Cheng-Han Huang

Summary

Affiliation: New York Blood Center
Country: USA

Publications

  1. ncbi request reprint The human Rh50 glycoprotein gene. Structural organization and associated splicing defect resulting in Rh(null) disease
    C H Huang
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
    J Biol Chem 273:2207-13. 1998
  2. ncbi request reprint Rhnull disease: the amorph type results from a novel double mutation in RhCe gene on D-negative background
    C H Huang
    Laboratory of Biochemistry, Lindsley F Kimball Research Institute, New York Blood Center, New York, NY 10021, USA
    Blood 92:664-71. 1998
  3. ncbi request reprint Rh50 glycoprotein gene and rhnull disease: a silent splice donor is trans to a Gly279-->Glu missense mutation in the conserved transmembrane segment
    C H Huang
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York, NY, USA
    Blood 92:1776-84. 1998
  4. pmc Rhmod syndrome: a family study of the translation-initiator mutation in the Rh50 glycoprotein gene
    C Huang
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York, NY 10021, USA
    Am J Hum Genet 64:108-17. 1999
  5. ncbi request reprint Molecular basis for Rh(null) syndrome: identification of three new missense mutations in the Rh50 glycoprotein gene
    C H Huang
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York 10021, USA
    Am J Hematol 62:25-32. 1999
  6. ncbi request reprint Evidence for a separate genetic origin of the partial D phenotype DBT in a Japanese family
    C H Huang
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
    Transfusion 39:1259-65. 1999
  7. ncbi request reprint A novel St(a) glycophorin produced via gene conversion of pseudoexon III from glycophorin E to glycophorin A gene
    C H Huang
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York 10021, USA
    Hum Mutat 15:533-40. 2000
  8. ncbi request reprint New insights into the Rh superfamily of genes and proteins in erythroid cells and nonerythroid tissues
    C H Huang
    Laboratory of Biochemistry and Molecular Genetics, New York Blood Center, New York, New York 10021, USA
    Blood Cells Mol Dis 27:90-101. 2001
  9. ncbi request reprint Characterization of STIP, a multi-domain nuclear protein, highly conserved in metazoans, and essential for embryogenesis in Caenorhabditis elegans
    Qiongmei Ji
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, 310 E 67th Street, New York, NY 10021, USA
    Exp Cell Res 313:1460-72. 2007
  10. doi request reprint A Krüppel-like factor in Caenorhabditis elegans with essential roles in fat regulation, cell death, and phagocytosis
    Sarwar Hashmi
    Laboratories of Developmental Biology, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York 10065, USA
    DNA Cell Biol 27:545-51. 2008

