Steven J Greco

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi request reprint Mesenchymal stem cells in drug/gene delivery: implications for cell therapy
    Steven J Greco
    University of Medicine and Dentistry of New Jersey New Jersey Medical School, MSB, Room E 579, 185 South Orange Ave, Newark, NJ 07103, USA
    Ther Deliv 3:997-1004. 2012
  2. pmc Developmental regulation of TAC1 in peptidergic-induced human mesenchymal stem cells: implication for spinal cord injury in zebrafish
    Nitixa Patel
    UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Stem Cells Dev 21:308-20. 2012
  3. doi request reprint Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells
    Philip K Lim
    New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Cancer Res 71:1550-60. 2011
  4. ncbi request reprint An interdisciplinary approach and characterization of neuronal cells transdifferentiated from human mesenchymal stem cells
    Steven J Greco
    Graduate School of Biomedical Sciences, New Jersey Medical School UMDNJ, Newark, NJ 07103, USA
    Stem Cells Dev 16:811-26. 2007
  5. doi request reprint Analysis of the transfer of circulating microRNA between cells mediated by gap junction
    Steven J Greco
    University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ, USA
    Methods Mol Biol 1024:87-96. 2013
  6. doi request reprint Exogenous CXCL12 activates protein kinase C to phosphorylate connexin 43 for gap junctional intercellular communication among confluent breast cancer cells
    Jacqueline M Park
    UMDNJ New Jersey Medical School, Department of Medicine, Newark, NJ 07103, USA
    Cancer Lett 331:84-91. 2013
  7. doi request reprint Immunostimulatory effects of mesenchymal stem cell-derived neurons: implications for stem cell therapy in allogeneic transplantations
    Marianne D Castillo
    Graduate School of Biomedical Science, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA
    Clin Transl Sci 1:27-34. 2008
  8. pmc RE-1-silencing transcription factor shows tumor-suppressor functions and negatively regulates the oncogenic TAC1 in breast cancer cells
    Bobby Y Reddy
    Department of Medicine Hematology Oncology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 106:4408-13. 2009
  9. ncbi request reprint Enhancing effect of IL-1alpha on neurogenesis from adult human mesenchymal stem cells: implication for inflammatory mediators in regenerative medicine
    Steven J Greco
    Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Immunol 179:3342-50. 2007
  10. pmc MicroRNAs regulate synthesis of the neurotransmitter substance P in human mesenchymal stem cell-derived neuronal cells
    Steven J Greco
    Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 104:15484-9. 2007

Collaborators

  • Mustapha Kandouz
  • Joseph McArdle
  • Hatem E Sabaawy
  • Nicholas M Ponzio
  • Yan zhong Guan
  • Tilman E Klassert
  • Pranela Rameshwar
  • Shyam A Patel
  • Sarah A Bliss
  • Jessian L Munoz
  • Jacqueline M Park
  • Margarette Bryan
  • Nitixa Patel
  • Bobby Y Reddy
  • Raghav G Murthy
  • Katarzyna A Trzaska
  • Peter Navarro
  • Philip K Lim
  • Prem S Patel
  • Marcelo Taborga
  • Jiang Hong Ye
  • Marianne D Castillo
  • Kyung Jin Cho
  • Brian Wong Won
  • Neil Campbell
  • Suresh Bhatt
  • Jeffrey A Shrensel
  • Lauren S Sherman
  • Simant Shah
  • Allan Siegel
  • Shakti H Ramkissoon
  • Guiqin Xie
  • Natalia Kokorina
  • Rekha S Bhatt
  • Meneka A Dave
  • Larissa A Gregory
  • Kelly E Corcoran
  • Justin R Meyer
  • Fu Shun Wang

