Research Topics
Genomes and Genes
| Emanuel DiCicco-BloomSummaryAffiliation: New Jersey Country: USA Publications
Research Grants
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Detail Information
Publications
The PACAP ligand/receptor system regulates cerebral cortical neurogenesisE Dicicco-Bloom
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, USA
Ann N Y Acad Sci 865:274-89. 1998..The dynamic interplay of positive and negative regulators would regulate the timing of cell cycle withdrawal, and thus neuronal phenotype and laminar position...- DNAse I pre-treatment markedly enhances detection of nuclear cyclin-dependent kinase inhibitor p57Kip2 and BrdU double immunostaining in embryonic rat brainWeizhen Ye
Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, RWJ SPH 362, Piscataway, NJ, 08854, USA
Histochem Cell Biol 127:195-203. 2007.... - The developmental neurobiology of autism spectrum disorderEmanuel DiCicco-Bloom
Department of Neuroscience, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
J Neurosci 26:6897-906. 2006 - Neuroscience. Neuron, know thy neighborEmanuel DiCicco-Bloom
Department of Neuroscience and Cell Biology/Pediatrics (Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Science 311:1560-2. 2006 
Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin EKelly Burke
Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Neurotoxicology 27:970-81. 2006..In aggregate, our observations identify the G1/S transition as an early target of MeHg toxicity and raise the possibility that cyclin E degradation contributes to both decreased proliferation and eventual cell death...- Basic fibroblast growth factor exhibits dual and rapid regulation of cyclin D1 and p27 to stimulate proliferation of rat cerebral cortical precursorsBaogang Li
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Dev Neurosci 26:197-207. 2004..However, in addition to increased D1 cyclin, we unexpectedly detected a 75% reduction in p27KIP1 protein at 8 h, suggesting that both pro- and antimitogenic regulators are targets of extracellular mitogens during brain development... - p57(KIP2) regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortexGeorges Mairet-Coello
Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08554, USA
Development 139:475-87. 2012.... - Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferationArnaud Nicot
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
J Neurosci 22:9244-54. 2002..These observations suggest that G-protein-coupled receptors, such as PAC1, serve as sensors of environmental cues, coordinating diverse neurogenetic signals... - N-acetyl cysteine treatment reduces mercury-induced neurotoxicity in the developing rat hippocampusAnthony Falluel-Morel
Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
J Neurosci Res 90:743-50. 2012..Altogether these results suggest that MeHg toxicity in the perinatal brain can be ameliorated by using NAC, opening potential avenues for therapeutic intervention... - Hippocampal granule neuron production and population size are regulated by levels of bFGFYinghong Cheng
Department of Neuroscience and Cell Biology UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Eur J Neurosci 15:3-12. 2002..P., Black, I.B. & DiCicco-Bloom, E. (1999) J. Neurosci., 19, 6006], these observations suggest distinct, stage-specific roles of bFGF in the dentate gyrus granule cell lineage... - Developmental mercury exposure elicits acute hippocampal cell death, reductions in neurogenesis, and severe learning deficits during pubertyAnthony Falluel-Morel
Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
J Neurochem 103:1968-81. 2007..In aggregate, these studies indicate that exposure to one dose of MeHg during the perinatal period acutely induces apoptotic cell death, which results in later deficits in hippocampal structure and function... - Insulin-like growth factor-1 promotes G(1)/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase/Akt pathway in developing rat cerebral cortexGeorges Mairet-Coello
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
J Neurosci 29:775-88. 2009..These results demonstrate a mitogenic role for IGF-1 that tightly controls both positive and negative cell cycle regulators, and indicate that the PI3K/Akt pathway mediates IGF-1 mitogenic signaling during corticogenesis... 
