J Kajstura

Summary

Affiliation: New York Medical College
Country: USA

Publications

  1. ncbi request reprint Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression
    Daniele Torella
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 94:514-24. 2004
  2. ncbi request reprint The telomere-telomerase axis and the heart
    Jan Kajstura
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Antioxid Redox Signal 8:2125-41. 2006
  3. pmc Telomere shortening is an in vivo marker of myocyte replication and aging
    J Kajstura
    Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Am J Pathol 156:813-9. 2000
  4. ncbi request reprint Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion
    Jan Kajstura
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 96:127-37. 2005
  5. ncbi request reprint IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress
    J Kajstura
    Department of Medicine, New York Medical College, Vosburgh Pavilion, Valhalla, New York, USA
    Diabetes 50:1414-24. 2001
  6. ncbi request reprint Canine ventricular myocytes possess a renin-angiotensin system that is upregulated with heart failure
    L Barlucchi
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 88:298-304. 2001
  7. pmc Inhibition of p53 function prevents renin-angiotensin system activation and stretch-mediated myocyte apoptosis
    A Leri
    Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Am J Pathol 157:843-57. 2000
  8. pmc Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart
    A Leri
    Departments of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 98:8626-31. 2001
  9. pmc Up-regulation of AT(1) and AT(2) receptors in postinfarcted hypertrophied myocytes and stretch-mediated apoptotic cell death
    A Leri
    Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Am J Pathol 156:1663-72. 2000
  10. ncbi request reprint Evidence that human cardiac myocytes divide after myocardial infarction
    A P Beltrami
    Department of Medicine, New York Medical College, Valhalla 10595, USA
    N Engl J Med 344:1750-7. 2001

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression
    Daniele Torella
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 94:514-24. 2004
    ..The differential response of TG mice to chronological age may result from preservation of functional CSCs undergoing myocyte commitment. In conclusion, senescence of CSCs and myocytes conditions the development of an aging myopathy...
  2. ncbi request reprint The telomere-telomerase axis and the heart
    Jan Kajstura
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Antioxid Redox Signal 8:2125-41. 2006
    ....
  3. pmc Telomere shortening is an in vivo marker of myocyte replication and aging
    J Kajstura
    Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Am J Pathol 156:813-9. 2000
    ..In conclusion, a significant fraction of myocytes divides repeatedly from birth to senescence, counteracting the continuous death of cells in the aging mammalian rat heart...
  4. ncbi request reprint Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion
    Jan Kajstura
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 96:127-37. 2005
    ..In conclusion, BMCs adopt the cardiac cell lineages and have an important therapeutic impact on ischemic heart failure...
  5. ncbi request reprint IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress
    J Kajstura
    Department of Medicine, New York Medical College, Vosburgh Pavilion, Valhalla, New York, USA
    Diabetes 50:1414-24. 2001
    ..This latter event might be responsible for the decrease in oxidative stress and myocyte death by IGF-1...
  6. ncbi request reprint Canine ventricular myocytes possess a renin-angiotensin system that is upregulated with heart failure
    L Barlucchi
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 88:298-304. 2001
    ..Ang II may promote myocyte growth and death, contributing to the development of heart failure...
  7. pmc Inhibition of p53 function prevents renin-angiotensin system activation and stretch-mediated myocyte apoptosis
    A Leri
    Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Am J Pathol 157:843-57. 2000
    ..Thus, a competitor of p53 function interfered with both stretch-induced Ang II formation and apoptosis, indicating that p53 is a major modulator of myocyte renin-angiotensin system and cell survival after mechanical deformation...
  8. pmc Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart
    A Leri
    Departments of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 98:8626-31. 2001
    ....
  9. pmc Up-regulation of AT(1) and AT(2) receptors in postinfarcted hypertrophied myocytes and stretch-mediated apoptotic cell death
    A Leri
    Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Am J Pathol 156:1663-72. 2000
    ..In conclusion, Ang II stimulated cell death through AT(1) receptor activation, whereas ligand binding to AT(2) receptor did not alter Ang II concentration and apoptosis in normal and postinfarcted hypertrophied myocytes...
  10. ncbi request reprint Evidence that human cardiac myocytes divide after myocardial infarction
    A P Beltrami
    Department of Medicine, New York Medical College, Valhalla 10595, USA
    N Engl J Med 344:1750-7. 2001
    ..CONCLUSIONS: Our results challenge the dogma that the adult heart is a postmitotic organ and indicate that the regeneration of myocytes may be a critical component of the increase in muscle mass of the myocardium...
