G Hasko

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi request reprint The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitis
    Jon Mabley
    Inotek Pharmaceuticals Corporation, Suite 419E, 100 Cummings Center, Beverly, MA 01915, USA
    Eur J Pharmacol 466:323-9. 2003
  2. pmc Regulation of macrophage function by adenosine
    Gyorgy Hasko
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, 07103, USA
    Arterioscler Thromb Vasc Biol 32:865-9. 2012
  3. pmc Role of A(2A) adenosine receptors in regulation of opsonized E. coli-induced macrophage function
    Balázs Csóka
    Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ, 07103, USA
    Purinergic Signal 3:447-52. 2007
  4. ncbi request reprint Dopamine suppresses IL-12 p40 production by lipopolysaccharide-stimulated macrophages via a beta-adrenoceptor-mediated mechanism
    Gyorgy Hasko
    Department of Surgery, UMD New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA
    J Neuroimmunol 122:34-9. 2002
  5. ncbi request reprint Inhibitors of ATP-binding cassette transporters suppress interleukin-12 p40 production and major histocompatibility complex II up-regulation in macrophages
    Gyorgy Hasko
    Department of Surgery, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey 07103, USA
    J Pharmacol Exp Ther 301:103-10. 2002
  6. ncbi request reprint Adenosine: a potential mediator of immunosuppression in multiple organ failure
    Gyorgy Hasko
    Department of Surgery, University of Medicine and Dentistry, New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA
    Curr Opin Pharmacol 2:440-4. 2002
  7. ncbi request reprint Adenosine: an endogenous regulator of innate immunity
    Gyorgy Hasko
    Department of Surgery, UMD New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA
    Trends Immunol 25:33-9. 2004
  8. pmc A(2B) adenosine receptors in immunity and inflammation
    Gyorgy Hasko
    Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, 07103, USA
    Trends Immunol 30:263-70. 2009
  9. pmc Adenosine receptor signaling in the brain immune system
    Gyorgy Hasko
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Trends Pharmacol Sci 26:511-6. 2005
  10. pmc Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
    Gyorgy Hasko
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, USA
    Nat Rev Drug Discov 7:759-70. 2008

Research Grants

  1. Adenosine in trauma and sepsis
    Gyorgy Hasko; Fiscal Year: 2010
  2. Adenosine in trauma and sepsis
    Gyorgy Hasko; Fiscal Year: 2007
  3. Adenosine in trauma and sepsis
    Gyorgy Hasko; Fiscal Year: 2005

