B G Haffty

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi BCL-2 (-938C > A) polymorphism is associated with breast cancer susceptibility
    Ning Zhang
    Department of Breast Surgery, Qilu Hospital, Shandong University, School of Medicine, Ji Nan, PR China
    BMC Med Genet 12:48. 2011
  2. ncbi Breast cancer in young women (YBC): prevalence of BRCA1/2 mutations and risk of secondary malignancies across diverse racial groups
    B G Haffty
    Department of Radiation Oncology, UMDNJ RWJMS and Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA
    Ann Oncol 20:1653-9. 2009
  3. ncbi Estrogen-dependent prognostic significance of cyclooxygenase-2 expression in early-stage invasive breast cancers treated with breast-conserving surgery and radiation
    Bruce G Haffty
    Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    Int J Radiat Oncol Biol Phys 71:1006-13. 2008
  4. ncbi Radiotherapy. Hypofractionation for breast cancer--clinical implications
    Bruce G Haffty
    Department of Radiation Oncology, UMDNJ Robert Wood Johnson Medical School, Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA
    Nat Rev Clin Oncol 7:304-6. 2010
  5. ncbi Evaluation of single nucleotide polymorphisms (SNPs) in the p53 binding protein 1 (TP53BP1) gene in breast cancer patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT)
    Bruce G Haffty
    Robert Wood Johnson Medical School Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08901, USA
    Int J Radiat Oncol Biol Phys 80:385-91. 2011
  6. ncbi Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer
    Bruce G Haffty
    Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903 2681, USA
    J Clin Oncol 24:5652-7. 2006
  7. ncbi Racial differences in the incidence of BRCA1 and BRCA2 mutations in a cohort of early onset breast cancer patients: African American compared to white women
    B G Haffty
    Radiation Oncology, Robert Wood Johnson Medical School, New Brunswick, NJ 08903 2681, USA
    J Med Genet 43:133-7. 2006
  8. ncbi Concurrent chemo-radiation in the conservative management of breast cancer
    Bruce G Haffty
    Department of Radiation Oncology UMDNJ Robert Wood Johnson Medical School and the Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA
    Int J Radiat Oncol Biol Phys 66:1306-12. 2006
  9. ncbi Outcomes in young women with breast cancer of triple-negative phenotype: the prognostic significance of CK19 expression
    Rahul R Parikh
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Int J Radiat Oncol Biol Phys 70:35-42. 2008
  10. ncbi Local therapy in BRCA1 and BRCA2 mutation carriers with operable breast cancer: comparison of breast conservation and mastectomy
    Lori J Pierce
    Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive Room 4308, Ann Arbor, MI 48109, USA
    Breast Cancer Res Treat 121:389-98. 2010

Detail Information

Publications84

  1. ncbi BCL-2 (-938C > A) polymorphism is associated with breast cancer susceptibility
    Ning Zhang
    Department of Breast Surgery, Qilu Hospital, Shandong University, School of Medicine, Ji Nan, PR China
    BMC Med Genet 12:48. 2011
    ..Furthermore, we also studied the effects of this SNP on Bcl-2 expression in vitro...
  2. ncbi Breast cancer in young women (YBC): prevalence of BRCA1/2 mutations and risk of secondary malignancies across diverse racial groups
    B G Haffty
    Department of Radiation Oncology, UMDNJ RWJMS and Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA
    Ann Oncol 20:1653-9. 2009
    ..The purpose of this study is to evaluate the prevalence of BRCA1/2 mutations and the association between BRCA1/2 mutation status and secondary malignancies among young women with breast cancer in these three racially diverse groups...
  3. ncbi Estrogen-dependent prognostic significance of cyclooxygenase-2 expression in early-stage invasive breast cancers treated with breast-conserving surgery and radiation
    Bruce G Haffty
    Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    Int J Radiat Oncol Biol Phys 71:1006-13. 2008
    ..To evaluate the prognostic significance of cyclooxygenase-2 (COX-2) in breast cancer patients treated with conservative surgery and radiation therapy (CS+RT)...
