Kristin C Gunsalus

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc UTRome.org: a platform for 3'UTR biology in C. elegans
    Marco Mangone
    Department of Biology and Center for Genomics and Systems Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Nucleic Acids Res 36:D57-62. 2008
  2. doi Networks in Caenorhabditis elegans
    Kristin C Gunsalus
    Center for Genomics and Systems Biology and Department of Biology, New York University, 12 Waverly Place, 8th Floor, New York, NY 10012, USA
    Curr Opin Genet Dev 21:787-98. 2011
  3. pmc RNAiDB and PhenoBlast: web tools for genome-wide phenotypic mapping projects
    Kristin C Gunsalus
    Center for Comparative Functional Genomics, Department of Biology, New York University, 1009 Silver Building, 100 Washington Square E, New York, NY 10003, USA
    Nucleic Acids Res 32:D406-10. 2004
  4. pmc A Caenorhabditis elegans genetic-interaction map wiggles into view
    Kristin C Gunsalus
    Center for Genomics and Systems Biology and Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA
    J Biol 7:8. 2008
  5. ncbi Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis
    Kristin C Gunsalus
    Center for Comparative Functional Genomics, Department of Biology, New York University, New York, New York 10003, USA
    Nature 436:861-5. 2005
  6. pmc The landscape of C. elegans 3'UTRs
    Marco Mangone
    Center for Genomics and Systems Biology, Department of Biology, New York University, 1009 Silver Center, New York, NY 10003, USA
    Science 329:432-5. 2010
  7. ncbi A genome-wide map of conserved microRNA targets in C. elegans
    Sabbi Lall
    Center for Comparative Functional Genomics, Department of Biology, New York University, New York, New York 10003, USA
    Curr Biol 16:460-71. 2006
  8. pmc Diverse roles of actin in C. elegans early embryogenesis
    Nathalie Velarde
    New York University, Department of Biology and Center for Comparative Functional Genomics, 100 Washington Square East, New York, NY 10003, USA
    BMC Dev Biol 7:142. 2007
  9. pmc New genes with roles in the C. elegans embryo revealed using RNAi of ovary-enriched ORFeome clones
    Anita G Fernandez
    Department of Biology, New York University, New York, New York 10003, USA
    Genome Res 15:250-9. 2005
  10. pmc Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans
    John Maciejowski
    Department of Biology, New York University, NY 10003, USA
    Genetics 169:1997-2011. 2005

Research Grants

Collaborators

Detail Information

Publications44

  1. pmc UTRome.org: a platform for 3'UTR biology in C. elegans
    Marco Mangone
    Department of Biology and Center for Genomics and Systems Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Nucleic Acids Res 36:D57-62. 2008
    ..The UTRome database thus represents a powerful tool to better understand the biology of 3'UTRs...
  2. doi Networks in Caenorhabditis elegans
    Kristin C Gunsalus
    Center for Genomics and Systems Biology and Department of Biology, New York University, 12 Waverly Place, 8th Floor, New York, NY 10012, USA
    Curr Opin Genet Dev 21:787-98. 2011
    ....
  3. pmc RNAiDB and PhenoBlast: web tools for genome-wide phenotypic mapping projects
    Kristin C Gunsalus
    Center for Comparative Functional Genomics, Department of Biology, New York University, 1009 Silver Building, 100 Washington Square E, New York, NY 10003, USA
    Nucleic Acids Res 32:D406-10. 2004
    ..RNAiDB could serve as a model database for distributing and navigating in vivo functional information from large-scale systematic phenotypic analyses in different organisms...
  4. pmc A Caenorhabditis elegans genetic-interaction map wiggles into view
    Kristin C Gunsalus
    Center for Genomics and Systems Biology and Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA
    J Biol 7:8. 2008
    ..A recent study of signaling pathways in Caenorhabditis elegans lays the next row of bricks in this foundation...
