B G Haffty

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc BCL-2 (-938C > A) polymorphism is associated with breast cancer susceptibility
    Ning Zhang
    Department of Breast Surgery, Qilu Hospital, Shandong University, School of Medicine, Ji Nan, PR China
    BMC Med Genet 12:48. 2011
  2. pmc Evaluation of single nucleotide polymorphisms (SNPs) in the p53 binding protein 1 (TP53BP1) gene in breast cancer patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT)
    Bruce G Haffty
    Robert Wood Johnson Medical School Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08901, USA
    Int J Radiat Oncol Biol Phys 80:385-91. 2011
  3. doi request reprint Breast cancer in young women (YBC): prevalence of BRCA1/2 mutations and risk of secondary malignancies across diverse racial groups
    B G Haffty
    Department of Radiation Oncology, UMDNJ RWJMS and Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA
    Ann Oncol 20:1653-9. 2009
  4. ncbi request reprint Estrogen-dependent prognostic significance of cyclooxygenase-2 expression in early-stage invasive breast cancers treated with breast-conserving surgery and radiation
    Bruce G Haffty
    Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    Int J Radiat Oncol Biol Phys 71:1006-13. 2008
  5. ncbi request reprint Concurrent chemo-radiation in the conservative management of breast cancer
    Bruce G Haffty
    Department of Radiation Oncology UMDNJ Robert Wood Johnson Medical School and the Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA
    Int J Radiat Oncol Biol Phys 66:1306-12. 2006
  6. pmc Racial differences in the incidence of BRCA1 and BRCA2 mutations in a cohort of early onset breast cancer patients: African American compared to white women
    B G Haffty
    Radiation Oncology, Robert Wood Johnson Medical School, New Brunswick, NJ 08903 2681, USA
    J Med Genet 43:133-7. 2006
  7. ncbi request reprint Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer
    Bruce G Haffty
    Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903 2681, USA
    J Clin Oncol 24:5652-7. 2006
  8. doi request reprint Radiotherapy. Hypofractionation for breast cancer--clinical implications
    Bruce G Haffty
    Department of Radiation Oncology, UMDNJ Robert Wood Johnson Medical School, Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA
    Nat Rev Clin Oncol 7:304-6. 2010
  9. doi request reprint Dosimetric feasibility and acute toxicity in a prospective trial of ultrashort-course accelerated partial breast irradiation (APBI) using a multi-lumen balloon brachytherapy device
    A J Khan
    Robert Wood Johnson University Hospital Cancer Institute of New Jersey, New Brunswick, NJ, USA
    Ann Surg Oncol 20:1295-301. 2013
  10. ncbi request reprint Outcomes in young women with breast cancer of triple-negative phenotype: the prognostic significance of CK19 expression
    Rahul R Parikh
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Int J Radiat Oncol Biol Phys 70:35-42. 2008

Detail Information

Publications85

  1. pmc BCL-2 (-938C > A) polymorphism is associated with breast cancer susceptibility
    Ning Zhang
    Department of Breast Surgery, Qilu Hospital, Shandong University, School of Medicine, Ji Nan, PR China
    BMC Med Genet 12:48. 2011
    ..Furthermore, we also studied the effects of this SNP on Bcl-2 expression in vitro...
  2. pmc Evaluation of single nucleotide polymorphisms (SNPs) in the p53 binding protein 1 (TP53BP1) gene in breast cancer patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT)
    Bruce G Haffty
    Robert Wood Johnson Medical School Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08901, USA
    Int J Radiat Oncol Biol Phys 80:385-91. 2011
    ..The purpose of this study was to evaluate the significance of a known common single nucleotide polymorphism in this gene (rs560191) in patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT)...
  3. doi request reprint Breast cancer in young women (YBC): prevalence of BRCA1/2 mutations and risk of secondary malignancies across diverse racial groups
    B G Haffty
    Department of Radiation Oncology, UMDNJ RWJMS and Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA
    Ann Oncol 20:1653-9. 2009
    ..The purpose of this study is to evaluate the prevalence of BRCA1/2 mutations and the association between BRCA1/2 mutation status and secondary malignancies among young women with breast cancer in these three racially diverse groups...
