Emanuel DiCicco-Bloom

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi request reprint The PACAP ligand/receptor system regulates cerebral cortical neurogenesis
    E Dicicco-Bloom
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, USA
    Ann N Y Acad Sci 865:274-89. 1998
  2. ncbi request reprint DNAse I pre-treatment markedly enhances detection of nuclear cyclin-dependent kinase inhibitor p57Kip2 and BrdU double immunostaining in embryonic rat brain
    Weizhen Ye
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, RWJ SPH 362, Piscataway, NJ, 08854, USA
    Histochem Cell Biol 127:195-203. 2007
  3. ncbi request reprint The developmental neurobiology of autism spectrum disorder
    Emanuel DiCicco-Bloom
    Department of Neuroscience, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    J Neurosci 26:6897-906. 2006
  4. ncbi request reprint Neuroscience. Neuron, know thy neighbor
    Emanuel DiCicco-Bloom
    Department of Neuroscience and Cell Biology Pediatrics Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Science 311:1560-2. 2006
  5. pmc Pro- and anti-mitogenic actions of pituitary adenylate cyclase-activating polypeptide in developing cerebral cortex: potential mediation by developmental switch of PAC1 receptor mRNA isoforms
    Yan Yan
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 33:3865-78. 2013
  6. ncbi request reprint Basic fibroblast growth factor exhibits dual and rapid regulation of cyclin D1 and p27 to stimulate proliferation of rat cerebral cortical precursors
    Baogang Li
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Dev Neurosci 26:197-207. 2004
  7. pmc Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin E
    Kelly Burke
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Neurotoxicology 27:970-81. 2006
  8. pmc p57(KIP2) regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortex
    Georges Mairet-Coello
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08554, USA
    Development 139:475-87. 2012
  9. ncbi request reprint Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation
    Arnaud Nicot
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 22:9244-54. 2002
  10. pmc N-acetyl cysteine treatment reduces mercury-induced neurotoxicity in the developing rat hippocampus
    Anthony Falluel-Morel
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Neurosci Res 90:743-50. 2012

Research Grants

  1. PACAP REGULATION OF NEUROGENESIS AND SURVIVAL
    Emanuel Dicicco Bloom; Fiscal Year: 2009
  2. PACAP REGULATION OF NEUROGENESIS AND SURVIVAL
    Emanuel Dicicco Bloom; Fiscal Year: 2001