  11. ncbi request reprint Overexpression of insulin-like growth factor-1 attenuates the myocyte renin-angiotensin system in transgenic mice
    A Leri
    Department of Medicine, New York Medical College, Valhalla, NY, USA
    Circ Res 84:752-62. 1999
    ..This may represent the molecular mechanism responsible for the effects of IGF-1 on cell viability and myocyte hypertrophy in the nonpathological and pathological heart in vivo...
  12. pmc Mobilized bone marrow cells repair the infarcted heart, improving function and survival
    D Orlic
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 98:10344-9. 2001
    ..In conclusion, mobilization of primitive BMC by cytokines might offer a noninvasive therapeutic strategy for the regeneration of the myocardium lost as a result of ischemic heart disease and, perhaps, other forms of cardiac pathology...
  13. ncbi request reprint Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
    ..The existence of these cells opens new opportunities for myocardial repair...
  14. ncbi request reprint Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death
    F Fiordaliso
    Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Diabetes 50:2363-75. 2001
    ..In conclusion, these in vitro results support the notion that hyperglycemia with diabetes promotes myocyte apoptosis mediated by activation of p53 and effector responses involving the local renin-angiotensin system...
  15. ncbi request reprint Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy
    D Cesselli
    Department of Medicine, New York Medical College, Valhalla, NY, USA
    Circ Res 89:279-86. 2001
    ..In conclusion, cardiac cell death precedes ventricular decompensation and correlates with the time-dependent deterioration of function in this model. Oxidative stress may be critical for activation of apoptosis in the overloaded heart...
  16. ncbi request reprint Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene
    Marcello Rota
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 99:42-52. 2006
    ..Together, these data point to a genetic link between diabetes and ROS, on the one hand, and CPC survival and growth, on the other...
  17. pmc Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function
    Axel Linke
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 102:8966-71. 2005
    ..These results suggest that strategies capable of activating the growth reserve of the myocardium may be important in cardiac repair after ischemic injury...
  18. pmc Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice
    K Reiss
    Department of Medicine, New York Medical College, Valhalla 10595, USA
    Proc Natl Acad Sci U S A 93:8630-5. 1996
    ..In contrast, myocyte cell volume was comparable in transgenic and control mice at all ages. In conclusion, overexpression of IGF-1 in myocytes leads to cardiomegaly mediated by an increased number of cells in the heart...
  19. ncbi request reprint Telomerase activity in rat cardiac myocytes is age and gender dependent
    A Leri
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    J Mol Cell Cardiol 32:385-90. 2000
    ..The greater growth potential of female myocytes may be critical for the longer lifespan and decreased incidence of heart failure in women...
  20. pmc Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure
    Konrad Urbanek
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 102:8692-7. 2005
    ..The loss of functionally competent CSCs in chronic ischemic cardiomyopathy may underlie the progressive functional deterioration and the onset of terminal failure...
  21. pmc Progenitor cells from the explanted heart generate immunocompatible myocardium within the transplanted donor heart
    David A D'Alessandro
    Department of Cardiothoracic Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, New York, USA
    Circ Res 105:1128-40. 2009
    ..Chronic rejection, accelerated coronary atherosclerosis, myocardial infarction, and ischemic heart failure determine the unfavorable evolution of the transplanted heart in humans...
  22. pmc Formation of large coronary arteries by cardiac progenitor cells
    Jochen Tillmanns
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 105:1668-73. 2008
    ..In conclusion, locally delivered activated CPCs generate de novo coronary vasculature and may be implemented clinically for restoration of blood supply to the ischemic myocardium...
  23. pmc Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy
    Konrad Urbanek
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 100:10440-5. 2003
    ..Their presence is consistent with the notion that myocyte hyperplasia significantly contributes to cardiac hypertrophy and accounts for the subpopulation of cycling myocytes...
  24. ncbi request reprint Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival
    Konrad Urbanek
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 97:663-73. 2005
    ..In conclusion, the heart has an endogenous reserve of CSCs-ECCs that can be activated to reconstitute dead myocardium and recover cardiac function...
  25. pmc Bone marrow cells adopt the cardiomyogenic fate in vivo
    Marcello Rota
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 104:17783-8. 2007
    ..This process occurs independently of cell fusion and ameliorates structurally and functionally the outcome of the heart after infarction...
  26. pmc Human cardiac stem cells
    Claudia Bearzi
    Department of Medicine, Cardiovascular Research Institute, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 104:14068-73. 2007
    ..Thus, hCSCs can be isolated and expanded in vitro for subsequent autologous regeneration of dead myocardium in patients affected by heart failure of ischemic and nonischemic origin...
