L I Golbe

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi request reprint The tau A0 allele in Parkinson's disease
    L I Golbe
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901, USA
    Mov Disord 16:442-7. 2001
  2. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
  3. ncbi request reprint A clinical rating scale for progressive supranuclear palsy
    Lawrence I Golbe
    Neurology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Brunswick, NJ 08840, USA
    Brain 130:1552-65. 2007
  4. ncbi request reprint Glutathione S-transferase polymorphisms and onset age in alpha-synuclein A53T mutant Parkinson's disease
    Lawrence I Golbe
    Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Am J Med Genet B Neuropsychiatr Genet 144:254-8. 2007
  5. ncbi request reprint BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study
    S Karamohamed
    Department of Neurology, Boston University School of Medicine, MA, USA
    Neurology 65:1823-5. 2005
  6. ncbi request reprint Genome-wide scan for Parkinson's disease: the GenePD Study
    A L DeStefano
    Department of Neurology, Boston University Schools of Medicine and of Public Health, Boston, MA 02118, USA
    Neurology 57:1124-6. 2001
  7. ncbi request reprint Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study
    Samer Karamohamed
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Mov Disord 20:1188-91. 2005
  8. ncbi request reprint A haplotype at the PARK3 locus influences onset age for Parkinson's disease: the GenePD study
    S Karamohamed
    Department of Neurology, Boston University School of Medicine, MA 02118, USA
    Neurology 61:1557-61. 2003
  9. ncbi request reprint Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: the GenePD Study
    J B Wilk
    Department of Neurology, Boston University School of Medicine, 715 Albany St, E 338, Boston, MA 02118, USA
    Neurology 67:2206-10. 2006
  10. pmc PARK3 influences age at onset in Parkinson disease: a genome scan in the GenePD study
    Anita L Destefano
    Department of Neurology, Boston University Schools of Medicine and of Public Health, Boston, MA 02118, USA
    Am J Hum Genet 70:1089-95. 2002

