Thomas F Franke

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi Intracellular signaling by Akt: bound to be specific
    Thomas F Franke
    Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Sci Signal 1:pe29. 2008
  2. ncbi Akt-interacting proteins: attractive opposites. focus on "Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways"
    Thomas F Franke
    Department of Psychiatry, Milhauser Laboratories, NYU School of Medicine, New York, NY 10016, USA
    Am J Physiol Cell Physiol 293:C1768-70. 2007
  3. ncbi Inhibition of 5-HT1A receptor-dependent cell survival by cAMP/protein kinase A: role of protein phosphatase 2A and Bax
    Shu chi Hsiung
    Division of Neuroscience, New York State Psychiatric Institute, New York, New York, USA
    J Neurosci Res 86:2326-38. 2008
  4. ncbi Roles of extracellular signal-regulated kinase and Akt signaling in coordinating nuclear transcription factor-kappaB-dependent cell survival after serotonin 1A receptor activation
    Shu-chi Hsiung
    Division of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurochem 95:1653-66. 2005
  5. ncbi PI3K/Akt and apoptosis: size matters
    Thomas F Franke
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, PH7 W318, New York, NY 10032, USA
    Oncogene 22:8983-98. 2003
  6. ncbi Calcium receptor-induced serotonin secretion by parafollicular cells: role of phosphatidylinositol 3-kinase-dependent signal transduction pathways
    Kuo-peing Liu
    Division of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 23:2049-57. 2003
  7. ncbi Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway
    Gerald E Stoica
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington DC 20057, USA
    Oncogene 22:7998-8011. 2003
  8. ncbi Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes
    Hui Qin Wang
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0609, USA
    J Biol Chem 278:45737-45. 2003
  9. ncbi Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway
    Gerald E Stoica
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Oncogene 22:2073-87. 2003
  10. ncbi Estradiol rapidly activates Akt via the ErbB2 signaling pathway
    Gerald E Stoica
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Mol Endocrinol 17:818-30. 2003

Collaborators

  • Adriana Stoica
  • L C Cantley
  • Julie R McMullen
  • Gerald E Stoica
  • Shu-chi Hsiung
  • Kuo-peing Liu
  • Hadassah Tamir
  • Ronald Reiter
  • Elisha Morgan
  • Anton Wellstein
  • Mary Beth Martin
  • Shu chi Hsiung
  • Heinz-Joachim List
  • Frank Czubayko
  • Heinz Joachim List
  • Hui Qin Wang
  • Jung-hsin Hsu
  • Wilfrid Rul
  • Tetsuo Shioi
  • Kuo peing Liu
  • Adrianne Tin
  • Mary C Iann
  • Abigail D Winder
  • Maria Moroni
  • Gary J Fisher
  • Mella Adlersberg
  • Andrew F Russo
  • Taihao Quan
  • John J Voorhees
  • Michael D Gershon
  • Tianyuan He
  • Susette Mueller
  • Myrna Fisher
  • Yijiang Shi
  • Alain Eychene
  • Peter M Kang
  • Liping Hu
  • Pierre Roux
  • Seigo Izumo
  • Philippe Lenormand
  • Carole Peyssonnaux
  • Pamela S Douglas
  • Olivier Zugasti
  • Philippe Fort
  • Ursula Hibner
  • Toshiyuki Obata
  • Alan Lichtenstein