  27. ncbi request reprint Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure
    Cristina Chimenti
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Vosburgh Pavilion, Room 302, Valhalla, NY 10595, USA
    Circ Res 93:604-13. 2003
    ..In conclusion, telomere erosion, cellular senescence, and death characterize aged diseased hearts and the development of cardiac failure in humans...
  28. ncbi request reprint Chimerism of the transplanted heart
    Federico Quaini
    Department of Medicine, New York Medical College, Valhalla 10595, USA
    N Engl J Med 346:5-15. 2002
    ..The Y chromosome can be used to detect migrated undifferentiated cells expressing stem-cell antigens and to discriminate between primitive cells derived from the recipient and those derived from the donor...
  29. pmc Stem cell niches in the adult mouse heart
    Konrad Urbanek
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 103:9226-31. 2006
    ..Thus, CSCs regulate myocyte turnover that is heterogeneous across the heart, faster at the apex and atria, and slower at the base-midregion of the ventricle...
  30. ncbi request reprint Myocyte proliferation and ventricular remodeling
    Annarosa Leri
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    J Card Fail 8:S518-25. 2002
    ..Conversely, myocyte proliferation, characterized by the parallel addition of cells, can be expected to increase wall thickness, decrease chamber size, and ameliorate cardiac performance...
  31. ncbi request reprint Cause of death: suicide
    Jan Kajstura
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Vosburgh Pavilion, Room 302, Valhalla, New York 10595, USA
    J Mol Cell Cardiol 40:425-37. 2006
    ..Moreover, the effect of cell death on ventricular remodeling and performance is analyzed. The impact of the identification of apoptosis in the heart on the current view of myocardium as a dynamic organ is discussed...
  32. ncbi request reprint Cardiac stem cells and myocardial regeneration
    Bernardo Nadal-Ginard
    Department of Medicine, Cardiovascular Research Institute, Vosburgh Pavilion, New York Medical College, Valhalla, NY 10595, USA
    Novartis Found Symp 265:142-54; discussion 155-7, 204-11. 2005
    ..Thus, although in the adult heart most cardiac myocytes are permanently withdrawn from the cell cycle, the heart has an intrinsic regenerative potential and it is not a terminally differentiated organ...
  33. ncbi request reprint Myocyte death, growth, and regeneration in cardiac hypertrophy and failure
    Bernardo Nadal-Ginard
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 92:139-50. 2003
    ..The possibility of reconstituting dead myocardium by stem-like cells is advanced and proposed as a major area of future research...
  34. ncbi request reprint Life and death of cardiac stem cells: a paradigm shift in cardiac biology
    Piero Anversa
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circulation 113:1451-63. 2006
  35. ncbi request reprint Cardiac regeneration
    Piero Anversa
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    J Am Coll Cardiol 47:1769-76. 2006
    ..These cell classes hold promise for the treatment of heart failure in humans...
  36. ncbi request reprint Myocyte growth in the failing heart
    Jan Kajstura
    New York Medical College, Valhalla, NY 10595, USA
    Surg Clin North Am 84:161-77. 2004
    ..The recognition that myocyte hypertrophy and regeneration, as well as myocyte necrosis and apoptosis, occur in cardiac diseases has contributed to enhancing our understanding of the plasticity of the human heart...
  37. pmc Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation
    Annarosa Leri
    Department of Medicine, Cardiovascular Research Institute, New York Medical College, Valhalla, NY 10595, USA
    EMBO J 22:131-9. 2003
    ..Telomere shortening with age could also contribute to cardiac failure in humans, opening the possibility for new therapies...
  38. ncbi request reprint Concise review: stem cells, myocardial regeneration, and methodological artifacts
    Piero Anversa
    Cardiovascular Research Institute, Vosburgh Pavilion, New York Medical College, Valhalla, NY 10595, USA
    Stem Cells 25:589-601. 2007
    ....
  39. ncbi request reprint The young mouse heart is composed of myocytes heterogeneous in age and function
    Marcello Rota
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Circ Res 101:387-99. 2007
    ..Thus, cardiac homeostasis and myocyte turnover regulate cardiac function...
  40. ncbi request reprint Myocyte growth and cardiac repair
    Piero Anversa
    Cardiovascular Research Institute, Department of Medicine, Valhalla, New York 10595, USA
    J Mol Cell Cardiol 34:91-105. 2002
    ..Methodologies are currently available to recognize and measure quantitatively the contribution of myocyte size, number and death to the adaptation of the overloaded heart and its progression to cardiac failure...
