M Grumet

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Nr-CAM: a cell adhesion molecule with ligand and receptor functions
    M Grumet
    Department of Pharmacology, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA
    Cell Tissue Res 290:423-8. 1997
  2. pmc Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta
    T Sakurai
    Department of Pharmacology, New York University Medical Center 10016, USA
    J Cell Biol 136:907-18. 1997
  3. ncbi request reprint Nr-CAM expression in the developing mouse nervous system: ventral midline structures, specific fiber tracts, and neuropilar regions
    M Lustig
    Department of Pharmacology, New York University Medical Center, New York, New York 10016, USA
    J Comp Neurol 434:13-28. 2001
  4. ncbi request reprint Expression of polypeptide variants of receptor-type protein tyrosine phosphatase beta: the secreted form, phosphacan, increases dramatically during embryonic development and modulates glial cell behavior in vitro
    T Sakurai
    Department of Pharmacology, New York University Medical Center, NY 10016, USA
    J Neurosci Res 43:694-706. 1996
  5. ncbi request reprint Reduced tumorigenicity of rat glioma cells in the brain when mediated by hygromycin phosphotransferase
    A Hormigo
    Department of Pharmacology, and Kaplan Comprehensive Cancer Center, New York University Medical Center, New York, USA
    J Neurosurg 94:596-604. 2001
  6. ncbi request reprint Nr-CAM and neurofascin interactions regulate ankyrin G and sodium channel clustering at the node of Ranvier
    M Lustig
    Department of Pharmacology, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA
    Curr Biol 11:1864-9. 2001
  7. ncbi request reprint Contactin-associated protein (Caspr) and contactin form a complex that is targeted to the paranodal junctions during myelination
    J C Rios
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 20:8354-64. 2000
  8. ncbi request reprint Vascular apoptosis and involution in gliomas precede neovascularization: a novel concept for glioma growth and angiogenesis
    D Zagzag
    Department of Pathology, Kaplan Cancer Center, New York University Medical Center, New York 10016, USA
    Lab Invest 80:837-49. 2000
  9. ncbi request reprint Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord
    M P Matise
    Howard Hughes Medical Institute and Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 126:3649-59. 1999
  10. ncbi request reprint Tenascin-C expression by angiogenic vessels in human astrocytomas and by human brain endothelial cells in vitro
    D Zagzag
    Department of Pathology, New York University Medical Center, New York 10016, USA
    Cancer Res 56:182-9. 1996

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Nr-CAM: a cell adhesion molecule with ligand and receptor functions
    M Grumet
    Department of Pharmacology, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA
    Cell Tissue Res 290:423-8. 1997
    ..This review summarizes the structure and expression of Nr-CAM and discusses its potential functions as a ligand and as a receptor during neural development...
  2. pmc Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta
    T Sakurai
    Department of Pharmacology, New York University Medical Center 10016, USA
    J Cell Biol 136:907-18. 1997
    ..These results suggest that binding of glial RPTPbeta to the contactin/Nr-CAM complex is important for neurite growth and neuronal differentiation...
  3. ncbi request reprint Nr-CAM expression in the developing mouse nervous system: ventral midline structures, specific fiber tracts, and neuropilar regions
    M Lustig
    Department of Pharmacology, New York University Medical Center, New York, New York 10016, USA
    J Comp Neurol 434:13-28. 2001
    ..In the hippocampus, however, TAG-1-positive areas are segregated from Nr-CAM-positive areas, suggesting that, in neuropilar regions, Nr-CAM interacts with molecules other than TAG-1...
  4. ncbi request reprint Expression of polypeptide variants of receptor-type protein tyrosine phosphatase beta: the secreted form, phosphacan, increases dramatically during embryonic development and modulates glial cell behavior in vitro
    T Sakurai
    Department of Pharmacology, New York University Medical Center, NY 10016, USA
    J Neurosci Res 43:694-706. 1996
    ..The results show that phosphacan increases dramatically during development, and indicate that secreted forms of RPTP beta can modulate glial cell adhesion and behavior...
  5. ncbi request reprint Reduced tumorigenicity of rat glioma cells in the brain when mediated by hygromycin phosphotransferase
    A Hormigo
    Department of Pharmacology, and Kaplan Comprehensive Cancer Center, New York University Medical Center, New York, USA
    J Neurosurg 94:596-604. 2001
    ..Interestingly. hygromycin resistance was lost in tumor cells that were recovered from a group of animals in which C6R-G/H cells formed tumors, confirming the correlation of HPT with reduced tumorigenicity...
  6. ncbi request reprint Nr-CAM and neurofascin interactions regulate ankyrin G and sodium channel clustering at the node of Ranvier
    M Lustig
    Department of Pharmacology, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA
    Curr Biol 11:1864-9. 2001
    ..These results provide the first evidence that neurofascin plays a major role in the formation of nodes, possibly via interactions with Nr-CAM...
  7. ncbi request reprint Contactin-associated protein (Caspr) and contactin form a complex that is targeted to the paranodal junctions during myelination
    J C Rios
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 20:8354-64. 2000
    ..These results strongly suggest that a preformed complex of Caspr and contactin is targeted to the paranodal junctions via extracellular interactions with myelinating glia...
  8. ncbi request reprint Vascular apoptosis and involution in gliomas precede neovascularization: a novel concept for glioma growth and angiogenesis
    D Zagzag
    Department of Pathology, Kaplan Cancer Center, New York University Medical Center, New York 10016, USA
    Lab Invest 80:837-49. 2000
    ..Moreover, Ang-2 is detected prior to the onset of apoptosis in vascular cells and could be linked to vascular involution...
