Harumi Jyonouchi

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi request reprint Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders
    Harumi Jyonouchi
    Department of Pediatrics, Division of Pulmonary, Allergy Immunology, and Infectious Diseases, New Jersey Medical School UMDNJ, 185 South Orange Avenue, Newark, NJ 07101 1709, USA
    J Pediatr 146:605-10. 2005
  2. ncbi request reprint Non-IgE mediated food allergy - update of recent progress in mucosal immunity
    Harumi Jyonouchi
    Division of Allergy Immunology and Infectious Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey New Jersey Medical School, F570A, MSB, 185 South Orange Ave, Newark, NJ 07101 1709, USA
    Inflamm Allergy Drug Targets 11:382-96. 2012
  3. pmc Immunological characterization and transcription profiling of peripheral blood (PB) monocytes in children with autism spectrum disorders (ASD) and specific polysaccharide antibody deficiency (SPAD): case study
    Harumi Jyonouchi
    Division of Allergy Immunology and Infectious Diseases, Department of Pediatrics, UMDN NJMS, 185 South Orange Ave, Newark, NJ 07101 1709, USA
    J Neuroinflammation 9:4. 2012
  4. doi request reprint Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes
    Harumi Jyonouchi
    Division of Allergy Immunology and Infection Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07101 1709, USA
    J Neuroimmunol 238:73-80. 2011
  5. pmc Age-dependent changes in peripheral blood dendritic cell subsets in normal children and children with specific polysaccharide antibody deficiency (SPAD)
    Harumi Jyonouchi
    Division of Allergy Immunology and Infectious Diseases, Department of Pediatrics, UMDNJ NJMS, Newark, NJ, USA
    Eur J Pediatr 169:1233-9. 2010
  6. doi request reprint Autism spectrum disorders and allergy: observation from a pediatric allergy/immunology clinic
    Harumi Jyonouchi
    Pediatrics, University of Medicine and Dentistry of New Jersey UMDNJ New Jersey Medical School NJMS, 185 South Orange Ave, Newark, NJ 07101, USA
    Expert Rev Clin Immunol 6:397-411. 2010
  7. doi request reprint Aberrant responses to TLR agonists in pediatric IBD patients; the possible association with increased production of Th1/Th17 cytokines in response to candida, a luminal antigen
    Harumi Jyonouchi
    Division of Allergy Immunology and Infectious Diseases, University of Medicine and Dentistry of New Jersey UMDNJ, New Jersey Medical School NJMS, Newark, NJ 07101 1709, USA
    Pediatr Allergy Immunol 21:e747-55. 2010
  8. ncbi request reprint Food allergy and autism spectrum disorders: is there a link?
    Harumi Jyonouchi
    Division of Allergy Immunology and Infectious Diseases, Pediatrics, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, F570A, MSB, Newark, NJ 07101, USA
    Curr Allergy Asthma Rep 9:194-201. 2009
  9. pmc Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study
    Harumi Jyonouchi
    Division of Allergy Immunology and Infectious Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey UMDNJ New Jersey Medical School NJMS, Newark, NJ, USA
    J Neuroinflammation 5:52. 2008
  10. ncbi request reprint Non-IgE mediated food allergy
    Harumi Jyonouchi
    Division of Allergy and Immunology, Department of Pediatrics, UMDNJ New Jersey Medical School, Newark, NJ 07101 1709, USA
    Inflamm Allergy Drug Targets 7:173-80. 2008

Detail Information

Publications20

  1. ncbi request reprint Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders
    Harumi Jyonouchi
    Department of Pediatrics, Division of Pulmonary, Allergy Immunology, and Infectious Diseases, New Jersey Medical School UMDNJ, 185 South Orange Avenue, Newark, NJ 07101 1709, USA
    J Pediatr 146:605-10. 2005
    ..To evaluate an association between cytokine production with common dietary proteins as a marker of non-allergic food hypersensitivity (NFH) and gastrointestinal (GI) symptoms in young children with autism spectrum disorders (ASD)...
  2. ncbi request reprint Non-IgE mediated food allergy - update of recent progress in mucosal immunity
    Harumi Jyonouchi
    Division of Allergy Immunology and Infectious Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey New Jersey Medical School, F570A, MSB, 185 South Orange Ave, Newark, NJ 07101 1709, USA
    Inflamm Allergy Drug Targets 11:382-96. 2012
    ..This review discusses recent progress in our understanding of the regulatory mechanisms of gut immune homeostasis and recently revealed widely variable clinical presentations of NFA with respect to it pathogenesis...