  4. ncbi request reprint Estrogen-dependent prognostic significance of cyclooxygenase-2 expression in early-stage invasive breast cancers treated with breast-conserving surgery and radiation
    Bruce G Haffty
    Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    Int J Radiat Oncol Biol Phys 71:1006-13. 2008
    ..To evaluate the prognostic significance of cyclooxygenase-2 (COX-2) in breast cancer patients treated with conservative surgery and radiation therapy (CS+RT)...
  5. ncbi request reprint Concurrent chemo-radiation in the conservative management of breast cancer
    Bruce G Haffty
    Department of Radiation Oncology UMDNJ Robert Wood Johnson Medical School and the Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA
    Int J Radiat Oncol Biol Phys 66:1306-12. 2006
    ..We report here the results of a retrospective analysis of all patients treated with CTX and RT, with specific focus on outcome as a function of sequencing of CTX with RT...
  6. pmc Racial differences in the incidence of BRCA1 and BRCA2 mutations in a cohort of early onset breast cancer patients: African American compared to white women
    B G Haffty
    Radiation Oncology, Robert Wood Johnson Medical School, New Brunswick, NJ 08903 2681, USA
    J Med Genet 43:133-7. 2006
    ..To evaluate the frequency and distribution of BRCA1 and BRCA2 mutations in a cohort of young women with breast cancer and to compare the distribution of mutations as a function of race...
  7. ncbi request reprint Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer
    Bruce G Haffty
    Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903 2681, USA
    J Clin Oncol 24:5652-7. 2006
    ..To determine the prognostic significance of triple negative breast cancers with respect to locoregional relapse and distant metastasis in conservatively managed breast cancer patients...
  8. doi request reprint Radiotherapy. Hypofractionation for breast cancer--clinical implications
    Bruce G Haffty
    Department of Radiation Oncology, UMDNJ Robert Wood Johnson Medical School, Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA
    Nat Rev Clin Oncol 7:304-6. 2010
    ..5 weeks) in patients with early-stage, node-negative breast cancer. The trial demonstrated equivalence of results with respect to overall survival,local control, toxicity and cosmetic outcomes...
  9. doi request reprint Dosimetric feasibility and acute toxicity in a prospective trial of ultrashort-course accelerated partial breast irradiation (APBI) using a multi-lumen balloon brachytherapy device
    A J Khan
    Robert Wood Johnson University Hospital Cancer Institute of New Jersey, New Brunswick, NJ, USA
    Ann Surg Oncol 20:1295-301. 2013
    ..We designed a prospective trial to identify and address the potential radiobiological and logistical shortcomings of single-fraction APBI...
  10. ncbi request reprint Outcomes in young women with breast cancer of triple-negative phenotype: the prognostic significance of CK19 expression
    Rahul R Parikh
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Int J Radiat Oncol Biol Phys 70:35-42. 2008
    ..In this study, we evaluated the luminal cytokeratin marker CK-19 in young women with breast cancer treated with conservative surgery and radiation therapy (CS+RT)...
  11. pmc Local therapy in BRCA1 and BRCA2 mutation carriers with operable breast cancer: comparison of breast conservation and mastectomy
    Lori J Pierce
    Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive Room 4308, Ann Arbor, MI 48109, USA
    Breast Cancer Res Treat 121:389-98. 2010
    ..However, women undergoing BCT have an elevated risk of a second in-breast event that is significantly reduced in the presence of chemotherapy. Contralateral breast cancer events are very common...
  12. doi request reprint Bcl-2 expression predicts local relapse for early-stage breast cancer receiving conserving surgery and radiotherapy
    Qifeng Yang
    Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School UMDNJ, 195 Little Albany St, New Brunswick, NJ 08901, USA
    Breast Cancer Res Treat 115:343-8. 2009
    ..This study was undertaken to evaluate the prognostic significance of Bcl-2, a apoptosis-related protein, in patients with early stage breast cancer treated with breast conservation treatment (BCT)...
  13. doi request reprint Timing of Chemotherapy after MammoSite radiation therapy system breast brachytherapy: analysis of the American Society of Breast Surgeons MammoSite breast brachytherapy registry trial
    Bruce G Haffty
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Int J Radiat Oncol Biol Phys 72:1441-8. 2008
    ..To evaluate cosmetic outcome and radiation recall in the American Society of Breast Surgeons registry trial, as a function of the interval between accelerated partial breast irradiation (APBI) and initiation of chemotherapy (CTX)...