Detail Information

Publications20

  1. ncbi request reprint Mesenchymal stem cells in drug/gene delivery: implications for cell therapy
    Steven J Greco
    University of Medicine and Dentistry of New Jersey New Jersey Medical School, MSB, Room E 579, 185 South Orange Ave, Newark, NJ 07103, USA
    Ther Deliv 3:997-1004. 2012
    ..Combined with their immune-privileged status, safe clinical profile and low tumorigenicity, MSCs offer vast potential to benefit patients with serious diseases, for which limited treatment options exist...
  2. pmc Developmental regulation of TAC1 in peptidergic-induced human mesenchymal stem cells: implication for spinal cord injury in zebrafish
    Nitixa Patel
    UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Stem Cells Dev 21:308-20. 2012
    ..Imaging and functional studies showed significant improvement in the fish. The repair mechanism involved the activation of JNK. The findings have long-term implications for SCI repair with MSCs...
  3. doi request reprint Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells
    Philip K Lim
    New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Cancer Res 71:1550-60. 2011
    ..This study shows that the transfer of miRNAs from BM stroma to BC cells might play a role in the dormancy of BM metastases...
  4. ncbi request reprint An interdisciplinary approach and characterization of neuronal cells transdifferentiated from human mesenchymal stem cells
    Steven J Greco
    Graduate School of Biomedical Sciences, New Jersey Medical School UMDNJ, Newark, NJ 07103, USA
    Stem Cells Dev 16:811-26. 2007
    ..Together, the improved induction protocol, combined with an interdisciplinary approach to verify that hMSCs can differentiate into neuronal cells, provides a step toward translational application with models of regenerative medicine...
  5. doi request reprint Analysis of the transfer of circulating microRNA between cells mediated by gap junction
    Steven J Greco
    University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ, USA
    Methods Mol Biol 1024:87-96. 2013
    ..To this end, we have developed a miRNA reporter assay to assess the ability of miRNAs to be transferred between stem and breast cancer cells and target a specific recognition sequence...
  6. doi request reprint Exogenous CXCL12 activates protein kinase C to phosphorylate connexin 43 for gap junctional intercellular communication among confluent breast cancer cells
    Jacqueline M Park
    UMDNJ New Jersey Medical School, Department of Medicine, Newark, NJ 07103, USA
    Cancer Lett 331:84-91. 2013
    ..These findings elucidate the importance of considering the microenvironment's role in micrometastasis in clinical studies pertaining to prospective breast cancer treatment...
  7. doi request reprint Immunostimulatory effects of mesenchymal stem cell-derived neurons: implications for stem cell therapy in allogeneic transplantations
    Marianne D Castillo
    Graduate School of Biomedical Science, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA
    Clin Transl Sci 1:27-34. 2008
    ..The release of neurotransmitters could be involved in initiating inflammation, underscoring the relevance of immune responses as consideration for stem cell therapies...
  8. pmc RE-1-silencing transcription factor shows tumor-suppressor functions and negatively regulates the oncogenic TAC1 in breast cancer cells
    Bobby Y Reddy
    Department of Medicine Hematology Oncology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 106:4408-13. 2009
    ..Together, these findings show a central role for REST in the oncogenic function of TAC1 and suggest a tumor-suppressor role for REST in breast cancer...
  9. ncbi request reprint Enhancing effect of IL-1alpha on neurogenesis from adult human mesenchymal stem cells: implication for inflammatory mediators in regenerative medicine
    Steven J Greco
    Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Immunol 179:3342-50. 2007
    ..The results provide evidence that inflammatory mediators need to be considered when deciding the course of MSC transplantation...
  10. pmc MicroRNAs regulate synthesis of the neurotransmitter substance P in human mesenchymal stem cell-derived neuronal cells
    Steven J Greco
    Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 104:15484-9. 2007
    ..Specific inhibition of miR-130a and miR-206 in the neuronal cells resulted in SP synthesis and release. The studies provide a different approach in ascribing a new regulatory role for miRNAs in regulating neurotransmitter synthesis...
  11. ncbi request reprint Tac1 regulation by RNA-binding protein and miRNA in bone marrow stroma: Implication for hematopoietic activity
    Raghav G Murthy
