David Fishman

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer
    David A Fishman
    Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Ave, NBV9N28, New York, NY 10016, USA
    Am J Obstet Gynecol 192:1214-21; discussion 1221-2. 2005
  2. ncbi Progress in biomarker discovery for diagnostic testing in epithelial ovarian cancer
    Radhika Gogoi
    New York University School of Medicine, 550 First Avenue, TH538, NY 10016, USA
    Expert Rev Mol Diagn 6:627-37. 2006
  3. ncbi S1P regulation of ovarian carcinoma invasiveness
    Yoel Smicun
    Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, NB 9N28, New York, NY 10016, USA
    Gynecol Oncol 103:952-9. 2006
  4. ncbi Matrilysin (MMP-7) promotes invasion of ovarian cancer cells by activation of progelatinase
    Feng Qiang Wang
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA
    Int J Cancer 114:19-31. 2005
  5. doi VEGFR-2 silencing by small interference RNA (siRNA) suppresses LPA-induced epithelial ovarian cancer (EOC) invasion
    Feng Qiang Wang
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Gynecol Oncol 115:414-23. 2009
  6. ncbi Inhibition of matrilysin expression by antisense or RNA interference decreases lysophosphatidic acid-induced epithelial ovarian cancer invasion
    Feng Qiang Wang
    Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, TH528, New York, NY 10016, USA
    Mol Cancer Res 4:831-41. 2006
  7. ncbi Vascular endothelial growth factor-regulated ovarian cancer invasion and migration involves expression and activation of matrix metalloproteinases
    Feng Qiang Wang
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA
    Int J Cancer 118:879-88. 2006
  8. ncbi Ultrasound and ovarian cancer
    Leeber Cohen
    Department of Obstetrics and Gynecology, Divisions of Ultrasound and Gynecologic Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
    Cancer Treat Res 107:119-32. 2002
  9. ncbi S1P and LPA have an attachment-dependent regulatory effect on invasion of epithelial ovarian cancer cells
    Yoel Smicun
    Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, NB 9N28, New York, NY 10016, USA
    Gynecol Oncol 107:298-309. 2007
  10. ncbi The scientific basis of early detection of epithelial ovarian cancer: the National Ovarian Cancer Early Detection Program (NOCEDP)
    David A Fishman
    Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, IL 60611, USA
    Cancer Treat Res 107:3-28. 2002

Collaborators

Detail Information

Publications48

  1. ncbi The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer
    David A Fishman
    Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Ave, NBV9N28, New York, NY 10016, USA
    Am J Obstet Gynecol 192:1214-21; discussion 1221-2. 2005
    ..We examined the usefulness of sonography in the detection of early-stage epithelial ovarian cancer in asymptomatic high-risk women who participated in the National Ovarian Cancer Early Detection Program...
  2. ncbi Progress in biomarker discovery for diagnostic testing in epithelial ovarian cancer
    Radhika Gogoi
    New York University School of Medicine, 550 First Avenue, TH538, NY 10016, USA
    Expert Rev Mol Diagn 6:627-37. 2006
    ....
  3. ncbi S1P regulation of ovarian carcinoma invasiveness
    Yoel Smicun
    Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, NB 9N28, New York, NY 10016, USA
    Gynecol Oncol 103:952-9. 2006
    ..We tested the in vitro effect of another bioactive lysophospholipid, sphingosine-1-phosphate (S1P), on the invasiveness of EOC cells...
  4. ncbi Matrilysin (MMP-7) promotes invasion of ovarian cancer cells by activation of progelatinase
    Feng Qiang Wang
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA
    Int J Cancer 114:19-31. 2005
    ..These results indicate MMP-7 is overexpressed in malignant ovarian epithelium and suggest MMP-7 may facilitate tumor cell invasion in vivo partly through the induction of progelatinase activation...
  5. doi VEGFR-2 silencing by small interference RNA (siRNA) suppresses LPA-induced epithelial ovarian cancer (EOC) invasion
    Feng Qiang Wang
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Gynecol Oncol 115:414-23. 2009
    ..However, the expression profile of VEGF and VEGFRs in EOC, their association with tumor aggressiveness, and their regulation by LPA remain unclear...
