Research Topics
Species | David FishmanSummaryAffiliation: New York University Country: USA Publications
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Publications
The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancerDavid A Fishman
Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Ave, NBV9N28, New York, NY 10016, USA
Am J Obstet Gynecol 192:1214-21; discussion 1221-2. 2005..We examined the usefulness of sonography in the detection of early-stage epithelial ovarian cancer in asymptomatic high-risk women who participated in the National Ovarian Cancer Early Detection Program...- Progress in biomarker discovery for diagnostic testing in epithelial ovarian cancerRadhika Gogoi
New York University School of Medicine, 550 First Avenue, TH538, NY 10016, USA
Expert Rev Mol Diagn 6:627-37. 2006.... - S1P regulation of ovarian carcinoma invasivenessYoel Smicun
Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, NB-9N28, New York, NY 10016, USA
Gynecol Oncol 103:952-9. 2006..Altogether this study demonstrates a complex role of S1P in EOC cell invasion, a process highly balanced and regulated by LPA and S1P within the tumor microenvironment... - Matrilysin (MMP-7) promotes invasion of ovarian cancer cells by activation of progelatinaseFeng Qiang Wang
Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA
Int J Cancer 114:19-31. 2005..These results indicate MMP-7 is overexpressed in malignant ovarian epithelium and suggest MMP-7 may facilitate tumor cell invasion in vivo partly through the induction of progelatinase activation... 
VEGFR-2 silencing by small interference RNA (siRNA) suppresses LPA-induced epithelial ovarian cancer (EOC) invasionFeng Qiang Wang
Department of Obstetrics, Gynecology, and Reproductive Sciences, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
Gynecol Oncol 115:414-23. 2009..However, the expression profile of VEGF and VEGFRs in EOC, their association with tumor aggressiveness, and their regulation by LPA remain unclear...- Inhibition of matrilysin expression by antisense or RNA interference decreases lysophosphatidic acid-induced epithelial ovarian cancer invasionFeng Qiang Wang
Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, TH528, New York, NY 10016, USA
Mol Cancer Res 4:831-41. 2006.... - Vascular endothelial growth factor-regulated ovarian cancer invasion and migration involves expression and activation of matrix metalloproteinasesFeng Qiang Wang
Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA
Int J Cancer 118:879-88. 2006..In summary, our results indicate that VEGF may regulate EOC invasion and migration through VEGFR-mediated secretion and activation of MMPs... - Ultrasound and ovarian cancerLeeber Cohen
Department of Obstetrics and Gynecology, Divisions of Ultrasound and Gynecologic Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
Cancer Treat Res 107:119-32. 2002..Transvaginal ultrasound in expert hands is sensitive but not ideally specific for discriminating benign from malignant disease. The judicious use of color Doppler evaluation may help discriminate with greater specificity... - S1P and LPA have an attachment-dependent regulatory effect on invasion of epithelial ovarian cancer cellsYoel Smicun
Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, NB 9N28, New York, NY 10016, USA
Gynecol Oncol 107:298-309. 2007..Here we investigate how cell attachment status affects response to S1P and examine the effects of S1P and LPA on cell-cell and cell-extracellular matrix (ECM) adhesion... - The scientific basis of early detection of epithelial ovarian cancer: the National Ovarian Cancer Early Detection Program (NOCEDP)David A Fishman
Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, IL 60611, USA
Cancer Treat Res 107:3-28. 2002 - LPA receptor 2 mediates LPA-induced endometrial cancer invasionJoanie Mayer Hope
Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA
Gynecol Oncol 112:215-23. 2009..We have previously shown that lysophosphatidic acid (LPA) promotes the ovarian cancer metastatic cascade. In this study, we evaluated the role of LPA on endometrial cancer invasion... - Lysophosphatidic acid (LPA) promotes E-cadherin ectodomain shedding and OVCA429 cell invasion in an uPA-dependent mannerOrlando D Gil
Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, TH 528, New York, NY 10016, USA
Gynecol Oncol 108:361-9. 2008..To evaluate the role of LPA in regulating E-cadherin cell surface expression, adhesion, and invasion in epithelial ovarian carcinoma (EOC) cells... - LPA-induced epithelial ovarian cancer (EOC) in vitro invasion and migration are mediated by VEGF receptor-2 (VEGF-R2)John So
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA
Gynecol Oncol 97:870-8. 2005..Further, the VEGFR-2-mediated signaling transduction pathway may be involved in LPA-induced EOC invasion and migration by regulating the secretion and activation of MMP-2 and uPA... - Translocation of Fas by LPA prevents ovarian cancer cells from anti-Fas-induced apoptosisYuru Meng
Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA
Gynecol Oncol 96:462-9. 2005..CONCLUSIONS: Our studies suggest that LPA induces translocation of Fas from the cell membrane to the cytosol, which may provide a mechanism by which ovarian cancer cells evade FasL-bearing immune cells... - New frontiers for ovarian cancer risk evaluation: proteomics and contrast-enhanced ultrasoundSonia Dutta
Department of Obstetrics, Gynecology, and Reproductive Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
AJR Am J Roentgenol 194:349-54. 2010..Thus, we propose that the use of proteomic-based biomarker discovery and contrast-enhanced ultrasound may serve as a promising combination to help accurately identify early-stage epithelial ovarian cancer to improve women's health care... - Conventional and proteomic technologies for the detection of early stage malignancies: markers for ovarian cancerCatherine J Lee
Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York 10016, USA
Crit Rev Clin Lab Sci 44:87-114. 2007..This endeavor also provides new insights into the biology of the disease, which may not only be applicable to detection but may also help to initiate new therapies and optimize patient care... - Lysophosphatidic acid enhances epithelial ovarian carcinoma invasion through the increased expression of interleukin-8John So
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, New York University School of Medicine, New York, NY 10016, USA
Gynecol Oncol 95:314-22. 2004..CONCLUSION: We have identified a separate mechanism of enhanced cellular invasion, which is independent of MMP2 activation and involves the increased expression of IL-8 and subsequent increased expression of MMP7... - Estradiol-induced ezrin overexpression in ovarian cancer: a new signaling domain for estrogenJoon Song
Department of Obstetrics and Gynecology, Yale University, P.O. Box 208063, 333 Cedar Street, FMB 331, New Haven, CT 06520-8063, USA
Cancer Lett 220:57-65. 2005..This previously unreported effect of estrogen on ezrin expression may play a role in the clinical course of estrogen-sensitive cancers and other normal or diseased cell actions... - Lysophosphatidic acid down-regulates stress fibers and up-regulates pro-matrix metalloproteinase-2 activation in ovarian cancer cellsThuy Vy Do
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago Illinois, USA
Mol Cancer Res 5:121-31. 2007..Collectively, these results were consistent with a model in which LPA stimulates the metastatic dissemination of EOC cells by initiating loss of adhesion and metalloproteinase activation... - S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment are mediated by Gi and RacKathleen M Devine
Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA
Gynecol Oncol 110:237-45. 2008..In this study, we investigated the mechanisms through which S1P affects EOC cell proteolysis, invasion, and adhesion in two cultured epithelial ovarian cancer cell lines... - Lysophosphatidic acid (LPA) effects on endometrial carcinoma in vitro proliferation, invasion, and matrix metalloproteinase activityFeng Qiang Wang
Department of Obstetrics, Gynecology and Reproductive Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
Gynecol Oncol 117:88-95. 2010..The goal of this study was to assess the regulation of (EC) microenvironment by LPA through the examination of its effect on cell proliferation, migration, invasion, uPA activity, and matrix metalloproteinase (MMP) secretion/activation... - The tumor microenvironment: key to early detectionEdgardo V Ariztia
Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA
Crit Rev Clin Lab Sci 43:393-425. 2006..Here we review the evolving concepts of the tumor microenvironment that, together with advances in proteomic technologies, hold the promise to facilitate the detection of early-stage cancer... - Telomerase prolongs the lifespan of normal human ovarian surface epithelial cells without inducing neoplastic phenotypeAyesha B Alvero
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Soc Gynecol Investig 11:553-61. 2004..The aim of this study was to determine the effects of exogenous expression of the catalytic subunit of telomerase (hTERT) on the lifespan, growth characteristics, and tumorigenicity of normal human ovarian surface epithelial (OSE) cells... - Roles of LPA in ovarian cancer development and progressionTarah L Pua
Gynecologic Oncology, New York University School of Medicine, New York, NY, USA