  4. ncbi Radiotherapy. Hypofractionation for breast cancer--clinical implications
    Bruce G Haffty
    Department of Radiation Oncology, UMDNJ Robert Wood Johnson Medical School, Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA
    Nat Rev Clin Oncol 7:304-6. 2010
    ..5 weeks) in patients with early-stage, node-negative breast cancer. The trial demonstrated equivalence of results with respect to overall survival,local control, toxicity and cosmetic outcomes...
  5. ncbi Evaluation of single nucleotide polymorphisms (SNPs) in the p53 binding protein 1 (TP53BP1) gene in breast cancer patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT)
    Bruce G Haffty
    Robert Wood Johnson Medical School Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08901, USA
    Int J Radiat Oncol Biol Phys 80:385-91. 2011
    ..The purpose of this study was to evaluate the significance of a known common single nucleotide polymorphism in this gene (rs560191) in patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT)...
  6. ncbi Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer
    Bruce G Haffty
    Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903 2681, USA
    J Clin Oncol 24:5652-7. 2006
    ..To determine the prognostic significance of triple negative breast cancers with respect to locoregional relapse and distant metastasis in conservatively managed breast cancer patients...
  7. ncbi Racial differences in the incidence of BRCA1 and BRCA2 mutations in a cohort of early onset breast cancer patients: African American compared to white women
    B G Haffty
    Radiation Oncology, Robert Wood Johnson Medical School, New Brunswick, NJ 08903 2681, USA
    J Med Genet 43:133-7. 2006
    ..To evaluate the frequency and distribution of BRCA1 and BRCA2 mutations in a cohort of young women with breast cancer and to compare the distribution of mutations as a function of race...
  8. ncbi Concurrent chemo-radiation in the conservative management of breast cancer
    Bruce G Haffty
    Department of Radiation Oncology UMDNJ Robert Wood Johnson Medical School and the Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA
    Int J Radiat Oncol Biol Phys 66:1306-12. 2006
    ..We report here the results of a retrospective analysis of all patients treated with CTX and RT, with specific focus on outcome as a function of sequencing of CTX with RT...
  9. ncbi Outcomes in young women with breast cancer of triple-negative phenotype: the prognostic significance of CK19 expression
    Rahul R Parikh
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Int J Radiat Oncol Biol Phys 70:35-42. 2008
    ..In this study, we evaluated the luminal cytokeratin marker CK-19 in young women with breast cancer treated with conservative surgery and radiation therapy (CS+RT)...
  10. ncbi Local therapy in BRCA1 and BRCA2 mutation carriers with operable breast cancer: comparison of breast conservation and mastectomy
    Lori J Pierce
    Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive Room 4308, Ann Arbor, MI 48109, USA
    Breast Cancer Res Treat 121:389-98. 2010
    ..However, women undergoing BCT have an elevated risk of a second in-breast event that is significantly reduced in the presence of chemotherapy. Contralateral breast cancer events are very common...
  11. ncbi Bcl-2 expression predicts local relapse for early-stage breast cancer receiving conserving surgery and radiotherapy
    Qifeng Yang
    Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School UMDNJ, 195 Little Albany St, New Brunswick, NJ 08901, USA
    Breast Cancer Res Treat 115:343-8. 2009
    ..This study was undertaken to evaluate the prognostic significance of Bcl-2, a apoptosis-related protein, in patients with early stage breast cancer treated with breast conservation treatment (BCT)...
  12. ncbi Ten-year multi-institutional results of breast-conserving surgery and radiotherapy in BRCA1/2-associated stage I/II breast cancer
    Lori J Pierce
    Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, MI 48109 0010, USA
    J Clin Oncol 24:2437-43. 2006
    ..We compared the outcome of breast-conserving surgery and radiotherapy in BRCA1/2 mutation carriers with breast cancer versus that of matched sporadic controls...
  13. ncbi Prognostic value of triple-negative phenotype at the time of locally recurrent, conservatively treated breast cancer
    Rahul R Parikh
    Department of Radiation Oncology, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Int J Radiat Oncol Biol Phys 72:1056-63. 2008
    ..To evaluate the prognostic value of triple-negative (TN) ER, PR, Her2/neu basal-like carcinoma of the breast, at the time of ipsilateral breast tumor recurrence (IBTR) after conservative surgery and radiation treatment (RT)...
