Marc Gartenberg

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi request reprint The Sir proteins of Saccharomyces cerevisiae: mediators of transcriptional silencing and much more
    M R Gartenberg
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Curr Opin Microbiol 3:132-7. 2000
  2. pmc Targeting of cohesin by transcriptionally silent chromatin
    Chuang Rung Chang
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, 08854, USA
    Genes Dev 19:3031-42. 2005
  3. pmc A tDNA establishes cohesion of a neighboring silent chromatin domain
    Rudra N Dubey
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Genes Dev 21:2150-60. 2007
  4. pmc Targeted sister chromatid cohesion by Sir2
    Ching Shyi Wu
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, United States of America
    PLoS Genet 7:e1002000. 2011
  5. pmc Life on the edge: telomeres and persistent DNA breaks converge at the nuclear periphery
    Marc R Gartenberg
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Genes Dev 23:1027-31. 2009
  6. doi request reprint Heterochromatin and the cohesion of sister chromatids
    Marc Gartenberg
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Chromosome Res 17:229-38. 2009
  7. pmc Condensin goes with the family but not with the flow
    Marc R Gartenberg
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Genome Biol 9:236. 2008
  8. doi request reprint Generation of DNA circles in yeast by inducible site-specific recombination
    Marc R Gartenberg
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA
    Methods Mol Biol 833:103-13. 2012
  9. ncbi request reprint Sir-mediated repression can occur independently of chromosomal and subnuclear contexts
    Marc R Gartenberg
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Cell 119:955-67. 2004
  10. pmc Swapping the gene-specific and regional silencing specificities of the Hst1 and Sir2 histone deacetylases
    Janet Mead
    Waksman Institute, 190 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Mol Cell Biol 27:2466-75. 2007

Collaborators

Detail Information

Publications15

  1. ncbi request reprint The Sir proteins of Saccharomyces cerevisiae: mediators of transcriptional silencing and much more
    M R Gartenberg
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Curr Opin Microbiol 3:132-7. 2000
    ....
  2. pmc Targeting of cohesin by transcriptionally silent chromatin
    Chuang Rung Chang
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, 08854, USA
    Genes Dev 19:3031-42. 2005
    ..The results are consistent with a model in which cohesin binds silent chromatin via topological linkage to individual chromatids...
  3. pmc A tDNA establishes cohesion of a neighboring silent chromatin domain
    Rudra N Dubey
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Genes Dev 21:2150-60. 2007
    ..The results reveal an unexpected role for tDNAs and RNA polymerase III-associated proteins in establishment of sister chromatid cohesion...
  4. pmc Targeted sister chromatid cohesion by Sir2
    Ching Shyi Wu
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, United States of America
    PLoS Genet 7:e1002000. 2011
    ..Taken together, these data define a unique role for Sir2 in cohesion of silent chromatin that is distinct from the enzyme's role as a histone deacetylase...
  5. pmc Life on the edge: telomeres and persistent DNA breaks converge at the nuclear periphery
    Marc R Gartenberg
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Genes Dev 23:1027-31. 2009
    ..Anchorage maintains telomere integrity and steers double-strand breaks toward specialized repair pathways. This work defines the nuclear periphery as a subcompartment where dangerous DNA elements can be handled with care...
  6. doi request reprint Heterochromatin and the cohesion of sister chromatids
    Marc Gartenberg
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Chromosome Res 17:229-38. 2009
    ..In this review I discuss recent work that relates to these relationships between heterochromatin and cohesin...
  7. pmc Condensin goes with the family but not with the flow
    Marc R Gartenberg
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Genome Biol 9:236. 2008
    ..Whereas cohesin translocates from these loading sites to mediate cohesion at secondary locations, condensin remains, bringing distant sites together into clusters...
  8. doi request reprint Generation of DNA circles in yeast by inducible site-specific recombination
    Marc R Gartenberg
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA
    Methods Mol Biol 833:103-13. 2012
    ..In this chapter, I discuss general considerations in using site-specific recombination to create DNA circles in yeast and the specific application of the R recombinase...
  9. ncbi request reprint Sir-mediated repression can occur independently of chromosomal and subnuclear contexts
    Marc R Gartenberg
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Cell 119:955-67. 2004
    ..In the absence of both proteins, rings move throughout the nucleoplasm yet remain silent. Thus, transcriptional repression can be sustained without perinuclear anchoring...
  10. pmc Swapping the gene-specific and regional silencing specificities of the Hst1 and Sir2 histone deacetylases
    Janet Mead
    Waksman Institute, 190 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Mol Cell Biol 27:2466-75. 2007
    ..These results suggest that the differences in the silencing and repression functions of Sir2 and Hst1 may not be due to differences in enzymatic activities of the proteins but rather may be the result of distinct cofactor specificities...
  11. pmc Bypassing Sir2 and O-acetyl-ADP-ribose in transcriptional silencing
    Chia Ching Chou
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Mol Cell 31:650-9. 2008
    ..Together, these data demonstrate that protein deacetylation is the only essential function of Sir2 in creating silenced chromatin...
  12. pmc Long-range communication between the silencers of HMR
    Lourdes Valenzuela
    Department of MCD Biology, Sinsheimer Labs, 1156 High Street, University of California, Santa Cruz, California 95064, USA
    Mol Cell Biol 28:1924-35. 2008
    ..We further show that silencing is necessary for these long-range interactions, and we present models for Sir-mediated silencing based upon these results...
  13. ncbi request reprint Multiple pathways tether telomeres and silent chromatin at the nuclear periphery: functional implications for sir-mediated repression
    Angela Taddei
    University of Geneva, Department of Molecular Biology and NCCR Frontiers in Genetics, Quai, Ernest Ansermet 30, CH 1211 Geneva 4, Switzerland
    Novartis Found Symp 264:140-56; discussion 156-65, 227-30. 2005
    ..Dual anchoring pathways thus cooperate to generate high concentrations of SIR proteins in perinuclear foci, which in turn promote repression...
  14. pmc Esc1, a nuclear periphery protein required for Sir4-based plasmid anchoring and partitioning
    Erik D Andrulis
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794 5215, USA
    Mol Cell Biol 22:8292-301. 2002
    ..Our data suggest that Esc1 is a component of a redundant pathway that functions to localize silencing complexes to the nuclear periphery...
  15. pmc Controlled exchange of chromosomal arms reveals principles driving telomere interactions in yeast
    Heiko Schober
    Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland
    Genome Res 18:261-71. 2008
    ..These results can be explained by the polarized Rabl arrangement of yeast centromeres and telomeres, which promote to telomere pairing by allowing contact between chromosome arms of equal length in anaphase...