  14. doi request reprint Prognostic value of triple-negative phenotype at the time of locally recurrent, conservatively treated breast cancer
    Rahul R Parikh
    Department of Radiation Oncology, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Int J Radiat Oncol Biol Phys 72:1056-63. 2008
    ..To evaluate the prognostic value of triple-negative (TN) ER, PR, Her2/neu basal-like carcinoma of the breast, at the time of ipsilateral breast tumor recurrence (IBTR) after conservative surgery and radiation treatment (RT)...
  15. ncbi request reprint Conservative management of Paget disease of the breast with radiotherapy: 10- and 15-year results
    Jennifer K Marshall
    Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Cancer 97:2142-9. 2003
    ....
  16. ncbi request reprint Ten-year multi-institutional results of breast-conserving surgery and radiotherapy in BRCA1/2-associated stage I/II breast cancer
    Lori J Pierce
    Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, MI 48109 0010, USA
    J Clin Oncol 24:2437-43. 2006
    ..We compared the outcome of breast-conserving surgery and radiotherapy in BRCA1/2 mutation carriers with breast cancer versus that of matched sporadic controls...
  17. ncbi request reprint BAG-1: a novel biomarker predicting long-term survival in early-stage breast cancer
    B C Turner
    Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA
    J Clin Oncol 19:992-1000. 2001
    ..We performed a retrospective correlative analysis of BAG-1 protein expression in breast tumors derived from a cohort of early-stage breast cancer patients...
  18. ncbi request reprint Carcinoma of the larynx treated with hypofractionated radiation and hyperbaric oxygen: long-term tumor control and complications
    B G Haffty
    Department of Radiation Oncology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Int J Radiat Oncol Biol Phys 45:13-20. 1999
    ....
  19. ncbi request reprint On the assay of brachytherapy sources
    Ning J Yue
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Med Phys 34:1975-82. 2007
    ....
  20. ncbi request reprint Current application and research directions for partial-breast irradiation
    Sharad Goyal
    Department of Radiation Oncology, UMDNJ Robert Wood Johnson, Medical School, New Brunswick, NJ 08903, USA
    Oncology (Williston Park) 21:449-61; discussion 461-2, 464, 470. 2007
    ..In this review, we hope to clarify the rationale behind APBI and discuss in depth data concerning various partial-breast irradiation techniques that are being used throughout the United States and around the world...
  21. ncbi request reprint Prognostic significance of IGF-1R expression in patients treated with breast-conserving surgery and radiation therapy
    Neil K Taunk
    Department of Radiation Oncology, The Cancer Institute of New Jersey, NJ, USA
    Radiother Oncol 96:204-8. 2010
    ..The purpose of this study is to evaluate the prognostic significance of IGF-1R expression in patients with breast cancer treated with breast conserving therapy...
  22. ncbi request reprint Optimization of couch translational corrections to compensate for rotational and deformable target deviations in image guided radiotherapy
    Ning J Yue
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Med Phys 35:4375-85. 2008
    ..The resultant dose coverage was compared to that without the optimization. The results showed that with the present strategy, rotational and deformable target deviations can be further compensated with translational couch correction...
  23. doi request reprint Ductal carcinoma in situ treated with breast-conserving surgery and accelerated partial breast irradiation: comparison of the Mammosite registry trial with intergroup study E5194
    Sharad Goyal
    Cancer Institute of New Jersey and UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Cancer 117:1149-55. 2011
    ....
  24. doi request reprint Evaluation of acute locoregional toxicity in patients with breast cancer treated with adjuvant radiotherapy in combination with bevacizumab
    Sharad Goyal
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Int J Radiat Oncol Biol Phys 79:408-13. 2011
    ..The purpose of this study was to analyze acute locoregional toxicity in patients with breast cancer receiving concurrent bevacizumab plus RT...
  25. doi request reprint Factors associated with optimal cosmetic results at 36 months in patients treated with accelerated partial breast irradiation (APBI) on the American Society of Breast Surgeons (ASBrS) MammoSite Breast Brachytherapy Registry Trial
    Sharad Goyal
    Department of Radiation Oncology, The Cancer Institute of New Jersey, New Brunswick, NJ, USA
    Ann Surg Oncol 16:2450-8. 2009
    ..To evaluate factors associated with optimal cosmetic results at 36 months for early-stage breast cancer patients enrolled on the American Society of Breast Surgeons (ASBrS) MammoSite Breast Brachytherapy registry trial...