Collaborators

Detail Information

Publications44

  1. ncbi request reprint The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitis
    Jon Mabley
    Inotek Pharmaceuticals Corporation, Suite 419E, 100 Cummings Center, Beverly, MA 01915, USA
    Eur J Pharmacol 466:323-9. 2003
    ..Thus activation of the adenosine A(3) receptor is effective in protecting against colitis...
  2. pmc Regulation of macrophage function by adenosine
    Gyorgy Hasko
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, 07103, USA
    Arterioscler Thromb Vasc Biol 32:865-9. 2012
    ..By regulating mononuclear phagocyte function adenosine dictates the course of inflammatory and vascular diseases and cancer...
  3. pmc Role of A(2A) adenosine receptors in regulation of opsonized E. coli-induced macrophage function
    Balázs Csóka
    Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ, 07103, USA
    Purinergic Signal 3:447-52. 2007
    ..In contrast, peritoneal macrophages may contribute to the suppressive effect of A(2A) receptor inactivation on IL-10 production during sepsis...
  4. ncbi request reprint Dopamine suppresses IL-12 p40 production by lipopolysaccharide-stimulated macrophages via a beta-adrenoceptor-mediated mechanism
    Gyorgy Hasko
    Department of Surgery, UMD New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA
    J Neuroimmunol 122:34-9. 2002
    ..These results indicate that dopamine has multiple anti-inflammatory effects mediated by both beta-adrenoceptor dependent and independent mechanisms...
  5. ncbi request reprint Inhibitors of ATP-binding cassette transporters suppress interleukin-12 p40 production and major histocompatibility complex II up-regulation in macrophages
    Gyorgy Hasko
    Department of Surgery, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey 07103, USA
    J Pharmacol Exp Ther 301:103-10. 2002
    ..Glibenclamide also suppressed IFN-gamma-induced up-regulation of major histocompatibility complex II. Taken together, our results indicate that ABC proteins regulate LPS and/or IFN-gamma-induced macrophage activation...
  6. ncbi request reprint Adenosine: a potential mediator of immunosuppression in multiple organ failure
    Gyorgy Hasko
    Department of Surgery, University of Medicine and Dentistry, New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA
    Curr Opin Pharmacol 2:440-4. 2002
    ..A deeper understanding of the role of adenosine in multiple organ failure may facilitate the development of adenosine-based therapeutic strategies...
  7. ncbi request reprint Adenosine: an endogenous regulator of innate immunity
    Gyorgy Hasko
    Department of Surgery, UMD New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA
    Trends Immunol 25:33-9. 2004
    ..The effects of adenosine, acting at its receptors, on the functions of the cells that mediate innate immune responses, will be reviewed...
  8. pmc A(2B) adenosine receptors in immunity and inflammation
    Gyorgy Hasko
    Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, 07103, USA
    Trends Immunol 30:263-70. 2009
    ..A(2B) receptors are, thus, potentially important pharmacological targets in treating immune system dysfunction and inflammation...
  9. pmc Adenosine receptor signaling in the brain immune system
    Gyorgy Hasko
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Trends Pharmacol Sci 26:511-6. 2005
    ..A more complete understanding of adenosine receptor function in the brain immune system should help develop novel therapeutic ways to treat brain disorders that are associated with a dysfunctional immune response...
  10. pmc Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
    Gyorgy Hasko
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, USA
    Nat Rev Drug Discov 7:759-70. 2008
    ....
  11. pmc Shaping of monocyte and macrophage function by adenosine receptors
    Gyorgy Hasko
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Pharmacol Ther 113:264-75. 2007
    ..A deeper insight into the regulation of monocyte and macrophage function by adenosine receptors should assist in developing new therapies for inflammatory diseases...
  12. pmc Adenosine promotes alternative macrophage activation via A2A and A2B receptors
    Balázs Csóka
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ, USA
    FASEB J 26:376-86. 2012
    ..We propose that adenosine receptor activation suppresses inflammation and promotes tissue restitution, in part, by promoting alternative macrophage activation...
  13. pmc A2A receptors in inflammation and injury: lessons learned from transgenic animals
    Gyorgy Hasko
    UMDNJ New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA
    J Leukoc Biol 83:447-55. 2008
    ....
  14. pmc Sulphasalazine inhibits macrophage activation: inhibitory effects on inducible nitric oxide synthase expression, interleukin-12 production and major histocompatibility complex II expression
    G Hasko
    Department of Surgery, UMD New Jersey Medical School, Newark, NJ 07103, USA
    Immunology 103:473-8. 2001
    ..Finally, sulphasalazine suppressed the IFN-gamma-induced expression of major histocompatibility complex class II. These results demonstrate that the M phi is an important target of the immunosuppressive effect of sulphasalazine...
  15. ncbi request reprint Receptor-mediated interaction between the sympathetic nervous system and immune system in inflammation
    G Hasko
    Department of Surgery, UMD New Jersey Medical School, Newark 07103, USA
    Neurochem Res 26:1039-44. 2001
    ....
  16. ncbi request reprint Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanisms
    G Hasko
    Inotek Corp, Beverly, Massachusetts 01915, USA
    FASEB J 14:2065-74. 2000