  9. ncbi request reprint Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord
    M P Matise
    Howard Hughes Medical Institute and Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 126:3649-59. 1999
    ....
  10. ncbi request reprint Tenascin-C expression by angiogenic vessels in human astrocytomas and by human brain endothelial cells in vitro
    D Zagzag
    Department of Pathology, New York University Medical Center, New York 10016, USA
    Cancer Res 56:182-9. 1996
    ..Furthermore, our results suggest that TN expression may be associated with endothelial cell activation and may play an important role in angiogenesis...
  11. pmc Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules
    P Milev
    Department of Pharmacology, New York University Medical Center, New York 10016
    J Cell Biol 127:1703-15. 1994
    ....
  12. ncbi request reprint Differential expression of the cell-adhesion molecule Nr-CAM in hyperplastic and neoplastic human pancreatic tissue
    K M Dhodapkar
    Department of Pediatric Hematology-Oncology, Kaplan Comprehensive Cancer Center, New York University Medical Center, New York, NY, USA
    Hum Pathol 32:396-400. 2001
    ..This differential regulation of Nr-CAM expression suggests that it may be involved in the pathogenesis and invasive/metastatic behavior of pancreatic cancers. HUM PATHOL 32:396-400...
  13. pmc Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding
    J Sap
    Department of Pharmacology, New York University Medical Center, New York 10016
    Mol Cell Biol 14:1-9. 1994
    ..The results suggest that R-PTPases may provide a link between cell-cell contact and cellular signaling events involving tyrosine phosphorylation...
  14. ncbi request reprint Nr-CAM and TAG-1 are expressed in distinct populations of developing precerebellar and cerebellar neurons
    S Backer
    INSERM U106, Hopital de la Salpetriere, 75013 Paris, France
    Neuroscience 113:743-8. 2002
    ..However, the pattern of cerebellar expression of TAG-1--early migrating Purkinje cells up to E14 and external granular cells--prevents the implication of this adhesion molecule in the organization of extracerebellar projections...
  15. ncbi request reprint The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin
    E Peles
    SUGEN, Incorporated, Redwood City, California 94063 4720, USA
    Cell 82:251-60. 1995
    ..The interaction between contactin and RPTP beta may generate unidirectional or bidirectional signals during neural development...
  16. pmc Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions
    E Peles
    SUGEN, Inc, Redwood City, CA 94063, USA
    EMBO J 16:978-88. 1997
    ..The binding of RPTPbeta to the contactin-Caspr complex could provide a mechanism for cell-cell communication between glial cells and neurons during development...
  17. pmc Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development
    T Sakurai
    W M Keck Center for Collaborative Neuroscience, Rutgers University, Piscataway, NJ 08854, USA
    J Cell Biol 154:1259-73. 2001
    ..The combined results indicate that Nr-CAM and L1 play a role in cerebellar granule cell development, and suggest that closely related molecules in the L1 family have overlapping functions...
  18. ncbi request reprint Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling
    E Peles
    Dept of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Trends Biochem Sci 23:121-4. 1998
    ..Here, the authors discuss the implications of such complexes for intercellular signaling, and the regulation of RPTP activity by cell-cell and cell-ECM contact...
  19. ncbi request reprint Radial glial cell line C6-R integrates preferentially in adult white matter and facilitates migration of coimplanted neurons in vivo
    A Hormigo
    W. M. Keck Center for Collaborative Neuroscience, Rutgers, State University of New Jersey, 604 Allison Road, Piscataway, New Jersey 08854-8082, USA
    Exp Neurol 168:310-22. 2001
    ..The results suggest that radial glial cell lines can serve as a scaffold for neuronal migration that may facilitate development of experimental models for neural transplantation and regeneration...
  20. pmc Structure of the chicken neuron-glia cell adhesion molecule, Ng-CAM: origin of the polypeptides and relation to the Ig superfamily
    M P Burgoon
    Rockefeller University, New York 10021
    J Cell Biol 112:1017-29. 1991
    ..These structural features of Ng-CAM provide a framework for understanding its multiple functions in neuron-neuron interactions, neurite fasciculation, and neuron-glia interactions...
  21. pmc The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth
    D R Friedlander
    Department of Pharmacology, New York University Medical Center, New York 10016
    J Cell Biol 125:669-80. 1994
    ....
  22. ncbi request reprint Interactions with tenascin and differential effects on cell adhesion of neurocan and phosphacan, two major chondroitin sulfate proteoglycans of nervous tissue
    M Grumet
    Department of Pharmacology, New York University Medical Center, New York 10016
    J Biol Chem 269:12142-6. 1994
    ....
  23. pmc Structure of a new nervous system glycoprotein, Nr-CAM, and its relationship to subgroups of neural cell adhesion molecules
    M Grumet
    Rockefeller University, New York, New York 10021
    J Cell Biol 113:1399-412. 1991
    ..abstract truncated at 400 words)..
  24. ncbi request reprint Neuronal cell adhesion molecule deletion induces a cognitive and behavioral phenotype reflective of impulsivity
    L D Matzel
    Department of Psychology, Program in Behavioural Neuroscience, Rutgers University, Piscataway, NJ 08854, USA
    Genes Brain Behav 7:470-80. 2008
    ....