  26. doi request reprint Clinicopathologic significance of excision repair cross-complementation 1 expression in patients treated with breast-conserving surgery and radiation therapy
    Sharad Goyal
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Int J Radiat Oncol Biol Phys 76:679-84. 2010
    ..The purpose of this study was to evaluate the clinicopathologic and prognostic significance of ERCC1 expression in a cohort of early-stage breast cancer patients treated with breast conservation therapy...
  27. doi request reprint Six-year analysis of treatment-related toxicities in patients treated with accelerated partial breast irradiation on the American Society of Breast Surgeons MammoSite Breast Brachytherapy registry trial
    A J Khan
    Department of Radiation Oncology, Cancer Institute of New Jersey, New Brunswick, NJ, USA
    Ann Surg Oncol 19:1477-83. 2012
    ..The American Society of Breast Surgeons (ASBrS) enrolled women in a registry trial to prospectively study patients treated with the MammoSite RTS device. This report presents 6-year data on treatment-related toxicities from the trial...
  28. ncbi request reprint Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study
    Wen Xie
    Division of Medical Oncology, Department of Internal Medicine, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Cancer Res 62:497-505. 2002
    ..Finally, analysis of a small cohort of hereditary breast cancers failed to reveal any association between BRCA1 or BRCA2 genotype and alterations in Smad signaling...
  29. ncbi request reprint A strategy to objectively evaluate the necessity of correcting detected target deviations in image guided radiotherapy
    Ning J Yue
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Med Phys 34:4340-7. 2007
    ..It is concluded that the proposed strategy is potentially useful in establishing objective criteria for the necessity of correction of the target deviations...
  30. doi request reprint American College of Radiology appropriateness criteria on conservative surgery and radiation: stages I and II breast carcinoma
    Julia R White
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 4801, USA
    J Am Coll Radiol 5:701-13. 2008
    ..Successful breast conservation relies on understanding key elements for patient selection, evaluation, treatment contraindications, radiation therapy methods, and integration with systemic therapy...
  31. ncbi request reprint A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer
    Diptee A Kulkarni
    Department of Medicine Division of Medical Oncology, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Carcinogenesis 30:1910-5. 2009
    ..2 years (P = 7 x 10(-5)) earlier than CC carriers in cohorts 1 and 2, respectively. No association was seen in ER-positive ductal cancers suggesting that the SNP in MDM4 only has a functional association in ER-negative breast cancer...
  32. ncbi request reprint Postoperative radiotherapy for stage II or III non-small-cell lung cancer using the surveillance, epidemiology, and end results database
    Brian E Lally
    Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1030, USA
    J Clin Oncol 24:2998-3006. 2006
    ..To investigate the association between survival and postoperative radiotherapy (PORT) in patients with resected non-small-cell lung cancer (NSCLC)...
  33. doi request reprint Improvement in interobserver accuracy in delineation of the lumpectomy cavity using fiducial markers
    Talha Shaikh
    Department of Radiation Oncology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Int J Radiat Oncol Biol Phys 78:1127-34. 2010
    ....
  34. ncbi request reprint Possession of ATM sequence variants as predictor for late normal tissue responses in breast cancer patients treated with radiotherapy
    Alice Y Ho
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Radiat Oncol Biol Phys 69:677-84. 2007
    ..The ATM gene product is a central component of cell cycle regulation and genomic surveillance. We hypothesized that DNA sequence alterations in ATM predict for adverse effects after external beam radiotherapy for early breast cancer...
  35. ncbi request reprint Ipsilateral breast tumor recurrence after breast conservation therapy: outcomes of salvage mastectomy vs. salvage breast-conserving surgery and prognostic factors for salvage breast preservation
    Tracy E Alpert
    Department of Radiation Oncology, Upstate Medical University, Syracuse, NY, USA
    Int J Radiat Oncol Biol Phys 63:845-51. 2005
    ..To compare outcomes of salvage mastectomy (SM) and salvage breast-conserving surgery (SBCS) and study the feasibility of SBCS...
  36. ncbi request reprint Conservative management of breast cancer in BRCA1/2 mutation carriers
    Tracy E Alpert
    Department of Radiation Oncology, SUNY Upstate Medical University, Syracuse, NY, USA
    Clin Breast Cancer 5:37-42. 2004
    ..The potential role of tamoxifen and oophorectomy in modifying the rate of second events is discussed...