Future Oncol 5:1659-73. 2009..We believe that elucidation of this complex transduction network will provide further opportunities to understand the mechanism of ovarian carcinogenesis, invasion and metastasis... - Biomarkers for ovarian cancer detection and therapySonia Dutta
Department of Obstetrics, Gynecology and Reproductive Sciences, Mount Sinai School of Medicine, New York, NY, USA
Cancer Biol Ther 9:668-77. 2010..Here, we review recent developments in EOC early detection and targeted therapy, as well as new technologies for the discovery of novel biomarkers... - Lysophosphatidic acid inhibits anti-Fas-mediated apoptosis enhanced by actin depolymerization in epithelial ovarian cancerYuru Meng
Department of Obstetrics and Gynecology, and R H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
FEBS Lett 579:1311-9. 2005.... - Upregulation of FasL by LPA on ovarian cancer cell surface leads to apoptosis of activated lymphocytesYuru Meng
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, IL 60611, USA
Gynecol Oncol 95:488-95. 2004..Pretreatment of Dov13 cells with LPA increased activated T cell apoptosis in cocultures. CONCLUSIONS: These data suggest that upregulation of FasL by LPA provides EOC immune-privilege and leads to apoptosis of activated T lymphocytes... - Matrilysin over-expression in MCF-7 cells enhances cellular invasiveness and pro-gelatinase activationFengqiang Wang
Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, NB-9N28, New York, NY 10016, USA
Cancer Lett 236:292-301. 2006..We conclude that MMP-7 over-expression correlates with breast cancer in vitro invasiveness and that MMP-7 may promote invasion by increasing the secretion and activation of proMMP-2 and proMMP-9... - Soluble epidermal growth factor receptor (sEGFR) [corrected] and cancer antigen 125 (CA125) as screening and diagnostic tests for epithelial ovarian cancerAndre T Baron
Department of Internal Medicine, Division of Hematology Oncology, Lucille P Markey Cancer Center, University of Kentucky, 408 Roach Building, 800 Rose Street, Lexington, KY 40536 0093, USA
Cancer Epidemiol Biomarkers Prev 14:306-18. 2005.... - Soluble epidermal growth factor receptor (sEGFR/sErbB1) as a potential risk, screening, and diagnostic serum biomarker of epithelial ovarian cancerAndre T Baron
Tumor Biology Program, Mayo Clinic-Rochester, Rochester, Minnesota 55905, USA
Cancer Epidemiol Biomarkers Prev 12:103-13. 2003..We conclude that serum sEGFR concentrations warrant additional investigation in the risk assessment, early detection, and/or diagnosis of EOC... - General keynote: proteomic patterns in sera serve as biomarkers of ovarian cancerLance A Liotta
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, USA
Gynecol Oncol 88:S25-8; discussion S37-42. 2003 - A robust biomarker discovery pipeline for high-performance mass spectrometry dataWayne G Fisher
Division of Translational Research, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Bioinform Comput Biol 5:1023-45. 2007..While the generalizability of these markers is currently unknown, we have demonstrated the ability of our analytical package to extract biomarker candidates from high-performance mass spectral data... - Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cellsJaime Symowicz
Departments of Cell and Molecular Biology and Pathology, Northwestern University Feinberg Medical School, Chicago, IL, USA
Cancer Res 67:2030-9. 2007..These data support a novel mechanism for posttranslational modification of E-cadherin function via MMP-9 induction initiated by cell-matrix contact and suggest a mechanism for promotion of EOC metastatic dissemination... - Clinical proteomics and biomarker discoveryDonald J Johann
NCI FDA Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Ann N Y Acad Sci 1022:295-305. 2004..Clinically engineered mass spectroscopy systems are essential for the further development and validation of multiplexed biomarkers that have shown tremendous promise for the early detection of disease... - Matrix metalloproteinase 9 is a mediator of epidermal growth factor-dependent e-cadherin loss in ovarian carcinoma cellsKaren D Cowden Dahl
Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, New Mexico, USA
Cancer Res 68:4606-13. 2008..These data suggest that regulation of MMP-9 by EGFR may represent a novel mechanism for down-modulation of E-cadherin in ovarian cancer... - Proinvasive properties of ovarian cancer ascites-derived membrane vesiclesLaura E Graves
Department of Cellular and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Cancer Res 64:7045-9. 2004..Our data suggest that vesicle-stimulated proteinase activation leads to increased extracellular matrix degradation, which may facilitate tumor cell invasion and metastasis... - Lysophosphatidic acid stimulates fas ligand microvesicle release from ovarian cancer cellsYuru Meng
