Genomes and Genes
T F Franke
Affiliation: New York University School of Medicine
- PI3K/Akt: getting it right mattersT F Franke
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Oncogene 27:6473-88. 2008..An emphasis is placed on the involvement of Akt in human diseases ranging from cancer to metabolic dysfunction and mental disease...
- Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signalingS G Lee
Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
Oncogene 27:1114-21. 2008..Activation of survival pathways may be one mechanism by which AEG-1 exerts its oncogenic properties...
- Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1A H Kim
Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Mol Cell Biol 21:893-901. 2001..These results provide the first direct link between Akt and the family of stress-activated kinases...
- Characterization of a novel isoform of caspase-9 that inhibits apoptosisJ M Angelastro
Department of Pathology, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Biol Chem 276:12190-200. 2001..Taken together, our observations indicate that casp-9-CTD acts as a dominant-negative variant. Its expression in various tissues indicates a physiological role in regulating cell death...