A L Joyner

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation
    R A Kimmel
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016 USA
    Genes Dev 14:1377-89. 2000
  2. ncbi request reprint Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
    H L Park
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology and Physiology and Neuroscience, New York University Medical School, New York, NY 10016, USA
    Development 127:1593-605. 2000
  3. ncbi request reprint Genetic inducible fate mapping in mouse: establishing genetic lineages and defining genetic neuroanatomy in the nervous system
    Alexandra L Joyner
    Howard Hughes Medical Institute and Developmental Genetics Program, Department of Cell Biology and Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    Dev Dyn 235:2376-85. 2006
  4. ncbi request reprint Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer
    A L Joyner
    Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Curr Opin Cell Biol 12:736-41. 2000
  5. ncbi request reprint FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate
    A Liu
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 126:4827-38. 1999
  6. ncbi request reprint EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region
    A Liu
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 128:181-91. 2001
  7. ncbi request reprint Gli1 can rescue the in vivo function of Gli2
    C B Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 128:5161-72. 2001
  8. ncbi request reprint Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
    M P Matise
    Developmental Genetics Program and Howard Hughes Medical Institute, and Department of Cell Biology and Physiology and Neuroscience, NYU Medical Center, New York, NY 10016, USA
    Development 125:2759-70. 1998
  9. ncbi request reprint Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression
    J Y Li
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 128:4979-91. 2001
  10. ncbi request reprint Alteration of limb and brain patterning in early mouse embryos by ultrasound-guided injection of Shh-expressing cells
    A Liu
    Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Mech Dev 75:107-15. 1998

Research Grants

  1. ROLES OF MOUSE GLI GENES IN HEDGEHOG SIGNALING
    Alexandra Joyner; Fiscal Year: 2007
  2. ROLES OF MOUSE GLI GENES IN HEDGEHOG SIGNALING
    Alexandra Joyner; Fiscal Year: 2006
  3. Fgf8 Function in Midbrain/r1 Borders and Patterning
    Alexandra Joyner; Fiscal Year: 2006