Department of Immunology, University of Illinois at Chicago, Chicago 60612, USA
Cancer Immunol Immunother 54:807-14. 2005..LPA may promote ovarian cancer metastasis by counterattacking peritoneal cavity anti-tumor immunity... - Use of proteomic patterns in serum to identify ovarian cancerEmanuel F Petricoin
Food and Drug Administration National Institutes of Health Clinical Proteomics Program, Department of Therapeutic Proteins Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
Lancet 359:572-7. 2002..We developed a bioinformatics tool and used it to identify proteomic patterns in serum that distinguish neoplastic from non-neoplastic disease within the ovary... - Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motilityLindsay Gillan
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Cancer Res 62:5358-64. 2002..We propose PN functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins to support adhesion and migration of ovarian epithelial cells... - Methylation profiles of sporadic ovarian tumors and nonmalignant ovaries from high-risk womenAsha Rathi
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75930, USA
Clin Cancer Res 8:3324-31. 2002..CONCLUSIONS: Our results suggest that aberrant methylation of specific genes, including two not described previously, may be important in ovarian cancer pathogenesis but not in ovaries at risk for cancer development... - Importance of communication between producers and consumers of publicly available experimental dataLance A Liotta
FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, National Cancer Institute, CCR, Bethesda, MD 20892, USA
J Natl Cancer Inst 97:310-4. 2005..Such disputes, however, should not divert us from the validation of this promising new approach... - Signal pathway profiling of ovarian cancer from human tissue specimens using reverse-phase protein microarraysJulia D Wulfkuhle
Center for Cancer Research, National Cancer Institute NIH, Building 29A Room 2B20, 8000 Rockville Pike, Bethesda, MD 20892, USA
Proteomics 3:2085-90. 2003.... - Selective induction of cyclooxygenase-2 plays a role in lysophosphatidic acid regulated Fas ligand cell surface presentationShijun Kang
Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
FEBS Lett 580:443-9. 2006.... - Genetic risk assessment for breast and ovarian cancerKate Pfeifer
National Ovarian Cancer Early Detection Program, Northwestern Memorial Hospital, Chicago, USA
Adv Nurse Pract 11:40-8. 2003 - Biomarker amplification by serum carrier protein bindingArpita I Mehta
Howard Hughes Medical Institute, Bethesda, MD 20814, USA
Dis Markers 19:1-10. 2003..These findings shift the focus of biomarker detection to the carrier protein and its biomarker content... - A comparison of ovarian cancer treatments: analysis of utility assessments of ovarian cancer patients, at-risk population, general population, and physiciansElizabeth A Calhoun
Obstetrics and Gynecology Gynecologic Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
Gynecol Oncol 93:164-9. 2004..In this study, we elicited assessments of toxicity from women with ovarian cancer, women at increased risk of developing ovarian cancer, women in the general population, and gynecologic oncologists... - Lessons from Kitty Hawk: from feasibility to routine clinical use for the field of proteomic pattern diagnosticsEmanuel F Petricoin
FDA NCI Clinical Proteomics Program, Office of Cell and Gene Therapies, CBER, FDA, Bethesda, MD 20892, USA
Proteomics 4:2357-60. 2004..We reflect on the important lessons gleaned from the Wright brothers' attempts at controlled heavier-than-air flight as a model for perseverance and a view to the very near future for proteomic pattern diagnostics... - Novel approaches to visualization and data mining reveals diagnostic information in the low amplitude region of serum mass spectra from ovarian cancer patientsDonald J Johann
NCI FDA Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Dis Markers 19:197-207. 2003..This region can then be selected and studied to identify the exact location and amplitude of the diagnostic biomarkers...
Research Grants
- Microvascular Perfusion Sonographic Imaging to Detect Early Stage Ovarian CancerDavid Fishman; Fiscal Year: 2007..These studies to accurately detect early stage EOC, if successful will have a significant impact on the morbidity and mortality associated with EOC. ..
- New Frontiers in Cancer Detection and DiagnosisDavid Fishman; Fiscal Year: 2002..In an atmosphere focused on uniting biology and technology, physicians, scientists and technologists will work together to bring science and technology into clinical application to improve patient care. ..