    ..In summary, adenosine inhibits IL-12 production via various adenosine receptors. These results support the notion that adenosine-based therapies might be useful in certain autoimmune and/or inflammatory diseases...
  17. ncbi request reprint Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock
    G Hasko
    Inotek Corp, Beverly, MA 01915, USA
    J Immunol 164:1013-9. 2000
    ..Taken together, inosine has multiple anti-inflammatory effects. These findings, coupled with the fact that inosine has very low toxicity, suggest that this agent may be useful in the treatment of inflammatory/ischemic diseases...
  18. ncbi request reprint Inhibition of the Na(+)/H(+) antiporter suppresses IL-12 p40 production by mouse macrophages
    Z H Nemeth
    Department of Surgery, UMD New Jersey Medical School, Newark, NJ 07103, USA
    Biochim Biophys Acta 1539:233-42. 2001
    ..In summary, the production of IL-12 p40 requires a functional Na(+)/H(+) antiporter...
  19. pmc Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes
    J G Mabley
    Inotek Corporation, Suite 419E, 100 Cummings Center, Beverly, Massachusetts MA 01915, USA
    Br J Pharmacol 133:909-19. 2001
    ....
  20. ncbi request reprint Inosine reduces inflammation and improves survival in a murine model of colitis
    J G Mabley
    Inotek Pharmaceuticals, Beverly, Massachusetts 01915, USA
    Am J Physiol Gastrointest Liver Physiol 284:G138-44. 2003
    ..Inosine also partially reduced these parameters in an experimental model of established colitis. Thus inosine treatment may be a potential therapy in colitis...
  21. pmc An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors
    Grace Pinhal-Enfield
    Department of Cell Biology and Molecular Medicine, New Jersey Medical School, UMDNJ, Newark, New Jersey 07013, USA
    Am J Pathol 163:711-21. 2003
    ..This angiogenic switch may play an important role in ischemia when TLR agonists are present, providing an interface between innate immunity and wound healing...
  22. pmc Suppression of PLCbeta2 by endotoxin plays a role in the adenosine A(2A) receptor-mediated switch of macrophages from an inflammatory to an angiogenic phenotype
    Stan Grinberg
    Department of Cell Biology and Molecular Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Am J Pathol 175:2439-53. 2009
    ..These results suggest that suppression of PLCbeta2 plays an important role in switching M1 macrophages into an M2-like state...
  23. ncbi request reprint NFkappaB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes
    J G Mabley
    Inotek Corporation, Suite 419E, 100 Cummings Center, Beverly, MA 01915, USA
    J Endocrinol 173:457-64. 2002
    ..Our data suggest that NFkappaB (p50) has an essential role in the development of autoimmune diabetes. Selective therapeutic blockade of this subunit may be beneficial in preventing IDDM...
  24. ncbi request reprint cDNA microarray analysis reveals a nuclear factor-kappaB-independent regulation of macrophage function by adenosine
    Zoltán H Németh
    Department of Surgery, University of Medicine and Dentistry New Jersey Medical School, Newark, NJ 07103, USA
    J Pharmacol Exp Ther 306:1042-9. 2003
    ..Together, our results suggest that the anti-inflammatory effects of adenosine are independent of NF-kappaB...
  25. pmc IL-12 as a therapeutic target for pharmacological modulation in immune-mediated and inflammatory diseases: regulation of T helper 1/T helper 2 responses
    G Hasko
    Inotek Corp, 100 Cummings Center, Beverly, Massachusetts 01915, USA
    Br J Pharmacol 127:1295-304. 1999
    ..Exploitation of these approaches may provide novel means for the experimental therapy of a variety of pathophysiological states...
  26. ncbi request reprint Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity
    E Szabo
    Inotek Corporation, Beverly, Massachusetts, USA
    J Invest Dermatol 117:74-80. 2001
    ..Our results indicate that peroxynitrite and poly(ADP-ribose) polymerase regulate keratinocyte function and death in contact hypersensitivity...
  27. pmc Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism
    Zoltán H Németh
    Department of Surgery, University of Medicine and Dentistry of New Jersey UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 175:8260-70. 2005
    ..Collectively, these studies identify a novel pathway in which activation of a G protein-coupled receptor augments translation of an anti-inflammatory gene...
  28. ncbi request reprint Lithium induces NF-kappa B activation and interleukin-8 production in human intestinal epithelial cells
    Zoltán H Németh
    Department of Surgery, UMD New Jersey Medical School, Newark, New Jersey 07103, USA
    J Biol Chem 277:7713-9. 2002
    ..These results demonstrate that lithium stimulates inflammatory gene expression via NF-kappa B and MAP kinase activation...
  29. pmc Differential regulation of HIF-1alpha isoforms in murine macrophages by TLR4 and adenosine A(2A) receptor agonists
    Madhuri Ramanathan
    Department of Cell Biology and Molecular Medicine and The Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    J Leukoc Biol 86:681-9. 2009
    ..LPS-induced expression of A(2A)Rs and HIF-1alpha and A(2A)R-dependent HIF-1alpha mRNA and protein stabilization provide mechanisms for the synergistic effects of LPS and A(2A)R agonists on macrophage VEGF expression...
  30. doi request reprint Induction of murine adenosine A(2A) receptor expression by LPS: analysis of the 5' upstream promoter
    G Elson
    Department of Cell Biology and Molecular Medicine and The Cardiovascular Research Institute, Newark, NJ, USA
    Genes Immun 14:147-53. 2013
    ..Further analysis of this promoter should provide valuable insights into regulation of A(2A)R expression in macrophages in response to inflammatory stimuli...
  31. ncbi request reprint The immunomodulatory effects of damage control abdominal packing on local and systemic neutrophil activity