Collaborators

Detail Information

Publications57

  1. pmc Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation
    R A Kimmel
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016 USA
    Genes Dev 14:1377-89. 2000
    ..Finally, fate mapping of AER domains in these mutants showed that En1 plays a part in positioning and maintaining the two lineage borders...
  2. ncbi request reprint Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
    H L Park
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology and Physiology and Neuroscience, New York University Medical School, New York, NY 10016, USA
    Development 127:1593-605. 2000
    ..Furthermore, Gli1 and Gli2, but not Gli1 and Gli3, have extensive overlapping functions that are likely downstream of SHH signaling...
  3. ncbi request reprint Genetic inducible fate mapping in mouse: establishing genetic lineages and defining genetic neuroanatomy in the nervous system
    Alexandra L Joyner
    Howard Hughes Medical Institute and Developmental Genetics Program, Department of Cell Biology and Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    Dev Dyn 235:2376-85. 2006
    ..We end with a look toward the future at a powerful new approach that combines genetic fate mapping with cellular phenotyping alleles to study cell morphology, physiology, and function using examples from the nervous system...
  4. ncbi request reprint Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer
    A L Joyner
    Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Curr Opin Cell Biol 12:736-41. 2000
    ..Recent experiments have shown that Otx2, Gbx2 and Fgf8 genes play a major role in the positioning and functioning of this organizing center...
  5. ncbi request reprint FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate
    A Liu
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 126:4827-38. 1999
    ....
  6. ncbi request reprint EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region
    A Liu
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 128:181-91. 2001
    ....
  7. ncbi request reprint Gli1 can rescue the in vivo function of Gli2
    C B Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 128:5161-72. 2001
    ..We show that the defects are enhanced when Gli3 function is reduced, demonstrating that an important difference between Gli1 and Gli2 is the ability of Gli1 to antagonize Gli3 function...
  8. ncbi request reprint Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
    M P Matise
    Developmental Genetics Program and Howard Hughes Medical Institute, and Department of Cell Biology and Physiology and Neuroscience, NYU Medical Center, New York, NY 10016, USA
    Development 125:2759-70. 1998
    ....
  9. ncbi request reprint Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression
    J Y Li
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 128:4979-91. 2001
    ..Furthermore, Otx2 and Gbx2 are required to suppress hindbrain and midbrain development, respectively, and thus allow establishment of the normal spatial domains of Fgf8 and other genes...
  10. ncbi request reprint Alteration of limb and brain patterning in early mouse embryos by ultrasound-guided injection of Shh-expressing cells
    A Liu
    Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Mech Dev 75:107-15. 1998
    ..In combination with the many available mouse mutants, this method offers a new approach for analyzing genetic interactions through gain-of-function studies performed in mutant mouse backgrounds...
  11. ncbi request reprint A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer
    S Millet
    Developmental Genetics Program and Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York, New York 10016, USA
    Nature 401:161-4. 1999
    ..5-10. We propose that formation of a normal MHB organizer depends on a sharp Otx2 caudal border and that Gbx2 is required to position and sharpen this border...
  12. ncbi request reprint Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs
    C A Loomis
    Ronald O Perelman Department of Dermatology, NYU Medical School, New York, NY 10016, USA
    Development 125:1137-48. 1998
    ..This leads to induction of a second zone of compaction ventrally, which in some cases goes on to form an autonomous secondary AER...
  13. ncbi request reprint Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms
    D J Epstein
    Developmental Genetics Program and Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, and Department of Cellular, Molecular and Developmental Biology, Harvard University, Cambridge MA, USA
    Development 126:281-92. 1999
    ..Taken together, our results support the existence of Hnf3-dependent and -independent mechanisms in the direct activation of Shh transcription within the CNS and axial mesoderm...
  14. ncbi request reprint Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord
    M P Matise
    Howard Hughes Medical Institute and Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 126:3649-59. 1999
    ....
  15. ncbi request reprint Engrailed, Wnt and Pax genes regulate midbrain--hindbrain development
    A L Joyner
    Department of Cell Biology, New York University Medical Center, NY 10016 0497, USA
    Trends Genet 12:15-20. 1996
    ..By analogy, segmentation of the rest of the brain might best be described in terms of 'genetic units' defined by genetic and transplantation data...
  16. pmc Embryonic origins of ZebrinII parasagittal stripes and establishment of topographic Purkinje cell projections
    R V Sillitoe
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Neuroscience 162:574-88. 2009