  14. ncbi Timing of Chemotherapy after MammoSite radiation therapy system breast brachytherapy: analysis of the American Society of Breast Surgeons MammoSite breast brachytherapy registry trial
    Bruce G Haffty
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Int J Radiat Oncol Biol Phys 72:1441-8. 2008
    ..To evaluate cosmetic outcome and radiation recall in the American Society of Breast Surgeons registry trial, as a function of the interval between accelerated partial breast irradiation (APBI) and initiation of chemotherapy (CTX)...
  15. ncbi Conservative management of Paget disease of the breast with radiotherapy: 10- and 15-year results
    Jennifer K Marshall
    Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Cancer 97:2142-9. 2003
    ....
  16. ncbi BAG-1: a novel biomarker predicting long-term survival in early-stage breast cancer
    B C Turner
    Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA
    J Clin Oncol 19:992-1000. 2001
    ..We performed a retrospective correlative analysis of BAG-1 protein expression in breast tumors derived from a cohort of early-stage breast cancer patients...
  17. ncbi Carcinoma of the larynx treated with hypofractionated radiation and hyperbaric oxygen: long-term tumor control and complications
    B G Haffty
    Department of Radiation Oncology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Int J Radiat Oncol Biol Phys 45:13-20. 1999
    ....
  18. ncbi Clinicopathologic significance of excision repair cross-complementation 1 expression in patients treated with breast-conserving surgery and radiation therapy
    Sharad Goyal
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Int J Radiat Oncol Biol Phys 76:679-84. 2010
    ..The purpose of this study was to evaluate the clinicopathologic and prognostic significance of ERCC1 expression in a cohort of early-stage breast cancer patients treated with breast conservation therapy...
  19. ncbi Ductal carcinoma in situ treated with breast-conserving surgery and accelerated partial breast irradiation: comparison of the Mammosite registry trial with intergroup study E5194
    Sharad Goyal
    Cancer Institute of New Jersey and UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Cancer 117:1149-55. 2011
    ....
  20. ncbi Current application and research directions for partial-breast irradiation
    Sharad Goyal
    Department of Radiation Oncology, UMDNJ Robert Wood Johnson, Medical School, New Brunswick, NJ 08903, USA
    Oncology (Williston Park) 21:449-61; discussion 461-2, 464, 470. 2007
    ..In this review, we hope to clarify the rationale behind APBI and discuss in depth data concerning various partial-breast irradiation techniques that are being used throughout the United States and around the world...
  21. ncbi On the assay of brachytherapy sources
    Ning J Yue
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Med Phys 34:1975-82. 2007
    ....
  22. ncbi Evaluation of acute locoregional toxicity in patients with breast cancer treated with adjuvant radiotherapy in combination with bevacizumab
    Sharad Goyal
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Int J Radiat Oncol Biol Phys 79:408-13. 2011
    ..The purpose of this study was to analyze acute locoregional toxicity in patients with breast cancer receiving concurrent bevacizumab plus RT...
  23. ncbi Factors associated with optimal cosmetic results at 36 months in patients treated with accelerated partial breast irradiation (APBI) on the American Society of Breast Surgeons (ASBrS) MammoSite Breast Brachytherapy Registry Trial
    Sharad Goyal
    Department of Radiation Oncology, The Cancer Institute of New Jersey, New Brunswick, NJ, USA
    Ann Surg Oncol 16:2450-8. 2009
    ..To evaluate factors associated with optimal cosmetic results at 36 months for early-stage breast cancer patients enrolled on the American Society of Breast Surgeons (ASBrS) MammoSite Breast Brachytherapy registry trial...
  24. ncbi Optimization of couch translational corrections to compensate for rotational and deformable target deviations in image guided radiotherapy
    Ning J Yue
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Med Phys 35:4375-85. 2008
    ..The resultant dose coverage was compared to that without the optimization. The results showed that with the present strategy, rotational and deformable target deviations can be further compensated with translational couch correction...
  25. ncbi Prognostic significance of IGF-1R expression in patients treated with breast-conserving surgery and radiation therapy
    Neil K Taunk
    Department of Radiation Oncology, The Cancer Institute of New Jersey, NJ, USA
    Radiother Oncol 96:204-8. 2010
    ..The purpose of this study is to evaluate the prognostic significance of IGF-1R expression in patients with breast cancer treated with breast conserving therapy...