  5. ncbi Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis
    Kristin C Gunsalus
    Center for Comparative Functional Genomics, Department of Biology, New York University, New York, New York 10003, USA
    Nature 436:861-5. 2005
    ..We assessed the overall predictive value of such molecular machine models by dynamic localization of ten previously uncharacterized proteins within the living embryo...
  6. pmc The landscape of C. elegans 3'UTRs
    Marco Mangone
    Center for Genomics and Systems Biology, Department of Biology, New York University, 1009 Silver Center, New York, NY 10003, USA
    Science 329:432-5. 2010
    ..We identified conserved 3'UTR motifs, isoform-specific predicted microRNA target sites, and polyadenylation of most histone genes. Our data reveal a rich complexity of 3'UTRs, both genome-wide and throughout development...
  7. ncbi A genome-wide map of conserved microRNA targets in C. elegans
    Sabbi Lall
    Center for Comparative Functional Genomics, Department of Biology, New York University, New York, New York 10003, USA
    Curr Biol 16:460-71. 2006
    ..Metazoan miRNAs regulate protein-coding genes by binding the 3' UTR of cognate mRNAs. Identifying targets for the 115 known C. elegans miRNAs is essential for understanding their function...
  8. pmc Diverse roles of actin in C. elegans early embryogenesis
    Nathalie Velarde
    New York University, Department of Biology and Center for Comparative Functional Genomics, 100 Washington Square East, New York, NY 10003, USA
    BMC Dev Biol 7:142. 2007
    ..The actin cytoskeleton plays critical roles in early development in Caenorhabditis elegans. To further understand the complex roles of actin in early embryogenesis we use RNAi and in vivo imaging of filamentous actin (F-actin) dynamics...
  9. pmc New genes with roles in the C. elegans embryo revealed using RNAi of ovary-enriched ORFeome clones
    Anita G Fernandez
    Department of Biology, New York University, New York, New York 10003, USA
    Genome Res 15:250-9. 2005
    ..Furthermore, we discovered a striking direct relationship between phylogenetic distribution and the penetrance level of embryonic lethality elicited by RNAi...
  10. pmc Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans
    John Maciejowski
    Department of Biology, New York University, NY 10003, USA
    Genetics 169:1997-2011. 2005
    ..We present hypotheses for evolutionary mechanisms that may underlie germ-line/soma subfunctionalization of duplicated genes, taking into account the role of X chromosome silencing in the germ line and analogous mammalian phenomena...
  11. ncbi RNAi as a tool to study cell biology: building the genome-phenome bridge
    Kristin C Gunsalus
    Center for Comparative Functional Genomics, Department of Biology, New York University, 1009 Silver Center, 100 Washington Sq E, New York, New York 10003, USA
    Curr Opin Cell Biol 17:3-8. 2005
    ..The transformation of complex phenotypic data into mineable 'digitized' formats is fostering the emergence of a new area of bioinformatics related to the phenome...
  12. pmc Browsing multidimensional molecular networks with the generic network browser (N-Browse)
    Huey Ling Kao
    New York University, New York, New York, USA
    Curr Protoc Bioinformatics . 2008
    ..The N-Browse client-server package is freely available for distribution, providing a convenient way for data producers and providers to distribute and offer interactive visualization of network-based data...
  13. pmc Rational design of temperature-sensitive alleles using computational structure prediction
    Christopher S Poultney
    Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America
    PLoS ONE 6:e23947. 2011
    ..We show that integrating Rosetta relax-derived features with sequence-based features results in accurate temperature-sensitive mutation predictions...
  14. ncbi Gene clustering based on RNAi phenotypes of ovary-enriched genes in C. elegans
    Fabio Piano
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Curr Biol 12:1959-64. 2002
    ..We find that phenoclusters correlate well with sequence-based functional predictions and thus may be useful in predicting functions of uncharacterized genes...
