Hodaka Fujii

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Inducible translocation trap: a system for detecting inducible nuclear translocation
    Akemi Hoshino
    Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mol Cell 15:153-9. 2004
  2. doi request reprint Novel reporter cell line to analyze cytokine-mediated expression regulation of c-myc gene
    Hodaka Fujii
    Department of Pathology, New York University School of Medicine, 550 First Avenue, MSB 126, New York, NY 10016, USA
    J Biosci Bioeng 108:438-40. 2009
  3. pmc Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction
    Hodaka Fujii
    Department of Pathology, New York University School of Medicine, 550 First Avenue, MSB 126, New York, NY 10016, USA
    Biochem Biophys Res Commun 354:825-9. 2007
  4. pmc Lack of nuclear translocation of cytoplasmic domains of IL-2/IL-15 receptor subunits
    Hodaka Fujii
    Department of Pathology, New York University School of Medicine, 550 First Avenue, MSB 126, NY 10016, USA
    Cytokine 46:302-8. 2009
  5. doi request reprint Receptor expression is essential for proliferation induced by dimerized Jak kinases
    Hodaka Fujii
    Department of Pathology, New York University School of Medicine, 550 First Avenue, MSB 126, New York, NY 10016, USA
    Biochem Biophys Res Commun 370:557-60. 2008
  6. pmc GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo
    Angela X Zhou
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 190:5057-64. 2013
  7. pmc Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon
    Shella Saint Fleur
    Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY, USA
    Blood 114:1355-65. 2009
  8. pmc Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells
    Rui Wang
    Department of Microbiology, NYU Cancer Institute and New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 106:13439-44. 2009
  9. pmc Cytokine-induced nuclear translocation of signaling proteins and their analysis using the inducible translocation trap system
    Shella Saint Fleur
    Department of Pathology, New York University School of Medicine, 550 First Avenue, MSB 126, New York, NY 10016, USA
    Cytokine 41:187-97. 2008
  10. ncbi request reprint Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase
    Akemi Hoshino
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 282:17706-11. 2007

