel in C6 cells was identified in the membrane of hippocampal astrocytes in acutely prepared slices...- Sulforhodamine 101 induces long-term potentiation of intrinsic excitability and synaptic efficacy in hippocampal CA1 pyramidal neuronsJ Kang
Department of Cell Biology and Anatomy, New York Medical College, Basic Science Building, Valhalla, NY 10595, USA
Neuroscience 169:1601-9. 2010..As such, SR101 can be used as an experimental tool to induce epileptic seizures... - Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neuronsNing Kang
Department. of Cell Biology and Anatomy, New York Medical College, Valhalla, 10595, USA
J Neurophysiol 94:4121-30. 2005..Our study provides a novel mechanism, astrocytic release of glutamate, for seizure initiation... - A central role of connexin 43 in hypoxic preconditioningJane H C Lin
Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 28:681-95. 2008..Thus, adaptive modulation of Cx43 can offset environmental stress by adenosine-mediated elevation of cellular resistance... - Presynaptic inactivation of action potentials and postsynaptic inhibition of GABAA currents contribute to KA-induced disinhibition in CA1 pyramidal neuronsNing Kang
Dept. of Cell Biology and Anatomy, New York Medical College, Basic Science Bldg, Rm. 220, Valhalla, NY 10595, USA
J Neurophysiol 92:873-82. 2004..Thus the postsynaptic KAR-mediated inhibition of GABA(A) currents may contribute to the KAR agonist-induced decrease in the potency of uIPSCs and KA-induced disinhibition... - Intercellular calcium signaling mediated by point-source burst release of ATPGregory Arcuino
Department of Cell Biology, Anatomy, and Pathology, New York Medical College, Valhalla, NY 10595, USA
Proc Natl Acad Sci U S A 99:9840-5. 2002.... - Astrocyte-mediated activation of neuronal kainate receptorsQing Song Liu
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
Proc Natl Acad Sci U S A 101:3172-7. 2004..By modulating the activity of interneurons, astrocytes may play a critical role in circuit function of hippocampus... - Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neuronsJun Xu
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 25:1750-60. 2005..This new form of hippocampal neuronal plasticity could be a cellular correlate of learning and memory besides synaptic LTP... - The mechanisms and functions of activity-dependent long-term potentiation of intrinsic excitabilityJun Xu
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
Rev Neurosci 16:311-23. 2005..These intrinsic plasticities and their cooperation enrich the functions fulfilled by neurons, and may serve as a supplementary mechanism for learning and memory... - Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cellsJane H C Lin
Departments of Pathology and Anatomy and Cell Biology, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 22:4302-11. 2002.... - A kainate receptor increases the efficacy of GABAergic synapsesL Jiang
Department of Cell Biology and Anatomy, New York Medical College, Basic Science Building, Room 220, Valhalla, NY 10595, USA
Neuron 30:503-13. 2001..The results suggest that glutamate released from excitatory synapses may also function as an intermediary between excitatory and inhibitory synapses to protect overexcitation of local circuits... - Receptor-mediated glutamate release from volume sensitive channels in astrocytesTakahiro Takano
Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 102:16466-71. 2005..Our observations indicate that volume-sensitive channel may constitute a previously uncharacterized target for modulation of astrocyte-neuronal interactions... - Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cellsNeeta Singh Roy
Department of Neurology, Cornell University Medical College, NYC, NY 10021, USA
Exp Neurol 196:224-34. 2005..These results suggest the utility of promoter/enhancer-based FACS for the isolation of specific phenotypes from hES cell populations as a means of purifying clinically appropriate vectors for cell therapy... - Glutamate-induced exocytosis of glutamate from astrocytesJun Xu
Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institutes, University of Texas Southwestern Medical Center, Dallas Texas 75390, USA
J Biol Chem 282:24185-97. 2007..These large vesicles could play important roles in the feedback control of neuronal circuits and epileptic seizures... - Estrogen-eluting stent implantation inhibits neointimal formation and extracellular signal-regulated kinase activationYaling Han
Department of Cardiology, Cardiovascular Research Institute, Shenyang Northern Hospital, Shenyang, China
Catheter Cardiovasc Interv 70:647-53. 2007..Preliminary trial of estrogen-eluting stent implantation in patients with coronary disease also suggests a reduction in restenosis... - Association of connexin 37 gene polymorphisms with risk of coronary artery disease in northern Han ChineseYaling Han
Department of Cardiology, Cardiovascular Research Institute, Northern Hospital, Shenyang, China
Cardiology 110:260-5. 2008..The aim of our study is to investigate the association between 3 GJA4 gene polymorphisms (-1930C/T, C1019T and I1297D) and the susceptibility to CAD in northern Han Chinese... - [The effect of TNP-470 on the proliferation and apoptosis of lung adenocarcinoma cells]Xiaochun Ma
Institute of Respiratory Disease, The First Clinical College, China Medical University, Shenyang 110001, China
Zhonghua Nei Ke Za Zhi 41:244-7. 2002..CONCLUSION: TNP-470 could inhibit the proliferation and promote the apoptosis of lung adenocarcinoma cells through reduction of the VEGF autocrine and down-regulation of the VEGF receptor... - Surgical embryo transfer resulted in birth of live offspring in farmed blue foxGuo Shi Liu