  41. ncbi request reprint Identity deception: not a crime for a stem cell
    Annarosa Leri
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York
    Physiology (Bethesda) 20:162-8. 2005
    ..To date, the most versatile cell discovered is the bone marrow progenitor cell...
  42. pmc A matter of life and death: cardiac myocyte apoptosis and regeneration
    Bernardo Nadal-Ginard
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    J Clin Invest 111:1457-9. 2003
  43. ncbi request reprint Myocardial aging--a stem cell problem
    Piero Anversa
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Vosburgh Pavilion, Valhalla, NY 10595, USA
    Basic Res Cardiol 100:482-93. 2005
    ..CSC therapy may become, perhaps, a novel strategy for the devastating problem of heart failure in the old population...
  44. pmc bcl-2 overexpression promotes myocyte proliferation
    Federica Limana
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 99:6257-62. 2002
    ..Taken together, these observations reveal a previously uncharacterized replication-enhancing function of Bcl-2 in myocytes in vivo in the absence of stressful conditions...
  45. doi request reprint Myocardial regeneration and stem cell repair
    Annarosa Leri
    Department of Medicine, New York Medical College, NY, USA
    Curr Probl Cardiol 33:91-153. 2008
    ..This monograph discusses our current understanding of myocardial regeneration and the roles that endogenous and exogenous stem cells may have in the future therapy of cardiovascular disease...
  46. ncbi request reprint Cardiac stem cells and mechanisms of myocardial regeneration
    Annarosa Leri
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY10595, USA
    Physiol Rev 85:1373-416. 2005
    ..Cardiac stem cells may become the most important cell for cardiac repair...
  47. ncbi request reprint Adeno-associated virus mediated gene delivery into coronary microvessels of chronically instrumented dogs
    Heiner Post
    Dept of Physiology, Basic Sciences Bldg, Rm 636, New York Medical College, Valhalla, NY 10595, USA
    J Appl Physiol 95:1688-94. 2003
    ..AAV is a potential vector for gene transfer into the coronary microcirculation in large animals, including perhaps humans...
  48. ncbi request reprint Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+ cell proliferation and differentiation
    Federica Limana
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Circ Res 97:e73-83. 2005
    ..Thus, HMGB1 appears to be a potent inducer of myocardial regeneration following myocardial infarction...
  49. ncbi request reprint Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties
    Xiongwen Chen
    Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Circ Res 100:536-44. 2007
    ..Myocyte number increases during adolescent cardiac growth. These new myocytes are initially small and functionally immature, with patterns of ion channel expression normally found in the fetal/neonatal period...
  50. ncbi request reprint If I can stop one heart from breaking
    Piero Anversa
    Circulation 115:829-32. 2007
  51. ncbi request reprint Heart failure and regenerative cardiology
    Annarosa Leri
    Regen Med 1:153-9. 2006
  52. ncbi request reprint Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes
    Isao Shiraishi
    The Children s Hospital Research Foundation, Division of Molecular Cardiovascular Biology Cincinnati, Ohio, USA
    Circ Res 94:884-91. 2004
    ....
  53. ncbi request reprint Some like it plastic
    Annarosa Leri
    Circ Res 94:132-4. 2004
  54. doi request reprint IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction
    Jun Ren
    School of Pharmacy, University of Wyoming, Laramie, WY 82071, USA
    Am J Physiol Regul Integr Comp Physiol 294:R793-802. 2008
    ..These results revealed that IGF-I benefits diabetic hearts via Rho inhibition and antagonism of diabetes-induced decrease in pAkt, eNOS uncoupling, and K+ channel expression...
  55. doi request reprint Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespan
    Arantxa Gonzalez
    Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circ Res 102:597-606. 2008
    ..The senescent heart phenotype and heart failure are corrected to some extent, leading to prolongation of maximum lifespan...
  56. ncbi request reprint Regeneration of the infarcted heart with stem cells derived by nuclear transplantation
    Robert Lanza
    Advanced Cell Technology, Worcester, Mass, USA
    Circ Res 94:820-7. 2004
    ..Importantly, the magnitude of myocardial regeneration obtained in this study is significantly superior to that achieved with adult bone marrow cells...
  57. ncbi request reprint Myocardial damage and repair
    Annarosa Leri
    J Mol Cell Cardiol 35:595-7. 2003
  58. pmc Myocardial induction of nucleostemin in response to postnatal growth and pathological challenge
    Sailay Siddiqi
    San Diego State University Heart Institute and Department of Biology, San Diego State University, CA 92182, USA
    Circ Res 103:89-97. 2008
    ....
