Research Topics
| Harumi JyonouchiSummaryAffiliation: New Jersey Country: USA Publications
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Detail Information
Publications
Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disordersHarumi Jyonouchi
Department of Pediatrics, Division of Pulmonary, Allergy Immunology, and Infectious Diseases, New Jersey Medical School UMDNJ, 185 South Orange Avenue, Newark, NJ 07101 1709, USA
J Pediatr 146:605-10. 2005..To evaluate an association between cytokine production with common dietary proteins as a marker of non-allergic food hypersensitivity (NFH) and gastrointestinal (GI) symptoms in young children with autism spectrum disorders (ASD)...- Non-IgE Mediated Food Allergy - Update of Recent Progress in Mucosal ImmunityHarumi Jyonouchi
Division of Allergy Immunology and Infectious Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey New Jersey Medical School, F570A, MSB, 185 South Orange Ave, Newark, NJ 07101 1709, USA
Inflamm Allergy Drug Targets 11:382-96. 2012..This review discusses recent progress in our understanding of the regulatory mechanisms of gut immune homeostasis and recently revealed widely variable clinical presentations of NFA with respect to it pathogenesis... - Immunological characterization and transcription profiling of peripheral blood (PB) monocytes in children with autism spectrum disorders (ASD) and specific polysaccharide antibody deficiency (SPAD): case studyHarumi Jyonouchi
Division of Allergy Immunology and Infectious Diseases, Department of Pediatrics, UMDN NJMS, 185 South Orange Ave, Newark, NJ 07101 1709, USA
J Neuroinflammation 9:4. 2012..This study assessed whether these ASD/SPAD children have distinct immunological findings in comparison with ASD/non-SPAD or non-ASD/SPAD children... - Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytesHarumi Jyonouchi
Division of Allergy Immunology and Infection Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07101 1709, USA
J Neuroimmunol 238:73-80. 2011..These results indicate dysregulated innate immune defense in the ASD/Inf+GI children, rendering them more vulnerable to common microbial infection/dysbiosis and possibly subsequent behavioral changes... - Age-dependent changes in peripheral blood dendritic cell subsets in normal children and children with specific polysaccharide antibody deficiency (SPAD)Harumi Jyonouchi
Division of Allergy Immunology and Infectious Diseases, Department of Pediatrics, UMDNJ NJMS, Newark, NJ, USA
Eur J Pediatr 169:1233-9. 2010..These results indicate lineage specific, age-dependent changes in DC subsets in normal children and possible altered development of these cells in SPAD children, emphasizing the importance of age-appropriate controls... - Autism spectrum disorders and allergy: observation from a pediatric allergy/immunology clinicHarumi Jyonouchi
Pediatrics, University of Medicine and Dentistry of New Jersey UMDNJ New Jersey Medical School NJMS, 185 South Orange Ave, Newark, NJ 07101, USA
Expert Rev Clin Immunol 6:397-411. 2010..However, they also need to be aware that certain symptoms often attributed to 'allergy' by caregivers may not be immune mediated and should understand that behavioral symptoms can also be affected by many non-IgE-mediated causes... - Aberrant responses to TLR agonists in pediatric IBD patients; the possible association with increased production of Th1/Th17 cytokines in response to candida, a luminal antigenHarumi Jyonouchi
Division of Allergy Immunology and Infectious Diseases, University of Medicine and Dentistry of New Jersey UMDNJ, New Jersey Medical School NJMS, Newark, NJ 07101 1709, USA
Pediatr Allergy Immunol 21:e747-55. 2010..CD but not UC PBMC produced more IFN-gamma and IL-17 with candida. Aberrant responses to TLR agonists may be associated with increase in IFN-gamma/IL-17 production against candida in CD children... - Food allergy and autism spectrum disorders: is there a link?Harumi Jyonouchi
Division of Allergy Immunology and Infectious Diseases, Pediatrics, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, F570A, MSB, Newark, NJ 07101, USA
Curr Allergy Asthma Rep 9:194-201. 2009..This review summarizes possible (or proposed) etiologies of GI symptoms in ASD children and discusses risks and possible benefits of intervention measures promoted by complementary and alternative practitioners, with emphasis on FA... - Impact of innate immunity in a subset of children with autism spectrum disorders: a case control studyHarumi Jyonouchi
Division of Allergy Immunology and Infectious Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey UMDNJ New Jersey Medical School NJMS, Newark, NJ, USA
