Research Topics
Species | G HaskoSummaryAffiliation: New Jersey Country: USA Publications
Research Grants
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Publications
The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitisJon Mabley
Inotek Pharmaceuticals Corporation, Suite 419E, 100 Cummings Center, Beverly, MA 01915, USA
Eur J Pharmacol 466:323-9. 2003..Thus activation of the adenosine A(3) receptor is effective in protecting against colitis...
Regulation of macrophage function by adenosineGyorgy Hasko
Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, 07103, USA
Arterioscler Thromb Vasc Biol 32:865-9. 2012..By regulating mononuclear phagocyte function adenosine dictates the course of inflammatory and vascular diseases and cancer...- Role of A(2A) adenosine receptors in regulation of opsonized E. coli-induced macrophage functionBalázs Csóka
Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ, 07103, USA
Purinergic Signal 3:447-52. 2007..In contrast, peritoneal macrophages may contribute to the suppressive effect of A(2A) receptor inactivation on IL-10 production during sepsis... - Dopamine suppresses IL-12 p40 production by lipopolysaccharide-stimulated macrophages via a beta-adrenoceptor-mediated mechanismGyorgy Hasko
Department of Surgery, UMD New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA
J Neuroimmunol 122:34-9. 2002..These results indicate that dopamine has multiple anti-inflammatory effects mediated by both beta-adrenoceptor dependent and independent mechanisms... - Adenosine receptor signaling in the brain immune systemGyorgy Hasko
Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
Trends Pharmacol Sci 26:511-6. 2005..A more complete understanding of adenosine receptor function in the brain immune system should help develop novel therapeutic ways to treat brain disorders that are associated with a dysfunctional immune response... - A2A receptors in inflammation and injury: lessons learned from transgenic animalsGyorgy Hasko
UMDNJ New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA
J Leukoc Biol 83:447-55. 2008.... - Shaping of monocyte and macrophage function by adenosine receptorsGyorgy Hasko
Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
Pharmacol Ther 113:264-75. 2007..A deeper insight into the regulation of monocyte and macrophage function by adenosine receptors should assist in developing new therapies for inflammatory diseases... - Adenosine: a potential mediator of immunosuppression in multiple organ failureGyorgy Hasko
Department of Surgery, University of Medicine and Dentistry, New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA
Curr Opin Pharmacol 2:440-4. 2002..A deeper understanding of the role of adenosine in multiple organ failure may facilitate the development of adenosine-based therapeutic strategies... - Inhibitors of ATP-binding cassette transporters suppress interleukin-12 p40 production and major histocompatibility complex II up-regulation in macrophagesGyorgy Hasko
Department of Surgery, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey 07103, USA
J Pharmacol Exp Ther 301:103-10. 2002..Glibenclamide also suppressed IFN-gamma-induced up-regulation of major histocompatibility complex II. Taken together, our results indicate that ABC proteins regulate LPS and/or IFN-gamma-induced macrophage activation... - Adenosine receptors: therapeutic aspects for inflammatory and immune diseasesGyorgy Hasko
Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, USA
Nat Rev Drug Discov 7:759-70. 2008.... - A(2B) adenosine receptors in immunity and inflammationGyorgy Hasko
Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, 07103, USA
Trends Immunol 30:263-70. 2009..A(2B) receptors are, thus, potentially important pharmacological targets in treating immune system dysfunction and inflammation... - Receptor-mediated interaction between the sympathetic nervous system and immune system in inflammationG Hasko
Department of Surgery, UMD New Jersey Medical School, Newark 07103, USA
Neurochem Res 26:1039-44. 2001.... - Sulphasalazine inhibits macrophage activation: inhibitory effects on inducible nitric oxide synthase expression, interleukin-12 production and major histocompatibility complex II expressionG Hasko
Department of Surgery, UMD New Jersey Medical School, Newark, NJ 07103, USA
Immunology 103:473-8. 2001..Finally, sulphasalazine suppressed the IFN-gamma-induced expression of major histocompatibility complex class II. These results demonstrate that the M phi is an important target of the immunosuppressive effect of sulphasalazine... - Adenosine: an endogenous regulator of innate immunityGyorgy Hasko
Department of Surgery, UMD New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA
Trends Immunol 25:33-9. 2004..The effects of adenosine, acting at its receptors, on the functions of the cells that mediate innate immune responses, will be reviewed... - Adenosine promotes alternative macrophage activation via A2A and A2B receptorsBalázs Csóka
Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ, USA
FASEB J 26:376-86. 2012..We propose that adenosine receptor activation suppresses inflammation and promotes tissue restitution, in part, by promoting alternative macrophage activation... - Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanismsG Hasko
Inotek Corp, Beverly, Massachusetts 01915, USA
FASEB J 14:2065-74. 2000..In summary, adenosine inhibits IL-12 production via various adenosine receptors. These results support the notion that adenosine-based therapies might be useful in certain autoimmune and/or inflammatory diseases... - Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shockG Hasko
Inotek Corp, Beverly, MA 01915, USA
