Gordon Fishell

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc Antagonism between Notch and bone morphogenetic protein receptor signaling regulates neurogenesis in the cerebellar rhombic lip
    Robert P Machold
    New York University School of Medicine, Smilow Neuroscience Program, Department of Cell Biology, 522 First Avenue, New York, NY 10016, USA
    Neural Dev 2:5. 2007
  2. ncbi request reprint Regionalization in the mammalian telencephalon
    G Fishell
    Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 550 First Avenue, New York, New York 11217, USA
    Curr Opin Neurobiol 7:62-9. 1997
  3. ncbi request reprint Neurons from radial glia: the consequences of asymmetric inheritance
    Gord Fishell
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 550 1st Avenue, New York, NY 10016, USA
    Curr Opin Neurobiol 13:34-41. 2003
  4. doi request reprint Pyramidal neurons grow up and change their mind
    Gord Fishell
    New York University School of Medicine, New York, NY 10016, USA
    Neuron 57:333-8. 2008
  5. pmc Mechanisms of inhibition within the telencephalon: "where the wild things are"
    Gord Fishell
    Smilow Neuroscience Program, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA
    Annu Rev Neurosci 34:535-67. 2011
  6. ncbi request reprint The Gsh2 homeodomain gene controls multiple aspects of telencephalic development
    J G Corbin
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Development 127:5007-20. 2000
  7. ncbi request reprint Cortical development: new concepts
    Gord Fishell
    The Skirball Developmental Genetics Program and, Department of Cell Biology, New York University School of Medicine, 550 1st Avenue, New York, New York 10016, USA
    Neuron 46:361-2. 2005
  8. ncbi request reprint Foxg1 suppresses early cortical cell fate
    Carina Hanashima
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Science 303:56-9. 2004
  9. ncbi request reprint The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations
    Susana Nery
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, New York 10016, USA
    Nat Neurosci 5:1279-87. 2002
  10. ncbi request reprint Radial glia serve as neuronal progenitors in all regions of the central nervous system
    Todd E Anthony
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 41:881-90. 2004