  26. ncbi Six-year analysis of treatment-related toxicities in patients treated with accelerated partial breast irradiation on the American Society of Breast Surgeons MammoSite Breast Brachytherapy registry trial
    A J Khan
    Department of Radiation Oncology, Cancer Institute of New Jersey, New Brunswick, NJ, USA
    Ann Surg Oncol 19:1477-83. 2012
    ..The American Society of Breast Surgeons (ASBrS) enrolled women in a registry trial to prospectively study patients treated with the MammoSite RTS device. This report presents 6-year data on treatment-related toxicities from the trial...
  27. ncbi A strategy to objectively evaluate the necessity of correcting detected target deviations in image guided radiotherapy
    Ning J Yue
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Med Phys 34:4340-7. 2007
    ..It is concluded that the proposed strategy is potentially useful in establishing objective criteria for the necessity of correction of the target deviations...
  28. ncbi Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study
    Wen Xie
    Division of Medical Oncology, Department of Internal Medicine, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Cancer Res 62:497-505. 2002
    ..Finally, analysis of a small cohort of hereditary breast cancers failed to reveal any association between BRCA1 or BRCA2 genotype and alterations in Smad signaling...
  29. ncbi Dosimetric feasibility and acute toxicity in a prospective trial of ultrashort-course accelerated partial breast irradiation (APBI) using a multi-lumen balloon brachytherapy device
    A J Khan
    Robert Wood Johnson University Hospital Cancer Institute of New Jersey, New Brunswick, NJ, USA
    Ann Surg Oncol 20:1295-301. 2013
    ..We designed a prospective trial to identify and address the potential radiobiological and logistical shortcomings of single-fraction APBI...
  30. ncbi Postoperative radiotherapy for stage II or III non-small-cell lung cancer using the surveillance, epidemiology, and end results database
    Brian E Lally
    Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1030, USA
    J Clin Oncol 24:2998-3006. 2006
    ..To investigate the association between survival and postoperative radiotherapy (PORT) in patients with resected non-small-cell lung cancer (NSCLC)...
  31. ncbi A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer
    Diptee A Kulkarni
    Department of Medicine Division of Medical Oncology, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Carcinogenesis 30:1910-5. 2009
    ..2 years (P = 7 x 10(-5)) earlier than CC carriers in cohorts 1 and 2, respectively. No association was seen in ER-positive ductal cancers suggesting that the SNP in MDM4 only has a functional association in ER-negative breast cancer...
  32. ncbi Possession of ATM sequence variants as predictor for late normal tissue responses in breast cancer patients treated with radiotherapy
    Alice Y Ho
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Radiat Oncol Biol Phys 69:677-84. 2007
    ..The ATM gene product is a central component of cell cycle regulation and genomic surveillance. We hypothesized that DNA sequence alterations in ATM predict for adverse effects after external beam radiotherapy for early breast cancer...
  33. ncbi American College of Radiology appropriateness criteria on conservative surgery and radiation: stages I and II breast carcinoma
    Julia R White
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 4801, USA
    J Am Coll Radiol 5:701-13. 2008
    ..Successful breast conservation relies on understanding key elements for patient selection, evaluation, treatment contraindications, radiation therapy methods, and integration with systemic therapy...
  34. ncbi Improvement in interobserver accuracy in delineation of the lumpectomy cavity using fiducial markers
    Talha Shaikh
    Department of Radiation Oncology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Int J Radiat Oncol Biol Phys 78:1127-34. 2010
    ....
  35. ncbi Ipsilateral breast tumor recurrence after breast conservation therapy: outcomes of salvage mastectomy vs. salvage breast-conserving surgery and prognostic factors for salvage breast preservation
    Tracy E Alpert
    Department of Radiation Oncology, Upstate Medical University, Syracuse, NY, USA
    Int J Radiat Oncol Biol Phys 63:845-51. 2005
    ..Patients who underwent SBCS had comparable outcomes as those who underwent SM, but remain at continued risk for IBTR. A prospective trial evaluating repeat lumpectomy and partial breast reirradiation is discussed...
