Joel D Ernst

Summary

Affiliation: New York University
Country: USA

Publications

  1. doi request reprint Meeting report: The International Conference on Human Immunity to Tuberculosis
    Joel D Ernst
    New York University School of Medicine, 522 First Avenue, Smilow 901, New York, NY 10016, USA
    Tuberculosis (Edinb) 92:440-4. 2012
  2. doi request reprint The immunological life cycle of tuberculosis
    Joel D Ernst
    Department of Medicine, New York University School of Medicine, 522 First Avenue, Smilow 901, New York, New York 10016, USA
    Nat Rev Immunol 12:581-91. 2012
  3. pmc Genomics and the evolution, pathogenesis, and diagnosis of tuberculosis
    Joel D Ernst
    Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, NY 10016, USA
    J Clin Invest 117:1738-45. 2007
  4. pmc Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope Database
    Joel D Ernst
    Division of Infectious Diseases, New York University School of Medicine, 522 First Avenue, Smilow 901, New York, NY 10016, USA
    Tuberculosis (Edinb) 88:366-70. 2008
  5. pmc Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs
    Andrea J Wolf
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 205:105-15. 2008
  6. ncbi request reprint Codominance of TLR2-dependent and TLR2-independent modulation of MHC class II in Mycobacterium tuberculosis infection in vivo
    Eleanor Z Kincaid
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Immunol 179:3187-95. 2007
  7. pmc Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells
    Robert Blomgran
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Cell Host Microbe 11:81-90. 2012
  8. pmc Ectopic activation of Mycobacterium tuberculosis-specific CD4+ T cells in lungs of CCR7-/- mice
    Sofia Olmos
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 184:895-901. 2010
  9. pmc Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis
    Ludovic Desvignes
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Immunity 31:974-85. 2009
  10. pmc Suboptimal activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in vivo
    Tyler D Bold
    Department of Pathology, New York University School of Medicine, New York City, New York, United States of America
    PLoS Pathog 7:e1002063. 2011

