Research Topics
| Daniel FineSummaryAffiliation: New Jersey Country: USA Publications
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Publications
Can salivary activity predict periodontal breakdown in A. actinomycetemcomitans infected adolescents?Daniel H Fine
Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, NJ 071003, United States Electronic address
Arch Oral Biol 58:611-20. 2013..This study was designed to determine whether specific salivary factors could distinguish between subjects who have Aa initially and remain healthy (H/AA) as compared to those who develop LAP (LAP/AA)...- Whole mouth antimicrobial effects after oral hygiene: comparison of three dentifrice formulationsDaniel H Fine
Department of Oral Biology, University of Medicine and Dentistry of New Jersey, New Jersey Dental School Umdnj, Newark, NJ 07103, USA
J Clin Periodontol 39:1056-64. 2012..This study compared the antimicrobial effects of three commercial dentifrice formulations: sodium fluoride/triclosan/copolymer (TCN/C), stannous fluoride/sodium hexametaphosphate/zinc lactate (SnF(2)/SHMP) and sodium fluoride (NaF)... 
Genome sequence of Aggregatibacter actinomycetemcomitans RHAA1, isolated from a rhesus macaque, an Old World primateMaribasappa Karched
Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA
J Bacteriol 194:1275-6. 2012..Aggregatibacter actinomycetemcomitans is implicated in localized aggressive periodontitis. We report the first genome sequence of an A. actinomycetemcomitans strain isolated from an Old World primate...- Lipopolysaccharide (LPS) potentiates hydrogen peroxide toxicity in T98G astrocytoma cells by suppression of anti-oxidative and growth factor gene expressionGang Yue
Department of Molecular Genetics, Microbiology and Immunology The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
BMC Genomics 9:608. 2008..These observations make it difficult to understand the role of LPS in brain parenchymal injury... 
Dr. Theodor Rosebury: grandfather of modern oral microbiologyDaniel H Fine
Department of Oral Biology, Center for Oral Infectious Diseases, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA
J Dent Res 85:990-5. 2006- The antimicrobial effect of a triclosan/copolymer dentifrice on oral microorganisms in vivoDaniel H Fine
Department of Oral Biology, University of Medicine and Dentistry of New Jersey, 185 S Orange Avenue, Newark, NJ 07103, USA
J Am Dent Assoc 137:1406-13. 2006..The authors compared the in vivo antimicrobial effects on microorganisms from dental plaque, saliva and the tongue in subjects who used a triclosan/copolymer dentifrice and a fluoride dentifrice (control)... - Listerine: past, present and future--a test of thymeDaniel H Fine
Department of Oral Biology, University of Medicine and Dentistry of New Jersey, New Jersey Dental School, Newark, New Jersey, USA
J Dent 38:S2-5. 2010..These issues will be discussed in the context of Listerine, its intricate and complicated past, and its connection to current uses in oral health and beyond... - In vivo antimicrobial effectiveness of an essential oil-containing mouth rinse 12 h after a single use and 14 days' useD H Fine
Dental Research Center, New Jersey Dental School, Newark, NJ 07103, USA
J Clin Periodontol 32:335-40. 2005..Materials and.. - The Actinobacillus actinomycetemcomitans autotransporter adhesin Aae exhibits specificity for buccal epithelial cells from humans and old world primatesDaniel H Fine
Medical Science Building, Room C 636, 185 S Orange Ave, Newark, NJ 07103, USA
Infect Immun 73:1947-53. 2005..Our findings indicate that Aae mediates binding of A. actinomycetemcomitans to BECs from humans and Old World primates and that this process may contribute to the host range specificity and tissue tropism exhibited by this bacterium... - Saliva from subjects harboring Actinobacillus actinomycetemcomitans kills Streptococcus mutans in vitroDaniel H Fine
Department of Oral Biology, University of Medicine and Dentistry of New Jersey, New Jersey Dental School, Newark, NJ 07101, USA
