Jacqueline A French

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. doi request reprint Development of new treatment approaches for epilepsy: unmet needs and opportunities
    Jacqueline A French
    Department of Neurology, NYU School of Medicine, New York, New York 10016, USA
    Epilepsia 54:3-12. 2013
  2. doi request reprint Designing a new proof-of-principle trial for treatment of partial seizures to demonstrate efficacy with minimal sample size and duration-a case study
    Jacqueline A French
    NYU Comprehensive Epilepsy Center, Department of Neurology, New York University, 223 East 34th Street, New York, NY 10016, USA
    Epilepsy Res 106:230-6. 2013
  3. doi request reprint Antiepileptic drug treatment: new drugs and new strategies
    Jacqueline A French
    Continuum (Minneap Minn) 19:643-55. 2013
  4. doi request reprint Evaluation of adjunctive perampanel in patients with refractory partial-onset seizures: results of randomized global phase III study 305
    Jacqueline A French
    NYU Comprehensive Epilepsy Center, New York, New York 10016, USA
    Epilepsia 54:117-25. 2013
  5. doi request reprint Analysis of three lamotrigine extended-release clinical trials: comparison of pragmatic ITT and LOCF methodologies
    Jacqueline A French
    NYU Comprehensive Epilepsy Center, 223 E 34th St, New York, NY 10016, United States
    Epilepsy Res 101:141-7. 2012
  6. pmc Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304
    Jacqueline A French
    NYU Comprehensive Epilepsy Center, New York, NY, USA
    Neurology 79:589-96. 2012
  7. pmc Lamotrigine XR conversion to monotherapy: first study using a historical control group
    Jacqueline A French
    NYU Comprehensive Epilepsy Center, New York, NY 10016, USA
    Neurotherapeutics 9:176-84. 2012
  8. pmc Virologic outcomes of HAART with concurrent use of cytochrome P450 enzyme-inducing antiepileptics: a retrospective case control study
    Jason F Okulicz
    Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    AIDS Res Ther 8:18. 2011
  9. doi request reprint Clinical practice. Initial management of epilepsy
    Jacqueline A French
    Department of Neurology, New York University School of Medicine, New York, USA
    N Engl J Med 359:166-76. 2008
  10. doi request reprint Adjunctive brivaracetam for refractory partial-onset seizures: a randomized, controlled trial
    J A French
    NYU Comprehensive Epilepsy Center, New York, NY 10016, USA
    Neurology 75:519-25. 2010

Collaborators

Detail Information

Publications49

  1. doi request reprint Development of new treatment approaches for epilepsy: unmet needs and opportunities
    Jacqueline A French
    Department of Neurology, NYU School of Medicine, New York, New York 10016, USA
    Epilepsia 54:3-12. 2013
    ..However, the group acknowledged that disease-modifying therapies (given after the first seizure or after the development of epilepsy) would be easier to study than AEG therapies...
  2. doi request reprint Designing a new proof-of-principle trial for treatment of partial seizures to demonstrate efficacy with minimal sample size and duration-a case study
    Jacqueline A French
    NYU Comprehensive Epilepsy Center, Department of Neurology, New York University, 223 East 34th Street, New York, NY 10016, USA
    Epilepsy Res 106:230-6. 2013
    ..These modeling results indicate that the efficacy of an antiepileptic drug can be demonstrated in a relatively short period of time with a reasonable sample size...
  3. doi request reprint Antiepileptic drug treatment: new drugs and new strategies
    Jacqueline A French
    Continuum (Minneap Minn) 19:643-55. 2013
    ..Special consideration must be given to populations such as women, older adults, patients with other medical comorbidities, and patients who are newly diagnosed...
  4. doi request reprint Evaluation of adjunctive perampanel in patients with refractory partial-onset seizures: results of randomized global phase III study 305
    Jacqueline A French
    NYU Comprehensive Epilepsy Center, New York, New York 10016, USA
    Epilepsia 54:117-25. 2013
    ..To assess the efficacy and safety of once-daily doses of perampanel 8 and 12 mg when added to 1-3 concomitantly administered, approved antiepileptic drugs (AEDs) in patients with uncontrolled partial-onset seizures...