Collaborators

Detail Information

Publications34

  1. doi request reprint Meeting report: The International Conference on Human Immunity to Tuberculosis
    Joel D Ernst
    New York University School of Medicine, 522 First Avenue, Smilow 901, New York, NY 10016, USA
    Tuberculosis (Edinb) 92:440-4. 2012
    ....
  2. doi request reprint The immunological life cycle of tuberculosis
    Joel D Ernst
    Department of Medicine, New York University School of Medicine, 522 First Avenue, Smilow 901, New York, New York 10016, USA
    Nat Rev Immunol 12:581-91. 2012
    ..tuberculosis that form an 'immunological life cycle'. It is hoped that this thesis will provide a framework for investigation to understand immunity to M. tuberculosis and to guide tuberculosis vaccine discovery and development...
  3. pmc Genomics and the evolution, pathogenesis, and diagnosis of tuberculosis
    Joel D Ernst
    Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, NY 10016, USA
    J Clin Invest 117:1738-45. 2007
    ..In this review, we describe some of the major progress in tuberculosis research that has resulted from knowledge of the genome sequence and note some of the problems that remain unsolved...
  4. pmc Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope Database
    Joel D Ernst
    Division of Infectious Diseases, New York University School of Medicine, 522 First Avenue, Smilow 901, New York, NY 10016, USA
    Tuberculosis (Edinb) 88:366-70. 2008
    ..tuberculosis. A workshop held in June, 2007 reviewed the existing database, discussed the utility of reference sets of epitopes, and identified knowledge gaps pertaining to epitopes and immune responses in tuberculosis...
  5. pmc Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs
    Andrea J Wolf
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 205:105-15. 2008
    ....
  6. ncbi request reprint Codominance of TLR2-dependent and TLR2-independent modulation of MHC class II in Mycobacterium tuberculosis infection in vivo
    Eleanor Z Kincaid
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Immunol 179:3187-95. 2007
    ..tuberculosis uses multiple pathways to abrogate the action of an important effector of adaptive immunity. This work was supported by National Institutes of Health Grants AI 065357-AI 020010...
  7. pmc Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells
    Robert Blomgran
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Cell Host Microbe 11:81-90. 2012
    ..Thus, pathogen modulation of apoptosis is beneficial at multiple levels, and enhancing phagocyte apoptosis promotes CD4 as well as CD8 T cell responses...
  8. pmc Ectopic activation of Mycobacterium tuberculosis-specific CD4+ T cells in lungs of CCR7-/- mice
    Sofia Olmos
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 184:895-901. 2010
    ..tuberculosis infection in CCR7(-/-) mice is compromised compared with wild-type mice...
  9. pmc Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis
    Ludovic Desvignes
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Immunity 31:974-85. 2009
    ..These results reveal a previously unsuspected role for IFN-gamma responsiveness in nonhematopoietic cells in regulation of immunity to M. tuberculosis and illustrate the role of IDO in the inhibition of Th17 cell responses...
  10. pmc Suboptimal activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in vivo
    Tyler D Bold
    Department of Pathology, New York University School of Medicine, New York City, New York, United States of America
    PLoS Pathog 7:e1002063. 2011
    ....
  11. pmc RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins
    Antje Blumenthal
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    Cell Host Microbe 5:35-46. 2009
    ..Our data identify RP105 as an accessory molecule for TLR2, forming part of the receptor complex for innate immune recognition of mycobacterial lipoproteins...
  12. pmc Dynamic roles of type I and type II IFNs in early infection with Mycobacterium tuberculosis
    Ludovic Desvignes
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 188:6205-15. 2012
    ..Together, our results imply a model in which type I IFN limit the number of target cells that M. tuberculosis can infect in the lungs, whereas IFN-γ enhances their ability to restrict bacterial growth...
  13. ncbi request reprint LspA-independent action of globomycin on Mycobacterium tuberculosis
    Niaz Banaiee
    Department of Medicine Division of Infectious Diseases, NYU School of Medicine, New York, NY 10016, USA
    J Antimicrob Chemother 60:414-6. 2007
    ..The objective of this study was to investigate the antimicrobial activity and specificity of globomycin, an inhibitor of lipoprotein signal peptidase II (LspA), against Mycobacterium tuberculosis...
  14. pmc Impaired fitness of Mycobacterium africanum despite secretion of ESAT-6
    Tyler D Bold
    Department of Medicine, New York University School of Medicine, New York, NY, USA
    J Infect Dis 205:984-90. 2012
    ..africanum less frequently demonstrate T-cell responses to the ESX-1-secreted virulence factor ESAT-6 than those infected with M. tuberculosis. We hypothesized that less frequent progression is caused by impaired secretion of ESAT-6...
  15. pmc Lung neutrophils facilitate activation of naive antigen-specific CD4+ T cells during Mycobacterium tuberculosis infection
    Robert Blomgran
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 186:7110-9. 2011
    ..These observations provide insight into a mechanism for neutrophils to facilitate initiation of adaptive immune responses in tuberculosis...
  16. pmc Lipoprotein processing is essential for resistance of Mycobacterium tuberculosis to malachite green
    Niaz Banaei
    Department of Medicine Division of Infectious Diseases, NYU School of Medicine, New York, New York 10016, USA
    Antimicrob Agents Chemother 53:3799-802. 2009
    ..In summary, lipoprotein processing by LspA is essential for resistance of M. tuberculosis to malachite green. A cell wall permeability defect is likely responsible for the hypersensitivity of lspA mutant to malachite green...
  17. pmc Cutting edge: Direct recognition of infected cells by CD4 T cells is required for control of intracellular Mycobacterium tuberculosis in vivo
    Smita Srivastava
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 191:1016-20. 2013
    ..tuberculosis. These results show that the effector mechanisms required for CD4 T cell control of distinct intracellular pathogens differ and that long-range cytokine diffusion does not contribute to control of M. tuberculosis. ..
  18. pmc CD4+ T cell-dependent IFN-γ production by CD8+ effector T cells in Mycobacterium tuberculosis infection
    Tyler D Bold
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 189:2530-6. 2012
    ..tuberculosis. Conversely, defects in these interactions may contribute to susceptibility to tuberculosis and other infections...
  19. doi request reprint Illuminating the black box of TNF action in tuberculous granulomas
    Elizabeth A Miller
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Immunity 29:175-7. 2008
    ..In this issue of Immunity, Clay et al. (2008) provide unique insights, using intravital microscopy and the zebrafish-embryo model of tuberculosis...
  20. pmc Anti-TNF immunotherapy and tuberculosis reactivation: another mechanism revealed
    Elizabeth A Miller
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Clin Invest 119:1079-82. 2009
    ..The study provides insight into host defense mechanisms that act to control TB infection and how they are affected during anti-TNF immunotherapy for autoimmune disease...
  21. pmc TLR2-dependent inhibition of macrophage responses to IFN-gamma is mediated by distinct, gene-specific mechanisms
    Sarah A Benson
    Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 4:e6329. 2009
    ..Taken together, these results indicate that TLR2-dependent inhibition of IFN-gamma-induced gene expression is mediated by distinct, gene-specific mechanisms that disrupt binding of the transcriptional machinery to the promoters...
  22. pmc Variation of Mycobacterium tuberculosis antigen-specific IFN-γ and IL-17 responses in healthy tuberculin skin test (TST)-positive human subjects
    Lin Fan
    Division of Infectious Diseases, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 7:e42716. 2012
    ..To determine the variation of IFN-γ and IL-17 responses to M. tuberculosis antigens in healthy TST+ humans...
  23. ncbi request reprint Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2
    Niaz Banaiee
    Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 176:3019-27. 2006
    ..These results establish that M. tuberculosis possesses multiple mechanisms of inhibiting responses to IFN-gamma...
  24. ncbi request reprint Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo
    Andrea J Wolf
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 179:2509-19. 2007
    ..These results indicate that Mtb targets DC migration and Ag presentation in vivo to promote persistent infection...
  25. doi request reprint CO-opting the host HO-1 pathway in tuberculosis and malaria
    Photini Sinnis
    Department of Medical Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA
    Cell Host Microbe 3:277-9. 2008
    ..Here we discuss these findings as well as some of the interesting questions they raise...
  26. doi request reprint Who benefits from granulomas, mycobacteria or host?
    Tyler D Bold
    Department of Medicine Infectious Diseases, New York University Langone Medical Center, New York, NY 10016, USA
    Cell 136:17-9. 2009
    ....
  27. pmc Equivalent T cell epitope promiscuity in ecologically diverse human pathogens
    Kirsten E Wiens
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    PLoS ONE 8:e73124. 2013
    ..To address this question, we compared the in silico HLA binding promiscuity of T cell epitopes from pathogens with distinct infection strategies and outcomes of human exposure...
  28. doi request reprint Tuberculosis pathogenesis and immunity
    Jennifer A Philips
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    Annu Rev Pathol 7:353-84. 2012
    ..In addition, it highlights topics that need to be better understood to provide improved means of controlling TB worldwide...
  29. pmc HIV and tuberculosis: a deadly human syndemic
    Candice K Kwan
    Division of Infectious Diseases, New York University School of Medicine, New York, NY 10016 USA
    Clin Microbiol Rev 24:351-76. 2011
    ..This review examines current knowledge of the state and impact of the HIV-TB syndemic and reviews the epidemiological, clinical, cellular, and molecular interactions between HIV and TB...
  30. ncbi request reprint Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma
    Vijaya Nagabhushanam
    Division of Infectious Diseases, University of California, and Loewenstein Laboratory for Tuberculosis Research, San Francisco General Hospital, San Francisco, CA 94110, USA
    J Immunol 171:4750-7. 2003
    ..These results reveal a novel function for IL-6 and indicate that IL-6 secreted by Mtb-infected macrophages may contribute to the inability of the cellular immune response to eradicate infection...
  31. ncbi request reprint CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis
    Wendy Peters
    Gladstone Institute of Cardiovascular Disease, PO Box 419100, San Francisco, CA 94141, USA
    J Immunol 172:7647-53. 2004
    ..Further investigation revealed a critical role for CCR2 in the recruitment of F4/80(dim) macrophages and CD11c(dim/intermediate) DCs to the infected lung...
  32. ncbi request reprint Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms
    Sarah M Fortune
    Division of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 172:6272-80. 2004
    ..tuberculosis without inhibiting production of NO. These results imply that inhibition of macrophage responses to IFN-gamma may contribute to the inability of an apparently effective immune response to eradicate M. tuberculosis...
  33. ncbi request reprint Mycobacterium tuberculosis exerts gene-selective inhibition of transcriptional responses to IFN-gamma without inhibiting STAT1 function
    Eleanor Z Kincaid
    Biomedical Sciences Graduate Program and Division of Infectious Diseases, University of California, San Francisco, CA 94143, USA
    J Immunol 171:2042-9. 2003
    ....
  34. ncbi request reprint Mechanisms of cell recruitment in the immune response to Mycobacterium tuberculosis
    Wendy Peters
    Gladstone Institute of Cardiovascular Disease, PO Box 419100, San Francisco, CA 94141 9100, USA
    Microbes Infect 5:151-8. 2003
    ..This review concentrates on the roles of these molecules and the immune response in tuberculosis, based on studies of humans and mice infected with Mycobacterium tuberculosis...