    ..5. These studies show that PC molecular patterning, efferent circuitry, and DCN nucleogenesis occur simultaneously, suggesting a link between these processes...
  17. ncbi request reprint Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development
    K J Briegel
    Howard Hughes Medical Institute, New York University School of Medicine, New York, New York 10016, USA
    Dev Biol 233:291-304. 2001
    ..Based on the molecular characteristics and the domain-specific expression pattern, it is possible that Lbh functions in synergy with other genes known to be required for heart and limb development...
  18. ncbi request reprint Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons
    M P Matise
    New York University Medical School, Skirball Institute of Biomolecular Medicine, Developmental Genetics Program, New York, New York 10016, USA
    J Neurosci 17:7805-16. 1997
    ..Rather, it is suggested that En-1 may function to distinguish a subset of interneurons during the later maturation of the spinal cord...
  19. ncbi request reprint Early anterior/posterior patterning of the midbrain and cerebellum
    A Liu
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Annu Rev Neurosci 24:869-96. 2001
    ..Subsequently, we discuss the molecular genetic studies that have revealed the roles for many genes in normal early patterning of this region. Finally, some of the remaining questions and future directions are discussed...
  20. ncbi request reprint FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors
    Aimin Liu
    Howard Hughes Medical Institute, Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Development 130:6175-85. 2003
    ..As Fgf17 and Fgf18 are co-expressed with Fgf8 in many tissues, our studies have broad implications for how these FGFs differentially control development...
  21. ncbi request reprint Morphogenetic and cellular movements that shape the mouse cerebellum; insights from genetic fate mapping
    Sema K Sgaier
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Neuron 45:27-40. 2005
    ..Thus, we show that progressive changes in the axes of the cerebellum underlie its genesis...
  22. ncbi request reprint The HD mutation causes progressive lethal neurological disease in mice expressing reduced levels of huntingtin
    W Auerbach
    Skirball Institute of Biomolecular Medicine and Howard Hughes Medical Institute, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Hum Mol Genet 10:2515-23. 2001
    ..These results raise the possibility that therapeutic elimination of huntingtin in HD patients could lead to unintended neurological, as well as developmental side-effects...
  23. ncbi request reprint Cell behaviors and genetic lineages of the mesencephalon and rhombomere 1
    Mark Zervas
    Howard Hughes Medical Institute, Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Neuron 43:345-57. 2004
    ..Finally, we also uncovered transient and differential genetic lineages of ventral midbrain dopaminergic and ventral hindbrain serotonergic neuronal precursors with respect to Wnt1 and Gli1 expression...
  24. ncbi request reprint Changing requirements for Gbx2 in development of the cerebellum and maintenance of the mid/hindbrain organizer
    James Y H Li
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York, NY 10016, USA
    Neuron 36:31-43. 2002
    ..Our work has uncovered distinct requirements for Gbx2 during cerebellum formation and provided a model for how a transcription factor can play multiple roles during development...
  25. ncbi request reprint Strain-dependent differences in the efficiency of transgenic mouse production
    Anna B Auerbach
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Transgenic Res 12:59-69. 2003
    ..Based on our studies, the procedure for transgenic mouse production can be modified for each egg donor strain in order to overcome any deficiencies, and thus to increase the overall efficiency of transgenic mouse production...
  26. ncbi request reprint How does Fgf signaling from the isthmic organizer induce midbrain and cerebellum development?
    Tatsuya Sato
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Dev Growth Differ 46:487-94. 2004
    ..A lower level of signaling transduced by Fgf8a, Fgf17 and Fgf18 induce midbrain development. Numerous feedback loops then maintain appropriate mesencephalon/rhombomere1 and organizer gene expression...
  27. ncbi request reprint Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development
    JoMichelle D Corrales
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 131:5581-90. 2004
    ..Taken together, these studies demonstrate that positive Shh signaling through Gli2 is required to generate a sufficient number of GCPs for proper lobe growth...
  28. pmc Cerebellum morphogenesis: the foliation pattern is orchestrated by multi-cellular anchoring centers
    Anamaria Sudarov
    Developmental Biology Program, Sloan Kettering Institute, York Avenue, New York, NY 10021, USA
    Neural Dev 2:26. 2007
    ..Since folia in mammals likely serve as a broad platform on which the anterior-posterior organization of the sensory-motor circuits of the cerebellum are built, it is important to understand how such complex morphology arises...
  29. ncbi request reprint Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region
    Sandra Blaess
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 133:1799-809. 2006
    ..Thus, the precise spatial and temporal regulation of Gli2A and Gli3R by Shh is instrumental in coordinating mid/hindbrain development in three dimensions...
  30. ncbi request reprint Establishment and chimera analysis of 129/SvEv- and C57BL/6-derived mouse embryonic stem cell lines
    W Auerbach