    J M Adams
    Department of Surgery, Division of Trauma, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Trauma 50:792-800. 2001
    ..Peritoneal mediator production after DCL may be ETX driven, and may contribute to systemic inflammatory response syndrome. DCL trades early hemostasis for later inflammation. This should be considered in planning management strategies...
  32. ncbi request reprint Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure
    P Pacher
    Inotek Corporation, Beverly, Massachusetts 01915, USA
    J Pharmacol Exp Ther 300:862-7. 2002
    ..Thus, PARP activation contributes to the cardiotoxicity of DOX. PARP inhibitors may exert protective effects against the development of severe cardiac complications associated with the DOX treatment...
  33. pmc A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli
    Balázs Csóka
    Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Blood 110:2685-95. 2007
    ..C/EBPbeta-deficient macrophages failed to produce IL-10 in response to adenosine and E coli. Our results suggest that the A(2A) receptor-C/EBPbeta axis is critical for IL-10 production after bacterial infection...
  34. pmc CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis
    Balázs Csóka
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 4:e6409. 2009
    ..Here we examined the role of CB(2) receptors in regulating the host's response to sepsis...
  35. doi request reprint Endotoxemia down-regulates bone marrow lymphopoiesis but stimulates myelopoiesis: the effect of G6PD deficiency
    Rachna Chandra
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Leukoc Biol 83:1541-50. 2008
    ..LPS-induced down-regulation of B cell production contributes to the generalized lymphopenia and lymphocyte dysfunction observed following nonspecific immune challenges...
  36. pmc A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation
    Balázs Csóka
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 185:542-50. 2010
    ..These results indicate that A(2B) receptor activation may offer a new therapeutic approach for the management of sepsis...
  37. ncbi request reprint Calcium entry inhibition during resuscitation from shock attenuates inflammatory lung injury
    Cindy Lee
    Department of Surgery, Division of Trauma, New Jersey Medical School, Newark, New Jersey, USA
    Shock 30:29-35. 2008
    ..Ca2+ entry inhibition is a candidate therapy for management of lung injury after shock...
  38. pmc Adenosine receptor activation ameliorates type 1 diabetes
    Zoltán H Németh
    Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Ave, University Heights, Newark, NJ 07103, USA
    FASEB J 21:2379-88. 2007
    ..These results demonstrate that adenosine receptor ligands are potential candidates for the treatment of type 1 diabetes...
  39. ncbi request reprint Disruption of the actin cytoskeleton results in nuclear factor-kappaB activation and inflammatory mediator production in cultured human intestinal epithelial cells
    Zoltán H Németh
    Department of Surgery, UMD NJ New Jersey Medical School, Newark, New Jersey 07103, USA
    J Cell Physiol 200:71-81. 2004
    ..These results demonstrate that the actin cytoskeleton plays an important role in the regulation of NF-kappaB activation and inflammatory events in intestinal epithelial cells...
  40. pmc Female X-chromosome mosaicism for gp91phox expression diversifies leukocyte responses during endotoxemia
    Rachna Chandra
    Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA
    Crit Care Med 38:2003-10. 2010
    ..This is in contrast with the conditions in males who carry exclusively the maternal X chromosome...
  41. pmc Inosine protects against the development of diabetes in multiple-low-dose streptozotocin and nonobese diabetic mouse models of type 1 diabetes
    Jon G Mabley
    Inotek Pharmaceuticals Corp, Beverly, MA 01915, USA
    Mol Med 9:96-104. 2003
    ..The use of inosine should be considered as a potential preventative therapy in humans susceptible to developing Type 1 diabetes and as a possible antirejection therapy for islet transplant recipients...
  42. ncbi request reprint Adenosine stimulates CREB activation in macrophages via a p38 MAPK-mediated mechanism
    Zoltán H Németh
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Biochem Biophys Res Commun 312:883-8. 2003
    ..Thus, some of the immunomodulatory effects of adenosine in macrophages may be explained by its augmenting effect on CREB activation...
  43. pmc Investigational A₃ adenosine receptor targeting agents
    Balázs Koscsó
    University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Department of Surgery, 185 South Orange Avenue, Newark, NJ 07103, USA
    Expert Opin Investig Drugs 20:757-68. 2011
    ..Since the discovery of A(3) adenosine receptors, accumulating evidence has identified these receptors as potential targets for therapeutic intervention...
  44. pmc Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis
    Zoltán H Németh
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Immunol 176:5616-26. 2006
    ..Similar to observations with A(2A)R KO mice, an A(2A)R antagonist increased survival even when administered in a delayed fashion. These studies demonstrate that A(2A)R blockade may be useful in the treatment of infection and sepsis...

Research Grants8

  1. Adenosine in trauma and sepsis
    Gyorgy Hasko; Fiscal Year: 2010
    ....
  2. Adenosine in trauma and sepsis
    Gyorgy Hasko; Fiscal Year: 2007
    ..abstract_text> ..
  3. Adenosine in trauma and sepsis
    Gyorgy Hasko; Fiscal Year: 2005
    ..We will test these hypotheses both in vitro using T cell and macrophage systems as well as in vivo using the mouse cecal ligation and puncture model of MOF. ..