  6. ncbi Inhibition of matrilysin expression by antisense or RNA interference decreases lysophosphatidic acid-induced epithelial ovarian cancer invasion
    Feng Qiang Wang
    Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, TH528, New York, NY 10016, USA
    Mol Cancer Res 4:831-41. 2006
    ....
  7. ncbi Vascular endothelial growth factor-regulated ovarian cancer invasion and migration involves expression and activation of matrix metalloproteinases
    Feng Qiang Wang
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA
    Int J Cancer 118:879-88. 2006
    ..In summary, our results indicate that VEGF may regulate EOC invasion and migration through VEGFR-mediated secretion and activation of MMPs...
  8. ncbi Ultrasound and ovarian cancer
    Leeber Cohen
    Department of Obstetrics and Gynecology, Divisions of Ultrasound and Gynecologic Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
    Cancer Treat Res 107:119-32. 2002
    ..Transvaginal ultrasound in expert hands is sensitive but not ideally specific for discriminating benign from malignant disease. The judicious use of color Doppler evaluation may help discriminate with greater specificity...
  9. ncbi S1P and LPA have an attachment-dependent regulatory effect on invasion of epithelial ovarian cancer cells
    Yoel Smicun
    Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, NB 9N28, New York, NY 10016, USA
    Gynecol Oncol 107:298-309. 2007
    ..Here we investigate how cell attachment status affects response to S1P and examine the effects of S1P and LPA on cell-cell and cell-extracellular matrix (ECM) adhesion...
  10. ncbi The scientific basis of early detection of epithelial ovarian cancer: the National Ovarian Cancer Early Detection Program (NOCEDP)
    David A Fishman
    Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, IL 60611, USA
    Cancer Treat Res 107:3-28. 2002
  11. doi LPA receptor 2 mediates LPA-induced endometrial cancer invasion
    Joanie Mayer Hope
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA
    Gynecol Oncol 112:215-23. 2009
    ..We have previously shown that lysophosphatidic acid (LPA) promotes the ovarian cancer metastatic cascade. In this study, we evaluated the role of LPA on endometrial cancer invasion...
  12. ncbi Lysophosphatidic acid (LPA) promotes E-cadherin ectodomain shedding and OVCA429 cell invasion in an uPA-dependent manner
    Orlando D Gil
    Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, TH 528, New York, NY 10016, USA
    Gynecol Oncol 108:361-9. 2008
    ..To evaluate the role of LPA in regulating E-cadherin cell surface expression, adhesion, and invasion in epithelial ovarian carcinoma (EOC) cells...
  13. ncbi LPA-induced epithelial ovarian cancer (EOC) in vitro invasion and migration are mediated by VEGF receptor-2 (VEGF-R2)
    John So
    Department of Obstetrics and Gynecology, Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA
    Gynecol Oncol 97:870-8. 2005
    ..Previous studies have shown that LPA induces epithelial ovarian cancer (EOC) in vitro metastasis. In this study, we examined the role of VEGF in LPA-induced EOC invasion and migration and underlying mechanisms...
  14. ncbi Translocation of Fas by LPA prevents ovarian cancer cells from anti-Fas-induced apoptosis
    Yuru Meng
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA
    Gynecol Oncol 96:462-9. 2005
    ..In this study, we observed the effect of lysophosphatidic acid (LPA) on Fas expression and function in ovarian cancer cells...
  15. doi New frontiers for ovarian cancer risk evaluation: proteomics and contrast-enhanced ultrasound
    Sonia Dutta
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    AJR Am J Roentgenol 194:349-54. 2010
    ..At present, no one biomarker exists with 100% specificity and sensitivity for the accurate detection of early-stage epithelial ovarian cancer...
  16. ncbi Conventional and proteomic technologies for the detection of early stage malignancies: markers for ovarian cancer
    Catherine J Lee
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York 10016, USA
    Crit Rev Clin Lab Sci 44:87-114. 2007
    ..This endeavor also provides new insights into the biology of the disease, which may not only be applicable to detection but may also help to initiate new therapies and optimize patient care...