Research Grants28

  1. Initiation of the Immune Response to M. tuberculosis
    JOEL ERNST; Fiscal Year: 2006
    ..tuberculosis. ..
  2. Initiation of the Immune Response to M. tuberculosis
    Joel D Ernst; Fiscal Year: 2010
    ....
  3. Type I Interferons in Immunity to Tuberculosis
    JOEL ERNST; Fiscal Year: 2007
    ..abstract_text> ..
  4. M. tuberculosis evasion of immune effector mechanisms
    JOEL ERNST; Fiscal Year: 2007
    ..The proposed experiments will provide high-resolution understanding of the mechanisms used by Mtb to block MO responses to IFNg, and will provide a basis for interventions to overcome the block and enhance immunity to Mtb. ..
  5. Mycobacterium tuberculosis evasion of CD4+ T cells in vivo
    Joel D Ernst; Fiscal Year: 2010
    ..We expect that understanding these mechanisms will allow us and others to develop novel ways to increase resistance of people to tuberculosis. ..
  6. M TUBERCULOSIS EVASION OF IMMUNE EFFECTOR MECHANISMS
    JOEL ERNST; Fiscal Year: 2003
    ..tuberculosis with the human immune system, particularly the ability of this pathogen to persist in the face of a seemingly appropriate immune response. ..
  7. Tuberculosis Immunity: Essential Host Genes
    JOEL ERNST; Fiscal Year: 2002
    ..In addition, they will determine the feasibility of analysis of gene expression in the lungs of specific strains of mice to ultimately identify genes that confer protection against tuberculosis. ..
  8. Mycobacterium tuberculosis antigen diversity
    Sebastien Gagneux; Fiscal Year: 2010
    ..The findings will have an important impact on development of new vaccines against tuberculosis. ..