  15. ncbi Programmatic implementation of blastocyst transfer in a university-based in vitro fertilization clinic: maximizing pregnancy rates and minimizing triplet rates
    James A Grifo
    New York University Fertility Center, New York University School of Medicine, New York, New York 10016, USA
    Fertil Steril 88:294-300. 2007
    ..e., those at <35 years of age (16.8% versus 6.8%), those at 35-37 years of age (13.0% versus 5.6%), and recipients of donated oocytes (11.2% versus 4.5%)...
  16. ncbi Low ectopic pregnancy rates after in vitro fertilization: do practice habits matter?
    Debbra A Keegan
    Division of Reproductive Endocrinology and Infertility, NYU School of Medicine, New York, New York 10016, USA
    Fertil Steril 88:734-6. 2007
    ..Aggressive management of tubal disease may contribute to low rates of EP, whereas blastocyst transfer may increase the rate...
  17. ncbi Increased risk of pregnancy-induced hypertension in young recipients of donated oocytes
    Debbra A Keegan
    Division of Reproductive Endocrinology and Infertility, NYU School of Medicine, New York, New York, USA
    Fertil Steril 87:776-81. 2007
    ..To assess the rates of select obstetric outcomes in oocyte donation (OD) recipients aged <35 years and > or =40 years and compare them to similarly aged IVF patients...
  18. ncbi Transabdominal ultrasound-assisted embryo transfer and pregnancy outcome
    Eric Flisser
    Program for In Vitro Fertilization, Reproductive Surgery and Infertility, New York University School of Medicine, New York, New York 10016, USA
    Fertil Steril 85:353-7. 2006
    ....
  19. doi Delivery rate using cryopreserved oocytes is comparable to conventional in vitro fertilization using fresh oocytes: potential fertility preservation for female cancer patients
    James A Grifo
    New York University Fertility Center, New York University School of Medicine, New York, New York, USA
    Fertil Steril 93:391-6. 2010
    ..Recently, several large reports of healthy births resulting from the transfer of embryos derived from frozen/thawed oocytes have been published. We sought to establish an oocyte cryopreservation program at our center...
  20. doi Optimizing embryo selection with day 5 transfer
    Andrea Reh
    New York University Fertility Center, New York University School of Medicine, New York, New York, USA
    Fertil Steril 93:609-15. 2010
    ..To compare rates of implantation, pregnancy, miscarriage, multiple gestation, and selective reduction between patients undergoing day 5 (d5) and day 3 (d3) ETs...
  21. pmc MINE: Module Identification in Networks
    Kahn Rhrissorrakrai
    Center for Genomics and Systems Biology, Department of Biology, New York University, New York, NY 10003, USA
    BMC Bioinformatics 12:192. 2011
    ..To address this problem, we have developed an agglomerative clustering method that is able to identify highly modular sets of gene products within highly interconnected molecular interaction networks...
  22. doi Monozygotic twinning: an eight-year experience at a large IVF center
    Jaime Knopman
    New York University Fertility Center, New York University Langone Medical Center, New York, NY 10021, USA
    Fertil Steril 94:502-10. 2010
    ..To characterize incidence, chorionicity, amnionicity, and pregnancy outcome for monozygotic twin pregnancy (MZT) after IVF...
  23. doi Early serum interleukin-8 evaluation may prove useful in localizing abnormally implanted human gestations after in vitro fertilization
    Sara S Morelli
    New York University Fertility Center, New York University School of Medicine, New York, New York 10016, USA
    Fertil Steril 90:2068-72. 2008
    ..To determine whether early measurement of the serum cytokines interleukin-2 receptor (IL-2R), IL-6, and IL-8 along with human chorionic gonadotropin (hCG) and progesterone (P(4)) can differentiate an ectopic from an intrauterine gestation...
  24. doi Fate of cryopreserved donor embryos
    Jaime M Knopman
    NYU Fertility Center, Langone Medical Center, New York, New York 10016, USA
    Fertil Steril 94:1689-92. 2010
    ..To review a center's experience with cryopreserved embryos generated from donor eggs and to analyze their long-term disposition...