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, NY 10016, USA
    Biotechniques 29:1024-8, 1030, 1032. 2000
    ..C56BL/6-derived ES cell lines, however, have a greater tendency than 129-derived ES cell lines to lose their ability to colonize the germline...
  31. ncbi request reprint Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice
    K A Platt
    The Skirball Institute of Biomolecular Medicine Developmental Genetics Program and Department of Cell Biology, Physiology and Neuroscience, New York University, NY 10016, USA
    Mech Dev 62:121-35. 1997
    ..These results are consistent with conservation of the Hh signal transduction pathway in mice with Gli potentially mediating Hh signaling in multiple regions of the developing embryo...
  32. pmc Genetic subdivision of the tectum and cerebellum into functionally related regions based on differential sensitivity to engrailed proteins
    Sema K Sgaier
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 134:2325-35. 2007
    ..Our study suggests that an ;engrailed code' is integral to partitioning the tectum and cerebellum into functional domains...
  33. ncbi request reprint The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation
    JoMichelle D Corrales
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, 540 First Avenue New York, NY 10016, USA
    Development 133:1811-21. 2006
    ..Our studies have uncovered a mechanism by which the level and length of Shh signaling could be integral to determining the distinct number of fissures in each species...
  34. pmc Engrailed homeobox genes determine the organization of Purkinje cell sagittal stripe gene expression in the adult cerebellum
    Roy V Sillitoe
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    J Neurosci 28:12150-62. 2008
    ..Our studies reveal that En1/2 are fundamental components of the genetic pathways that pattern the two intersecting coordinate systems of the Cb, morphological divisions and the molecular code...
  35. pmc Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling
    Sandra Blaess
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 511, New York, NY 10021, USA
    Development 135:2093-103. 2008
    ..0) through regulation of cell proliferation and viability. In conclusion, our results show that Gli3 is essential for the coordinated three-dimensional patterning and growth of the dorsal mes/r1...
  36. ncbi request reprint New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression
    James Y H Li
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 132:1971-81. 2005
    ..Our studies provide new insights into the regulatory interactions that maintain isthmic organizer gene expression and the consequences of altered levels of organizer gene expression on cell survival...
  37. pmc Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain
    Shaun K Olsen
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Genes Dev 20:185-98. 2006
    ..Consistent with the indispensable role of FGF8 in embryonic development, we show that the FGF8 mode of receptor binding appeared as early as in nematodes and has been preserved throughout evolution...
  38. pmc The duration of Fgf8 isthmic organizer expression is key to patterning different tectal-isthmo-cerebellum structures
    Tatsuya Sato
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, Box 511, New York, NY 10021, USA
    Development 136:3617-26. 2009
    ..Thus, the duration as well as the strength of Fgf8 signaling is key to patterning of the mid/hindbrain region. By extrapolation, the length of Fgf8 expression could be crucial to Fgf8 function in other embryonic organizers...
  39. pmc The Engrailed homeobox genes determine the different foliation patterns in the vermis and hemispheres of the mammalian cerebellum
    Yulan Cheng
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Development 137:519-29. 2010
    ..Thus, the En genes represent a new class of genes that are fundamental to patterning cerebellum foliation throughout the mediolateral axis and that act late in development...
  40. ncbi request reprint Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development
    Marc Fuccillo
    Developmental Genetics Program and the Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Nat Rev Neurosci 7:772-83. 2006
    ..Here we review our present knowledge of the hedgehog signalling pathway and speculate about areas in which further insights into this versatile pathway might be forthcoming...
  41. pmc Engrailed homeobox genes regulate establishment of the cerebellar afferent circuit map
    Roy V Sillitoe
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    J Neurosci 30:10015-24. 2010
    ..In summary, our data suggest that En1/2 are master regulators of three-dimensional organization of the cerebellum and coordinately regulate morphology, patterned gene expression, and afferent topography...
  42. pmc Sonic hedgehog regulates discrete populations of astrocytes in the adult mouse forebrain
    A Denise R Garcia
    Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, New York 10065, USA
    J Neurosci 30:13597-608. 2010
    ..Collectively, our findings demonstrate a role for neuron-derived Shh in regulating specific populations of differentiated astrocytes...
  43. ncbi request reprint All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 6:103-15. 2004
    ..Therefore, in the spinal cord all Hh signaling is Gli dependent. Furthermore, a combination of Gli2 and Gli3 is required to regulate motor neuron development and spatial patterning of ventral spinal cord progenitors...
  44. ncbi request reprint Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning
    Sohyun Ahn