The multiple roles of the cyclin-dependent kinase inhibitory protein p57(KIP2) in cerebral cortical neurogenesisAnna Tury
Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
Dev Neurobiol 72:821-42. 2012..Here, we focus our discussion on the multiple roles played by p57(KIP2) during cortical development, making comparisons to p27(KIP1) as well as the INK4 family of CKIs...- Patterns of p57Kip2 expression in embryonic rat brain suggest roles in progenitor cell cycle exit and neuronal differentiationWeizhen Ye
Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
Dev Neurobiol 69:1-21. 2009.... - The cyclin-dependent kinase inhibitor p57Kip2 regulates cell cycle exit, differentiation, and migration of embryonic cerebral cortical precursorsAnna Tury
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Cereb Cortex 21:1840-56. 2011..These observations suggest p57(Kip2) coordinates multiple stages of corticogenesis and exhibits distinct and common activities compared with related family member p27(Kip1)... - Methylmercury (MeHg) elicits mitochondrial-dependent apoptosis in developing hippocampus and acts at low exposuresKatie Sokolowski
Joint Graduate Program in Toxicology, Graduate School of Biomedical Sciences at Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Neurotoxicology 32:535-44. 2011..6 μg/g) than previously reported. Thus mitochondrial-dependent cell death in the hippocampus may serve as a sensitive index for teratogenic insults to the developing brain... - Moderate lead exposure elicits neurotrophic effects in cerebral cortical precursor cells in cultureZev Davidovics
Department of Neuroscience and Cell Biology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, 08854, USA
J Neurosci Res 80:817-25. 2005..Consequently, alterations in neural circuitry may underlie some of the neurological effects of Pb exposure during brain development... - Granule cell survival is deficient in PAC1-/- mutant cerebellumAnthony Falluel-Morel
Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Room RWJSPH 362, Piscataway, NJ 08854, USA
J Mol Neurosci 36:38-44. 2008..In aggregate, these results suggest that endogenous PACAP plays an important role in cell survival during cerebellar development, through the activation of the PAC1 receptor... - Pituitary adenylate cyclase activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is regulated by p57Kip2-dependent CDK2 activityRebecca G Carey
Department of Neuroscience and Cell Biology, Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
J Neurosci 22:1583-91. 2002..These observations establish a mechanism whereby anti-mitogenic signals actively induce cell cycle withdrawal in developing cortex... - Amphiregulin is a novel growth factor involved in normal bone development and in the cellular response to parathyroid hormone stimulationLing Qin
Physiology and Biophysics and Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
J Biol Chem 280:3974-81. 2005..Moreover, AR null mice displayed significantly less tibial trabecular bone than wild-type mice. Taken together, we have identified a novel growth factor that is PTH-regulated and appears to have an important role in bone metabolism... - Direct cAMP signaling through G-protein-coupled receptors mediates growth cone attraction induced by pituitary adenylate cyclase-activating polypeptideCarmine Guirland
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08852, USA
J Neurosci 23:2274-83. 2003..Such a direct cAMP pathway could potentially operate in other guidance systems for the accurate wiring of the nervous system... - Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locusRym Benayed
Center for Advanced Biotechnology and Medicine, Piscataway, NJ, 08854 5638, USA
Am J Hum Genet 77:851-68. 2005.... - Altered social behavior in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient miceArnaud Nicot
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
J Neurosci 24:8786-95. 2004..In turn, these studies raise the potential clinical relevance of PACAP signaling dysfunctions in neuropsychiatric disorders characterized by social reciprocity impairments such as autism spectrum disorders...
Research Grants
- PACAP REGULATION OF NEUROGENESIS AND SURVIVALEmanuel Dicicco Bloom; Fiscal Year: 2009..3) Define effects of anti-mitogenic signaling on cell fate of mitotic precursors in culture and in vivo using over-expression vectors. Thus, we may gain insight into fundamental processes generating cellular diversity. ..
- PACAP REGULATION OF NEUROGENESIS AND SURVIVALEmanuel Dicicco Bloom; Fiscal Year: 2001....