Ute Frevert

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Plasmodium sporozoite passage across the sinusoidal cell layer
    Ute Frevert
    NYU School of Medicine, Department of Medical Parasitology, 341 E 25 Street, New York, New York 10010, USA
    Subcell Biochem 47:182-97. 2008
  2. ncbi request reprint Sneaking in through the back entrance: the biology of malaria liver stages
    Ute Frevert
    Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 E 25 Street, New York, NY 10010, USA
    Trends Parasitol 20:417-24. 2004
  3. pmc Exoerythrocytic development of Plasmodium gallinaceum in the White Leghorn chicken
    Ute Frevert
    Department of Medical Parasitology, New York University School of Medicine, New York, NY 10010, USA
    Int J Parasitol 38:655-72. 2008
  4. pmc Intravital observation of Plasmodium berghei sporozoite infection of the liver
    Ute Frevert
    Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, USA
    PLoS Biol 3:e192. 2005
  5. ncbi request reprint Nomadic or sessile: can Kupffer cells function as portals for malaria sporozoites to the liver?
    Ute Frevert
    Department of Medical Parasitology, New York University School of Medicine, New York, NY 10010, USA
    Cell Microbiol 8:1537-46. 2006
  6. ncbi request reprint Malaria circumsporozoite protein inhibits the respiratory burst in Kupffer cells
    Ivan Usynin
    Department of Medical Parasitology, New York University School of Medicine, 341 E 25 St, New York, NY 10010, USA
    Cell Microbiol 9:2610-28. 2007
  7. pmc Protective humoral immunity elicited by a needle-free malaria vaccine comprised of a chimeric Plasmodium falciparum circumsporozoite protein and a Toll-like receptor 5 agonist, flagellin
    Daniel Carapau
    Department of Microbiology, Division of Medical Parasitology, New York University School of Medicine, New York, New York, USA
    Infect Immun 81:4350-62. 2013
  8. pmc Plasmodium yoelii sporozoites modulate cytokine profile and induce apoptosis in murine Kupffer cells
    Christian Klotz
    Department of Medical Parasitology, New York University School of Medicine, 341 E 25 Street, New York, NY 10010, USA
    Int J Parasitol 38:1639-50. 2008
  9. pmc Release of hepatic Plasmodium yoelii merozoites into the pulmonary microvasculature
    Kerstin Baer
    Department of Medical Parasitology, New York University School of Medicine, New York, New York, United States of America
    PLoS Pathog 3:e171. 2007
  10. pmc Imaging effector functions of human cytotoxic CD4+ T cells specific for Plasmodium falciparum circumsporozoite protein
    Ute Frevert
    Department of Medical Parasitology, New York University School of Medicine, 341 E 25 St, New York, NY 10010, USA
    Int J Parasitol 39:119-32. 2009

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Plasmodium sporozoite passage across the sinusoidal cell layer
    Ute Frevert
    NYU School of Medicine, Department of Medical Parasitology, 341 E 25 Street, New York, New York 10010, USA
    Subcell Biochem 47:182-97. 2008
    ..Recent cell biological, microscopic, and genetic approaches have considerably enhanced our understanding of the initial events leading to the establishment of a malaria infection in the liver...
  2. ncbi request reprint Sneaking in through the back entrance: the biology of malaria liver stages
    Ute Frevert
    Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 E 25 Street, New York, NY 10010, USA
    Trends Parasitol 20:417-24. 2004
    ..By choosing the liver as their initial site of replication, Plasmodium sporozoites can exploit the tolerogenic properties of this unique immune organ to evade the host's immune response...
  3. pmc Exoerythrocytic development of Plasmodium gallinaceum in the White Leghorn chicken
    Ute Frevert
    Department of Medical Parasitology, New York University School of Medicine, New York, NY 10010, USA
    Int J Parasitol 38:655-72. 2008
    ....
  4. pmc Intravital observation of Plasmodium berghei sporozoite infection of the liver
    Ute Frevert
    Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, USA
    PLoS Biol 3:e192. 2005
    ..In summary, malaria sporozoites bind tightly to the sinusoidal cell layer, cross Kupffer cells, and leave behind a trail of dead hepatocytes when migrating to their final destination in the liver...
  5. ncbi request reprint Nomadic or sessile: can Kupffer cells function as portals for malaria sporozoites to the liver?
    Ute Frevert
    Department of Medical Parasitology, New York University School of Medicine, New York, NY 10010, USA
    Cell Microbiol 8:1537-46. 2006
    ....
  6. ncbi request reprint Malaria circumsporozoite protein inhibits the respiratory burst in Kupffer cells
    Ivan Usynin
    Department of Medical Parasitology, New York University School of Medicine, 341 E 25 St, New York, NY 10010, USA
    Cell Microbiol 9:2610-28. 2007
    ..This allows the sporozoites to safely pass through these professional phagocytes and to develop inside neighbouring hepatocytes...
  7. pmc Protective humoral immunity elicited by a needle-free malaria vaccine comprised of a chimeric Plasmodium falciparum circumsporozoite protein and a Toll-like receptor 5 agonist, flagellin
    Daniel Carapau
    Department of Microbiology, Division of Medical Parasitology, New York University School of Medicine, New York, New York, USA
    Infect Immun 81:4350-62. 2013
    ..n. immunization with a flagellin-modified P. falciparum CS protein and raise the potential of a scalable, safe, needle-free vaccine for the 40% of the world's population at risk of malaria. ..