Research Grants

Collaborators

Detail Information

Publications43

  1. pmc Antagonism between Notch and bone morphogenetic protein receptor signaling regulates neurogenesis in the cerebellar rhombic lip
    Robert P Machold
    New York University School of Medicine, Smilow Neuroscience Program, Department of Cell Biology, 522 First Avenue, New York, NY 10016, USA
    Neural Dev 2:5. 2007
    ....
  2. ncbi request reprint Regionalization in the mammalian telencephalon
    G Fishell
    Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 550 First Avenue, New York, New York 11217, USA
    Curr Opin Neurobiol 7:62-9. 1997
    ..The mechanisms underlying the commitment of telencephalic cells to specific regional identities have been examined through recent transplantation experiments...
  3. ncbi request reprint Neurons from radial glia: the consequences of asymmetric inheritance
    Gord Fishell
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 550 1st Avenue, New York, NY 10016, USA
    Curr Opin Neurobiol 13:34-41. 2003
    ..We suggest two models that make opposite predictions as to whether the radial glia or nascent neuron inherit the radial glial fiber or the majority of the Numb protein...
  4. doi request reprint Pyramidal neurons grow up and change their mind
    Gord Fishell
    New York University School of Medicine, New York, NY 10016, USA
    Neuron 57:333-8. 2008
    ..Here, we discuss these new findings in the context of our present understanding of cortical cell specification...
  5. pmc Mechanisms of inhibition within the telencephalon: "where the wild things are"
    Gord Fishell
    Smilow Neuroscience Program, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA
    Annu Rev Neurosci 34:535-67. 2011
    ..Finally we speculate regarding the attractiveness and challenges of establishing a unifying nomenclature to describe inhibitory neuron diversity throughout the telencephalon...
  6. ncbi request reprint The Gsh2 homeodomain gene controls multiple aspects of telencephalic development
    J G Corbin
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Development 127:5007-20. 2000
    ..Taken together, our data support a model in which Gsh2, in response to sonic hedgehog signaling, plays a crucial role in multiple aspects of telencephalic development...
  7. ncbi request reprint Cortical development: new concepts
    Gord Fishell
    The Skirball Developmental Genetics Program and, Department of Cell Biology, New York University School of Medicine, 550 1st Avenue, New York, New York 10016, USA
    Neuron 46:361-2. 2005
  8. ncbi request reprint Foxg1 suppresses early cortical cell fate
    Carina Hanashima
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Science 303:56-9. 2004
    ..Hence, the competence to generate the earliest born neurons during later cortical development is actively suppressed but not lost...
  9. ncbi request reprint The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations
    Susana Nery
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, New York 10016, USA
    Nat Neurosci 5:1279-87. 2002
    ..Moreover, we report that the migratory fate of cells from the CGE is intrinsically determined by embryonic day 13.5 (E13.5). Together, these results provide the first insights into the development and fate of the CGE...
  10. ncbi request reprint Radial glia serve as neuronal progenitors in all regions of the central nervous system
    Todd E Anthony
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 41:881-90. 2004
    ..Thus, radial glial populations within different CNS regions are not heterogeneous with regard to their potential to generate neurons versus glia...
  11. pmc The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes
    Simon J B Butt
    Smilow Neuroscience Program and the Department of Cell Biology, New York University, New York, NY 10016, USA
    Neuron 59:722-32. 2008
    ..Our strategy reveals a causal link between the embryonic genetic specification by Nkx2-1 in progenitors and the functional attributes of their neuronal progeny in the mature nervous system...
  12. ncbi request reprint Perspectives on the developmental origins of cortical interneuron diversity
    Gordon Fishell
    Smilow Neuroscience Program, Department of Cell Biology, Floor Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA
    Novartis Found Symp 288:21-35; discussion 35-44, 96-8. 2007
    ..A primary challenge in the future will be to investigate what aspects of interneuron diversity are determined by intrinsic genetic programmes within each lineage versus those properties imposed by the local environment in the cortex...
  13. pmc Gene expression in cortical interneuron precursors is prescient of their mature function
    Renata Batista-Brito
    Smilow Neuroscience Program and the Department of Cell Biology, Smilow Research Building, New York University Medical Center, 522 First Avenue, New York, NY 10016, USA
    Cereb Cortex 18:2306-17. 2008
    ..Moreover, our work has revealed that many of the genes expressed in cortical interneuron precursors have been independently linked to neurological disorders in both mice and humans...
  14. ncbi request reprint The role of notch in promoting glial and neural stem cell fates
    Nicholas Gaiano
    Developmental Genetics Program, and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, NY 10016, USA
    Annu Rev Neurosci 25:471-90. 2002
    ..This review examines the role of Notch during gliogenesis in both fruit flies and vertebrates, as well as evidence in vertebrates that some glia may be stem cells...
  15. ncbi request reprint Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors
    Goichi Miyoshi
    Neuroscience Program and Department of Cell Biology, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 27:7786-98. 2007
    ..We observe that the physiological subtypes of cortical interneurons are, to a large degree, unique to their time point of generation...
  16. doi request reprint Math1: waiting to inhale
    Robert P Machold
    Smilow Neuroscience Program, Smilow Research Center, New York University School of Medicine, New York, NY 10016, USA
    Neuron 64:293-5. 2009
    ....
  17. pmc Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
    Bernardo Rudy
    Smilow Neuroscience Program, Smilow Research Center, New York University School of Medicine, 550 First Avenue, New York, NY, 10016, USA
    Dev Neurobiol 71:45-61. 2011
    ..The universal modulation of these neurons by serotonin and acetylcholine via ionotropic receptors suggests that they might be involved in shaping cortical circuits during specific brain states and behavioral contexts...
  18. ncbi request reprint Neural stem cells: progenitors or panacea?
    Corinna Klein
    Developmental Genetics Program, The Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University Medical Center, New York, NY 10016, USA
    Dev Neurosci 26:82-92. 2004
    ..We compare the data garnered from in vitro analysis to what has been learned from the transplantation of NSCs into the developing, adult or lesioned brain...
  19. doi request reprint Cortex shatters the glass ceiling
    Edmund Au
    Smilow Neuroscience Program, Department of Cell Biology, NYU Langone Medical Center, 522 First Avenue, New York, NY 10016, USA
    Cell Stem Cell 3:472-4. 2008
    ..Recent studies in Cell Stem Cell (Eiraku et al., 2008) and Nature (Gaspard et al., 2008) demonstrate that embryonic stem cells can recapitulate early cortical development, enabling them to generate specific cortical subtypes...
  20. ncbi request reprint Loss of notch activity in the developing central nervous system leads to increased cell death
    Heather A Mason
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Dev Neurosci 28:49-57. 2006
    ....
  21. ncbi request reprint Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors
    Rob Machold
    Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, New York 10016, USA
    Neuron 48:17-24. 2005
    ..Thus, we demonstrate that the cerebellar rhombic lip gives rise to multiple cell types within rhombomere 1...
  22. pmc Genetic fate mapping reveals that the caudal ganglionic eminence produces a large and diverse population of superficial cortical interneurons
    Goichi Miyoshi
    Smilow Neuroscience Program and the Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 30:1582-94. 2010