  59. pmc Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function
    Marcello Rota
    Department of Anesthesia and Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 103:107-16. 2008
    ..These forms of treatments could be repeated over time to reduce progressively tissue scarring and expand the working myocardium...
  60. ncbi request reprint Circulating progenitor cells: search for an identity
    Piero Anversa
    Circulation 110:3158-60. 2004
  61. ncbi request reprint Cardiac-specific overexpression of insulin-like growth factor 1 attenuates aging-associated cardiac diastolic contractile dysfunction and protein damage
    Qun Li
    Div of Pharmaceutical Science and Center for Cardiovascular Research and Alternative Medicine, Univ of Wyoming, Laramie, WY 82071 3375, USA
    Am J Physiol Heart Circ Physiol 292:H1398-403. 2007
    ..Collectively, our data suggest a beneficial role of IGF-1 in aging-induced cardiac contractile dysfunction, possibly related to improved Ca(2+) uptake...
  62. ncbi request reprint Endothelial progenitor cells: neovascularization or more?
    Jan Kajstura
    J Mol Cell Cardiol 40:1-8. 2006
  63. ncbi request reprint Bone marrow stem cells regenerate infarcted myocardium
    Donald Orlic
    Hematopoiesis Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute NIH, Building 49, Room 3W16, 49 Convent Drive, Bethesda, MD 20892, USA
    Pediatr Transplant 7:86-8. 2003
    ..In both experimental protocols, the BMSC gave rise to new cardiac myocytes and coronary blood vessels. This BMSC-derived myocardial regeneration resulted in improved cardiac function and survival...
  64. ncbi request reprint Regenerating the myocardium: a reality today
    Annarosa Leri
    Can J Cardiol 21:361-2. 2005
  65. pmc Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function
    Buddhadeb Dawn
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, USA
    Proc Natl Acad Sci U S A 102:3766-71. 2005
    ..The results establish CSCs as candidates for cardiac regeneration and support an approach in which the heart's own stem cells could be collected, expanded, and stored for subsequent therapeutic repair...
  66. ncbi request reprint Primitive cells and tissue regeneration
    Piero Anversa
    Circ Res 92:579-82. 2003
  67. ncbi request reprint Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population
    Natalie Gude
    San Diego State University Heart Institute and Department of Biology, San Diego State University, San Diego, CA 92182, USA
    Circ Res 99:381-8. 2006
    ....
  68. ncbi request reprint Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice
    Sara Welch
    Divisions of Molecular Cardiovascular Biology, Children s Hospital Research Foundation, Cincinnati, Ohio, USA
    Circ Res 90:641-8. 2002
    ....
  69. ncbi request reprint [Bone marrow cells and cardiac repair]
    Annarosa Leri
    Arq Bras Cardiol 87:71-2. 2006
  70. pmc Postinfarct cytokine therapy regenerates cardiac tissue and improves left ventricular function
    Buddhadeb Dawn
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    Circ Res 98:1098-105. 2006
    ....
  71. pmc Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy
    Yasuyuki Tsujita
    San Diego State University Heart Institute, Department of Biology, CA 92182, USA
    Proc Natl Acad Sci U S A 103:11946-51. 2006
    ....
  72. pmc Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling
    Laura Calvillo
    Mario Negri Institute of Pharmacological Research, 20157 Milan, Italy
    Proc Natl Acad Sci U S A 100:4802-6. 2003
    ....
  73. ncbi request reprint Metalloproteinase inhibitor counters high-energy phosphate depletion and AMP deaminase activity enhancing ventricular diastolic compliance in subacute heart failure
    Nazareno Paolocci
    Division of Cardiology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Pharmacol Exp Ther 317:506-13. 2006
    ..Interaction between MMP activation and HEP metabolism may play an important role in mediating diastolic dysfunction. Furthermore, these data highlight a potential major role for increased AMP deaminase activity in diastolic dysfunction...
  74. ncbi request reprint Pim-1 regulates cardiomyocyte survival downstream of Akt
    John A Muraski
    San Diego State University Heart Institute, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA
    Nat Med 13:1467-75. 2007
    ..Collectively, these data suggest that Pim-1 is a crucial facet of cardioprotection downstream of Akt...
  75. pmc Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload
    John A Muraski
    San Diego State Heart Institute, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USA
    Proc Natl Acad Sci U S A 105:13889-94. 2008
    ..These data support a pivotal role for Pim-1 in modulation of hypertrophy by impacting responses on molecular, cellular, and organ levels...
  76. ncbi request reprint Endothelial progenitor cells: unexpected disclosures
    Annarosa Leri
    Circ Res 97:299-301. 2005