Detail Information

Publications16

  1. ncbi request reprint The human Rh50 glycoprotein gene. Structural organization and associated splicing defect resulting in Rh(null) disease
    C H Huang
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
    J Biol Chem 273:2207-13. 1998
    ..These results identify the donor splicing defect, for the first time, as a loss-of-function mutation at the RH50 locus and pinpoint the importance of the C-terminal region of Rh50 in Rh complex formation via protein-protein interactions...
  2. ncbi request reprint Rhnull disease: the amorph type results from a novel double mutation in RhCe gene on D-negative background
    C H Huang
    Laboratory of Biochemistry, Lindsley F Kimball Research Institute, New York Blood Center, New York, NY 10021, USA
    Blood 92:664-71. 1998
    ..Our findings establish the molecular identity of an amorph Rhnull disease gene, showing that Rh30 and Rh50 are both essential for the functioning of the Rh structures as a multisubunit complex in the plasma membrane...
  3. ncbi request reprint Rh50 glycoprotein gene and rhnull disease: a silent splice donor is trans to a Gly279-->Glu missense mutation in the conserved transmembrane segment
    C H Huang
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York, NY, USA
    Blood 92:1776-84. 1998
    ..These findings provide new insight into the diversity of Rhnull disease and suggest that the C-terminal region of Rh50 may also participate in protein-protein interactions involving Rh complex formation...
  4. pmc Rhmod syndrome: a family study of the translation-initiator mutation in the Rh50 glycoprotein gene
    C Huang
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York, NY 10021, USA
    Am J Hum Genet 64:108-17. 1999
    ..Our findings point to incomplete penetrance of the Rhmod mutation, in the form of "leaky" translation, leading to some posttranslational defects affecting the structure, interaction, and processing of Rh50 glycoprotein...
  5. ncbi request reprint Molecular basis for Rh(null) syndrome: identification of three new missense mutations in the Rh50 glycoprotein gene
    C H Huang
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York 10021, USA
    Am J Hematol 62:25-32. 1999
    ..These results correlate each mutation with a structural defect in the respective TM domain of Rh50 glycoprotein...
  6. ncbi request reprint Evidence for a separate genetic origin of the partial D phenotype DBT in a Japanese family
    C H Huang
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
    Transfusion 39:1259-65. 1999
    ..In a Moroccan family, the partial D phenotype DBT is defined by an RHD-CE-D gene in which exons 5 to 7 of RHD were replaced by those of RHCE. In this study, the molecular basis and inheritance of DBT in a Japanese family are described...
  7. ncbi request reprint A novel St(a) glycophorin produced via gene conversion of pseudoexon III from glycophorin E to glycophorin A gene
    C H Huang
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York 10021, USA
    Hum Mutat 15:533-40. 2000
    ..Thus, the inactivation of GPA exon III by conversion of a silent GPE donor splice site portrays a new molecular mechanism for St(a) antigen expression in human erythrocytes...
  8. ncbi request reprint New insights into the Rh superfamily of genes and proteins in erythroid cells and nonerythroid tissues
    C H Huang
    Laboratory of Biochemistry and Molecular Genetics, New York Blood Center, New York, New York 10021, USA
    Blood Cells Mol Dis 27:90-101. 2001
    ..Further inquires into the structure, function, biosynthesis, and interaction of Rh proteins will shed new light on ammonia homeostasis in a wide range of human physiological and pathological states...
  9. ncbi request reprint Characterization of STIP, a multi-domain nuclear protein, highly conserved in metazoans, and essential for embryogenesis in Caenorhabditis elegans
    Qiongmei Ji
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, 310 E 67th Street, New York, NY 10021, USA
    Exp Cell Res 313:1460-72. 2007
    ..Our data provide the first direct evidence that STIP have a conserved essential nuclear function across metazoans from worms to humans...
  10. doi request reprint A Krüppel-like factor in Caenorhabditis elegans with essential roles in fat regulation, cell death, and phagocytosis
    Sarwar Hashmi
    Laboratories of Developmental Biology, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York 10065, USA
    DNA Cell Biol 27:545-51. 2008
    ..elegans Krüppel-like transcription factors together with their interactions and pathway activities with other molecular partners should yield significant insights into mammalian KLF proteins...
  11. ncbi request reprint Mutations in GYPB exon 5 drive the S-s-U+(var) phenotype in persons of African descent: implications for transfusion
    Jill R Storry
    Immunohematology Laboratory, New York Blood Center, New York, New York 10021, USA
    Transfusion 43:1738-47. 2003
    ..Variable reactivity of S-s-U+var RBCs with monoclonal anti-He or by anti-U has been demonstrated, however the underlying molecular bases for this phenotype remain to be established...
  12. ncbi request reprint Magmas gene structure and evolution
    Jianbin Peng
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York, NY 10021, USA
    In Silico Biol 5:251-63. 2005
    ..These studies demonstrate that Magmas members constitute an important family of conserved proteins having multifunctional activities, and provide a basis for future experiments...
  13. pmc Evolutionary conservation and diversification of Rh family genes and proteins
    Cheng Han Huang
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:15512-7. 2005
    ....
  14. pmc CeRh1 (rhr-1) is a dominant Rhesus gene essential for embryonic development and hypodermal function in Caenorhabditis elegans
    Qiongmei Ji
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:5881-6. 2006
    ..Taken together, our data provide direct evidence for the essentiality of the CeRh1 gene in C. elegans, establishing a useful animal model for investigating CO(2) channel function by cross-species complementation...
  15. ncbi request reprint Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain
    Jianbin Peng
    Biochemistry and Molecular Genetics Laboratory, Lindsley F Kimball Research Institute, New York Blood Center, 310 East, 67th St, New York, NY 10021, USA
    Biochim Biophys Acta 1759:562-72. 2006
    ..Taken together, Dusty is a unique evolutionarily selected group of divergent protein kinases that may play important functional roles in the brain and other tissues of vertebrates...
  16. pmc Rhesus expression in a green alga is regulated by CO(2)
    Eric Soupene
    Department of Plant and Microbial Biology, University of California, 111 Koshland Hall, Berkeley, CA 94720 3102, USA
    Proc Natl Acad Sci U S A 99:7769-73. 2002
    ..Conversely, RH1 expression was low for cells grown in air (0.035% CO(2)) or shifted from high CO(2) to air for 3 h. These results make viable the hypothesis that Rh1 and Rh proteins generally are gas channels for CO(2)...