  5. doi request reprint Analysis of three lamotrigine extended-release clinical trials: comparison of pragmatic ITT and LOCF methodologies
    Jacqueline A French
    NYU Comprehensive Epilepsy Center, 223 E 34th St, New York, NY 10016, United States
    Epilepsy Res 101:141-7. 2012
    ..We propose that the P-ITT may be a simpler, more informative method for evaluating the effectiveness of a drug, especially in comparison to another active drug(s)...
  6. pmc Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304
    Jacqueline A French
    NYU Comprehensive Epilepsy Center, New York, NY, USA
    Neurology 79:589-96. 2012
    ....
  7. pmc Lamotrigine XR conversion to monotherapy: first study using a historical control group
    Jacqueline A French
    NYU Comprehensive Epilepsy Center, New York, NY 10016, USA
    Neurotherapeutics 9:176-84. 2012
    ..LTG XR (250 mg or 300 mg once daily) is effective for conversion-to-monotherapy treatment of partial seizures in patients ≥13 years old...
  8. pmc Virologic outcomes of HAART with concurrent use of cytochrome P450 enzyme-inducing antiepileptics: a retrospective case control study
    Jason F Okulicz
    Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    AIDS Res Ther 8:18. 2011
    ..abstract:..
  9. doi request reprint Clinical practice. Initial management of epilepsy
    Jacqueline A French
    Department of Neurology, New York University School of Medicine, New York, USA
    N Engl J Med 359:166-76. 2008
  10. doi request reprint Adjunctive brivaracetam for refractory partial-onset seizures: a randomized, controlled trial
    J A French
    NYU Comprehensive Epilepsy Center, New York, NY 10016, USA
    Neurology 75:519-25. 2010
    ....
  11. doi request reprint Rational polytherapy
    Jacqueline A French
    New York University School of Medicine, New York, New York, USA
    Epilepsia 50:63-8. 2009
    ..However, more animal and human research is needed, with attention to the effects of various combinations on both toxicity and seizure control...
  12. doi request reprint Historical control monotherapy design in the treatment of epilepsy
    Jacqueline A French
    Department of Neurology, New York University, New York, New York, USA
    Epilepsia 51:1936-43. 2010
    ..Such an approach reduces patient risk that would result from exposure to pseudo-placebo. In this article, we present the data submitted to the FDA to justify a historical control...
  13. doi request reprint Invited article: comparative effectiveness research, evidence-based medicine, and the AAN
    Jacqueline A French
    New York University Comprehensive Epilepsy Center, New York, NY, USA
    Neurology 75:562-7. 2010
    ..The neurology community must help inform the process of CER to ensure the highest-quality research, which in turn will result in the most valid outcomes...
  14. doi request reprint Randomized, double-blind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy
    J A French
    NYU Comprehensive Epilepsy Center, 223 East 34th Street, New York, NY 10016, USA
    Neurology 76:1555-63. 2011
    ....
  15. doi request reprint Long-term behavioral, electrophysiological, and neurochemical monitoring of the safety of an experimental antiepileptic implant, the muscimol-delivering Subdural Pharmacotherapy Device in monkeys
    Nandor Ludvig
    Department of Neurology, Comprehensive Epilepsy Center, NYU Langone Medical Center School of Medicine, New York, New York 10016, USA
    J Neurosurg 117:162-75. 2012
    ....
  16. doi request reprint Periodic transmeningeal muscimol maintains its antiepileptic efficacy over three weeks without inducing tolerance, in rats
    Hai M Tang
    NYU Comprehensive Epilepsy Center, NYU School of Medicine Langone Medical Center, 223 East 34th Street, New York, NY, USA
    Neurosci Lett 494:135-8. 2011
    ..These results suggest that periodic transmeningeal administrations of a relatively low concentration of muscimol into the neocortex over three weeks do not induce tolerance to the localized antiepileptic effects of this drug...
  17. doi request reprint Transmeningeal muscimol can prevent focal EEG seizures in the rat neocortex without stopping multineuronal activity in the treated area
    Nandor Ludvig
    NYU Comprehensive Epilepsy Center, NYU School of Medicine Langone Medical Center, New York, NY 10016, USA
    Brain Res 1385:182-91. 2011
    ....
  18. ncbi request reprint Seizure-free outcome in randomized add-on trials of the new antiepileptic drugs
    Deana M Gazzola
    Hospital of the University of Pennsylvania, Department of Neurology, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 48:1303-7. 2007
    ..The goal of this study is to (1) provide clinically useful, previously unpublished comparative analyses of seizure-freedom rates for newer antiepileptic drugs (AEDs), and (2) recommend a standard for data presentation and analysis...