    UMDNJ New Jersey Medical School, MSB, Room E 579, 185 South Orange Ave, Newark, NJ 07103, USA
    Brain Behav Immun 22:442-50. 2008
    ..The broad categories of cytokines as hematopoietic stimulators or inhibitors might depend on the avidity of RNA-binding protein(s) for Tac1 mRNA, as well as the ability to degrade or stabilize the specific miRNAs...
  12. pmc An indirect role for oncomir-519b in the expression of truncated neurokinin-1 in breast cancer cells
    Peter Navarro
    UMDNJ New Jersey Medical School, 185 South Orange Avenue, MSB E 585, Newark, NJ 07103, United States
    Exp Cell Res 318:2604-15. 2012
    ..In addition, the findings have implications for therapy with NK1 antagonists. The oncogenic effect of NK1-Tr must be considered to improve the efficacy of current drugs to NK1...
  13. pmc Feline bone marrow-derived mesenchymal stromal cells (MSCs) show similar phenotype and functions with regards to neuronal differentiation as human MSCs
    Jessian L Munoz
    Department of Medicine Hematology Oncology University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ 07103, USA
    Differentiation 84:214-22. 2012
    ..The findings indicate that the cat may constitute a promising biomedical model for evaluation of novel therapies such as stem cell therapy in such neurological disorders as Alzheimer's disease and stroke...
  14. doi request reprint A reporter assay to detect transfer and targeting of miRNAs in stem cell-breast cancer co-cultures
    Steven J Greco
    University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ, USA
    Methods Mol Biol 879:195-201. 2012
    ..To this end, we have developed a miRNA reporter assay to assess the ability of miRNAs to be transferred between stem and breast cancer cells and target a specific recognition sequence...
  15. ncbi request reprint Synergy between the RE-1 silencer of transcription and NFkappaB in the repression of the neurotransmitter gene TAC1 in human mesenchymal stem cells
    Steven J Greco
    Department of Medicine, Division of Hematology Oncology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    J Biol Chem 282:30039-50. 2007
    ..Together, the results support the novel finding of synergism between REST and NFkappaB in the suppression of TAC1 in non-neuronal cells...
  16. ncbi request reprint Functional similarities among genes regulated by OCT4 in human mesenchymal and embryonic stem cells
    Steven J Greco
    Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, New Jersey 07103, USA
    Stem Cells 25:3143-54. 2007
    ..The results suggest similar regulatory mechanisms for OCT4 in MSCs and ESCs and have implications regarding MSC plasticity. Disclosure of potential conflicts of interest is found at the end of this article...
  17. doi request reprint Recent advances and novel approaches in deriving neurons from stem cells
    Steven J Greco
    Department of Medicine, Division of Hematology Oncology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ, USA
    Mol Biosyst 6:324-8. 2010
    ..In this review, we highlight recent literature demonstrating cutting-edge, interdisciplinary approaches, which induce neuronal differentiation into a variety of phenotypes and discuss the potential impact of these works...
  18. doi request reprint Mesenchymal stem cells protect breast cancer cells through regulatory T cells: role of mesenchymal stem cell-derived TGF-beta
    Shyam A Patel
    Division of Hematology and Oncology, Department of Medicine, New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 184:5885-94. 2010
    ..These findings demonstrate immune protection by MSCs to BCCs. The reduction in immune cell proliferation and recruitment mediated by MSCs has implications for treatment of breast cancer with chemotherapy...
  19. pmc Hierarchy of breast cancer cells: key to reverse dormancy for therapeutic intervention
    Sarah A Bliss
    Department of Medicine, Hematology Oncology, New Jersey Medical School and Graduate School of Biomedical Sciences, Rutgers University, Newark, New Jersey, USA
    Stem Cells Transl Med 3:782-6. 2014
    ..This will allow for intervention to reverse dormancy for targeted treatment. The treatment will require studies within the normal organ functions to ensure treatment without toxicity. ..
  20. ncbi request reprint Neurons derived from human mesenchymal stem cells show synaptic transmission and can be induced to produce the neurotransmitter substance P by interleukin-1 alpha
    Kyung Jin Cho
    Department of Medicine, Hematology Oncology, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Stem Cells 23:383-91. 2005
    ..This study reports on the ability of MSCs to be transdifferentiated into neurons with functional synapses with the potential to become polarized towards producing specific neurotransmitters...