Detail Information

Publications13

  1. ncbi Intracellular signaling by Akt: bound to be specific
    Thomas F Franke
    Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Sci Signal 1:pe29. 2008
    ..Akt-interacting molecules may have important roles in Akt signal transduction both under physiological and pathological conditions...
  2. ncbi Akt-interacting proteins: attractive opposites. focus on "Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways"
    Thomas F Franke
    Department of Psychiatry, Milhauser Laboratories, NYU School of Medicine, New York, NY 10016, USA
    Am J Physiol Cell Physiol 293:C1768-70. 2007
  3. ncbi Inhibition of 5-HT1A receptor-dependent cell survival by cAMP/protein kinase A: role of protein phosphatase 2A and Bax
    Shu chi Hsiung
    Division of Neuroscience, New York State Psychiatric Institute, New York, New York, USA
    J Neurosci Res 86:2326-38. 2008
    ..Our data suggest a central role of cAMP/PKA-dependent PP2A in shifting the homeostasis of intracellular signaling downstream of activated 5-HT(1A) receptor toward cell death in biological systems linked to neuropsychiatric disorders...
  4. ncbi Roles of extracellular signal-regulated kinase and Akt signaling in coordinating nuclear transcription factor-kappaB-dependent cell survival after serotonin 1A receptor activation
    Shu-chi Hsiung
    Division of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurochem 95:1653-66. 2005
    ....
  5. ncbi PI3K/Akt and apoptosis: size matters
    Thomas F Franke
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, PH7 W318, New York, NY 10032, USA
    Oncogene 22:8983-98. 2003
    ..Here, we hope to establish the mechanisms of apoptosis suppression by Akt kinase as a framework for a more general understanding of growth factor-dependent regulation of cell survival...
  6. ncbi Calcium receptor-induced serotonin secretion by parafollicular cells: role of phosphatidylinositol 3-kinase-dependent signal transduction pathways
    Kuo-peing Liu
    Division of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 23:2049-57. 2003
    ..The betagamma cascade subsequently activates PI3-Kbeta-dependent signaling that is coupled to PDK1 and the downstream effector PKCzeta, and results in an increase in 5-HT release...
  7. ncbi Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway
    Gerald E Stoica
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington DC 20057, USA
    Oncogene 22:7998-8011. 2003
    ..This results in the activation of PI 3-K and Akt. Akt, in turn, may interact with nuclear ER-alpha, altering its expression and activity...
  8. ncbi Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes
    Hui Qin Wang
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0609, USA
    J Biol Chem 278:45737-45. 2003
    ..These data demonstrate that PI3K/Akt is essential for protecting human KCs against UV-induced apoptosis, whereas NF-kappaB pathway provides little, if any, protective role...
  9. ncbi Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway
    Gerald E Stoica
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Oncogene 22:2073-87. 2003
    ..Akt leads to nuclear ER-alpha phosphorylation, thereby altering its expression and transcriptional activity...
  10. ncbi Estradiol rapidly activates Akt via the ErbB2 signaling pathway
    Gerald E Stoica
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Mol Endocrinol 17:818-30. 2003
    ..Taken together, our data suggest that estradiol, bound to membrane ERalpha, interacts with and activates an ErbB dimer containing ErbB2, inducing activation of PI 3-K/Akt...
  11. ncbi Activation of ERK, controlled by Rac1 and Cdc42 via Akt, is required for anoikis
    Wilfrid Rul
    , CNRS UMR5535, 1919 Route de Mende, F-34293 Montpellier Cedex 5, France
    Ann N Y Acad Sci 973:145-8. 2002
    ..The moderate level of ERK activation that accompanies anoikis is an essential component of proapoptotic signaling; whereas sustained, high-intensity ERK signaling promotes survival in the same experimental system...
  12. ncbi Akt/protein kinase B promotes organ growth in transgenic mice
    Tetsuo Shioi
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Mol Cell Biol 22:2799-809. 2002
    ..In conclusion, Akt is sufficient to induce a marked increase in heart size and is likely to be one of the effectors of the PI3K pathway in mediating heart growth...
  13. ncbi Role of the AKT kinase in expansion of multiple myeloma clones: effects on cytokine-dependent proliferative and survival responses
    Jung-hsin Hsu
    Department of Medicine and Pathology, West LA VA-UCLA Medical Center and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, CA 90073, USA
    Oncogene 21:1391-400. 2002
    ..DOI: 10.1038/sj/onc/1205194..