  19. doi request reprint An implantable triple-function device for local drug delivery, cerebrospinal fluid removal and EEG recording in the cranial subdural/subarachnoid space of primates
    Nandor Ludvig
    NYU Comprehensive Epilepsy Center, New York University School of Medicine NYU Langone Medical Center, 223 East 34th Street, New York, NY 10016, USA
    J Neurosci Methods 203:275-83. 2012
    ....
  20. ncbi request reprint Likelihood of seizure remission in an adult population with refractory epilepsy
    Brian C Callaghan
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 62:382-9. 2007
    ..We aimed to determine the likelihood of remission and its clinical predictors in adult patients meeting a strict definition of refractory epilepsy. We also wanted to investigate the influence of treatment regimen on remission...
  21. doi request reprint Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalin
    Deborah E Briggs
    Department of Neurology, University of Pennsylvania Health System, Philadelphia, PA, United States
    Epilepsy Res 82:86-92. 2008
    ..To determine whether pregabalin reduces SGTC seizures in clinically refractory epilepsy...
  22. ncbi request reprint Effects of intermittent levetiracetam dosing in a patient with refractory daily seizures
    Daniel Friedman
    Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Neurology 66:590-1. 2006
    ..These results suggest a useful treatment strategy for patients with refractory epilepsy who have developed resistance to AEDs...
  23. ncbi request reprint Guidelines for new antiepileptic drug evaluation
    John D Hixson
    Department of Neurology, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Rev Neurol Dis 1:S18-26. 2004
    ..Neurologists are encouraged to integrate the AAN guidelines with clinical experience, opinion, and other considerations of special populations until an exhaustive set of guidelines is available for a wide variety of seizure types...
  24. doi request reprint Suicidal ideation and behavior screening in intractable focal epilepsy eligible for drug trials
    Dale C Hesdorffer
    GH Sergievsky Center and Department of Epidemiology, Columbia University, New York, New York 10032, USA
    Epilepsia 54:879-87. 2013
    ..This was done to determine which instrument was optimal for use in epilepsy...
  25. doi request reprint Clinical trials for therapeutic assessment of antiepileptic drugs in the 21st century: obstacles and solutions
    Daniel Friedman
    NYU Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, NY 10016, USA
    Lancet Neurol 11:827-34. 2012
    ..Novel trial designs, such as time-to-event adjunctive therapy and historical-control monotherapy, might be more acceptable to patients and their doctors because they restrict exposure to placebo or ineffective treatments...
  26. doi request reprint Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats
    Shirn L Baptiste
    NYU Comprehensive Epilepsy Center, New York University School of Medicine, NYU Langone Medical Center, New York 10016, USA
    Neurosci Lett 469:421-4. 2010
    ..These results suggest that when used at low concentration muscimol was the best of the five drugs for transmeningeal pharmacotherapy trials for focal neocortical epilepsy...
  27. pmc Common data elements in epilepsy research: development and implementation of the NINDS epilepsy CDE project
    David W Loring
    Department of Neurology, Emory University, Atlanta, Georgia, USA
    Epilepsia 52:1186-91. 2011
    ..This article describes the NINDS CDE Initiative, the process used in developing Epilepsy CDEs, and the benefits of CDEs for the clinical investigator and NINDS...
  28. ncbi request reprint Fear sensitivity and the psychological profile of patients with psychogenic nonepileptic seizures
    John D Hixson
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Epilepsy Behav 9:587-92. 2006
    ..This finding may reflect an elevated internal "setpoint" for appraising the intensity of emotional settings...
  29. ncbi request reprint Refractory epilepsy: clinical overview
    Jacqueline A French
    Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Epilepsia 48:3-7. 2007
    ....
  30. doi request reprint Hospital-onset seizures: an inpatient study
    Madeline C Fields
    Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Pl, New York, NY 10029, USA
    JAMA Neurol 70:360-4. 2013
    ..To describe demographic and clinical characteristics of patients with hospital-onset seizure (HOS) and to explore current practices in their management...
  31. ncbi request reprint First-choice drug for newly diagnosed epilepsy
    Jacqueline A French
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Lancet 369:970-1. 2007
  32. ncbi request reprint Can evidence-based guidelines and clinical trials tell us how to treat patients?