  17. ncbi Lysophosphatidic acid enhances epithelial ovarian carcinoma invasion through the increased expression of interleukin-8
    John So
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, New York University School of Medicine, New York, NY 10016, USA
    Gynecol Oncol 95:314-22. 2004
    ..Here, we investigate a second mechanism in which LPA enhances cellular invasion through the increased expression of IL-8, independent of the expression or activation of MMP2...
  18. ncbi Estradiol-induced ezrin overexpression in ovarian cancer: a new signaling domain for estrogen
    Joon Song
    Department of Obstetrics and Gynecology, Yale University, P O Box 208063, 333 Cedar Street, FMB 331, New Haven, CT 06520 8063, USA
    Cancer Lett 220:57-65. 2005
    ..This previously unreported effect of estrogen on ezrin expression may play a role in the clinical course of estrogen-sensitive cancers and other normal or diseased cell actions...
  19. ncbi Lysophosphatidic acid down-regulates stress fibers and up-regulates pro-matrix metalloproteinase-2 activation in ovarian cancer cells
    Thuy Vy Do
    Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago Illinois, USA
    Mol Cancer Res 5:121-31. 2007
    ..Collectively, these results were consistent with a model in which LPA stimulates the metastatic dissemination of EOC cells by initiating loss of adhesion and metalloproteinase activation...
  20. doi S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment are mediated by Gi and Rac
    Kathleen M Devine
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA
    Gynecol Oncol 110:237-45. 2008
    ..In this study, we investigated the mechanisms through which S1P affects EOC cell proteolysis, invasion, and adhesion in two cultured epithelial ovarian cancer cell lines...
  21. doi Lysophosphatidic acid (LPA) effects on endometrial carcinoma in vitro proliferation, invasion, and matrix metalloproteinase activity
    Feng Qiang Wang
    Department of Obstetrics, Gynecology and Reproductive Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Gynecol Oncol 117:88-95. 2010
    ..The goal of this study was to assess the regulation of (EC) microenvironment by LPA through the examination of its effect on cell proliferation, migration, invasion, uPA activity, and matrix metalloproteinase (MMP) secretion/activation...
  22. ncbi The tumor microenvironment: key to early detection
    Edgardo V Ariztia
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA
    Crit Rev Clin Lab Sci 43:393-425. 2006
    ..Here we review the evolving concepts of the tumor microenvironment that, together with advances in proteomic technologies, hold the promise to facilitate the detection of early-stage cancer...
  23. ncbi Telomerase prolongs the lifespan of normal human ovarian surface epithelial cells without inducing neoplastic phenotype
    Ayesha B Alvero
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Soc Gynecol Investig 11:553-61. 2004
    ..The aim of this study was to determine the effects of exogenous expression of the catalytic subunit of telomerase (hTERT) on the lifespan, growth characteristics, and tumorigenicity of normal human ovarian surface epithelial (OSE) cells...
  24. doi Roles of LPA in ovarian cancer development and progression
    Tarah L Pua
    Gynecologic Oncology, New York University School of Medicine, New York, NY, USA
    Future Oncol 5:1659-73. 2009
    ..We believe that elucidation of this complex transduction network will provide further opportunities to understand the mechanism of ovarian carcinogenesis, invasion and metastasis...
  25. ncbi Biomarkers for ovarian cancer detection and therapy
    Sonia Dutta
    Department of Obstetrics, Gynecology and Reproductive Sciences, Mount Sinai School of Medicine, New York, NY, USA
    Cancer Biol Ther 9:668-77. 2010
    ..Here, we review recent developments in EOC early detection and targeted therapy, as well as new technologies for the discovery of novel biomarkers...
  26. ncbi Lysophosphatidic acid inhibits anti-Fas-mediated apoptosis enhanced by actin depolymerization in epithelial ovarian cancer
    Yuru Meng
    Department of Obstetrics and Gynecology, and R H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    FEBS Lett 579:1311-9. 2005
    ....
  27. ncbi Upregulation of FasL by LPA on ovarian cancer cell surface leads to apoptosis of activated lymphocytes
    Yuru Meng
    Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, IL 60611, USA
    Gynecol Oncol 95:488-95. 2004
    ....