  25. pmc Electrical activity can impose time of day on the circadian transcriptome of pacemaker neurons
    Dogukan Mizrak
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Curr Biol 22:1871-80. 2012
    ..Circadian pacemaker neurons contain molecular clocks that control 24 hr rhythms in gene expression that in turn regulate electrical activity rhythms to control behavior...
  26. pmc Tertiary structure-based analysis of microRNA-target interactions
    Hin Hark Gan
    Department of Biology, New York University, New York, NY 10003, USA
    RNA 19:539-51. 2013
    ..Collectively, these results demonstrate that tertiary structure-based modeling of miRNA interactions can reveal structural mechanisms not accessible with current secondary structure-based methods...
  27. pmc Oocyte cryopreservation: is it time to remove its experimental label?
    Nicole Noyes
    NYU Fertility Center, NYU School of Medicine, New York, NY 10016, USA
    J Assist Reprod Genet 27:69-74. 2010
    ..Given such, oocyte cryopreservation's experimental designation and need for IRB approval should thus be revisited...
  28. ncbi Impact of developmental stage at cryopreservation and transfer on clinical outcome of frozen embryo cycles
    Nicole Noyes
    NYU Fertility Center, New York University School of Medicine, New York, New York 10016, USA
    Reprod Biomed Online 19:9-15. 2009
    ..Barring government regulation, an IVF programme's day for cryopreservation generally depends on its management of and success with fresh embryo transfer...
  29. doi Are gonadotropin-releasing hormone agonists losing popularity? Current trends at a large fertility center
    Andrea Reh
    New York University Fertility Center, New York University School of Medicine, New York, New York, USA
    Fertil Steril 93:101-8. 2010
    ..To explore the long- and short-term trends in LH-suppression protocol use and patient profile characteristics...
  30. ncbi Combinatorial microRNA target predictions
    Azra Krek
    Center for Comparative Functional Genomics, Department of Biology, New York University, 100 Washington Square East, New York, New York 10003, USA
    Nat Genet 37:495-500. 2005
    ..In particular, we experimentally validate common regulation of Mtpn by miR-375, miR-124 and let-7b and thus provide evidence for coordinate microRNA control in mammals...
  31. pmc Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway
    Kristian Dreij
    Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA
    Carcinogenesis 31:1149-57. 2010
    ..This is the first demonstration that a strong inflammatory response is triggered in normal fibroblasts by BPDE and that this occurs through coordinated regulation with other cellular processes...
  32. doi Oocyte cryopreservation outcomes including pre-cryopreservation and post-thaw meiotic spindle evaluation following slow cooling and vitrification of human oocytes
    Nicole Noyes
    New York University Fertility Center, New York University School of Medicine, New York, New York 10021, USA
    Fertil Steril 94:2078-82. 2010
    ..To report our oocyte cryopreservation (OC) outcomes including meiotic spindle (MS) evaluation of metaphase II (MII) oocytes destined for OC and thaw...
  33. ncbi Embryo biopsy: the fate of abnormal pronuclear embryos
    Nicole Noyes
    NYU Fertility Centre, New York University School of Medicine, New York, New York, USA
    Reprod Biomed Online 17:782-8. 2008
    ..Many different meiotic and fertilization errors can result in 0PN or 1PN zygotes; these results indicate that the resultant embryos should not be transferred, especially when normally fertilized embryos are available...
  34. ncbi Evaluating the role of exogenous luteinizing hormone in poor responders undergoing in vitro fertilization with gonadotropin-releasing hormone antagonists
    Karine Chung
    New York University Program for Infertility, Reproductive Surgery, and In Vitro Fertilization, New York, New York, USA
    Fertil Steril 84:313-8. 2005
    ..To evaluate the importance of exogenous LH in poor responders undergoing IVF with GnRH antagonists...