  37. ncbi request reprint First analysis of patient demographics, technical reproducibility, cosmesis, and early toxicity: results of the American Society of Breast Surgeons MammoSite breast brachytherapy trial
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Cancer 104:1138-48. 2005
    ..Patient demographics, technical reproducibility, cosmesis, and early toxicity were evaluated...
  38. ncbi request reprint Basal subtype, as approximated by triple-negative phenotype, is associated with locoregional recurrence in a case-control study of women with 0-3 positive lymph nodes after mastectomy
    A J Khan
    Department of Radiation Oncology, Robert Wood Johnson University Hospital, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA
    Ann Surg Oncol 21:1963-8. 2014
    ..Indications for postmastectomy RT (PMRT) in women with 0-3 positive lymph nodes remain unclear. We evaluated the importance of biologic subtype in a cohort of women with LRR after mastectomy...
  39. ncbi request reprint Low local recurrence rate without postmastectomy radiation in node-negative breast cancer patients with tumors 5 cm and larger
    Scott R Floyd
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 66:358-64. 2006
    ..To assess the need for adjuvant radiotherapy following mastectomy for patients with node-negative breast tumors 5 cm or larger...
  40. ncbi request reprint Frequent alterations of Smad signaling in human head and neck squamous cell carcinomas: a tissue microarray analysis
    Wen Xie
    Division of Medical Oncology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Oncol Res 14:61-73. 2003
    ..These results indicate that inactivation of TGF-beta/Smad signaling occurs frequently in HNSCC and might have an adverse effect on patient outcome...
  41. doi request reprint Hypofractionation in adjuvant breast radiotherapy
    Atif Khan
    Department of Radiation Oncology, UMDNJ RWJMS, Cancer Institute of New Jersey, 195 Little Albany St, New Brunswick, NJ 08901, USA
    Breast 19:168-71. 2010
    ..The current status of hypofractionated radiation and future directions for research are discussed...
  42. ncbi request reprint Incidence of BRCA1 and BRCA2 mutations in young Korean breast cancer patients
    Doo Ho Choi
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Clin Oncol 22:1638-45. 2004
    ..The prevalence of BRCA-associated breast carcinoma in the Korean population has not been evaluated extensively...
  43. ncbi request reprint Should intensity-modulated radiation therapy be the standard of care in the conservatively managed breast cancer patient?
    Bruce G Haffty
    J Clin Oncol 26:2072-4. 2008
  44. ncbi request reprint Evaluation of local recurrence and second malignancy in patients with T1 and T2 squamous cell carcinoma of the larynx
    Joseph M Colasanto
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Cancer J 10:61-6. 2004
    ..Evaluate outcome in patients with T1 and T2 laryngeal cancer treated with radiation therapy...
  45. ncbi request reprint Molecular markers for prognosis after isolated postmastectomy chest wall recurrence
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8040, USA
    Cancer 100:252-63. 2004
    ..The objective of the current study was to assess the prognostic value of molecular markers at the time of local recurrence and to compare these markers with clinical variables...
  46. ncbi request reprint Repeat breast-conserving surgery for in-breast local breast carcinoma recurrence: the potential role of partial breast irradiation
    Henry M Kuerer
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 100:2269-80. 2004
    ..Recent advances in conformal radiation delivery and single-center published reports concerning repeat breast-conserving therapy support well designed prospective trials to formally test this hypothesis...
  47. ncbi request reprint End results of salvage therapy after failure of breast-conservation surgery
    Donald R Lannin
    Department of Surgery, Yale Breast Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Oncology (Williston Park) 18:272-9; discussion 280-2, 285-6, 292. 2004
    ..Prognostic factors at the time of IBTR and implications for local and systemic therapy are discussed...
  48. ncbi request reprint A comparison of five immunohistochemical biomarkers and HER-2/neu gene amplification by fluorescence in situ hybridization in white and Korean patients with early-onset breast carcinoma
    Doo Ho Choi
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer 98:1587-95. 2003
    ..The objective of this article was to compare five tumor markers between white women in the U.S. and native Korean women with early-onset breast carcinoma...