  3. pmc Immunological characterization and transcription profiling of peripheral blood (PB) monocytes in children with autism spectrum disorders (ASD) and specific polysaccharide antibody deficiency (SPAD): case study
    Harumi Jyonouchi
    Division of Allergy Immunology and Infectious Diseases, Department of Pediatrics, UMDN NJMS, 185 South Orange Ave, Newark, NJ 07101 1709, USA
    J Neuroinflammation 9:4. 2012
    ..This study assessed whether these ASD/SPAD children have distinct immunological findings in comparison with ASD/non-SPAD or non-ASD/SPAD children...
  4. doi request reprint Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes
    Harumi Jyonouchi
    Division of Allergy Immunology and Infection Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07101 1709, USA
    J Neuroimmunol 238:73-80. 2011
    ..These results indicate dysregulated innate immune defense in the ASD/Inf+GI children, rendering them more vulnerable to common microbial infection/dysbiosis and possibly subsequent behavioral changes...
  5. pmc Age-dependent changes in peripheral blood dendritic cell subsets in normal children and children with specific polysaccharide antibody deficiency (SPAD)
    Harumi Jyonouchi
    Division of Allergy Immunology and Infectious Diseases, Department of Pediatrics, UMDNJ NJMS, Newark, NJ, USA
    Eur J Pediatr 169:1233-9. 2010
    ..These results indicate lineage specific, age-dependent changes in DC subsets in normal children and possible altered development of these cells in SPAD children, emphasizing the importance of age-appropriate controls...
  6. doi request reprint Autism spectrum disorders and allergy: observation from a pediatric allergy/immunology clinic
    Harumi Jyonouchi
    Pediatrics, University of Medicine and Dentistry of New Jersey UMDNJ New Jersey Medical School NJMS, 185 South Orange Ave, Newark, NJ 07101, USA
    Expert Rev Clin Immunol 6:397-411. 2010
    ..However, they also need to be aware that certain symptoms often attributed to 'allergy' by caregivers may not be immune mediated and should understand that behavioral symptoms can also be affected by many non-IgE-mediated causes...
  7. doi request reprint Aberrant responses to TLR agonists in pediatric IBD patients; the possible association with increased production of Th1/Th17 cytokines in response to candida, a luminal antigen
    Harumi Jyonouchi
    Division of Allergy Immunology and Infectious Diseases, University of Medicine and Dentistry of New Jersey UMDNJ, New Jersey Medical School NJMS, Newark, NJ 07101 1709, USA
    Pediatr Allergy Immunol 21:e747-55. 2010
    ..CD but not UC PBMC produced more IFN-gamma and IL-17 with candida. Aberrant responses to TLR agonists may be associated with increase in IFN-gamma/IL-17 production against candida in CD children...
  8. ncbi request reprint Food allergy and autism spectrum disorders: is there a link?
    Harumi Jyonouchi
    Division of Allergy Immunology and Infectious Diseases, Pediatrics, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, F570A, MSB, Newark, NJ 07101, USA
    Curr Allergy Asthma Rep 9:194-201. 2009
    ..This review summarizes possible (or proposed) etiologies of GI symptoms in ASD children and discusses risks and possible benefits of intervention measures promoted by complementary and alternative practitioners, with emphasis on FA...
  9. pmc Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study
    Harumi Jyonouchi
    Division of Allergy Immunology and Infectious Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey UMDNJ New Jersey Medical School NJMS, Newark, NJ, USA
    J Neuroinflammation 5:52. 2008
    ..This study assessed whether these clinical features of this ASD subset are associated with atopy, asthma, food allergy (FA), primary immunodeficiency (PID), or innate immune responses important in viral infections...
  10. ncbi request reprint Non-IgE mediated food allergy
    Harumi Jyonouchi
    Division of Allergy and Immunology, Department of Pediatrics, UMDNJ New Jersey Medical School, Newark, NJ 07101 1709, USA
    Inflamm Allergy Drug Targets 7:173-80. 2008
    ....