J Periodontol 78:518-26. 2007..The purpose of this study was to determine whether the saliva of LAgP patients and subjects with Aa had higher levels of bicarbonate, or an elevated pH, and/or reduced survival of Sm... - Aggregatibacter actinomycetemcomitans and its relationship to initiation of localized aggressive periodontitis: longitudinal cohort study of initially healthy adolescentsDaniel H Fine
Department of Oral Biology, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA
J Clin Microbiol 45:3859-69. 2007..01). A. actinomycetemcomitans serotype did not appear to influence survival. These findings suggest that detection of A. actinomycetemcomitans in periodontally healthy children can serve as a risk marker for initiation of LAP... - Effect of rinsing with an essential oil-containing mouthrinse on subgingival periodontopathogensDaniel H Fine
Department of Oral Biology, New Jersey Dental School University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
J Periodontol 78:1935-42. 2007..The purpose of this study was to investigate the effect of rinsing with an essential oil antimicrobial mouthrinse on levels of representative subgingival bacteria in subjects with mild to moderate periodontitis... - An improved cost-effective, reproducible method for evaluation of bone loss in a rodent modelDaniel H Fine
Department of Oral Biology, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
J Clin Periodontol 36:106-13. 2009..This study was designed to investigate the utility of two "new" definitions for assessment of bone loss in a rodent model of periodontitis... - An investigation of the effect of an essential oil mouthrinse on induced bacteraemia: a pilot studyDaniel H Fine
Department of Oral Biology, University of Medicine and Dentistry of New Jersey, New Jersey Dental School, Newark, NJ 07103, USA
J Clin Periodontol 37:840-7. 2010..This pilot study was designed to assess the effect of an essential oil antiseptic mouthrinse (EOM) in reducing bloodstream bacteria after chewing an apple... - Mapping the epithelial-cell-binding domain of the Aggregatibacter actinomycetemcomitans autotransporter adhesin AaeDaniel H Fine
Department of Oral Biology, New Jersey Dental School, Newark, NJ 07103, USA
Microbiology 156:3412-20. 2010..We propose that these proof-of-principle experiments demonstrate that peptides can be designed to interfere with Aa binding mediated by host-cell receptors specific for Aae adhesins... - Aggregatibacter actinomycetemcomitans as an early colonizer of oral tissues: epithelium as a reservoir?Daniel H Fine
Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New York, Medical Sciences Building, Rm C 636, 185 South Orange Avenue, Newark, NJ 07103, USA
J Clin Microbiol 48:4464-73. 2010..In vivo, A. actinomycetemcomitans colonized HA within 6 h and thus can be considered an early colonizer. BECs are a likely reservoir for A. actinomycetemcomitans tooth colonization... - Effect of an essential oil-containing antimicrobial mouthrinse on specific plaque bacteria in vivoDaniel H Fine
Department of Oral Biology, New Jersey Dental School, University of Dentistry and Medicine of New Jersey, Newark, NJ 07101, USA
J Clin Periodontol 34:652-7. 2007..This study was conducted to investigate the effect of rinsing with an essential oil-containing mouthrinse on levels of specific supra and subgingival bacteria in subjects with gingivitis... - Clinical use of antibiotics in dental practiceD H Fine
Department of Oral Pathology and Biology, University of Medicine and Dentistry of New Jersey, New Jersey Dental School, Newark 07103, USA
Int J Antimicrob Agents 9:235-8. 1998..Recent evidence underscores the important role of antibiotics in the treatment and prevention of diseases initiated in the oral cavity that have the potential to spread to distant organs in the body... - Tenacious adhesion of Actinobacillus actinomycetemcomitans strain CU1000 to salivary-coated hydroxyapatiteD H Fine
Department of Oral Pathololgy and Biology, University of Medicine and Dentistry of New Jersey, New Jersey Dental School, Dental Research Center, Newark 07103, USA
Arch Oral Biol 44:1063-76. 1999..The characteristics described for the actinobacillus in this study have been previously underestimated, appear to be mediated by glycoconjugates, and may resemble attachment described for several biofilm-forming, non-oral pathogens... - Lactoferrin iron levels affect attachment of Actinobacillus actinomycetemcomitans to buccal epithelial cellsD H Fine