J Immunol 164:1013-9. 2000..Taken together, inosine has multiple anti-inflammatory effects. These findings, coupled with the fact that inosine has very low toxicity, suggest that this agent may be useful in the treatment of inflammatory/ischemic diseases... - Inhibition of the Na(+)/H(+) antiporter suppresses IL-12 p40 production by mouse macrophagesZ H Nemeth
Department of Surgery, UMD New Jersey Medical School, Newark, NJ 07103, USA
Biochim Biophys Acta 1539:233-42. 2001..In summary, the production of IL-12 p40 requires a functional Na(+)/H(+) antiporter... - Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetesJ G Mabley
Inotek Corporation, Suite 419E, 100 Cummings Center, Beverly, Massachusetts MA 01915, USA
Br J Pharmacol 133:909-19. 2001.... - Inosine reduces inflammation and improves survival in a murine model of colitisJ G Mabley
Inotek Pharmaceuticals, Beverly, Massachusetts 01915, USA
Am J Physiol Gastrointest Liver Physiol 284:G138-44. 2003..Inosine also partially reduced these parameters in an experimental model of established colitis. Thus inosine treatment may be a potential therapy in colitis... - Suppression of PLCbeta2 by endotoxin plays a role in the adenosine A(2A) receptor-mediated switch of macrophages from an inflammatory to an angiogenic phenotypeStan Grinberg
Department of Cell Biology and Molecular Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
Am J Pathol 175:2439-53. 2009..These results suggest that suppression of PLCbeta2 plays an important role in switching M1 macrophages into an M2-like state... - An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptorsGrace Pinhal-Enfield
Department of Cell Biology and Molecular Medicine, New Jersey Medical School, UMDNJ, Newark, New Jersey 07013, USA
Am J Pathol 163:711-21. 2003..This angiogenic switch may play an important role in ischemia when TLR agonists are present, providing an interface between innate immunity and wound healing... - NFkappaB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetesJ G Mabley
Inotek Corporation, Suite 419E, 100 Cummings Center, Beverly, MA 01915, USA
J Endocrinol 173:457-64. 2002..Our data suggest that NFkappaB (p50) has an essential role in the development of autoimmune diabetes. Selective therapeutic blockade of this subunit may be beneficial in preventing IDDM... - cDNA microarray analysis reveals a nuclear factor-kappaB-independent regulation of macrophage function by adenosineZoltán H Németh
Department of Surgery, University of Medicine and Dentistry New Jersey Medical School, Newark, NJ 07103, USA
J Pharmacol Exp Ther 306:1042-9. 2003..Together, our results suggest that the anti-inflammatory effects of adenosine are independent of NF-kappaB... - IL-12 as a therapeutic target for pharmacological modulation in immune-mediated and inflammatory diseases: regulation of T helper 1/T helper 2 responsesG Hasko
Inotek Corp, 100 Cummings Center, Beverly, Massachusetts 01915, USA
Br J Pharmacol 127:1295-304. 1999..Exploitation of these approaches may provide novel means for the experimental therapy of a variety of pathophysiological states... - Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivityE Szabo
Inotek Corporation, Beverly, Massachusetts, USA
J Invest Dermatol 117:74-80. 2001..Our results indicate that peroxynitrite and poly(ADP-ribose) polymerase regulate keratinocyte function and death in contact hypersensitivity... - Differential regulation of HIF-1alpha isoforms in murine macrophages by TLR4 and adenosine A(2A) receptor agonistsMadhuri Ramanathan
Department of Cell Biology and Molecular Medicine and The Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
J Leukoc Biol 86:681-9. 2009..LPS-induced expression of A(2A)Rs and HIF-1alpha and A(2A)R-dependent HIF-1alpha mRNA and protein stabilization provide mechanisms for the synergistic effects of LPS and A(2A)R agonists on macrophage VEGF expression... - Lithium induces NF-kappa B activation and interleukin-8 production in human intestinal epithelial cellsZoltán H Németh
Department of Surgery, UMD New Jersey Medical School, Newark, New Jersey 07103, USA
J Biol Chem 277:7713-9. 2002..These results demonstrate that lithium stimulates inflammatory gene expression via NF-kappa B and MAP kinase activation... - Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanismZoltán H Németh
Department of Surgery, University of Medicine and Dentistry of New Jersey UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
J Immunol 175:8260-70. 2005..Collectively, these studies identify a novel pathway in which activation of a G protein-coupled receptor augments translation of an anti-inflammatory gene... - The immunomodulatory effects of damage control abdominal packing on local and systemic neutrophil activityJ M Adams
Department of Surgery, Division of Trauma, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
J Trauma 50:792-800. 2001..Peritoneal mediator production after DCL may be ETX driven, and may contribute to systemic inflammatory response syndrome. DCL trades early hemostasis for later inflammation. This should be considered in planning management strategies... - Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failureP Pacher
Inotek Corporation, Beverly, Massachusetts 01915, USA
J Pharmacol Exp Ther 300:862-7. 2002..Thus, PARP activation contributes to the cardiotoxicity of DOX. PARP inhibitors may exert protective effects against the development of severe cardiac complications associated with the DOX treatment... - A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coliBalázs Csóka
Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
Blood 110:2685-95. 2007..C/EBPbeta-deficient macrophages failed to produce IL-10 in response to adenosine and E coli. Our results suggest that the A(2A) receptor-C/EBPbeta axis is critical for IL-10 production after bacterial infection... 