Laboratory of Animal Embryonic Biotechnology, College of Animal Science and Technology, China Agricultural University, Beijing, PR China
Anim Reprod Sci 105:424-9. 2008..Two of the recipients littered 46-49 days after embryo transfer; one gave birth to 7 pups and the other 1 pup. This report describes the first successful embryo transfer in the farmed blue fox in China... - Adenovirus-mediated intra-arterial delivery of cellular repressor of E1A-stimulated genes inhibits neointima formation in rabbits after balloon injuryYaling Han
Cardiovascular Research Institute and Department of Cardiology, Shenyang Northern Hospital, Shenyang, China
J Vasc Surg 48:201-9. 2008..This study examined the effect on neointimal hyperplasia of adenovirus-mediated delivery of cellular repressor of E1A-stimulated genes (CREG) to the artery after balloon injury... - Extracellular matrix secreted by senescent fibroblasts induced by UVB promotes cell proliferation in HaCaT cells through PI3K/AKT and ERK signaling pathwaysJian Kang
Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, P R China
Int J Mol Med 21:777-84. 2008..Pharmacological manipulation of those signaling components may lead to the prevention and treatment of skin cancer induced by chronic solar exposure... - [Association of C1019T polymorphism in the connexin 37 gene and coronary artery disease in Chinese Han population]Ya Ling Han
Department of Cardiology, Shenyang General Hospital, Cardiovascular Research Institute of PLA, Shenyang 110016, China
Zhonghua Yi Xue Za Zhi 87:100-4. 2007..To investigate the association between the connexin 37 (CX37) C1019T polymorphism and the susceptibility to coronary artery disease (CAD) in northern Han population of China... - [Cardioprotective effects of sodium ferulate mediated by nitric oxide on ischemia-reperfusion injured myocardium: experiment with isolated rat hearts]Ji chun Liu
Department of Cardiothoracic Surgery, First Affiliated Hospital, Nanchang University, Nanchang 330006, China
Zhonghua Yi Xue Za Zhi 86:987-91. 2006..To investigate the cardioprotective effects of sodium ferulate (SF) mediated by nitric oxide on ischemia-reperfusion injured myocardium... - Astrocytic Ca2+ signaling evoked by sensory stimulation in vivoXiaohai Wang
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Nat Neurosci 9:816-23. 2006..These findings indicate that astrocytes respond to synaptic input, by means of spillover or ectopic release of glutamate, and that increases in astrocytic Ca(2+) occur independently of postsynaptic excitatory activity... - Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppressionJian Kang
Division of Biological Sciences, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0322, USA
Mol Cell Biol 25:661-70. 2005..Therefore, NBS1, H2AX, and p53 play synergistic roles in ATM-dependent DNA damage responses and tumor suppression... - Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cordNeeta S Roy
Department of Neurology and Neuroscience, Cornell University Medical Center, New York, New York 10021, USA
Nat Biotechnol 22:297-305. 2004..The cells have survived >168 doublings in vitro, with karyotypic normalcy and without replicative senescence. hTERT overexpression thus permits the generation of progenitor lines able to give rise to phenotypically restricted neurons... - [Cell apoptosis and the change of Fas/FasL gene in experimental pulmonary fibrosis.]Jin-zhao Li
Institute of Respiratory Disease, First Affiliated Hospital, China Medical University, Shenyang 110001, China
Zhonghua Jie He He Hu Xi Za Zhi 28:184-7. 2005..03, 12.81, < 0.01). CONCLUSION: The apoptosis index of lung cells, Fas/FasL genes and protein were up-regulated in lung tissue of pulmonary fibrosis, which may play an important role in the development of disease... - An astrocytic basis of epilepsyGuo-Feng Tian
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Nat Med 11:973-81. 2005..Our results show an unanticipated key role for astrocytes in seizure activity. As such, these findings identify astrocytes as a proximal target for the treatment of epileptic disorders... - Targeted disruption of NBS1 reveals its roles in mouse development and DNA repairJian Kang
Section of Molecular Biology, Division of Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0322, USA
EMBO J 21:1447-55. 2002..Thus, NBS1 and ATM have overlapping and distinct functions in animal development and DNA repair... - Experimental treatment of human neuroblastoma using live-attenuated poliovirusHidemi Toyoda
Department of Pediatrics, Mie University School of Medicine, Tsu, Mie 514-8507, Japan
Int J Oncol 24:49-58. 2004.... - Lenalidomide inhibits proliferation of Namalwa CSN.70 cells and interferes with Gab1 phosphorylation and adaptor protein complex assemblyAnita K Gandhi
Celgene Corporation, 86 Morris Avenue, Summit, NJ 07901, United States
Leuk Res 30:849-58. 2006..These studies provide evidence for the mechanism of action of lenalidomide in chromosome 5 deleted hematopoietic tumors in vitro, and may provide a better understanding of the drug's activity in clinical applications... - Expression of short-form caspase 8 correlates with decreased sensitivity to Fas-mediated apoptosis in neuroblastoma cellsRodrick R Kisenge
Department of Pediatrics, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
Cancer Sci 94:598-605. 2003..These results indicate that the profile of caspase 8 expression is an important determinant of the response of neuroblastoma cells to Fas-mediated cell death...
Research Grants
- ASTROCYTE MEDIATED LTPJian Kang; Fiscal Year: 2002....
- DIFFERENTIAL MODULATION OF GABAERGIC SYNAPSES BY KARSJian Kang; Fiscal Year: 2005..The KAR-mediated modulation of GABAergic synapses provides a fundamental new mechanism for glutamate-mediated interaction between excitatory and inhibitory synapses. ..