  49. ncbi request reprint Clinical outcome and cosmesis in African-American patients treated with conservative surgery and radiation therapy
    Nimi L Tuamokumo
    Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8040, USA
    Cancer J 9:313-20. 2003
    ..The purpose of this study was to evaluate the prognostic significance of race in breast cancer patients treated with lumpectomy and radiation therapy...
  50. ncbi request reprint Local-regional breast cancer recurrence: prognostic groups based on patterns of failure
    Meena S Moran
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Breast J 8:81-7. 2002
    ..Placing patients with breast cancer and local-regional relapse into these prognostic categories may be helpful in decision making regarding the role of systemic therapy at the time of local-regional relapse...
  51. ncbi request reprint Outcome of conservatively managed early-onset breast cancer by BRCA1/2 status
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Lancet 359:1471-7. 2002
    ..This study assessed the long-term risks of ipsilateral and contralateral breast cancer in a cohort of young women who underwent breast-conserving surgery followed by radiotherapy...
  52. ncbi request reprint Molecular and genetic markers in the local-regional management of breast cancer
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Semin Radiat Oncol 12:329-40. 2002
    ..The available rature regarding the use of genetic and molecular markers in the local-regional management of breast cancer is summarized in this review...
  53. ncbi request reprint Correlation of clinical and pathologic features with outcome in patients with ductal carcinoma in situ of the breast treated with breast-conserving surgery and radiotherapy
    Neesha Rodrigues
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Int J Radiat Oncol Biol Phys 54:1331-5. 2002
    ..The purpose of this study was to evaluate the impact of clinical and pathologic features on long-term outcome in a cohort of DCIS patients treated with breast-conserving surgery plus RT...
  54. ncbi request reprint Differences in the pathologic and molecular features of intraductal breast carcinoma between younger and older women
    Neesha A Rodrigues
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer 97:1393-403. 2003
    ....
  55. ncbi request reprint BRCA status, molecular markers, and clinical variables in early, conservatively managed breast cancer
    Sung Kim
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Breast J 9:167-74. 2003
    ..Patients with BRCA mutations have a unique molecular profile. These data can be helpful in understanding differences in the biologic behavior of patients with familial breast cancers...
  56. ncbi request reprint Cyclooxygenase-2 expression in postmastectomy chest wall relapse
    Janet H Kim
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Cancer Res 11:5199-205. 2005
    ..The purpose of this study was to assess the prognostic significance and clinical correlations of COX-2 expression (COX) in a cohort of patients treated with radiation for postmastectomy chest wall relapse...
  57. ncbi request reprint Radiation therapy and the risk of contralateral breast cancer
    Bruce G Haffty
    Int J Radiat Oncol Biol Phys 56:920-1. 2003
  58. ncbi request reprint Local recurrence of breast cancer after breast conservation therapy in patients examined by means of stereotactic core-needle biopsy
    Allen M Chen
    Department of Diagnostic Radiology, Yale University School of Medicine, 333 Cedar St, PO Box 208042, New Haven, CT 06520 8042, USA
    Radiology 225:707-12. 2002
    ....
  59. ncbi request reprint Sequence of radiotherapy with tamoxifen in conservatively managed breast cancer does not affect local relapse rates
    Peter H Ahn
    Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA
    J Clin Oncol 23:17-23. 2005
    ..To evaluate whether the sequencing of tamoxifen (TAM) relative to radiation (RT) affects outcome in breast cancer patients treated with conservative surgery (CS) plus RT (lumpectomy with RT)...
  60. ncbi request reprint Accelerated partial breast irradiation: where do we go from here?
    Bruce G Haffty
    Breast J 11:303-5. 2005
  61. ncbi request reprint Clinicopathologic features and long-term outcome of patients with medullary breast carcinoma managed with breast-conserving therapy (BCT)
    Ha Vu-Nishino
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Int J Radiat Oncol Biol Phys 62:1040-7. 2005
    ..The purpose of this study is to compare the clinical characteristics and outcome of medullary carcinoma to infiltrating ductal carcinoma of the breast in a large cohort of conservatively managed patients with long-term follow-up...
  62. ncbi request reprint Rationalization and regionalization of treatment for ductal carcinoma in situ of the breast
    Grace L Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Int J Radiat Oncol Biol Phys 65:1397-403. 2006
    ..We evaluated national patterns of DCIS treatment from 1996 to 2001 by patient risk profile...