Endotoxemia down-regulates bone marrow lymphopoiesis but stimulates myelopoiesis: the effect of G6PD deficiencyRachna Chandra
Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
J Leukoc Biol 83:1541-50. 2008..LPS-induced down-regulation of B cell production contributes to the generalized lymphopenia and lymphocyte dysfunction observed following nonspecific immune challenges...- CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsisBalázs Csóka
Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
PLoS ONE 4:e6409. 2009..Here we examined the role of CB(2) receptors in regulating the host's response to sepsis... - A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammationBalázs Csóka
Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
J Immunol 185:542-50. 2010..These results indicate that A(2B) receptor activation may offer a new therapeutic approach for the management of sepsis... - Calcium entry inhibition during resuscitation from shock attenuates inflammatory lung injuryCindy Lee
Department of Surgery, Division of Trauma, New Jersey Medical School, Newark, New Jersey, USA
Shock 30:29-35. 2008..Ca2+ entry inhibition is a candidate therapy for management of lung injury after shock... - Adenosine receptor activation ameliorates type 1 diabetesZoltán H Németh
Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Ave, University Heights, Newark, NJ 07103, USA
FASEB J 21:2379-88. 2007..These results demonstrate that adenosine receptor ligands are potential candidates for the treatment of type 1 diabetes... - Disruption of the actin cytoskeleton results in nuclear factor-kappaB activation and inflammatory mediator production in cultured human intestinal epithelial cellsZoltán H Németh
Department of Surgery, UMD NJ New Jersey Medical School, Newark, New Jersey 07103, USA
J Cell Physiol 200:71-81. 2004..These results demonstrate that the actin cytoskeleton plays an important role in the regulation of NF-kappaB activation and inflammatory events in intestinal epithelial cells... - Inosine protects against the development of diabetes in multiple-low-dose streptozotocin and nonobese diabetic mouse models of type 1 diabetesJon G Mabley
Inotek Pharmaceuticals Corp, Beverly, MA 01915, USA
Mol Med 9:96-104. 2003..The use of inosine should be considered as a potential preventative therapy in humans susceptible to developing Type 1 diabetes and as a possible antirejection therapy for islet transplant recipients... - Female X-chromosome mosaicism for gp91phox expression diversifies leukocyte responses during endotoxemiaRachna Chandra
Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA
Crit Care Med 38:2003-10. 2010..This is in contrast with the conditions in males who carry exclusively the maternal X chromosome... - Adenosine stimulates CREB activation in macrophages via a p38 MAPK-mediated mechanismZoltán H Németh
Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
Biochem Biophys Res Commun 312:883-8. 2003..Thus, some of the immunomodulatory effects of adenosine in macrophages may be explained by its augmenting effect on CREB activation... - Investigational A₃ adenosine receptor targeting agentsBalázs Koscsó
University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Department of Surgery, 185 South Orange Avenue, Newark, NJ 07103, USA
Expert Opin Investig Drugs 20:757-68. 2011.... - Adenosine A2A receptor inactivation increases survival in polymicrobial sepsisZoltán H Németh
Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
J Immunol 176:5616-26. 2006..Similar to observations with A(2A)R KO mice, an A(2A)R antagonist increased survival even when administered in a delayed fashion. These studies demonstrate that A(2A)R blockade may be useful in the treatment of infection and sepsis...
Research Grants
- Adenosine in trauma and sepsisGyorgy Hasko; Fiscal Year: 2007..abstract_text> ..
- Adenosine in trauma and sepsisGyorgy Hasko; Fiscal Year: 2010....
- Adenosine in trauma and sepsisGyorgy Hasko; Fiscal Year: 2005..We will test these hypotheses both in vitro using T cell and macrophage systems as well as in vivo using the mouse cecal ligation and puncture model of MOF. ..