  36. ncbi Conservative management of breast cancer in BRCA1/2 mutation carriers
    Tracy E Alpert
    Department of Radiation Oncology, SUNY-Upstate Medical University, Syracuse, NY, USA
    Clin Breast Cancer 5:37-42. 2004
    ..The potential role of tamoxifen and oophorectomy in modifying the rate of second events is discussed...
  37. ncbi First analysis of patient demographics, technical reproducibility, cosmesis, and early toxicity: results of the American Society of Breast Surgeons MammoSite breast brachytherapy trial
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Cancer 104:1138-48. 2005
    ..Patient demographics, technical reproducibility, cosmesis, and early toxicity were evaluated...
  38. ncbi Low local recurrence rate without postmastectomy radiation in node-negative breast cancer patients with tumors 5 cm and larger
    Scott R Floyd
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 66:358-64. 2006
    ..LVI was significantly associated with LRF in our series, indicating that patients with this risk factor require careful consideration with regard to further local therapy...
  39. ncbi Hypofractionation in adjuvant breast radiotherapy
    Atif Khan
    Department of Radiation Oncology, UMDNJ RWJMS, Cancer Institute of New Jersey, 195 Little Albany St, New Brunswick, NJ 08901, USA
    Breast 19:168-71. 2010
    ..The current status of hypofractionated radiation and future directions for research are discussed...
  40. ncbi Frequent alterations of Smad signaling in human head and neck squamous cell carcinomas: a tissue microarray analysis
    Wen Xie
    Division of Medical Oncology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Oncol Res 14:61-73. 2003
    ..These results indicate that inactivation of TGF-beta/Smad signaling occurs frequently in HNSCC and might have an adverse effect on patient outcome...
  41. ncbi Molecular markers for prognosis after isolated postmastectomy chest wall recurrence
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8040, USA
    Cancer 100:252-63. 2004
    ..The objective of the current study was to assess the prognostic value of molecular markers at the time of local recurrence and to compare these markers with clinical variables...
  42. ncbi Evaluation of local recurrence and second malignancy in patients with T1 and T2 squamous cell carcinoma of the larynx
    Joseph M Colasanto
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Cancer J 10:61-6. 2004
    ..Gender, age, anteriorcommissure involvement, treatment energy, treatment interruption, and alcohol use did not significantly correlate with local relapse rates. The risk of second malignancies is comparable to that of local relapse...
  43. ncbi End results of salvage therapy after failure of breast-conservation surgery
    Donald R Lannin
    Department of Surgery, Yale Breast Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Oncology (Williston Park) 18:272-9; discussion 280-2, 285-6, 292. 2004
    ..Prognostic factors at the time of IBTR and implications for local and systemic therapy are discussed...
  44. ncbi Incidence of BRCA1 and BRCA2 mutations in young Korean breast cancer patients
    Doo Ho Choi
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Clin Oncol 22:1638-45. 2004
    ..The prevalence of BRCA-associated breast carcinoma in the Korean population has not been evaluated extensively...
  45. ncbi Repeat breast-conserving surgery for in-breast local breast carcinoma recurrence: the potential role of partial breast irradiation
    Henry M Kuerer
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 100:2269-80. 2004
    ..Recent advances in conformal radiation delivery and single-center published reports concerning repeat breast-conserving therapy support well designed prospective trials to formally test this hypothesis...
  46. ncbi Clinical outcome and cosmesis in African-American patients treated with conservative surgery and radiation therapy
    Nimi L Tuamokumo
    Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8040, USA
    Cancer J 9:313-20. 2003
    ..The explanation for a slightly higher local relapse rate and poorer cosmetic result requires further investigation...
  47. ncbi A comparison of five immunohistochemical biomarkers and HER-2/neu gene amplification by fluorescence in situ hybridization in white and Korean patients with early-onset breast carcinoma
    Doo Ho Choi
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer 98:1587-95. 2003
    ..Further research will be needed to identify biologic and genetic factors and their effects on the survival between different racial groups...
  48. ncbi Should intensity-modulated radiation therapy be the standard of care in the conservatively managed breast cancer patient?