  63. ncbi request reprint Effectiveness of radiation therapy for older women with early breast cancer
    Benjamin D Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    J Natl Cancer Inst 98:681-90. 2006
    ..Recent clinical trials have questioned the necessity of breast radiation therapy for older women with early breast cancer. However, the effectiveness of radiation therapy for older women in the community setting has not been addressed...
  64. ncbi request reprint Double heterozygotes for non-Caucasian families with mutations in BRCA-1 and BRCA-2 genes
    Doo Ho Choi
    Department of Radiation Oncology and Surgery, College of Medicine, Soonchungyang University, Seoul, Korea
    Breast J 12:216-20. 2006
    ..We describe here two cases of deleterious mutations in both genes in a cohort of Korean women with early onset breast cancer...
  65. ncbi request reprint Chest wall relapse after mastectomy for ductal carcinoma in situ: a report of 10 cases with a review of the literature
    Janet H Kim
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Cancer J 12:92-101. 2006
    ..Postmastectomy chest wall relapses in patients with DCIS are an uncommon event. Patients treated aggressively with resection of the lesion followed by radiation therapy to the chest wall have a favorable prognosis...
  66. ncbi request reprint Five-year update of an expanded phase II study of dose-dense and -intense doxorubicin, paclitaxel and cyclophosphamide (ATC) in high-risk breast cancer
    Maysa M Abu-Khalaf
    Jersey Shore University Medical Center, Neptune, N J, USA
    Oncology 69:372-83. 2005
    ..This study evaluated the safety and efficacy of dose-dense and -intense sequential doxorubicin (A), paclitaxel (T) and cyclophosphamide (C) as adjuvant therapy for breast cancer (BC) with >or=4 ipsilateral axillary lymph nodes...
  67. pmc Patterns of reduced nipple aspirate fluid production and ductal lavage cellularity in women at high risk for breast cancer
    Susan A Higgins
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Breast Cancer Res 7:R1017-22. 2005
    ..However, we observed a significantly lower proportion of fluid-yielding subjects in a similar series of high-risk women. The purpose of the present study was to identify variables associated with this reduction...
  68. ncbi request reprint Can molecular markers predict local, regional and distant metastasis in head and neck cancer?
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale School of Medicine and Yale New Haven Hospital, New Haven, CT 06520 8040, USA
    Nat Clin Pract Oncol 2:132-3. 2005
  69. ncbi request reprint Immunohistochemical biomarkers in patients with early-onset breast carcinoma by tissue microarray
    Doo Ho Choi
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Cancer J 11:404-11. 2005
    ..We investigated the association of estrogen receptor, progesterone receptor, Bcl-2, HER-2/neu, p53, and Ki-67 with clinicopathologic features and outcome in young women with breast cancer...
  70. ncbi request reprint Effects of breast-conserving therapy on lactation after pregnancy
    Meena S Moran
    Department of Therapeutic Radiology, Yale University School of Medicine, Yale New Haven Hospital, New Haven, Connecticut 06520 8040, USA
    Cancer J 11:399-403. 2005
    ..Our objective was to evaluate lactation outcomes in patients with early-stage breast cancer treated with breast-conserving therapy...
  71. ncbi request reprint Management of suspicious or indeterminate calcifications and impact on local control
    Brian E Lally
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer 103:2236-40. 2005
    ..The current study was undertaken to determine the potential advantage associated with complete removal of suspicious or indeterminate calcifications (SIC) before the initiation of irradiation as part of breast conservation therapy (BCT)...
  72. ncbi request reprint Initial outcomes for patients treated on the American Society of Breast Surgeons MammoSite clinical trial for ductal carcinoma-in-situ of the breast
    Jacqueline S Jeruss
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Ann Surg Oncol 13:967-76. 2006
    ..We hypothesized that APBI delivered with the MammoSite device would be well tolerated and be associated with a good cosmetic outcome in patients with ductal carcinoma-in-situ (DCIS)...
  73. ncbi request reprint Effectiveness of radiation therapy in older women with ductal carcinoma in situ
    Benjamin D Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    J Natl Cancer Inst 98:1302-10. 2006
    ..In a cohort of older women with DCIS, we sought to determine whether radiation therapy was associated with a clinically significant benefit...
  74. ncbi request reprint Regional nodal recurrence in breast cancer patients treated with conservative surgery and radiation therapy (BCS+RT)
    Sunanda Pejavar
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Int J Radiat Oncol Biol Phys 66:1320-7. 2006
    ..To review regional nodal (RN) management and identify predictors of RN relapse in patients treated with breast conserving surgery and radiation therapy (BCS+RT)...