  11. ncbi request reprint Monozygous twins with a microdeletion syndrome involving BTK, DDP1, and two other genes; evidence of intact dendritic cell development and TLR responses
    Harumi Jyonouchi
    Department of Pediatrics, Division of Pulmonary, Allergy, Immunology, and Infectious Diseases, UMDNJ New Jersey Medical School, Newark, NJ 07101 1709, USA
    Eur J Pediatr 167:317-21. 2008
    ..CONCLUSION: Our results do not indicate the essential role of Btk in TLR signaling and DC development...
  12. ncbi request reprint Effects of exogenous interferon gamma on patients with treatment-resistant chronic rhinosinusitis and dysregulated interferon gamma production: a pilot study
    Harumi Jyonouchi
    Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis, USA
    Arch Otolaryngol Head Neck Surg 129:563-9. 2003
    ..To evaluate the effects of exogenous interferon gamma treatment in patients with chronic rhinosinusitis and evidence of aberrant production of interferon gamma (IFN-gamma) and its regulatory cytokines...
  13. ncbi request reprint SAPHO osteomyelitis and sarcoid dermatitis in a patient with DiGeorge syndrome
    Harumi Jyonouchi
    Division of Pulmonary, Allergy Immunology, and Infectious Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey UMDNJ New Jersey Medical School, Newark, NJ 07101 1709, USA
    Eur J Pediatr 165:370-3. 2006
    ..This case suggests that patients with the DGS can present with unusual sterile inflammatory lesions triggered by environmental factors, further broadening the clinical spectrum of this syndrome...
  14. ncbi request reprint Dysregulated innate immune responses in young children with autism spectrum disorders: their relationship to gastrointestinal symptoms and dietary intervention
    Harumi Jyonouchi
    Department of Pediatrics, New Jersey Medical School, UMDNJ, Newark, NJ 07101 1709, USA
    Neuropsychobiology 51:77-85. 2005
    ..This study further explored possible dysregulated production of proinflammatory and counter-regulatory cytokines with LPS in ASD children and its relationship to GI symptoms and the effects of dietary intervention measures...
  15. ncbi request reprint Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder
    Harumi Jyonouchi
    Department of Pediatrics, University of Minnesota, Minneapolis, Minn, USA
    Neuropsychobiology 46:76-84. 2002
    ..This may predispose ASD children to sensitization to common dietary proteins (DP), leading to GI inflammation and aggravation of some behavioral symptoms...
  16. ncbi request reprint Fetal sensitization to cow's milk protein and wheat: cow's milk protein and wheat-specific TNF-alpha production by umbilical cord blood cells and subsequent decline of TNF-alpha production by peripheral blood mononuclear cells following dietary interventi
    Carla M Ward
    Division of Allergy and Immunology, Department of Pediatrics, UMDNJ New Jersey Medical School, Newark, NJ 07101 1709, USA
    Pediatr Allergy Immunol 18:276-80. 2007
    ..This finding may indicate active suppressive mechanisms for maintaining oral tolerance...
  17. doi request reprint Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report
    Timothy Buie
    Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 125:S1-18. 2010
    ..For these patients, integration of behavioral and medical care may be most beneficial. Priorities for future research are identified to advance our understanding and management of gastrointestinal disorders in persons with ASDs...
  18. ncbi request reprint Dietary ribonucleotides increase antigen-specific type 1 T-helper cells in the regional draining lymph nodes in young BALB/cJ mice
    Harumi Jyonouchi
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Nutrition 19:41-6. 2003
    ..We assessed the mechanisms of ribonucleotide action on type 1 T-helper cell (Th1) responses against ovalbumin (OVA) in Th2-biased BALB/cJ mice...
  19. ncbi request reprint Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency
    Carla M Ward
    Division of Pulmonology, Allergy Immunology, and Infectious Diseases, Department of Pediatrics, New Jersey Medical School UMDNJ, 185 South Orange Avenue, Newark, NJ 07101 1709, USA
    Eur J Pediatr 166:981-5. 2007
    ..This is the first report of a complete IFNGR1 deficiency treated with adjuvant IFN-alpha2b for disseminated MAC infection...
  20. ncbi request reprint Cerebrospinal fluid and serum markers of inflammation in autism
    Andrew W Zimmerman
    Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore Maryland 21205, USA
    Pediatr Neurol 33:195-201. 2005
    ..Alternatively, they may be produced by microglia but remain localized and not expressed in cerebrospinal fluid...