    Bruce G Haffty
    J Clin Oncol 26:2072-4. 2008
  49. ncbi Local-regional breast cancer recurrence: prognostic groups based on patterns of failure
    Meena S Moran
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520-8040, USA
    Breast J 8:81-7. 2002
    ..Placing patients with breast cancer and local-regional relapse into these prognostic categories may be helpful in decision making regarding the role of systemic therapy at the time of local-regional relapse...
  50. ncbi Outcome of conservatively managed early-onset breast cancer by BRCA1/2 status
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Lancet 359:1471-7. 2002
    ..This study assessed the long-term risks of ipsilateral and contralateral breast cancer in a cohort of young women who underwent breast-conserving surgery followed by radiotherapy...
  51. ncbi Molecular and genetic markers in the local-regional management of breast cancer
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Semin Radiat Oncol 12:329-40. 2002
    ..The available rature regarding the use of genetic and molecular markers in the local-regional management of breast cancer is summarized in this review...
  52. ncbi Correlation of clinical and pathologic features with outcome in patients with ductal carcinoma in situ of the breast treated with breast-conserving surgery and radiotherapy
    Neesha Rodrigues
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520-8040, USA
    Int J Radiat Oncol Biol Phys 54:1331-5. 2002
    ..Although none of the patients receiving tamoxifen had a recurrence in the ipsilateral or contralateral breast, longer follow-up is required to assess the effect of tamoxifen on these end points...
  53. ncbi Local recurrence of breast cancer after breast conservation therapy in patients examined by means of stereotactic core-needle biopsy
    Allen M Chen
    Department of Diagnostic Radiology, Yale University School of Medicine, 333 Cedar St, PO Box 208042, New Haven, CT 06520-8042, USA
    Radiology 225:707-12. 2002
    ..03). CONCLUSION: In the present series to date, cancers diagnosed by means of SCNB were not associated with an increased incidence of local recurrence after breast conservation surgery and radiation therapy...
  54. ncbi Differences in the pathologic and molecular features of intraductal breast carcinoma between younger and older women
    Neesha A Rodrigues
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer 97:1393-403. 2003
    ..Further studies are needed to assess whether this difference holds independent of grade and to evaluate the prognostic significance of HER-2/neu overexpression in DCIS...
  55. ncbi BRCA status, molecular markers, and clinical variables in early, conservatively managed breast cancer
    Sung Kim
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Breast J 9:167-74. 2003
    ..Patients with BRCA mutations have a unique molecular profile. These data can be helpful in understanding differences in the biologic behavior of patients with familial breast cancers...
  56. ncbi Cyclooxygenase-2 expression in postmastectomy chest wall relapse
    Janet H Kim
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Cancer Res 11:5199-205. 2005
    ..If confirmed with larger studies, these data have implications with respect to the concurrent use of COX-2 inhibitors and radiation for postmastectomy chest wall relapse...
  57. ncbi Radiation therapy and the risk of contralateral breast cancer
    Bruce G Haffty
    Int J Radiat Oncol Biol Phys 56:920-1. 2003
  58. ncbi Sequence of radiotherapy with tamoxifen in conservatively managed breast cancer does not affect local relapse rates
    Peter H Ahn
    Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA
    J Clin Oncol 23:17-23. 2005
    ....
  59. ncbi Concurrent chemo-radiotherapy with mitomycin C compared with porfiromycin in squamous cell cancer of the head and neck: final results of a randomized clinical trial
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Int J Radiat Oncol Biol Phys 61:119-28. 2005
    ..We conducted a randomized trial comparing MC with porfiromycin (POR) in combination with RT in the management of SCCHN...
  60. ncbi Clinicopathologic features and long-term outcome of patients with medullary breast carcinoma managed with breast-conserving therapy (BCT)
    Ha Vu-Nishino
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Int J Radiat Oncol Biol Phys 62:1040-7. 2005
    ..These findings suggest that patients diagnosed with medullary carcinoma are appropriate candidates for BCT and are associated with favorable long-term prognosis...
  61. ncbi Rationalization and regionalization of treatment for ductal carcinoma in situ of the breast
    Grace L Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Int J Radiat Oncol Biol Phys 65:1397-403. 2006
    ..Additional follow up is needed to determine whether geographic variation in care influences long-term outcomes...