  8. pmc Plasmodium yoelii sporozoites modulate cytokine profile and induce apoptosis in murine Kupffer cells
    Christian Klotz
    Department of Medical Parasitology, New York University School of Medicine, 341 E 25 Street, New York, NY 10010, USA
    Int J Parasitol 38:1639-50. 2008
    ..Together, the in vitro data indicate that Plasmodium possesses mechanisms to render Kupffer cells insensitive to pro-inflammatory stimuli and eventually eliminates these macrophages by forcing them into programmed cell death...
  9. pmc Release of hepatic Plasmodium yoelii merozoites into the pulmonary microvasculature
    Kerstin Baer
    Department of Medical Parasitology, New York University School of Medicine, New York, New York, United States of America
    PLoS Pathog 3:e171. 2007
    ..We believe this previously unknown part of the plasmodial life cycle ensures an effective transition from the liver to the blood phase of the malaria infection...
  10. pmc Imaging effector functions of human cytotoxic CD4+ T cells specific for Plasmodium falciparum circumsporozoite protein
    Ute Frevert
    Department of Medical Parasitology, New York University School of Medicine, 341 E 25 St, New York, NY 10010, USA
    Int J Parasitol 39:119-32. 2009
    ....
  11. pmc Neuroimmunological blood brain barrier opening in experimental cerebral malaria
    Adéla Nacer
    Division of Medical Parasitology, Department of Microbiology, New York University School of Medicine, New York, New York, United States of America
    PLoS Pathog 8:e1002982. 2012
    ..Thus, it appears that neurological signs and coma in ECM are due to regulated opening of paracellular-junctional and transcellular-vesicular fluid transport pathways at the neuroimmunological BBB...
  12. ncbi request reprint Kupffer cells are obligatory for Plasmodium yoelii sporozoite infection of the liver
    Kerstin Baer
    Department of Medical Parasitology, New York University School of Medicine, 341 E 25 St, New York, NY 10010, USA
    Cell Microbiol 9:397-412. 2007
    ..Together these data provide strong support for the hypothesis that Kupffer cells are the portal for sporozoites to hepatocytes and critical for the onset of a malaria infection...
  13. ncbi request reprint Intravital microscopy demonstrating antibody-mediated immobilisation of Plasmodium berghei sporozoites injected into skin by mosquitoes
    Jerome P Vanderberg
    Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA
    Int J Parasitol 34:991-6. 2004
    ....
  14. ncbi request reprint Arrest in the liver--a genetically defined malaria vaccine?
    Ute Frevert
    Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, USA
    N Engl J Med 352:1600-2. 2005
  15. pmc Compounds of the upper gastrointestinal tract induce rapid and efficient excystation of Entamoeba invadens
    Biswa Nath Mitra
    Department of Medical Parasitology, New York University School of Medicine, NY 10010, USA
    Int J Parasitol 40:751-60. 2010
    ....
  16. doi request reprint Cellular effector mechanisms against Plasmodium liver stages
    Ute Frevert
    Department of Medical Parasitology, New York University School of Medicine, 341 E 25 St, New York, NY 10010, USA
    Cell Microbiol 10:1956-67. 2008
    ..Considering the unique immune properties of the liver, it is conceivable that these different hepatic antigen-presenting cells fulfil distinct but complementary roles during the effector phase against Plasmodium liver stages...
  17. pmc Imaging Plasmodium immunobiology in the liver, brain, and lung
    Ute Frevert
    Division of Medical Parasitology, Department of Microbiology, New York University School of Medicine, 341 E 25 Street, New York, NY 10010, USA Electronic address
    Parasitol Int 63:171-86. 2014
    ....
  18. ncbi request reprint Defective sorting of the thrombospondin-related anonymous protein (TRAP) inhibits Plasmodium infectivity
    Purnima Bhanot
    Michael Heidelberger Division of Immunology, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Mol Biochem Parasitol 126:263-73. 2003
    ..However, there is no significant difference in the amounts of TRAP secreted into the culture medium by wild type and mutant parasites, suggesting that TRAP destined for secretion bypasses micronemal localization...
  19. ncbi request reprint Proteoglycans mediate malaria sporozoite targeting to the liver
    Gabriele Pradel
    Department of Medical and Molecular Parasitology, New York University School of Medicine, New York 10010, USA
    Mol Microbiol 45:637-51. 2002
    ....
  20. ncbi request reprint Quantitative isolation and in vivo imaging of malaria parasite liver stages
    Alice S Tarun
    Seattle Biomedical Research Institute, Seattle, WA 98109, USA
    Int J Parasitol 36:1283-93. 2006
    ..Intravital imaging thus reveals new, important information on the malaria parasite's transition from tissue to blood stage...
  21. pmc Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface
    Ann Kristin Mueller
    Department of Parasitology, Heidelberg University School of Medicine, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 102:3022-7. 2005
    ..Genetically attenuated liver stages may thus induce immune responses, which inhibit subsequent infection of the liver with WT parasites...
  22. ncbi request reprint A mosquito-specific protein family includes candidate receptors for malaria sporozoite invasion of salivary glands
    Svetlana Korochkina
    Center for Microbial and Plant Genomics, and Department of Microbiology, University of Minnesota, St Paul, MN 55108, USA
    Cell Microbiol 8:163-75. 2006
    ..Phylogenomic analysis suggests that an SGS ancestor was involved in a lateral gene transfer...