  28. ncbi Matrilysin over-expression in MCF-7 cells enhances cellular invasiveness and pro-gelatinase activation
    Fengqiang Wang
    Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, NB 9N28, New York, NY 10016, USA
    Cancer Lett 236:292-301. 2006
    ..We conclude that MMP-7 over-expression correlates with breast cancer in vitro invasiveness and that MMP-7 may promote invasion by increasing the secretion and activation of proMMP-2 and proMMP-9...
  29. ncbi Soluble epidermal growth factor receptor (sEGFR) [corrected] and cancer antigen 125 (CA125) as screening and diagnostic tests for epithelial ovarian cancer
    Andre T Baron
    Department of Internal Medicine, Division of Hematology Oncology, Lucille P Markey Cancer Center, University of Kentucky, 408 Roach Building, 800 Rose Street, Lexington, KY 40536 0093, USA
    Cancer Epidemiol Biomarkers Prev 14:306-18. 2005
    ....
  30. ncbi Soluble epidermal growth factor receptor (sEGFR/sErbB1) as a potential risk, screening, and diagnostic serum biomarker of epithelial ovarian cancer
    Andre T Baron
    Tumor Biology Program, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 12:103-13. 2003
    ..We conclude that serum sEGFR concentrations warrant additional investigation in the risk assessment, early detection, and/or diagnosis of EOC...
  31. ncbi General keynote: proteomic patterns in sera serve as biomarkers of ovarian cancer
    Lance A Liotta
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, USA
    Gynecol Oncol 88:S25-8; discussion S37-42. 2003
  32. ncbi A robust biomarker discovery pipeline for high-performance mass spectrometry data
    Wayne G Fisher
    Division of Translational Research, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Bioinform Comput Biol 5:1023-45. 2007
    ..While the generalizability of these markers is currently unknown, we have demonstrated the ability of our analytical package to extract biomarker candidates from high-performance mass spectral data...
  33. ncbi Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells
    Jaime Symowicz
    Departments of Cell and Molecular Biology and Pathology, Northwestern University Feinberg Medical School, Chicago, IL, USA
    Cancer Res 67:2030-9. 2007
    ..These data support a novel mechanism for posttranslational modification of E-cadherin function via MMP-9 induction initiated by cell-matrix contact and suggest a mechanism for promotion of EOC metastatic dissemination...
  34. ncbi Clinical proteomics and biomarker discovery
    Donald J Johann
    NCI FDA Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 1022:295-305. 2004
    ..Clinically engineered mass spectroscopy systems are essential for the further development and validation of multiplexed biomarkers that have shown tremendous promise for the early detection of disease...
  35. pmc Matrix metalloproteinase 9 is a mediator of epidermal growth factor-dependent e-cadherin loss in ovarian carcinoma cells
    Karen D Cowden Dahl
    Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, New Mexico, USA
    Cancer Res 68:4606-13. 2008
    ..These data suggest that regulation of MMP-9 by EGFR may represent a novel mechanism for down-modulation of E-cadherin in ovarian cancer...
  36. ncbi Proinvasive properties of ovarian cancer ascites-derived membrane vesicles
    Laura E Graves
    Department of Cellular and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Cancer Res 64:7045-9. 2004
    ..Our data suggest that vesicle-stimulated proteinase activation leads to increased extracellular matrix degradation, which may facilitate tumor cell invasion and metastasis...
  37. ncbi Lysophosphatidic acid stimulates fas ligand microvesicle release from ovarian cancer cells
    Yuru Meng
    Department of Immunology, University of Illinois at Chicago, Chicago 60612, USA
    Cancer Immunol Immunother 54:807-14. 2005
    ..LPA may promote ovarian cancer metastasis by counterattacking peritoneal cavity anti-tumor immunity...
  38. ncbi Use of proteomic patterns in serum to identify ovarian cancer
    Emanuel F Petricoin
    Food and Drug Administration National Institutes of Health Clinical Proteomics Program, Department of Therapeutic Proteins Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    Lancet 359:572-7. 2002
    ..We developed a bioinformatics tool and used it to identify proteomic patterns in serum that distinguish neoplastic from non-neoplastic disease within the ovary...