  62. ncbi Effectiveness of radiation therapy for older women with early breast cancer
    Benjamin D Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    J Natl Cancer Inst 98:681-90. 2006
    ..Recent clinical trials have questioned the necessity of breast radiation therapy for older women with early breast cancer. However, the effectiveness of radiation therapy for older women in the community setting has not been addressed...
  63. ncbi Double heterozygotes for non-Caucasian families with mutations in BRCA-1 and BRCA-2 genes
    Doo Ho Choi
    Department of Radiation Oncology and Surgery, College of Medicine, Soonchungyang University, Seoul, Korea
    Breast J 12:216-20. 2006
    ..We describe here two cases of deleterious mutations in both genes in a cohort of Korean women with early onset breast cancer...
  64. ncbi Chest wall relapse after mastectomy for ductal carcinoma in situ: a report of 10 cases with a review of the literature
    Janet H Kim
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Cancer J 12:92-101. 2006
    ..Postmastectomy chest wall relapses in patients with DCIS are an uncommon event. Patients treated aggressively with resection of the lesion followed by radiation therapy to the chest wall have a favorable prognosis...
  65. ncbi Five-year update of an expanded phase II study of dose-dense and -intense doxorubicin, paclitaxel and cyclophosphamide (ATC) in high-risk breast cancer
    Maysa M Abu-Khalaf
    Jersey Shore University Medical Center, Neptune, N.J, USA
    Oncology 69:372-83. 2005
    ..CONCLUSIONS: ATC is a feasible regimen for adjuvant therapy of high-risk BC, with a relatively low rate of relapse at the 5-year follow up...
  66. ncbi Patterns of reduced nipple aspirate fluid production and ductal lavage cellularity in women at high risk for breast cancer
    Susan A Higgins
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Breast Cancer Res 7:R1017-22. 2005
    ..However, we observed a significantly lower proportion of fluid-yielding subjects in a similar series of high-risk women. The purpose of the present study was to identify variables associated with this reduction...
  67. ncbi Can molecular markers predict local, regional and distant metastasis in head and neck cancer?
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale School of Medicine and Yale New Haven Hospital, New Haven, CT 06520 8040, USA
    Nat Clin Pract Oncol 2:132-3. 2005
  68. ncbi Immunohistochemical biomarkers in patients with early-onset breast carcinoma by tissue microarray
    Doo Ho Choi
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Cancer J 11:404-11. 2005
    ..Further studies are needed to find other biologic markers associated with local failure in this group of patients...
  69. ncbi Effects of breast-conserving therapy on lactation after pregnancy
    Meena S Moran
    Department of Therapeutic Radiology, Yale University School of Medicine, Yale New Haven Hospital, New Haven, Connecticut 06520 8040, USA
    Cancer J 11:399-403. 2005
    ..Our objective was to evaluate lactation outcomes in patients with early-stage breast cancer treated with breast-conserving therapy...
  70. ncbi Management of suspicious or indeterminate calcifications and impact on local control
    Brian E Lally
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer 103:2236-40. 2005
    ..CONCLUSIONS: Patients with DRC were found to have better local control than patients with NDRC. In addition, the presence of SIC on a PREMAMMO was associated with a high probability of detecting residual disease...
  71. ncbi Initial outcomes for patients treated on the American Society of Breast Surgeons MammoSite clinical trial for ductal carcinoma-in-situ of the breast
    Jacqueline S Jeruss
    Department of Surgical Oncology, Unit 444, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Ann Surg Oncol 13:967-76. 2006
    ..Long-term follow-up data regarding patient satisfaction, cosmesis, and efficacy are needed and will be determined from a recently opened large randomized study...
  72. ncbi Should all patients undergoing breast conserving therapy for DCIS receive radiation therapy? Yes. Radiation therapy, an important component of breast conserving treatment for patients with ductal carcinoma in situ of the breast
    Thomas A Buchholz
    J Surg Oncol 95:610-3. 2007
  73. ncbi Accelerated partial breast irradiation: where do we go from here?
    Bruce G Haffty
    Breast J 11:303-5. 2005
  74. ncbi Postmastectomy radiation and survival in older women with breast cancer
    Benjamin D Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    J Clin Oncol 24:4901-7. 2006
    ..As recent evidence suggests that certain adjuvant treatments appropriate for younger women may only be marginally beneficial for older women, we sought to determine whether PMRT improves survival for older women with breast cancer...