    ..Thus, in conjunction with previous studies, we have now determined the spatial and temporal origins of the vast majority of cortical interneuron subtypes...
  23. ncbi request reprint Removal of Pax6 partially rescues the loss of ventral structures in Shh null mice
    Marc Fuccillo
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Cereb Cortex 16:i96-102. 2006
    ..Together, our findings are consistent with Pax6 function being required for aspects of Gli3-mediated telencephalic patterning...
  24. doi request reprint The developmental integration of cortical interneurons into a functional network
    Renata Batista-Brito
    Smilow Neuroscience Program, New York University Medical Center, New York, USA
    Curr Top Dev Biol 87:81-118. 2009
    ..Finally, we will conclude by calling the readers attention to the devastating consequences that result from developmental failures in the formation of inhibitory circuits within the cortex...
  25. pmc The distinct temporal origins of olfactory bulb interneuron subtypes
    Renata Batista-Brito
    Smilow Neuroscience Program and Department of Cell Biology, New York University Medical Center, New York, New York 10016, USA
    J Neurosci 28:3966-75. 2008
    ..Together we provide the first comprehensive analysis of the temporal generation of OB interneuron subtypes and demonstrate that the timing by which these populations are produced is tightly orchestrated...
  26. pmc Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain
    Vitor H Sousa
    Smilow Neuroscience Program, Department of Cell Biology, New York University Langone Medical Center, New York, NY 10016, USA
    Curr Opin Genet Dev 20:391-9. 2010
    ..We suggest these developmental changes in competence are mediated by a transcriptional mechanism that intrinsically integrates information from the distinct signaling pathways that act to pattern the telencephalic neuroepithelium...
  27. pmc The cell-intrinsic requirement of Sox6 for cortical interneuron development
    Renata Batista-Brito
    Smilow Neuroscience Program and the Department of Cell Biology, Smilow Research Building, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA
    Neuron 63:466-81. 2009
    ..It is, however, necessary for their normal positioning and maturation. As a consequence, the specific removal of Sox6 from this population results in a severe epileptic encephalopathy...
  28. pmc Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells
    Todd E Anthony
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 19:1028-33. 2005
    ..These results identify Blbp as the first predominantly CNS-specific Notch target gene and suggest that it mediates some aspects of Notch signaling in radial glia...
  29. ncbi request reprint The temporal and spatial origins of cortical interneurons predict their physiological subtype
    Simon J B Butt
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, New York 10016, USA
    Neuron 48:591-604. 2005
    ..5 CGE. Thus, we provide evidence that the spatial and temporal origin of interneuron precursors in the developing telencephalic eminences predicts the intrinsic physiological properties of mature interneurons...
  30. ncbi request reprint Cerebellum- and forebrain-derived stem cells possess intrinsic regional character
    Corinna Klein
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Development 132:4497-508. 2005
    ..Most notably, upon transplantation to the perinatal cerebellum, cerebellar stem cells from all ages are able to acquire the position and mature electrophysiological properties of cerebellar granule cells...
  31. ncbi request reprint Notch signaling coordinates the patterning of striatal compartments
    Heather A Mason
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Development 132:4247-58. 2005
    ..These results indicate that Notch signaling is required in neural progenitor cells to control cell fate in the striatum, but is dispensable during subsequent phases of neuronal migration and differentiation...
  32. ncbi request reprint Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches
    Robert Machold
    Developmental Genetics Program and Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Neuron 39:937-50. 2003
    ..These results suggest that hedgehog signaling is required to maintain progenitor cells in the postnatal telencephalon...
  33. ncbi request reprint The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes
    Carina Hanashima
    Smilow Neuroscience Program and Department of Cell Biology, Smilow Research Center, New York University, New York, New York 10016, USA
    J Neurosci 27:11103-11. 2007
    ....
  34. ncbi request reprint Directing neuron-specific transgene expression in the mouse CNS
    Goichi Miyoshi
    Smilow Neuroscience Program and the Department of Cell Biology, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA
    Curr Opin Neurobiol 16:577-84. 2006
    ..As a result, the promise of being able to use transgenics to target specific neuronal populations is now being realized...
  35. ncbi request reprint Hedgehog patterns midbrain ARChitecture
    Robert Machold
    Developmental Genetics Program and the Dept of Cell Biology, The Skirball Institute of Biomolecular Medicine, NYU Medical Center, 540 First Avenue, NY 10016, USA
    Trends Neurosci 25:10-1. 2002
    ..These results are discussed in the context of the purported role of Shh as a morphogen...
  36. ncbi request reprint Dlx2 progenitor migration in wild type and Nkx2.1 mutant telencephalon
    Susana Nery
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Cereb Cortex 13:895-903. 2003
    ..This recovery may be, at least in part, a result of the late migration of Dlx2 progenitors from the caudal ganglionic eminences (CGE), which, based on our previous work, does not appear to require Nkx2.1 gene function...
  37. ncbi request reprint Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling
    Murielle Rallu
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York 10016, USA
    Development 129:4963-74. 2002
    ..In addition these results support the idea that, in addition to hedgehog signaling, a Shh-independent pathways must act during development to pattern the telencephalon...
  38. ncbi request reprint Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons
    Francesca Balordi
    Smilow Neuroscience Program and the Department of Cell Biology, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 27:5936-47. 2007
    ..These results suggest that Hedgehog signaling is required for the maintenance of the B and C cell populations and indirectly for the migration of the neurons that are generated from the adult stem cell niche...
  39. ncbi request reprint Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-type stem cells have a limited capacity for self-renewal
    Francesca Balordi
    Smilow Neuroscience Program and the Department of Cell Biology, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 27:14248-59. 2007
    ..These results demonstrate that ongoing hedgehog signaling is required to maintain adult neural stem cells and that their ability to self-renew is limited...
  40. ncbi request reprint Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development
    Marc Fuccillo
    Developmental Genetics Program and the Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Nat Rev Neurosci 7:772-83. 2006
    ..Here we review our present knowledge of the hedgehog signalling pathway and speculate about areas in which further insights into this versatile pathway might be forthcoming...
  41. ncbi request reprint Building bridges to the cortex
    Carina Hanashima
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Cell 125:24-7. 2006
    ....
  42. ncbi request reprint Temporal requirement for hedgehog signaling in ventral telencephalic patterning
    Marc Fuccillo
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Development 131:5031-40. 2004
    ..0 and E12 is essential for the patterning of ventral regions and the generation of cell types that are thought to largely arise from them...
  43. pmc Characterization of Nkx6-2-derived neocortical interneuron lineages
    Vitor H Sousa
    Neuroscience Program, Smilow Research Center, New York University, New York, NY 10016, USA
    Cereb Cortex 19:i1-10. 2009
    ....