  39. ncbi Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility
    Lindsay Gillan
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Cancer Res 62:5358-64. 2002
    ..We propose PN functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins to support adhesion and migration of ovarian epithelial cells...
  40. ncbi Methylation profiles of sporadic ovarian tumors and nonmalignant ovaries from high-risk women
    Asha Rathi
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75930, USA
    Clin Cancer Res 8:3324-31. 2002
    ..The purpose of this research was to examine the DNA methylation profiles of primary sporadic ovarian cancers and ovarian tissues from high-risk women...
  41. ncbi Importance of communication between producers and consumers of publicly available experimental data
    Lance A Liotta
    FDA NCI Clinical Proteomics Program, Laboratory of Pathology, National Cancer Institute, CCR, Bethesda, MD 20892, USA
    J Natl Cancer Inst 97:310-4. 2005
    ..Such disputes, however, should not divert us from the validation of this promising new approach...
  42. ncbi Signal pathway profiling of ovarian cancer from human tissue specimens using reverse-phase protein microarrays
    Julia D Wulfkuhle
    Center for Cancer Research, National Cancer Institute NIH, Building 29A Room 2B20, 8000 Rockville Pike, Bethesda, MD 20892, USA
    Proteomics 3:2085-90. 2003
    ....
  43. ncbi Selective induction of cyclooxygenase-2 plays a role in lysophosphatidic acid regulated Fas ligand cell surface presentation
    Shijun Kang
    Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    FEBS Lett 580:443-9. 2006
    ....
  44. ncbi Genetic risk assessment for breast and ovarian cancer
    Jennifer O'Rourke Tiffen
    National Ovarian Cancer Early Detection Program, Northwestern Memorial Hospital, Chicago, USA
    Adv Nurse Pract 11:40-8. 2003
  45. ncbi Biomarker amplification by serum carrier protein binding
    Arpita I Mehta
    Howard Hughes Medical Institute, Bethesda, MD 20814, USA
    Dis Markers 19:1-10. 2003
    ..These findings shift the focus of biomarker detection to the carrier protein and its biomarker content...
  46. ncbi A comparison of ovarian cancer treatments: analysis of utility assessments of ovarian cancer patients, at-risk population, general population, and physicians
    Elizabeth A Calhoun
    Obstetrics and Gynecology Gynecologic Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
    Gynecol Oncol 93:164-9. 2004
    ..In this study, we elicited assessments of toxicity from women with ovarian cancer, women at increased risk of developing ovarian cancer, women in the general population, and gynecologic oncologists...
  47. ncbi Lessons from Kitty Hawk: from feasibility to routine clinical use for the field of proteomic pattern diagnostics
    Emanuel F Petricoin
    FDA NCI Clinical Proteomics Program, Office of Cell and Gene Therapies, CBER, FDA, Bethesda, MD 20892, USA
    Proteomics 4:2357-60. 2004
    ..We reflect on the important lessons gleaned from the Wright brothers' attempts at controlled heavier-than-air flight as a model for perseverance and a view to the very near future for proteomic pattern diagnostics...
  48. ncbi Novel approaches to visualization and data mining reveals diagnostic information in the low amplitude region of serum mass spectra from ovarian cancer patients
    Donald J Johann
    NCI FDA Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Dis Markers 19:197-207. 2003
    ..This region can then be selected and studied to identify the exact location and amplitude of the diagnostic biomarkers...

Research Grants4

  1. Microvascular Perfusion Sonographic Imaging to Detect Early Stage Ovarian Cancer
    David Fishman; Fiscal Year: 2007
    ..These studies to accurately detect early stage EOC, if successful will have a significant impact on the morbidity and mortality associated with EOC. ..
  2. New Frontiers in Cancer Detection and Diagnosis
    David Fishman; Fiscal Year: 2002
    ..In an atmosphere focused on uniting biology and technology, physicians, scientists and technologists will work together to bring science and technology into clinical application to improve patient care. ..