Dental Research Center and Department of Oral Pathology and Biology, University of Medicine and Dentistry of New Jersey, New Jersey Dental School, Newark 07103, USA
J Periodontol 73:616-23. 2002..The purpose of this work was to study the effect of LF iron levels on survival and attachment of well-preserved clinical isolates of Aa... - Lactoferrin iron levels are reduced in saliva of patients with localized aggressive periodontitisD H Fine
Department of Oral Pathology and Biology, University of Medicine and Dentistry of New Jersey, New Jersey Dental School, Newark 07103, USA
J Periodontol 73:624-30. 2002..The purpose of this study was to examine the relationship of LF iron levels in saliva of LAgP patients as compared to their age-, gender-, and race-matched controls... - Colonization and persistence of rough and smooth colony variants of Actinobacillus actinomycetemcomitans in the mouths of ratsD H Fine
Department of Oral Pathology and Biology, University of Medicine and Dentistry of New Jersey, New Jersey Dental School, Dental Research Center, 110 Bergen Street, Newark, NJ 07103, USA
Arch Oral Biol 46:1065-78. 2001..The model provides convincing evidence that, unlike laboratory variants, clinical isolates colonize, persist and integrate into an already established, albeit reduced, econiche... - Clinical implications of the oral manifestations of HIV infection in childrenDaniel H Fine
Dental Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Dental School, Health Sciences Building, Room C 636, 185 South Orange Avenue, Newark, NJ 07103, USA
Dent Clin North Am 47:159-74, xi-xii. 2003..The authors speculated, however, that examinations at intervals more frequent than every 6 months might be required to determine whether oral lesions can predict frank AIDS and lowered CD4 cell counts... - A model for clinical evaluation of anti-microbial effects of agents on plaque colonizationD H Fine
Dental Research Center, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark 07103, USA
Am J Dent 13:153-8. 2000.... - Comparative antimicrobial activities of antiseptic mouthrinses against isogenic planktonic and biofilm forms of Actinobacillus actinomycetemcomitansD H Fine
Dental Research Center, New Jersey Dental School, Newark, NJ 07103, USA
J Clin Periodontol 28:697-700. 2001.... - Sequence diversity in the major fimbrial subunit gene (flp-1) of Actinobacillus actinomycetemcomitansJ B Kaplan
Department of Oral Biology, New Jersey Dental School, Newark, NJ, USA
Oral Microbiol Immunol 17:354-9. 2002..Our findings provide a framework for future biochemical, immunological and genetic studies of A. actinomycetemcomitans fimbriae... - Toothbrush bristle wear and adherence of Streptococcus mutansRobert N Goldsmith
University of Medicine and Dentistry of New Jersey, USA
Pediatr Dent 29:243-7. 2007..The purpose of this study was conducted to determine if bristle wear impacts the adherence of Streptococcus mutans on toothbrushes and to evaluate whether it affects the extent of adherence at 0, 8, and 24 hours after air-drying... - Structural and genetic analyses of O polysaccharide from Actinobacillus actinomycetemcomitans serotype fJ B Kaplan
Department of Oral Pathology, Biology and Diagnostic Sciences, New Jersey Dental School, Newark, New Jersey 07103 2714, USA
Infect Immun 69:5375-84. 2001..The finding of an A. actinomycetemcomitans serotype showing serological cross-reactivity with anti-serotype b-specific antiserum suggests that a reevaluation of strains previously classified as serotype b may be warranted... - Aggregatibacter actinomycetemcomitans serotype f O-polysaccharide mediates coaggregation with Fusobacterium nucleatumD Rupani
Department of Oral Biology, New Jersey Dental School, Newark, NJ, USA
Oral Microbiol Immunol 23:127-30. 2008..Intergeneric bacterial coaggregation may play an important role in plaque development... - A comparison of periodontal disease in HIV-infected children and household peers: a two year reportD H Schoen
Department of General Dentistry and Community Health, UMD New Jersey Dental School, USA