    Jacqueline A French
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 48:1264-7. 2007
  33. ncbi request reprint Levetiracetam safety profiles and tolerability in epilepsy patients
    Deborah E Briggs
    Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Expert Opin Drug Saf 3:415-24. 2004
    ..Adjustments in dosing are required for decreases in renal clearance...
  34. ncbi request reprint Electrical stimulation of the anterior nucleus of the thalamus for the treatment of intractable epilepsy
    John F Kerrigan
    Department of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    Epilepsia 45:346-54. 2004
    ....
  35. ncbi request reprint Neurosyphilis and status epilepticus: case report and literature review
    Beau M Ances
    Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Epilepsy Res 59:67-70. 2004
    ..Neurosyphilis should be considered in the differential diagnosis of patients presenting with status epilepticus...
  36. ncbi request reprint Evaluation of carisbamate, a novel antiepileptic drug, in photosensitive patients: an exploratory, placebo-controlled study
    Dorothée G A Kasteleijn Nolst Trenité
    University La Sapienza II, Via Vitorchiano 81, 00189 Roma, Italy
    Epilepsy Res 74:193-200. 2007
    ....
  37. ncbi request reprint Postmarketing surveillance of new antiepileptic drugs: the tribulations of trials
    Jacqueline A French
    Epilepsia 43:951-5. 2002
  38. ncbi request reprint A workshop on antiepileptic drug monotherapy indications
    Jacqueline A French
    The Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 43:3-27. 2002
  39. ncbi request reprint Is refractory epilepsy preventable?
    Santiago Arroyo
    Epilepsy Unit, Hospital Clinic i Provincial, Barcelona, Spain
    Epilepsia 43:437-44. 2002
    ..The early initiation of aggressive therapy may improve outcome and overall quality of life...
  40. ncbi request reprint October 2002: 27-year-old female with epilepsy
    Zissimos Mourelatos
    Division of Neuropathology, Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, USA
    Brain Pathol 13:233-4, 239. 2003
    ..The treatment of choice is functionally complete hemispherectomy with complete disconnection of the frontal and occipital lobes...
  41. ncbi request reprint Role of levetiracetam in the treatment of epilepsy
    Martin J Brodie
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, United Kingdom
    Epileptic Disord 5:S65-72. 2003
    ..Levetiracetam has specific characteristics that make it an optimal choice for many patient populations...
  42. ncbi request reprint A past psychiatric history may be a risk factor for topiramate-related psychiatric and cognitive adverse events
    Andres M Kanner
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Rush Medical College, 1653 West Congress Parkway, Chicago, IL 60612, USA
    Epilepsy Behav 4:548-52. 2003
    ....
  43. ncbi request reprint Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society
    Jacqueline A French
    Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 45:410-23. 2004
    ....
  44. ncbi request reprint Meta-analysis and indirect comparisons of levetiracetam with other second-generation antiepileptic drugs in partial epilepsy
    Christian Otoul
    UCB Pharma, Braine l Alleud, Belgium
    Clin Neuropharmacol 28:72-8. 2005
    ..These meta-analyses give only short-term efficacy and safety data. Comparative clinical trials and long-term studies of these agents are needed to confirm these findings...
  45. ncbi request reprint Antiepileptic drugs for the elderly: using the old to focus on the new
    Jacqueline A French
    Neurology 64:1834-5. 2005
  46. ncbi request reprint VNS Therapy versus the latest antiepileptic drug
    Elinor Ben-Menachem
    Department of Clinical Neuroscience, Sahlgren University Hospital, Sweden
    Epileptic Disord 7:S22-6. 2005
    ....
  47. ncbi request reprint New antiepileptic drugs--discovery, development, and update
    Roger J Porter
    Neurotherapeutics 4:2-3. 2007
  48. ncbi request reprint Guidelines--are they useful?
    Elinor Ben-Menachem
    Department of Clinical Neuroscience, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Epilepsia 47:62-4. 2006
    ..Although guidelines may not answer all questions it is critical that clinicians using them consider the available evidence, as well as the quality of the evidence, when incorporating the information in their decision making...
  49. ncbi request reprint Active control trials for epilepsy: avoiding bias in head-to-head trials
    Jacqueline A French
    Neurology 66:1294-5. 2006