  35. doi Cryopreserved oocytes can serve as the treatment for secondary infertility: a novel model for egg donation
    Jaime M Knopman
    New York University Fertility Center, New York University School of Medicine, New York, New York 10016, USA
    Fertil Steril 93:2413.e7-9. 2010
    ..To report the use of previously cryopreserved oocytes for the treatment of secondary infertility...
  36. pmc A protein domain-based interactome network for C. elegans early embryogenesis
    Mike Boxem
    Center for Cancer Systems Biology and Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 134:534-45. 2008
    ..This interactome modeling strategy revealed insights into C. elegans centrosome function and is applicable to other biological processes in this and other organisms...
  37. pmc A map of the interactome network of the metazoan C. elegans
    Siming Li
    Dana Farber Cancer Institute and Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Science 303:540-3. 2004
    ..Topological and biological features of this interactome network, as well as its integration with phenome and transcriptome data sets, lead to numerous biological hypotheses...
  38. ncbi Integrating interactome, phenome, and transcriptome mapping data for the C. elegans germline
    Albertha J M Walhout
    Dana Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 12:1952-8. 2002
    ..Similar integration of interactome, phenome, and transcriptome data should be possible for other biological processes in the nematode and for other organisms, including humans...
  39. ncbi Network modeling links breast cancer susceptibility and centrosome dysfunction
    Miguel Angel Pujana
    Center for Cancer Systems Biology CCSB, Dana Farber Cancer Institute and Department of Genetics, Harvard Medical School, 44 Binney St, Boston, Massachusetts 02115, USA
    Nat Genet 39:1338-49. 2007
    ..Our network modeling strategy should be useful for the discovery of additional cancer-associated genes...
  40. ncbi Feo, the Drosophila homolog of PRC1, is required for central-spindle formation and cytokinesis
    Fiammetta Vernì
    Istituto Pasteur Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari del Consiglio Nazionale delle Ricerche, Dipartimento di Genetica e Biologia Molecolare, Universita di Roma La Sapienza, P le A Moro 5, 00185 Roma, Italy
    Curr Biol 14:1569-75. 2004
    ..The phenotype of Feo-depleted telophases suggests that Feo interacts with the plus ends of central spindle MTs so as to maintain their precise interdigitation during anaphase-telophase MT elongation and antiparallel sliding...
  41. ncbi Backbone 1H, 15N and 13C assignments for the 21 kDa Caenorhabditis elegans homologue of "brain-specific" protein
    Daniel Monleon
    J Biomol NMR 28:91-2. 2004
  42. pmc Mating induces an immune response and developmental switch in the Drosophila oviduct
    Anat Kapelnikov
    Department of Entomology, Hebrew University, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 105:13912-7. 2008
    ..Our combined results indicate that mating triggers molecular and biochemical changes that mediate progression from a "poised" state to a mature, functional stage...
  43. ncbi Robotic cloning and Protein Production Platform of the Northeast Structural Genomics Consortium
    Thomas B Acton
    Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
    Methods Enzymol 394:210-43. 2005
    ..These improved robotic and?or parallel cloning, expression, protein production, and biophysical screening technologies will be of broad value to the structural biology, functional proteomics, and structural genomics communities...
  44. ncbi Twinstar, the Drosophila homolog of cofilin/ADF, is required for planar cell polarity patterning
    Adrienne Blair
    Department of Molecular Cell and Developmental Biology, and Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Development 133:1789-97. 2006
    ..These results argue that actin remodeling is not only required in the manufacture of wing hairs, but also in the PCP read-out that directs where a wing hair will be secreted...

Research Grants3

  1. A systems biology approach to mammalian early embryogenesis
    Kristin Gunsalus; Fiscal Year: 2009
    ..differentiation. ..
  2. A systems biology approach to mammalian early embryogenesis
    Nicole Noyes; Fiscal Year: 2010
    ..differentiation. ..