  75. ncbi Effectiveness of radiation therapy in older women with ductal carcinoma in situ
    Benjamin D Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    J Natl Cancer Inst 98:1302-10. 2006
    ..In a cohort of older women with DCIS, we sought to determine whether radiation therapy was associated with a clinically significant benefit...
  76. ncbi Regional nodal recurrence in breast cancer patients treated with conservative surgery and radiation therapy (BCS+RT)
    Sunanda Pejavar
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Int J Radiat Oncol Biol Phys 66:1320-7. 2006
    ..CONCLUSIONS: In patients undergoing BCS+RT, both regional nodal irradiation and AXD (including SNB) resulted in equally high rates of regional nodal control. Nodal RT may also be an effective treatment for SN-positive patients...
  77. ncbi Characterization of the HER-2/neu oncogene by immunohistochemical and fluorescence in situ hybridization analysis in oral and oropharyngeal squamous cell carcinoma
    Atif J Khan
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Clin Cancer Res 8:540-8. 2002
    ....
  78. ncbi Cyclin d1 is a valuable prognostic marker in oropharyngeal squamous cell carcinoma
    Ziwei Yu
    Department of Otolaryngology, Yale University School of Medicine, New Haven, CT 06520, USA
    Clin Cancer Res 11:1160-6. 2005
    ..In this study, we sought to determine the prognostic significance of the cell cycle regulator cyclin D1 in oropharyngeal squamous cell carcinoma (OSCC)...
  79. ncbi Use of postmastectomy radiotherapy in older women
    Benjamin D Smith
    Radiation Oncology Flight, Wilford Hall Medical Center, Lackland Air Force Base, TX, USA
    Int J Radiat Oncol Biol Phys 71:98-106. 2008
    ..Using the Surveillance, Epidemiology, and End Results-Medicare cohort, we sought to characterize the adoption of PMRT from 1992 to 2002 and identify risk factors for PMRT omission among high-risk older patients...
  80. ncbi Prognostic significance of cyclooxygenase-2 in oropharyngeal squamous cell carcinoma
    Bryan W Chang
    Department of Therapeutic Radiology, Yale University, New Haven, Connecticut 06520 8040, USA
    Clin Cancer Res 10:1678-84. 2004
    ..To determine the relative prognostic significance of cyclooxygenase (COX)-2 expression in patients with oropharyngeal squamous cell carcinoma (SCC)...
  81. ncbi Prognostic significance of vascular endothelial growth factor protein levels in T1-2 N0 laryngeal cancer treated with primary radiation therapy
    Rahul R Parikh
    Albany Medical College, Albany, New York, USA
    Cancer 109:566-73. 2007
    ..The purpose of this study was to assess the prognostic value of vascular endothelial growth factor protein levels in a large cohort of patients with T1-T2 N0 laryngeal cancer treated with primary radiation therapy (XRT)...
  82. ncbi Postmastectomy radiation and mortality in women with T1-2 node-positive breast cancer
    Benjamin D Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    J Clin Oncol 23:1409-19. 2005
    ..82; 95% CI, 0.72 to 0.93 for cause-specific mortality). CONCLUSION: For women with T1-2 breast cancer, PMRT is associated with a 15% to 20% relative reduction in mortality for patients with seven or more involved regional lymph nodes...
  83. ncbi Prognostic significance of pretreatment hemoglobin for local control and overall survival in T1-T2N0 larynx cancer treated with external beam radiotherapy
    Edward I Cho
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Int J Radiat Oncol Biol Phys 58:1135-40. 2004
    ..This relationship has potential therapeutic implications regarding correcting anemia before the initiation of radiotherapy for optimal outcome...
  84. ncbi Tissue microarray analysis reveals prognostic significance of COX-2 expression for local relapse in T1-2N0 larynx cancer treated with primary radiation therapy
    Edward I Cho
    Departments of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520-8040, USA
    Laryngoscope 114:2001-8. 2004
    ..This relationship may have potential therapeutic implications regarding the use of COX-2 inhibitors during radiation therapy for optimal outcome...