Research Grants

Detail Information

Publications26

  1. ncbi request reprint The tau A0 allele in Parkinson's disease
    L I Golbe
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901, USA
    Mov Disord 16:442-7. 2001
    ..We conclude that the tau protein may play a small role in the pathogenesis of PD and that biochemical characterization of this role may suggest opportunities for PD prophylaxis...
  2. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
    ..Studies of the penetrance of LRRK2 mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD...
  3. ncbi request reprint A clinical rating scale for progressive supranuclear palsy
    Lawrence I Golbe
    Neurology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Brunswick, NJ 08840, USA
    Brain 130:1552-65. 2007
    ..We conclude that the PSPRS is a practical measure that is sensitive to disease progression and could be useful as a dependent variable in observational or interventional trials and as an indicator of prognosis in clinical practice...
  4. ncbi request reprint Glutathione S-transferase polymorphisms and onset age in alpha-synuclein A53T mutant Parkinson's disease
    Lawrence I Golbe
    Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Am J Med Genet B Neuropsychiatr Genet 144:254-8. 2007
    ..Nevertheless, our results suggest that further investigation in GSTP1 variants and PD pathogenesis is warranted in sporadic PD and that a search for toxins that accelerate PD OA should pay particular attention to GST-P1 substrates...
  5. ncbi request reprint BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study
    S Karamohamed
    Department of Neurology, Boston University School of Medicine, MA, USA
    Neurology 65:1823-5. 2005
    ..Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age...
  6. ncbi request reprint Genome-wide scan for Parkinson's disease: the GenePD Study
    A L DeStefano
    Department of Neurology, Boston University Schools of Medicine and of Public Health, Boston, MA 02118, USA
    Neurology 57:1124-6. 2001
    ..The chromosome 9 region overlaps the genes for dopamine beta-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others...
  7. ncbi request reprint Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study
    Samer Karamohamed
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Mov Disord 20:1188-91. 2005
    ..None of the variants were found in the GenePD families. Our results suggest that other variants or genes account for the familial risk of PD within the GenePD study...
  8. ncbi request reprint A haplotype at the PARK3 locus influences onset age for Parkinson's disease: the GenePD study
    S Karamohamed
    Department of Neurology, Boston University School of Medicine, MA 02118, USA
    Neurology 61:1557-61. 2003
    ..To identify a haplotype influencing onset age for Parkinson's disease (PD) in the PARK3 region on chromosome 2p13...
  9. ncbi request reprint Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: the GenePD Study
    J B Wilk
    Department of Neurology, Boston University School of Medicine, 715 Albany St, E 338, Boston, MA 02118, USA
    Neurology 67:2206-10. 2006
    ..Using the GenePD Study sample of familial PD cases, we explored whether GSTP1 polymorphisms were associated with the age at onset of PD symptoms and whether that relation was modified by exposure to herbicides...
  10. pmc PARK3 influences age at onset in Parkinson disease: a genome scan in the GenePD study
    Anita L Destefano
    Department of Neurology, Boston University Schools of Medicine and of Public Health, Boston, MA 02118, USA
    Am J Hum Genet 70:1089-95. 2002
    ....
  11. ncbi request reprint Segregation analysis of Parkinson disease revealing evidence for a major causative gene
    N E Maher
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Med Genet 109:191-7. 2002
    ..Such gene environment interactions, involving reduced penetrance in PD, may explain the low concordance rates among monozygotic twins for this disease...
  12. ncbi request reprint Epidemiologic study of 203 sibling pairs with Parkinson's disease: the GenePD study
    N E Maher
    Department of Neurology, Boston University School of Medicine, MA 02118, USA
    Neurology 58:79-84. 2002
    ..To examine patterns of familial aggregation and factors influencing onset age in a sample of siblings with PD...
  13. pmc Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: the GenePD study
    Christopher F McNicoll
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts 02118, USA
    Mov Disord 23:1596-601. 2008
    ..No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD...
  14. ncbi request reprint Alpha-synuclein and Parkinson's disease
    Lawrence I Golbe
    Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Adv Neurol 91:165-74. 2003
  15. doi request reprint Movement disorders and pregnancy: a review of the literature
    Sarah M Kranick
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mov Disord 25:665-71. 2010
    ..This review summarizes retrospective series and case reports to both guide clinicians and to stimulate and direct the design of prospective studies...
  16. ncbi request reprint Woman with a 26-year history of parkinsonism, supranuclear ophthalmoplegia, and loss of postural reflexes
    Paul H Gordon
    Department of Neurology, Division of Movement Disorders, Columbia Presbyterian Medical Center, New York, New York 10032, USA
    Mov Disord 19:950-61. 2004
    ..A woman who had her first serious fall at age 48 years subsequently developed neurological symptoms. Her case is described, differential diagnoses are presented, pathology is discussed, and a final diagnosis is reached...
  17. ncbi request reprint Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred
    John E Duda
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Pennsylvania, USA
    Acta Neuropathol 104:7-11. 2002
    ..We suggest that it is important to recognize that the neurodegenerative process caused by the Ala53Thr mutation in alpha-synuclein is not identical to that seen in typical idiopathic Parkinson's disease brains...
  18. ncbi request reprint Initiation and synergistic fibrillization of tau and alpha-synuclein
    Benoit I Giasson
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine
    Science 300:636-40. 2003
    ..This suggests that interactions between alpha-syn and tau can promote their fibrillization and drive the formation of pathological inclusions in human neurodegenerative diseases...
  19. pmc Replication of association between ELAVL4 and Parkinson disease: the GenePD study
    Anita L Destefano
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Crosstown Center, 3rd Floor, Boston, MA 02118, USA
    Hum Genet 124:95-9. 2008
    ..This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene...
  20. ncbi request reprint Predictors of deterioration in health-related quality of life in Parkinson's disease: results from the DATATOP trial
    Connie Marras
    Division of Neurology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 23:653-9; quiz 776. 2008
    ..Our focus in clinical care needs to be broadened beyond assessing and treating Parkinsonism, recognizing the impact of mood, cognition and function on HRQOL...
  21. ncbi request reprint Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation
    Paul T Kotzbauer
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Neurol 187:279-88. 2004
    ..Our data implicate fibrillization of alpha-syn and tau in the pathogenesis of PD, and suggest that distinct amyloidogenic proteins may cross-seed each other in neurodegenerative diseases...
  22. pmc Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms
    Stacey Melquist
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Am J Hum Genet 80:769-78. 2007
    ..Since DNA damage and lysosomal dysfunction have been implicated in aging and neurodegenerative processes, both genes are viable candidates for conferring risk of disease...
  23. pmc Neurodegeneration in the age of molecular biology
    Lawrence I Golbe
    BMJ 324:1467-8. 2002
  24. ncbi request reprint Alpha-synuclein in Parkinson's disease: light from two new angles
    Lawrence I Golbe
    Ann Neurol 55:153-6. 2004
  25. ncbi request reprint HS1-BP3 gene variant is common in familial essential tremor
    Joseph J Higgins
    Center for Human Genetics and Child Neurology, Mid Hudson Family Health Institute, New Paltz, New York, USA
    Mov Disord 21:306-9. 2006
    ..The HS1-BP3 gene plays a putative role in regulating catecholamine and serotonin metabolism, but the functional consequences of the amino acid substitution (A265G) caused by this genetic variant is unknown...
  26. ncbi request reprint Influence of heterozygosity for parkin mutation on onset age in familial Parkinson disease: the GenePD study
    Mei Sun
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Arch Neurol 63:826-32. 2006
    ..The PARK2 gene at 6q26 encodes parkin, whose inactivation is implicated in an early-onset autosomal recessive form of Parkinson disease (PD)...

Research Grants1

  1. Glutathione S-transferase polymorphisms in PARK1 parkin*
    Lawrence Golbe; Fiscal Year: 2003
    ..abstract_text> ..