Research Grants

  1. Cytokine signal transduction in immune system
    Hodaka Fujii; Fiscal Year: 2007

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Inducible translocation trap: a system for detecting inducible nuclear translocation
    Akemi Hoshino
    Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mol Cell 15:153-9. 2004
    ..ITT may be a useful tool for dissecting dynamic translocation in various biological systems...
  2. doi request reprint Novel reporter cell line to analyze cytokine-mediated expression regulation of c-myc gene
    Hodaka Fujii
    Department of Pathology, New York University School of Medicine, 550 First Avenue, MSB 126, New York, NY 10016, USA
    J Biosci Bioeng 108:438-40. 2009
    ..Kinetics of GFP mRNA expression was similar to that of endogenous c-myc mRNA. The reporter cell line will be a useful tool for studies of cell proliferation regulation through analysis of cytokine-induced c-myc gene expression...
  3. pmc Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction
    Hodaka Fujii
    Department of Pathology, New York University School of Medicine, 550 First Avenue, MSB 126, New York, NY 10016, USA
    Biochem Biophys Res Commun 354:825-9. 2007
    ..These data suggest a critical role of Jak3 in IL-2 signaling in the fibroblast cell line and may provide further insight into the cell type-specific mechanism of cytokine signaling...
  4. pmc Lack of nuclear translocation of cytoplasmic domains of IL-2/IL-15 receptor subunits
    Hodaka Fujii
    Department of Pathology, New York University School of Medicine, 550 First Avenue, MSB 126, NY 10016, USA
    Cytokine 46:302-8. 2009
    ..Collectively, these results indicated that potential nuclear function of cleaved type I cytokine receptor subunits is not plausible...
  5. doi request reprint Receptor expression is essential for proliferation induced by dimerized Jak kinases
    Hodaka Fujii
    Department of Pathology, New York University School of Medicine, 550 First Avenue, MSB 126, New York, NY 10016, USA
    Biochem Biophys Res Commun 370:557-60. 2008
    ..The present study indicates that re-evaluation of this conclusion is necessary and that interpretation of functional analysis of signaling molecules using chemical dimerizers needs more careful assessment...
  6. pmc GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo
    Angela X Zhou
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 190:5057-64. 2013
    ..These findings suggest a role for GARP in natural and induced Treg development through activation of bound latent TGF-β and signaling, which negatively regulates GARP expression on Tregs...
  7. pmc Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon
    Shella Saint Fleur
    Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY, USA
    Blood 114:1355-65. 2009
    ..We think that our data provide insight into expression regulation of Fas in T cells...
  8. pmc Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells
    Rui Wang
    Department of Microbiology, NYU Cancer Institute and New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 106:13439-44. 2009
    ..Our findings highlight the significance of GARP both in dissecting duality of Treg/Th17 cell differentiation and as a marker to identify bona fide Tregs during diseases with chronic immune activation...
  9. pmc Cytokine-induced nuclear translocation of signaling proteins and their analysis using the inducible translocation trap system
    Shella Saint Fleur
    Department of Pathology, New York University School of Medicine, 550 First Avenue, MSB 126, New York, NY 10016, USA
    Cytokine 41:187-97. 2008
    ..Finally, analysis of "nuclear translocatome", the entire set of proteins that translocate into or out of the nucleus in response to extracellular stimuli, by ITT is discussed...
  10. ncbi request reprint Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase
    Akemi Hoshino
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 282:17706-11. 2007
    ....
  11. pmc Temporal regulation of Stat5 activity in determination of cell differentiation program
    Akemi Hoshino
    Department of Pathology, New York University School of Medicine, 550 First Avenue, MSB 126, New York, NY 10016, USA
    Biochem Biophys Res Commun 358:914-9. 2007
    ..The acidic region of the IL-2 receptor beta-chain was essential for this inhibition. These results underscore the importance of temporal regulation of Stat activity for regulation of cytokine-specific cell differentiation...
  12. pmc Nuclear translocation of 2-amino-3-ketobutyrate coenzyme A ligase by cold and osmotic stress
    Akemi Hoshino
    Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Cell Stress Chaperones 12:186-91. 2007
    ..A large region of KBL was required for stress-induced nuclear translocation. The KBL reporter system will be a useful tool for the investigation of cold and osmotic stress responses...
  13. pmc Regulation of Stat1 protein expression by phenylalanine 172 in the coiled-coil domain
    Akemi Hoshino
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Biochem Biophys Res Commun 346:1062-6. 2006
    ..These results suggest a novel potential mechanism of determination of specificity of Stat proteins and showed that the ITT system is a powerful technique to identify mutants of nuclear translocating signal transducers...
  14. pmc Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression
    Rui Wang
    Department of Microbiology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 3:e2705. 2008
    ..These findings reveal a novel cell surface molecule-mediated regulatory mechanism, with implications for modulating aberrant immune responses...
  15. ncbi request reprint Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite
    Agam Prasad Singh
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Cell 131:492-504. 2007
    ..The presence of CS in the hepatocyte enhances parasite growth of the liver stages in vitro and in vivo. These findings have far reaching implications for drug and vaccine development against the liver stages of the malaria parasite...
  16. doi request reprint Insertional chromatin immunoprecipitation: a method for isolating specific genomic regions
    Akemi Hoshino
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Biosci Bioeng 108:446-9. 2009
    ..The iChIP method will be a useful tool for dissecting chromatin structure of genomic region of interest...
  17. pmc Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon
    Akemi Hoshino
    Department of Pathology, New York University School of Medicine, 550 First Avenue, MSB 126, New York, NY 10016, USA
    FEBS Lett 581:975-80. 2007
    ..A novel transient reporter assay revealed that mouse cyclon promoter contains redundant elements for IL-3-induced gene expression...
  18. ncbi request reprint Enforced expression of the Ikaros isoform IK5 decreases the numbers of extrathymic intraepithelial lymphocytes and natural killer 1.1+ T cells
    Sean N Tucker
    Department of Immunology, University of Washington, Seattle 98195, USA
    Blood 99:513-9. 2002
    ..The study concludes that modest changes in the ratio of short to long Ikaros isoforms can substantially perturb T-cell development, and the development of IELs and NK T cells is particularly sensitive to such changes...

Research Grants1

  1. Cytokine signal transduction in immune system
    Hodaka Fujii; Fiscal Year: 2007
    ..Detailed information gained from the proposed experiments will be valuable for elucidation of molecular mechanisms of oncogenesis and autoimmune diseases caused by dysregulation of cytokine signaling. ..