Eunsung Junn

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc Repression of alpha-synuclein expression and toxicity by microRNA-7
    Eunsung Junn
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 106:13052-7. 2009
  2. pmc MicroRNAs in neurodegenerative diseases and their therapeutic potential
    Eunsung Junn
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Pharmacol Ther 133:142-50. 2012
  3. ncbi request reprint MicroRNAs in neurodegenerative disorders
    Eunsung Junn
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ, USA
    Cell Cycle 9:1717-21. 2010
  4. pmc DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway
    Joo Young Im
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Hum Mol Genet 21:3013-24. 2012
  5. pmc DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex
    Joo Young Im
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Neurosci Res 67:203-8. 2010
  6. pmc Apoptosis signal-regulating kinase 1 mediates MPTP toxicity and regulates glial activation
    Kang Woo Lee
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
    PLoS ONE 7:e29935. 2012
  7. pmc Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's disease
    Kang Woo Lee
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, UMDNJ Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, Piscataway, NJ 08854, USA
    Neurotherapeutics 10:143-53. 2013
  8. pmc Mitochondrial localization of DJ-1 leads to enhanced neuroprotection
    Eunsung Junn
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci Res 87:123-9. 2009
  9. pmc Apoptosis signal-regulating kinase 1 modulates the phenotype of α-synuclein transgenic mice
    Kang Woo Lee
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA
    Neurobiol Aging 36:519-26. 2015
  10. pmc Inhibition of miR-34b and miR-34c enhances α-synuclein expression in Parkinson's disease
    Savan Kabaria
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    FEBS Lett 589:319-25. 2015

Collaborators

Detail Information

Publications17

  1. pmc Repression of alpha-synuclein expression and toxicity by microRNA-7
    Eunsung Junn
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 106:13052-7. 2009
    ..These findings provide a mechanism by which alpha-synuclein levels are regulated in neurons, have implications for the pathogenesis of PD, and suggest miR-7 as a therapeutic target for PD and other alpha-synucleinopathies...
  2. pmc MicroRNAs in neurodegenerative diseases and their therapeutic potential
    Eunsung Junn
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Pharmacol Ther 133:142-50. 2012
    ..In this review, the implications of miRNAs in several neurodegenerative disorders and their potential as therapeutic interventions are discussed...
  3. ncbi request reprint MicroRNAs in neurodegenerative disorders
    Eunsung Junn
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ, USA
    Cell Cycle 9:1717-21. 2010
    ..Detailed understanding of these mechanisms can provide potential new therapeutic approaches to slow down or halt the progression of neurodegenerative diseases...
  4. pmc DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway
    Joo Young Im
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Hum Mol Genet 21:3013-24. 2012
    ..These findings provide a new mechanism to support the antioxidant function of DJ-1 by increasing Trx1 expression via Nrf2-mediated transcriptional induction...
  5. pmc DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex
    Joo Young Im
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Neurosci Res 67:203-8. 2010
    ..These findings point to yet another mechanism through which DJ-1 has anti-oxidant and cytoprotective properties by regulating the Trx1/ASK1 complex and controlling the availability of ASK1 to effect apoptosis...
  6. pmc Apoptosis signal-regulating kinase 1 mediates MPTP toxicity and regulates glial activation
    Kang Woo Lee
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
    PLoS ONE 7:e29935. 2012
    ..These findings demonstrate that ASK1 is an important effector of MPTP-induced toxicity and suggest that inhibiting this kinase is a plausible therapeutic strategy for protecting dopamine neurons in PD...
  7. pmc Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's disease
    Kang Woo Lee
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, UMDNJ Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, Piscataway, NJ 08854, USA
    Neurotherapeutics 10:143-53. 2013
    ..Our data, therefore, reveal a strong beneficial effect of a novel component of coffee in multiple endpoints relevant to PD...
  8. pmc Mitochondrial localization of DJ-1 leads to enhanced neuroprotection
    Eunsung Junn
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci Res 87:123-9. 2009
    ..These findings further highlight the multifaceted functions of DJ-1 as a cytoprotector in different cellular compartments...
  9. pmc Apoptosis signal-regulating kinase 1 modulates the phenotype of α-synuclein transgenic mice
    Kang Woo Lee
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA
    Neurobiol Aging 36:519-26. 2015
    ..These conclusions raise the possibility that potent antioxidants and anti-inflammatory agents may ameliorate the phenotype of α-synucleinopathies...
  10. pmc Inhibition of miR-34b and miR-34c enhances α-synuclein expression in Parkinson's disease
    Savan Kabaria
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    FEBS Lett 589:319-25. 2015
    ..Our results suggest that down-regulation of miR-34b and miR-34c in the brain, as well as an SNP in the 3'-UTR of α-syn can increase α-syn expression, possibly contributing to PD pathogenesis. ..
  11. pmc Transglutaminase 2 exacerbates α-synuclein toxicity in mice and yeast
    Hilary Grosso
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA and
    FASEB J 28:4280-91. 2014
    ..Our findings demonstrate that TG2 promotes the aggregation of α-synuclein in vivo and that this is associated with aggravated toxicity of α-synuclein and its downstream neuropathologic consequences...
  12. pmc MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression
    Savan Kabaria
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA
    Free Radic Biol Med 89:548-556. 2015
    ..These findings point to a new mechanism by which miR-7 exerts cytoprotective effects by regulating the Nrf2 pathway...
  13. pmc MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell Death
    Amrita Datta Chaudhuri
    From the Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey 08854
    J Biol Chem 290:12425-34. 2015
    ..This protective effect of microRNA-7 could be exploited to correct the defects in oxidative phosphorylation in Parkinson disease. ..
  14. doi request reprint Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model
    Kang Woo Lee
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 31:6963-71. 2011
    ..These findings support the notion that serine 129 phosphorylation of α-Syn is of pathogenetic significance and that promoting PP2A activity is a viable disease-modifying therapeutic strategy for α-synucleinopathies such as PD...
  15. pmc The role of oxidative stress in Parkinson's disease
    Vera Dias
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA
    J Parkinsons Dis 3:461-91. 2013
    ..Recent knowledge gained about the specific mechanisms related to PD gene products that modulate ROS production and the response of neurons to stress may provide targeted new approaches towards neuroprotection. ..
  16. pmc Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
    Eunsung Junn
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 102:9691-6. 2005
    ..These findings suggest that the regulated sequestration of Daxx in the nucleus and keeping apoptosis signal-regulating kinase 1 activation in check is a critical mechanism by which DJ-1 exerts its cytoprotective function...
  17. pmc MicroRNA-7 protects against 1-methyl-4-phenylpyridinium-induced cell death by targeting RelA
    Doo chul Choi
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, and
    J Neurosci 34:12725-37. 2014
    ....