  75. ncbi request reprint Concurrent chemo-radiotherapy with mitomycin C compared with porfiromycin in squamous cell cancer of the head and neck: final results of a randomized clinical trial
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Int J Radiat Oncol Biol Phys 61:119-28. 2005
    ..We conducted a randomized trial comparing MC with porfiromycin (POR) in combination with RT in the management of SCCHN...
  76. ncbi request reprint Postmastectomy radiation and survival in older women with breast cancer
    Benjamin D Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    J Clin Oncol 24:4901-7. 2006
    ..As recent evidence suggests that certain adjuvant treatments appropriate for younger women may only be marginally beneficial for older women, we sought to determine whether PMRT improves survival for older women with breast cancer...
  77. ncbi request reprint Should all patients undergoing breast conserving therapy for DCIS receive radiation therapy? Yes. Radiation therapy, an important component of breast conserving treatment for patients with ductal carcinoma in situ of the breast
    Thomas A Buchholz
    J Surg Oncol 95:610-3. 2007
  78. ncbi request reprint Characterization of the HER-2/neu oncogene by immunohistochemical and fluorescence in situ hybridization analysis in oral and oropharyngeal squamous cell carcinoma
    Atif J Khan
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Clin Cancer Res 8:540-8. 2002
    ....
  79. ncbi request reprint Cyclin d1 is a valuable prognostic marker in oropharyngeal squamous cell carcinoma
    Ziwei Yu
    Department of Otolaryngology, Yale University School of Medicine, New Haven, CT 06520, USA
    Clin Cancer Res 11:1160-6. 2005
    ..In this study, we sought to determine the prognostic significance of the cell cycle regulator cyclin D1 in oropharyngeal squamous cell carcinoma (OSCC)...
  80. ncbi request reprint Prognostic significance of vascular endothelial growth factor protein levels in T1-2 N0 laryngeal cancer treated with primary radiation therapy
    Rahul R Parikh
    Albany Medical College, Albany, New York, USA
    Cancer 109:566-73. 2007
    ..The purpose of this study was to assess the prognostic value of vascular endothelial growth factor protein levels in a large cohort of patients with T1-T2 N0 laryngeal cancer treated with primary radiation therapy (XRT)...
  81. ncbi request reprint Use of postmastectomy radiotherapy in older women
    Benjamin D Smith
    Radiation Oncology Flight, Wilford Hall Medical Center, Lackland Air Force Base, TX, USA
    Int J Radiat Oncol Biol Phys 71:98-106. 2008
    ..Using the Surveillance, Epidemiology, and End Results-Medicare cohort, we sought to characterize the adoption of PMRT from 1992 to 2002 and identify risk factors for PMRT omission among high-risk older patients...
  82. ncbi request reprint Postmastectomy radiation and mortality in women with T1-2 node-positive breast cancer
    Benjamin D Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    J Clin Oncol 23:1409-19. 2005
    ..To determine the relationship between postmastectomy radiotherapy (PMRT) and mortality in a population-based cohort of women with T1-2 node-positive breast cancer...
  83. ncbi request reprint Prognostic significance of cyclooxygenase-2 in oropharyngeal squamous cell carcinoma
    Bryan W Chang
    Department of Therapeutic Radiology, Yale University, New Haven, Connecticut 06520 8040, USA
    Clin Cancer Res 10:1678-84. 2004
    ..To determine the relative prognostic significance of cyclooxygenase (COX)-2 expression in patients with oropharyngeal squamous cell carcinoma (SCC)...
  84. ncbi request reprint Prognostic significance of pretreatment hemoglobin for local control and overall survival in T1-T2N0 larynx cancer treated with external beam radiotherapy
    Edward I Cho
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Int J Radiat Oncol Biol Phys 58:1135-40. 2004
    ..To elucidate a relationship between pretreatment hemoglobin and local control in patients with T1-T2N0 larynx cancer treated with radiotherapy...
  85. ncbi request reprint Tissue microarray analysis reveals prognostic significance of COX-2 expression for local relapse in T1-2N0 larynx cancer treated with primary radiation therapy
    Edward I Cho
    Departments of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Laryngoscope 114:2001-8. 2004
    ....