PETER FREDERIKSE

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc Lens defects and age-related fiber cell degeneration in a mouse model of increased AbetaPP gene dosage in Down syndrome
    Peter H Frederikse
    Department of Pharmacology and Physiology, Rutgers UMDNJ Integrative Neurosciences Program, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 S Orange Avenue, MSB H 645 Newark, NJ 07103, USA
    Am J Pathol 161:1985-90. 2002
  2. pmc HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens
    Claudine L Bitel
    Department of Pharmacology and Physiology and Rutgers UMDNJ Integrative Neurosciences Program, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Mol Vis 16:2301-16. 2010
  3. doi request reprint Parallels between neuron and lens fiber cell structure and molecular regulatory networks
    Peter H Frederikse
    Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, MSB H645, Newark, NJ 07103, United States
    Dev Biol 368:255-60. 2012
  4. pmc Increased expression and local accumulation of the prion protein, Alzheimer Aβ peptides, superoxide dismutase 1, and nitric oxide synthases 1 & 2 in muscle in a rabbit model of diabetes
    Claudine L Bitel
    Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, 185 S, Orange Ave, Newark, NJ 07103, USA
    BMC Physiol 10:18. 2010
  5. ncbi request reprint Prion protein expression in mammalian lenses
    P H Frederikse
    Department of Ophthalmology, Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Curr Eye Res 20:137-43. 2000
  6. ncbi request reprint Amyloid-like protein structure in mammalian ocular lenses
    P H Frederikse
    Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Curr Eye Res 20:462-8. 2000
  7. ncbi request reprint Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation
    Peter H Frederikse
    Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Mol Vis 10:794-804. 2004
  8. ncbi request reprint miRNA and Dicer in the mammalian lens: expression of brain-specific miRNAs in the lens
    Peter H Frederikse
    Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, 185 South Orange Ave MSB H 64, Newark, NJ 07103, USA
    Histochem Cell Biol 126:1-8. 2006
  9. ncbi request reprint Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens
    Guanghui Li
    Department of Pharmacology and Physiology and the Integrative Neuroscience Program, UMDNJ New Jersey Medical School, 07103, USA
    Mol Vis 9:179-83. 2003

Research Grants

  1. ALZHEIMER PATHOPHYSIOLOGY IN HUMAN CATARACT FORMATION
    PETER FREDERIKSE; Fiscal Year: 2000
  2. ALZHEIMER PATHOPHYSIOLOGY IN HUMAN CATARACT FORMATION
    PETER FREDERIKSE; Fiscal Year: 2002
  3. Alzheimer disease biomarkers in lens
    PETER FREDERIKSE; Fiscal Year: 2007
  4. Alzheimer disease biomarkers in lens
    PETER FREDERIKSE; Fiscal Year: 2009
  5. Alzheimer disease biomarkers in lens
    Peter H Frederikse; Fiscal Year: 2010
  6. ALZHEIMER PATHOPHYSIOLOGY IN HUMAN CATARACT FORMATION
    PETER FREDERIKSE; Fiscal Year: 2001

Collaborators

Detail Information

Publications9

  1. pmc Lens defects and age-related fiber cell degeneration in a mouse model of increased AbetaPP gene dosage in Down syndrome
    Peter H Frederikse
    Department of Pharmacology and Physiology, Rutgers UMDNJ Integrative Neurosciences Program, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 S Orange Avenue, MSB H 645 Newark, NJ 07103, USA
    Am J Pathol 161:1985-90. 2002
    ..Finally, our findings provide further support for our hypothesis that Alzheimer pathophysiology contributes to the cataract formation that is increasing in the aging population...
  2. pmc HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens
    Claudine L Bitel
    Department of Pharmacology and Physiology and Rutgers UMDNJ Integrative Neurosciences Program, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Mol Vis 16:2301-16. 2010
    ....
  3. doi request reprint Parallels between neuron and lens fiber cell structure and molecular regulatory networks
    Peter H Frederikse
    Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, MSB H645, Newark, NJ 07103, United States
    Dev Biol 368:255-60. 2012
    ..This review discusses these extensive parallels between neurons and fiber cells and implications regarding common themes in lens and neural cell physiology and disease, which may also suggest related evolutionary processes...
  4. pmc Increased expression and local accumulation of the prion protein, Alzheimer Aβ peptides, superoxide dismutase 1, and nitric oxide synthases 1 & 2 in muscle in a rabbit model of diabetes
    Claudine L Bitel
    Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, 185 S, Orange Ave, Newark, NJ 07103, USA
    BMC Physiol 10:18. 2010
    ..This wild-type rabbit model includes systemic physiological expression of human-like Alzheimer precursor proteins and Aβ peptides that are considered key in Alzheimer protein studies...
  5. ncbi request reprint Prion protein expression in mammalian lenses
    P H Frederikse
    Department of Ophthalmology, Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Curr Eye Res 20:137-43. 2000
    ..The purpose of the present study is to extend our studies of amyloid disease-related protein expression in mammalian lenses...
  6. ncbi request reprint Amyloid-like protein structure in mammalian ocular lenses
    P H Frederikse
    Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Curr Eye Res 20:462-8. 2000
    ..The present study examines the presence of amyloid protein supramolecular order of lens protein beta-pleated sheet arrays...
  7. ncbi request reprint Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation
    Peter H Frederikse
    Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Mol Vis 10:794-804. 2004
    ..In the present study we examine lens expression and regulation of a complement of genes associated with cargo and synaptic vesicle transport in neurons...
  8. ncbi request reprint miRNA and Dicer in the mammalian lens: expression of brain-specific miRNAs in the lens
    Peter H Frederikse
    Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, 185 South Orange Ave MSB H 64, Newark, NJ 07103, USA
    Histochem Cell Biol 126:1-8. 2006
    ....
  9. ncbi request reprint Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens
    Guanghui Li
    Department of Pharmacology and Physiology and the Integrative Neuroscience Program, UMDNJ New Jersey Medical School, 07103, USA
    Mol Vis 9:179-83. 2003
    ..Here we investigate lens expression of beta-secretases, nicastrin and NEP proteins, and compare their protein distribution to Notch and Presenilin in lens...

Research Grants7

  1. ALZHEIMER PATHOPHYSIOLOGY IN HUMAN CATARACT FORMATION
    PETER FREDERIKSE; Fiscal Year: 2000
    ..abstract_text> ..
  2. ALZHEIMER PATHOPHYSIOLOGY IN HUMAN CATARACT FORMATION
    PETER FREDERIKSE; Fiscal Year: 2002
    ..abstract_text> ..
  3. Alzheimer disease biomarkers in lens
    PETER FREDERIKSE; Fiscal Year: 2007
    ..These studies build on our earlier studies to understand the role of AbetaPP and Abeta in the lens which are already providing a new and specific conceptual basis for understanding cataract and its links with the brain. ..
  4. Alzheimer disease biomarkers in lens
    PETER FREDERIKSE; Fiscal Year: 2009
    ..These studies build on our earlier studies to understand the role of AbetaPP and Abeta in the lens which are already providing a new and specific conceptual basis for understanding cataract and its links with the brain. ..
  5. Alzheimer disease biomarkers in lens
    Peter H Frederikse; Fiscal Year: 2010
    ..These studies build on our earlier studies to understand the role of AbetaPP and Abeta in the lens which are already providing a new and specific conceptual basis for understanding cataract and its links with the brain. ..
  6. ALZHEIMER PATHOPHYSIOLOGY IN HUMAN CATARACT FORMATION
    PETER FREDERIKSE; Fiscal Year: 2001
    ..abstract_text> ..