Research Grants18

  1. Chromosome Architecture: Cohesion of Transcriptionally Silenced Domains
    Marc R Gartenberg; Fiscal Year: 2010
    ..We will also isolate heterochromatin fragments to examine the binding mode of cohesin in vitro. Last, we will use molecular genetic assays to assess the role of cohesion in heterochromatic silencing and genome stability. ..
  2. Chromosome Architecture: Cohesion of Transcriptionally Silenced Domains
    Marc Gartenberg; Fiscal Year: 2009
    ..We will also isolate heterochromatin fragments to examine the binding mode of cohesin in vitro. Last, we will use molecular genetic assays to assess the role of cohesion in heterochromatic silencing and genome stability. ..
  3. Chromosome Architecture: Cohesion of Transcriptionally Silenced Domains
    Marc Gartenberg; Fiscal Year: 2007
    ..We will also isolate heterochromatin fragments to examine the binding mode of cohesin in vitro. Last, we will use molecular genetic assays to assess the role of cohesion in heterochromatic silencing and genome stability. ..
  4. CHROMOSOME ARCHITECTURE AND DOMAINS OF REPRESSION
    Marc Gartenberg; Fiscal Year: 2006
    ..Genetic methods will be used to investigate how one nuclear periphery protein, Esc 1, contributes to silencing. ..
  5. CHROMOSOME ARCHITECTURE AND DOMAINS OF REPRESSION
    Marc Gartenberg; Fiscal Year: 2004
    ..Genetic methods will be used to investigate how one nuclear periphery protein, Esc 1, contributes to silencing. ..
  6. CHROMOSOME ARCHITECTURE AND DOMAINS OF REPRESSION
    Marc Gartenberg; Fiscal Year: 2005
    ..Genetic methods will be used to investigate how one nuclear periphery protein, Esc 1, contributes to silencing. ..
  7. Chromosome Architecture: Cohesion of Transcriptionally Silenced Domains
    Marc R Gartenberg; Fiscal Year: 2010
    ..We will also isolate heterochromatin fragments to examine the binding mode of cohesin in vitro. Last, we will use molecular genetic assays to assess the role of cohesion in heterochromatic silencing and genome stability. ..
  8. CHROMOSOME ARCHITECTURE AND DOMAINS OF REPRESSION
    Marc Gartenberg; Fiscal Year: 2003
    ..Genetic methods will be used to investigate how one nuclear periphery protein, Esc 1, contributes to silencing. ..
  9. CHROMOSOME ARCHITECTURE AND DOMAINS OF REPRESSION
    Marc Gartenberg; Fiscal Year: 2002
    ..Factors that can function as boundaries of silent chromosomal domains will be identify by a simple genetic selection. ..
  10. CHROMOSOME ARCHITECTURE AND DOMAINS OF REPRESSION
    Marc Gartenberg; Fiscal Year: 2001
    ..Factors that can function as boundaries of silent chromosomal domains will be identify by a simple genetic selection. ..
  11. CHROMOSOME ARCHITECTURE AND DOMAINS OF REPRESSION
    Marc Gartenberg; Fiscal Year: 2000
    ..Factors that can function as boundaries of silent chromosomal domains will be identify by a simple genetic selection. ..
  12. CHROMOSOME ARCHITECTURE AND DOMAINS OF REPRESSION
    Marc Gartenberg; Fiscal Year: 1999
    ..Factors that can function as boundaries of silent chromosomal domains will be identify by a simple genetic selection. ..
  13. CHROMOSOME ARCHITECTURE AND DOMAINS OF REPRESSION
    Marc Gartenberg; Fiscal Year: 2004
    ..Genetic methods will be used to investigate how one nuclear periphery protein, Esc 1, contributes to silencing. ..