David R Fooksman

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc Functional anatomy of T cell activation and synapse formation
    David R Fooksman
    Department of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, NYU School of Medicine, New York, 10016, USA
    Annu Rev Immunol 28:79-105. 2010
  2. pmc A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center
    Tanja A Schwickert
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 208:1243-52. 2011
  3. pmc Development and migration of plasma cells in the mouse lymph node
    David R Fooksman
    Program in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Immunity 33:118-27. 2010
  4. doi request reprint Myeloid cells limit production of antibody-secreting cells after immunization in the lymph node
    David R Fooksman
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016
    J Immunol 192:1004-12. 2014
  5. pmc Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter
    Gabriel D Victora
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    Cell 143:592-605. 2010
  6. pmc Measuring rotational diffusion of MHC class I on live cells by polarized FPR
    David R Fooksman
    Department of Chemistry, Colorado State University, Ft Collins, CO 80523, USA
    Biophys Chem 130:10-6. 2007
  7. pmc Affinity measured by microcluster
    David R Fooksman
    Martin and Helen Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 207:907-9. 2010

Collaborators

Detail Information

Publications7

  1. pmc Functional anatomy of T cell activation and synapse formation
    David R Fooksman
    Department of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, NYU School of Medicine, New York, 10016, USA
    Annu Rev Immunol 28:79-105. 2010
    ..In this review, we examine the molecular components, geometry, and timing underlying kinapses and synapses. We integrate recent molecular and physiological data to provide a synthesis and suggest ways forward...
  2. pmc A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center
    Tanja A Schwickert
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 208:1243-52. 2011
    ..We propose a model in which T cell help is restricted to the B cells with the highest amounts of pMHC, thus allowing for a dynamic affinity threshold to be imposed on antigen-binding B cells...
  3. pmc Development and migration of plasma cells in the mouse lymph node
    David R Fooksman
    Program in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Immunity 33:118-27. 2010
    ..Taken together, we suggest pre-PCs undergo a persistent random walk to find the medullary cords, where localized chemokines help retain these cells until they undergo differentiation and arrest in situ...
  4. doi request reprint Myeloid cells limit production of antibody-secreting cells after immunization in the lymph node
    David R Fooksman
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016
    J Immunol 192:1004-12. 2014
    ..Inhibition of ASCs by these myeloid cells in the LN provides a new regulatory mechanism with implications for tuning Ab responses. ..
  5. pmc Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter
    Gabriel D Victora
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    Cell 143:592-605. 2010
    ..Thus, T cell help, and not direct competition for antigen, is the limiting factor in GC selection...
  6. pmc Measuring rotational diffusion of MHC class I on live cells by polarized FPR
    David R Fooksman
    Department of Chemistry, Colorado State University, Ft Collins, CO 80523, USA
    Biophys Chem 130:10-6. 2007
    ..This result points the way to use of engineered fluorescent fusion proteins to measure rotational diffusion in native cell membranes...
  7. pmc Affinity measured by microcluster
    David R Fooksman
    Martin and Helen Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 207:907-9. 2010
    ..New work suggests that the early dynamics of BCR mobility and microcluster formation "translate" BCR affinity for antigen into B cell responsiveness...