- Neural network-based prediction of mutation-induced protein stability changes in Staphylococcal nuclease at 20 residue positionsChristopher M Frenz
Department of Biochemistry, New York Medical College, Basic Sciences Building, Valhalla, New York 10595, USA
Proteins 59:147-51. 2005..Neural network-based relative stability predictions for 55 sequences containing mutation combinations not found in the training set had an accuracy of 92.8%...
- Electrostatic analysis of the hepatitis C virus NS3 helicase reveals both active and allosteric site locationsDavid N Frick
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
Nucleic Acids Res 32:5519-28. 2004..When DNA was present in the structure, the calculated pK(a)s shifted for both Lys210 and Asp290, demonstrating how DNA binding might lead to electrostatic changes that stimulate ATP hydrolysis...