Pediatr Dent 22:365-9. 2000..The purpose of this study was to compare the incidence and progression of periodontal disease in HIV-infected children to HIV-negative household peers. This paper reports the findings after two years... - A non-conservative, coding single-nucleotide polymorphism in the N-terminal region of lactoferrin is associated with aggressive periodontitis in an African-American, but not a Caucasian populationW J Jordan
Department of Oral Biology, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
Genes Immun 6:632-5. 2005..A Caucasian population of 77 patients and 131 controls showed no such association (P=0.5201, odds ratio=0.862, 95% CI=0.548-1.356). The data presented provide a new insight into the genetic susceptibility to aggressive periodontitis... - Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal diseaseY Li
Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
Mol Oral Microbiol 25:275-92. 2010..The study provides a rationale for a link between periodontal disease and other systemic diseases... - Population structure and genetic diversity of Actinobacillus actinomycetemcomitans strains isolated from localized juvenile periodontitis patientsJeffrey B Kaplan
Department of Oral Biology, New Jersey Dental School, Newark, New Jersey 07103-2714, USA
J Clin Microbiol 40:1181-7. 2002..Strains from all three major lineages were recovered from LJP patients, suggesting that phylogenetically diverse strains of A. actinomycetemcomitans carry pathogenic potential... - A second Aggregatibacter actinomycetemcomitans autotransporter adhesin exhibits specificity for buccal epithelial cells in humans and Old World primatesGang Yue
Department of Oral Biology, New Jersey Dental School, Newark, NJ 07103, USA
Infect Immun 75:4440-8. 2007..actinomycetemcomitans to human BECs. Since the BEC is a prominent reservoir for A. actinomycetemcomitans, identification of this second adhesin could lead to important therapeutic strategies... - Tight-adherence genes of Actinobacillus actinomycetemcomitans are required for virulence in a rat modelHelen C Schreiner
Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
Proc Natl Acad Sci U S A 100:7295-300. 2003..These results demonstrate the critical importance of the tad locus in the colonization and pathogenesis of A. actinomycetemcomitans... - The effects of a new therapeutic triclosan/copolymer/sodium-fluoride dentifrice on oral bacteria, including odorigenic speciesDavid Furgang
Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA
Compend Contin Educ Dent 24:14-9; quiz 42. 2003.... - Efficacy of chlorhexidine gluconate rinse for treatment and prevention of oral candidiasis in HIV-infected children: a pilot studyAndrei Barasch
Department of Diagnostic Sciences, University of Detroit Mercy School of Dentistry, Detroit, MI 48219 0900, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:204-7. 2004..We evaluated the effect of chlorhexidine (CHX) 0.12% rinses on the clinical and microbiologic manifestations of oral candidiasis in HIV-infected children... - Enzymatic detachment of Staphylococcus epidermidis biofilmsJeffrey B Kaplan
Medical Science Building, Room C 636, 185 S Orange Avenue, Newark NJ 07103, USA
Antimicrob Agents Chemother 48:2633-6. 2004..Precoating surfaces with the enzyme prevented S. epidermidis biofilm formation. Our findings demonstrate that biofilm-releasing enzymes can exhibit broad-spectrum activity and that these enzymes may be useful as antibiofilm agents... - The Widespread Colonization Island of Actinobacillus actinomycetemcomitansPaul J Planet
Department of Microbiology, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, New York 10032, USA
Nat Genet 34:193-8. 2003..We present evidence for a specific horizontal transfer event leading to the establishment of this region as a determinant of disease... - Biofilm growth and detachment of Actinobacillus actinomycetemcomitansJeffrey B Kaplan
Department of Oral Biology, New Jersey Dental School Electron Microscopy Facility, New Jersey Medical School, Newark, New Jersey 07103, USA
