Yong Jiu Jin

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc Alkylating HIV-1 Nef - a potential way of HIV intervention
    Yong Jiu Jin
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    AIDS Res Ther 7:26. 2010
  2. ncbi request reprint CD4 phosphorylation partially reverses Nef down-regulation of CD4
    Yong Jiu Jin
    Skirball Institute of Biomedical Research, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 173:5495-500. 2004
  3. ncbi request reprint HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent
    Yong Jiu Jin
    Skirball Institute of Biomedical Research, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 175:3157-64. 2005
  4. doi request reprint Two sorting motifs, a ubiquitination motif and a tyrosine motif, are involved in HIV-1 and simian immunodeficiency virus Nef-mediated receptor endocytosis
    Catherine Yi Cai
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 186:5807-14. 2011
  5. ncbi request reprint Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling
    Roben Fragoso
    Skirball Institute of Biomedical Research, New York University School of Medicine, New York 10016, USA
    J Immunol 170:913-21. 2003
  6. ncbi request reprint Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation
    Yong Jiu Jin
    Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 180:7878-86. 2008
  7. doi request reprint Identification of a novel binding site between HIV type 1 Nef C-terminal flexible loop and AP2 required for Nef-mediated CD4 downregulation
    Yong Jiu Jin
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    AIDS Res Hum Retroviruses 29:725-31. 2013
  8. ncbi request reprint Fratricide of CD8+ cytotoxic T lymphocytes is dependent on cellular activation and perforin-mediated killing
    Michael Wei Chih Su
    Dana Farber Cancer Institute, Department of Pediatric Oncology, Harvard Medical School, Boston, USA
    Eur J Immunol 34:2459-70. 2004

Collaborators

  • Xiaoping Zhang
  • Roberto Sanchez
  • Steven J Burakoff
  • Catherine Yi Cai
  • Michael Wei Chih Su
  • Roben Fragoso
  • Patrick J Sinko
  • Chao Lan Yu
  • Peter Walden
  • Saiju Pyarajan
  • York Dieter Stierhof
  • Jin Hong Chang
  • Dejian Ren

Detail Information

Publications8

  1. pmc Alkylating HIV-1 Nef - a potential way of HIV intervention
    Yong Jiu Jin
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    AIDS Res Ther 7:26. 2010
    ..In search of chemicals that inhibit Nef function, we discovered that TPCK and TLCK alkylated HIV Nef...
  2. ncbi request reprint CD4 phosphorylation partially reverses Nef down-regulation of CD4
    Yong Jiu Jin
    Skirball Institute of Biomedical Research, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 173:5495-500. 2004
    ..We propose that this dissociation switches CD4 internalization from the Nef-mediated, nearly complete down-regulation to a phosphorylation-dependent, partial down-regulation, resulting in a net gain of CD4 on the T cell surface...
  3. ncbi request reprint HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent
    Yong Jiu Jin
    Skirball Institute of Biomedical Research, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 175:3157-64. 2005
    ....
  4. doi request reprint Two sorting motifs, a ubiquitination motif and a tyrosine motif, are involved in HIV-1 and simian immunodeficiency virus Nef-mediated receptor endocytosis
    Catherine Yi Cai
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 186:5807-14. 2011
    ..Thus, our study demonstrated that Nef-mediated receptor endocytosis involves the ubiquitination motif and tyrosine motif...
  5. ncbi request reprint Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling
    Roben Fragoso
    Skirball Institute of Biomedical Research, New York University School of Medicine, New York 10016, USA
    J Immunol 170:913-21. 2003
    ..Thus, our data suggest that CD4-induced aggregation of lipid rafts may play an additional role in CD4 signaling besides its adhesion to MHC molecules and association with Lck...
  6. ncbi request reprint Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation
    Yong Jiu Jin
    Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 180:7878-86. 2008
    ..These data suggest that ubiquitination of Nef, particularly diubiquitination of the lysine 144, is necessary for Nef-mediated CD4 down-regulation...
  7. doi request reprint Identification of a novel binding site between HIV type 1 Nef C-terminal flexible loop and AP2 required for Nef-mediated CD4 downregulation
    Yong Jiu Jin
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    AIDS Res Hum Retroviruses 29:725-31. 2013
    ....
  8. ncbi request reprint Fratricide of CD8+ cytotoxic T lymphocytes is dependent on cellular activation and perforin-mediated killing
    Michael Wei Chih Su
    Dana Farber Cancer Institute, Department of Pediatric Oncology, Harvard Medical School, Boston, USA
    Eur J Immunol 34:2459-70. 2004
    ..Collectively, these findings reveal that fratricide is mediated by T cell activation and perforin-mediated cytolysis. These results may have implications for the regulation of CD8+ CTL in immune responses...