M Hampsey

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc Molecular genetics of the RNA polymerase II general transcriptional machinery
    M Hampsey
    Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854 5635, USA
    Microbiol Mol Biol Rev 62:465-503. 1998
  2. ncbi request reprint RNA polymerase II as a control panel for multiple coactivator complexes
    M Hampsey
    Department of Biochemistry, Division of Nucleic Acids Enzymology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
    Curr Opin Genet Dev 9:132-9. 1999
  3. ncbi request reprint A Gal4-sigma 54 hybrid protein that functions as a potent activator of RNA polymerase II transcription in yeast
    B S Chen
    Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854-5635, USA
    J Biol Chem 276:23881-7. 2001
  4. pmc A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae
    Z W Sun
    Department of Biochemistry, Division of Nucleic Acids Enzymology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genetics 152:921-32. 1999
  5. pmc Mutational analysis of yeast TFIIB. A functional relationship between Ssu72 and Sub1/Tsp1 defined by allele-specific interactions with TFIIB
    W H Wu
    Department of Biochemistry, Louisiana State University Medical Center, Shreveport, Louisiana 71130, USA
    Genetics 153:643-52. 1999
  6. pmc Functional interaction between Ssu72 and the Rpb2 subunit of RNA polymerase II in Saccharomyces cerevisiae
    D L Pappas
    Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 20:8343-51. 2000
  7. ncbi request reprint The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins
    G Orphanides
    Howard Hughes Medical Institute, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854, USA
    Nature 400:284-8. 1999
  8. pmc Genetic analysis of the YDR1-BUR6 repressor complex reveals an intricate balance among transcriptional regulatory proteins in yeast
    S Kim
    Howard Hughes Medical Institute, Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854 5635, USA
    Mol Cell Biol 20:2455-65. 2000
  9. pmc An activation-specific role for transcription factor TFIIB in vivo
    W H Wu
    Department of Biochemistry, Division of Nucleic Acids Enzymology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854 5635, USA
    Proc Natl Acad Sci U S A 96:2764-9. 1999
  10. ncbi request reprint SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex
    Y Zhang
    Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School Piscataway, New Jersey 08854, USA
    Mol Cell 1:1021-31. 1998

Collaborators

  • S Kim
  • Y Zhang
  • W H Wu
  • B S Chen
  • Z W Sun
  • D L Pappas
  • G Orphanides
  • D Reinberg
  • W S Lane
  • I Pinto

Detail Information

Publications10

  1. pmc Molecular genetics of the RNA polymerase II general transcriptional machinery
    M Hampsey
    Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854 5635, USA
    Microbiol Mol Biol Rev 62:465-503. 1998
    ..Emphasis is placed on the role that yeast genetics has played in identifying these factors and their associated functions...
  2. ncbi request reprint RNA polymerase II as a control panel for multiple coactivator complexes
    M Hampsey
    Department of Biochemistry, Division of Nucleic Acids Enzymology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
    Curr Opin Genet Dev 9:132-9. 1999
    ..Recent developments regarding the composition and function of RNA polymerase II complexes suggest, however, that the concept of the holoenzyme, as defined in bacteria, might not be relevant to eukaryotes...
  3. ncbi request reprint A Gal4-sigma 54 hybrid protein that functions as a potent activator of RNA polymerase II transcription in yeast
    B S Chen
    Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854-5635, USA
    J Biol Chem 276:23881-7. 2001
    ..As such, Gal4-final sigma(54) represents a novel tool with the potential to provide insight into the mechanism by which natural activators function in eukaryotic cells...
  4. pmc A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae
    Z W Sun
    Department of Biochemistry, Division of Nucleic Acids Enzymology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genetics 152:921-32. 1999
    ..Strikingly, deletion of GCN5, which encodes a histone acetyltransferase, enhances silencing in a manner similar to deletion of RPD3. A model that integrates the effects of rpd3Delta, gcn5Delta, and cac3Delta on silencing is proposed...
  5. pmc Mutational analysis of yeast TFIIB. A functional relationship between Ssu72 and Sub1/Tsp1 defined by allele-specific interactions with TFIIB
    W H Wu
    Department of Biochemistry, Louisiana State University Medical Center, Shreveport, Louisiana 71130, USA
    Genetics 153:643-52. 1999
    ..These results demonstrate functional interactions among TFIIB, Ssu72, and Sub1 and suggest that these interactions play a role in the mechanism of start site selection by RNA polymerase II...
  6. pmc Functional interaction between Ssu72 and the Rpb2 subunit of RNA polymerase II in Saccharomyces cerevisiae
    D L Pappas
    Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 20:8343-51. 2000
    ..These results define Ssu72 as a highly conserved factor that physically and functionally interacts with the RNAP II core machinery during transcription initiation...
  7. ncbi request reprint The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins
    G Orphanides
    Howard Hughes Medical Institute, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854, USA
    Nature 400:284-8. 1999
    ..In support of this model, we show that FACT activity is abrogated by covalently crosslinking nucleosomal histones...
  8. pmc Genetic analysis of the YDR1-BUR6 repressor complex reveals an intricate balance among transcriptional regulatory proteins in yeast
    S Kim
    Howard Hughes Medical Institute, Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854 5635, USA
    Mol Cell Biol 20:2455-65. 2000
    ..These results define a delicate balance between positive and negative regulators of transcription operating through the Ydr1-Bur6 repressor complex...
  9. pmc An activation-specific role for transcription factor TFIIB in vivo
    W H Wu
    Department of Biochemistry, Division of Nucleic Acids Enzymology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854 5635, USA
    Proc Natl Acad Sci U S A 96:2764-9. 1999
    ..These results define an activation-specific role for TFIIB in vivo and suggest that certain activators induce a conformational change in TFIIB as part of their mechanism of transcriptional stimulation...
  10. ncbi request reprint SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex
    Y Zhang
    Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School Piscataway, New Jersey 08854, USA
    Mol Cell 1:1021-31. 1998
    ..These results define SAP30 as a component of a histone deacetylase complex conserved among eukaryotic organisms...