J Bacteriol 185:1399-404. 2003..actinomycetemcomitans biofilm growth and detachment are discrete processes and that biofilm cell detachment evidently involves the formation of nonaggregated cells inside the biofilm colony that are destined for release from the colony... - How we got attached to Actinobacillus actinomycetemcomitans: A model for infectious diseasesDaniel H Fine
Center for Oral Infectious Diseases, Department of Oral Biology, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA
Periodontol 2000 42:114-57. 2006 - The TadV protein of Actinobacillus actinomycetemcomitans is a novel aspartic acid prepilin peptidase required for maturation of the Flp1 pilin and TadE and TadF pseudopilinsMladen Tomich
Department of Microbiology, College of Physicians and Surgeons, Columbia University, 1516 HHSC, 701 West 168th Street, New York, NY 10032, USA
J Bacteriol 188:6899-914. 2006..Together, our results indicate that the A. actinomycetemcomitans TadV protein is a member of a novel subclass of nonmethylating aspartic acid prepilin peptidases... - Biofilm dispersal of Neisseria subflava and other phylogenetically diverse oral bacteriaJeffrey B Kaplan
Department of Oral Biology, New Jersey Dental School, Newark, New Jersey 07103, USA
Appl Environ Microbiol 68:4943-50. 2002..This in vitro spreading phenotype could be a useful tool for studying biofilm dispersal in these and other nonflagellated bacteria and may have physiological relevance to biofilm dispersal in the oral cavity... - One of two human lactoferrin variants exhibits increased antibacterial and transcriptional activation activities and is associated with localized juvenile periodontitisKabilan Velliyagounder
Department of Oral Biology, New Jersey Dental School, Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
Infect Immun 71:6141-7. 2003..Our findings suggest that these two lactoferrin variants are functionally different and that these differences may contribute to the pathogenesis of localized juvenile periodontitis... - Detachment of Actinobacillus actinomycetemcomitans biofilm cells by an endogenous beta-hexosaminidase activityJeffrey B Kaplan
Department of Oral Biology, New Jersey Dental School, Newark, New Jersey 07103, USA
J Bacteriol 185:4693-8. 2003..We concluded that dspB encodes a soluble beta-N-acetylglucosaminidase that causes detachment and dispersion of A. actinomycetemcomitans biofilm cells... - Aggressive periodontitis in adolescents in MoroccoBruce L Pihlstrom
Department of Preventive Sciences School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
Lancet 371:188-9. 2008 - Fc gamma receptor genes as risk markers for localized aggressive periodontitis in African-AmericansYali Fu
Dental Research Center, University of Medicine and Dentistry of New Jersey, Newark, USA
J Periodontol 73:517-23. 2002.... - tfoX (sxy)-dependent transformation of Aggregatibacter (Actinobacillus) actinomycetemcomitansMrinal K Bhattacharjee
Department of Microbiology, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY 10032, USA
Gene 399:53-64. 2007..The cloning and induction of tfoX makes it possible to transform nearly any strain of A. actinomycetemcomitans, and allelic exchange has proven to be important for site-directed mutagenesis...
Research Grants
- Microbial Markers for Periodontal Disease in ChildrenDaniel Fine; Fiscal Year: 2005....
- Oral Immunology/Microbiology Annual MeetingDaniel Fine; Fiscal Year: 2003..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
- Localized Aggressive Periodontitis: Microbial & Host Markers for SusceptibilityDaniel H Fine; Fiscal Year: 2010....
- Localized Aggressive Periodontitis: Microbial & Host Markers for SusceptibilityDaniel Fine; Fiscal Year: 2009....
- Attachment of Oral Actinobacillus to EpitheliumDaniel Fine; Fiscal Year: 2007..The longterm goal of this application is to use this information to identify targets for therapeutic agents that can interfere with attachment of Aa to oral tissues and thus prevent colonization leading to LAP. ..
- Oral Immunology/Microbiology Research Group Annual MtgDaniel Fine; Fiscal Year: 2003..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
- Localized Aggressive Periodontitis: Microbial & Host Markers for SusceptibilityDaniel Fine; Fiscal Year: 2009....