Research Grants40

  1. Regional and Genetic Diversity of Cortical Interneurons
    GORDON J FISHELL; Fiscal Year: 2010
    ..Moreover, through the genetic profiling of these cells we expect to be able to directly link the function of these cells to specific genetically inherited disorders in human patients. ..
  2. Sonic Hedgehog Signaling in the Mammalian Telencephalon
    Gordon Fishell; Fiscal Year: 2007
    ..Together this proposal will provide a comprehensive examination of Shh signaling during telencephalic development. ..
  3. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
    ..abstract_text> ..
  4. Analysis of Notch Signaling in Telencephalic Development
    Gordon Fishell; Fiscal Year: 2006
    ....
  5. Cell Fate Determination in the Cerebellum
    Gordon Fishell; Fiscal Year: 2007
    ..Our studies will reveal the mechanisms by which these populations are generated and thus provide the first step towards finding a cure to these disorders. ..
  6. Cell Fate Determination in the Cerebellum
    GORDON J FISHELL; Fiscal Year: 2010
    ..Our studies will reveal the mechanisms by which these populations are generated and thus provide the first step towards finding a cure to these disorders. ..
  7. Regional and Genetic Diversity of Cortical Interneurons
    Gordon Fishell; Fiscal Year: 2009
    ..This proposal will therefore provide the first comprehensive analysis of the developmental origins of cortical interneuron diversity. ..
  8. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 1999
    ..The position, morphology and gene expression within clones resulting from control versus ectopic expression viral vector infections will allow us to evaluated the function of these genes during neural development. ..
  9. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2002
    ..Together the sets of experiments described in this proposal will examine the establishment of the subdivisions of forebrain and their significance to the determination of regional cell identity. ..
  10. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    Gordon Fishell; Fiscal Year: 2003
    ....
  11. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
    ..If we can understand how this population is generated, we will take the first step towards assessing whether we can use gene or cell therapies to ameliorate the devasting consequences associated with cortical interneuron dysfunction. ..