J Neuroinflammation 5:52. 2008..This study assessed whether these clinical features of this ASD subset are associated with atopy, asthma, food allergy (FA), primary immunodeficiency (PID), or innate immune responses important in viral infections... - Non-IgE mediated food allergyHarumi Jyonouchi
Division of Allergy and Immunology, Department of Pediatrics, UMDNJ New Jersey Medical School, Newark, NJ 07101 1709, USA
Inflamm Allergy Drug Targets 7:173-80. 2008.... - Monozygous twins with a microdeletion syndrome involving BTK, DDP1, and two other genes; evidence of intact dendritic cell development and TLR responsesHarumi Jyonouchi
Department of Pediatrics, Division of Pulmonary, Allergy, Immunology, and Infectious Diseases, UMDNJ New Jersey Medical School, Newark, NJ 07101 1709, USA
Eur J Pediatr 167:317-21. 2008..CONCLUSION: Our results do not indicate the essential role of Btk in TLR signaling and DC development... - Effects of exogenous interferon gamma on patients with treatment-resistant chronic rhinosinusitis and dysregulated interferon gamma production: a pilot studyHarumi Jyonouchi
Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis, USA
Arch Otolaryngol Head Neck Surg 129:563-9. 2003..To evaluate the effects of exogenous interferon gamma treatment in patients with chronic rhinosinusitis and evidence of aberrant production of interferon gamma (IFN-gamma) and its regulatory cytokines... - SAPHO osteomyelitis and sarcoid dermatitis in a patient with DiGeorge syndromeHarumi Jyonouchi
Division of Pulmonary, Allergy Immunology, and Infectious Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey UMDNJ New Jersey Medical School, Newark, NJ 07101 1709, USA
Eur J Pediatr 165:370-3. 2006..This case suggests that patients with the DGS can present with unusual sterile inflammatory lesions triggered by environmental factors, further broadening the clinical spectrum of this syndrome... - Dysregulated innate immune responses in young children with autism spectrum disorders: their relationship to gastrointestinal symptoms and dietary interventionHarumi Jyonouchi
Department of Pediatrics, New Jersey Medical School, UMDNJ, Newark, NJ 07101 1709, USA
Neuropsychobiology 51:77-85. 2005..This study further explored possible dysregulated production of proinflammatory and counter-regulatory cytokines with LPS in ASD children and its relationship to GI symptoms and the effects of dietary intervention measures... - Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorderHarumi Jyonouchi
Department of Pediatrics, University of Minnesota, Minneapolis, Minn, USA
Neuropsychobiology 46:76-84. 2002..CONCLUSION: Immune reactivity to DPs may be associated with apparent DPI and GI inflammation in ASD children that may be partly associated with aberrant innate immune response against endotoxin, a product of the gut bacteria... - Fetal sensitization to cow's milk protein and wheat: cow's milk protein and wheat-specific TNF-alpha production by umbilical cord blood cells and subsequent decline of TNF-alpha production by peripheral blood mononuclear cells following dietary interventiCarla M Ward
Division of Allergy and Immunology, Department of Pediatrics, UMDNJ New Jersey Medical School, Newark, NJ 07101 1709, USA
Pediatr Allergy Immunol 18:276-80. 2007..This finding may indicate active suppressive mechanisms for maintaining oral tolerance... - Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus reportTimothy Buie
Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
Pediatrics 125:S1-18. 2010..For these patients, integration of behavioral and medical care may be most beneficial. Priorities for future research are identified to advance our understanding and management of gastrointestinal disorders in persons with ASDs... - Dietary ribonucleotides increase antigen-specific type 1 T-helper cells in the regional draining lymph nodes in young BALB/cJ miceHarumi Jyonouchi
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
Nutrition 19:41-6. 2003..We assessed the mechanisms of ribonucleotide action on type 1 T-helper cell (Th1) responses against ovalbumin (OVA) in Th2-biased BALB/cJ mice... - Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiencyCarla M Ward
Division of Pulmonology, Allergy Immunology, and Infectious Diseases, Department of Pediatrics, New Jersey Medical School UMDNJ, 185 South Orange Avenue, Newark, NJ 07101 1709, USA
Eur J Pediatr 166:981-5. 2007..This is the first report of a complete IFNGR1 deficiency treated with adjuvant IFN-alpha2b for disseminated MAC infection... - Cerebrospinal fluid and serum markers of inflammation in autismAndrew W Zimmerman
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore Maryland 21205, USA
Pediatr Neurol 33:195-201. 2005..Alternatively, they may be produced by microglia but remain localized and not expressed in cerebrospinal fluid...