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York, NY 10016, USA
    Cell 118:505-16. 2004
    ..Finally, by fate mapping Shh-responding cells in Gli2 and Gli3 mutant limbs, we demonstrate that a specific level of positive Hh signaling is not required to specify digit identities...
  45. ncbi request reprint Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 129:4753-61. 2002
    ..Our studies demonstrate that, in mammals, Gli1 is not required for Shh signaling and that Gli2 mediates inappropriate activation of the pathway due to loss of the negative regulator Ptc...
  46. ncbi request reprint Fate map of mouse ventral limb ectoderm and the apical ectodermal ridge
    Qiuxia Guo
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Biol 264:166-78. 2003
    ..These studies have uncovered new aspects of the cellular mechanisms involved in AER formation and in partitioning the ventral ectoderm in mouse limb...
  47. doi request reprint Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential
    Natalie A Thomas
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 135:3789-99. 2008
    ..Thus, Hh signaling plays an essential early role in defining the optimal number of cardiomyocytes, making it an attractive target for manipulation of multipotent progenitor cells...
  48. ncbi request reprint Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh
    Karoline J Briegel
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 132:3305-16. 2005
    ..Our findings implicate LBH as a candidate gene for CHD associated with partial trisomy 2p syndrome and suggest an important role of Lbh in transcriptional control during normal cardiogenesis...
  49. ncbi request reprint Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1
    Howard L Weiner
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Cancer Res 62:6385-9. 2002
    ..We have developed an efficient mouse model of medulloblastoma and shown that Gli1 is not required for tumorigenesis when Shh signaling is activated upstream in the pathway...
  50. ncbi request reprint In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog
    Sohyun Ahn
    Howard Hughes Medical Institute, Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nature 437:894-7. 2005
    ..Furthermore, we show that the neural stem cell niches in the subventricular zone and dentate gyrus are established sequentially and not until late embryonic stages...
  51. doi request reprint Genetic fate mapping using site-specific recombinases
    Emilie Legue
    Memorial Sloan Kettering Cancer Center, New York, USA
    Methods Enzymol 477:153-81. 2010
    ....
  52. ncbi request reprint Morphology, molecular codes, and circuitry produce the three-dimensional complexity of the cerebellum
    Roy V Sillitoe
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Annu Rev Cell Dev Biol 23:549-77. 2007
    ..Finally, we discuss how abnormal cerebellar organization may result in neurological disorders like autism...
  53. pmc In vivo MRI of neural cell migration dynamics in the mouse brain
    Brian J Nieman
    Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, NY, NY 10016, USA
    Neuroimage 50:456-64. 2010
    ..The use of MRI in future studies tracking endogenous NB cells will permit a more complete evaluation of their role during homeostasis at various developmental stages and during disease progression...
  54. ncbi request reprint Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse
    Radhika Atit
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
    Dev Biol 296:164-76. 2006
    ..Our results indicate that the mouse central dermomyotome gives rise to dermis, muscle, and brown fat, and that Wnt signalling normally instructs cells to select the dorsal dermal fate...
  55. pmc Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development
    M Albert Basson
    Department of Anatomy and Program in Developmental Biology, University of California San Francisco, CA 94158, USA
    Development 135:889-98. 2008
    ..We suggest a molecular explanation for this phenomenon by providing evidence that FGF signaling functions to inhibit the BMP signaling that promotes roof plate development...
  56. pmc Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
    Yong Pan
    Weill Medical College of Cornell University, 1300 York Avenue, Room W404, New York, NY 10021, USA
    Mol Cell Biol 26:3365-77. 2006
    ..Both processing and degradation of Gli2 are suppressed by Shh signaling in vivo. Our findings provide the first demonstration of a molecular mechanism by which the Gli2 transcriptional activity is regulated by Shh signaling...
  57. pmc The exon 8-containing prosaposin gene splice variant is dispensable for mouse development, lysosomal function, and secretion
    Tsadok Cohen
    Department of Cell Research and Immunology, Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel
    Mol Cell Biol 25:2431-40. 2005
    ....

Research Grants3

  1. ROLES OF MOUSE GLI GENES IN HEDGEHOG SIGNALING
    Alexandra Joyner; Fiscal Year: 2007
    ....
  2. ROLES OF MOUSE GLI GENES IN HEDGEHOG SIGNALING
    Alexandra Joyner; Fiscal Year: 2006
    ..4. To determine whether some cells receiving Shh signaling move away from the source of Shh and thus receive a shorter exposure to Shh than other cells using a Cre/loxP fate mapping approach with Gli1- CreEr mice. ..
  3. Fgf8 Function in Midbrain/r1 Borders and Patterning
    Alexandra Joyner; Fiscal Year: 2006
    ..Does Fgf8 induces different midbrain and hindbrain structures along the anterior/posterior axis directly through setting up a gradient of Fgf proteins? 5. Is Fgf8 or Wnt1 signaling required to maintain compartment borders? ..