Collaborators

Detail Information

Publications24

  1. ncbi request reprint The PACAP ligand/receptor system regulates cerebral cortical neurogenesis
    E Dicicco-Bloom
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, USA
    Ann N Y Acad Sci 865:274-89. 1998
    ..The dynamic interplay of positive and negative regulators would regulate the timing of cell cycle withdrawal, and thus neuronal phenotype and laminar position...
  2. ncbi request reprint DNAse I pre-treatment markedly enhances detection of nuclear cyclin-dependent kinase inhibitor p57Kip2 and BrdU double immunostaining in embryonic rat brain
    Weizhen Ye
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, RWJ SPH 362, Piscataway, NJ, 08854, USA
    Histochem Cell Biol 127:195-203. 2007
    ....
  3. ncbi request reprint The developmental neurobiology of autism spectrum disorder
    Emanuel DiCicco-Bloom
    Department of Neuroscience, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    J Neurosci 26:6897-906. 2006
  4. ncbi request reprint Neuroscience. Neuron, know thy neighbor
    Emanuel DiCicco-Bloom
    Department of Neuroscience and Cell Biology Pediatrics Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Science 311:1560-2. 2006
  5. pmc Pro- and anti-mitogenic actions of pituitary adenylate cyclase-activating polypeptide in developing cerebral cortex: potential mediation by developmental switch of PAC1 receptor mRNA isoforms
    Yan Yan
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 33:3865-78. 2013
    ..5. These observations suggest that PACAP elicits temporally specific effects on cortical proliferation via developmentally regulated expression of specific receptor isoforms...
  6. ncbi request reprint Basic fibroblast growth factor exhibits dual and rapid regulation of cyclin D1 and p27 to stimulate proliferation of rat cerebral cortical precursors
    Baogang Li
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Dev Neurosci 26:197-207. 2004
    ..However, in addition to increased D1 cyclin, we unexpectedly detected a 75% reduction in p27KIP1 protein at 8 h, suggesting that both pro- and antimitogenic regulators are targets of extracellular mitogens during brain development...
  7. pmc Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin E
    Kelly Burke
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Neurotoxicology 27:970-81. 2006
    ..In aggregate, our observations identify the G1/S transition as an early target of MeHg toxicity and raise the possibility that cyclin E degradation contributes to both decreased proliferation and eventual cell death...
  8. pmc p57(KIP2) regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortex
    Georges Mairet-Coello
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08554, USA
    Development 139:475-87. 2012
    ....
  9. ncbi request reprint Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation
    Arnaud Nicot
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 22:9244-54. 2002
    ..These observations suggest that G-protein-coupled receptors, such as PAC1, serve as sensors of environmental cues, coordinating diverse neurogenetic signals...
  10. pmc N-acetyl cysteine treatment reduces mercury-induced neurotoxicity in the developing rat hippocampus
    Anthony Falluel-Morel
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Neurosci Res 90:743-50. 2012
    ..Altogether these results suggest that MeHg toxicity in the perinatal brain can be ameliorated by using NAC, opening potential avenues for therapeutic intervention...
  11. ncbi request reprint Hippocampal granule neuron production and population size are regulated by levels of bFGF
    Yinghong Cheng
    Department of Neuroscience and Cell Biology UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Eur J Neurosci 15:3-12. 2002
    ..P., Black, I.B. & DiCicco-Bloom, E. (1999) J. Neurosci., 19, 6006], these observations suggest distinct, stage-specific roles of bFGF in the dentate gyrus granule cell lineage...
  12. pmc Insulin-like growth factor-1 promotes G(1)/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase/Akt pathway in developing rat cerebral cortex
    Georges Mairet-Coello
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Neurosci 29:775-88. 2009
    ..These results demonstrate a mitogenic role for IGF-1 that tightly controls both positive and negative cell cycle regulators, and indicate that the PI3K/Akt pathway mediates IGF-1 mitogenic signaling during corticogenesis...
  13. pmc Developmental mercury exposure elicits acute hippocampal cell death, reductions in neurogenesis, and severe learning deficits during puberty
    Anthony Falluel-Morel
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    J Neurochem 103:1968-81. 2007
    ..In aggregate, these studies indicate that exposure to one dose of MeHg during the perinatal period acutely induces apoptotic cell death, which results in later deficits in hippocampal structure and function...
  14. doi request reprint The multiple roles of the cyclin-dependent kinase inhibitory protein p57(KIP2) in cerebral cortical neurogenesis
    Anna Tury
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Dev Neurobiol 72:821-42. 2012
    ..Here, we focus our discussion on the multiple roles played by p57(KIP2) during cortical development, making comparisons to p27(KIP1) as well as the INK4 family of CKIs...
  15. pmc Patterns of p57Kip2 expression in embryonic rat brain suggest roles in progenitor cell cycle exit and neuronal differentiation
    Weizhen Ye
    Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Dev Neurobiol 69:1-21. 2009
    ....
  16. pmc The cyclin-dependent kinase inhibitor p57Kip2 regulates cell cycle exit, differentiation, and migration of embryonic cerebral cortical precursors
    Anna Tury
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Cereb Cortex 21:1840-56. 2011
    ..These observations suggest p57(Kip2) coordinates multiple stages of corticogenesis and exhibits distinct and common activities compared with related family member p27(Kip1)...
  17. pmc Methylmercury (MeHg) elicits mitochondrial-dependent apoptosis in developing hippocampus and acts at low exposures
    Katie Sokolowski
    Joint Graduate Program in Toxicology, Graduate School of Biomedical Sciences at Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Neurotoxicology 32:535-44. 2011
    ..6 μg/g) than previously reported. Thus mitochondrial-dependent cell death in the hippocampus may serve as a sensitive index for teratogenic insults to the developing brain...
  18. ncbi request reprint Moderate lead exposure elicits neurotrophic effects in cerebral cortical precursor cells in culture
    Zev Davidovics
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, 08854, USA
    J Neurosci Res 80:817-25. 2005
    ..Consequently, alterations in neural circuitry may underlie some of the neurological effects of Pb exposure during brain development...
  19. ncbi request reprint Pituitary adenylate cyclase activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is regulated by p57Kip2-dependent CDK2 activity
    Rebecca G Carey
    Department of Neuroscience and Cell Biology, Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 22:1583-91. 2002
    ..These observations establish a mechanism whereby anti-mitogenic signals actively induce cell cycle withdrawal in developing cortex...
  20. doi request reprint Granule cell survival is deficient in PAC1-/- mutant cerebellum
    Anthony Falluel-Morel
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Room RWJSPH 362, Piscataway, NJ 08854, USA
    J Mol Neurosci 36:38-44. 2008
    ..In aggregate, these results suggest that endogenous PACAP plays an important role in cell survival during cerebellar development, through the activation of the PAC1 receptor...
  21. ncbi request reprint Amphiregulin is a novel growth factor involved in normal bone development and in the cellular response to parathyroid hormone stimulation
    Ling Qin
    Physiology and Biophysics and Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:3974-81. 2005
    ..Moreover, AR null mice displayed significantly less tibial trabecular bone than wild-type mice. Taken together, we have identified a novel growth factor that is PTH-regulated and appears to have an important role in bone metabolism...
  22. ncbi request reprint Direct cAMP signaling through G-protein-coupled receptors mediates growth cone attraction induced by pituitary adenylate cyclase-activating polypeptide
    Carmine Guirland
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08852, USA
    J Neurosci 23:2274-83. 2003
    ..Such a direct cAMP pathway could potentially operate in other guidance systems for the accurate wiring of the nervous system...
  23. pmc Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus
    Rym Benayed
    Center for Advanced Biotechnology and Medicine, Piscataway, NJ, 08854 5638, USA
    Am J Hum Genet 77:851-68. 2005
    ....
  24. ncbi request reprint Altered social behavior in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice
    Arnaud Nicot
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 24:8786-95. 2004
    ..In turn, these studies raise the potential clinical relevance of PACAP signaling dysfunctions in neuropsychiatric disorders characterized by social reciprocity impairments such as autism spectrum disorders...

Research Grants13

  1. PACAP REGULATION OF NEUROGENESIS AND SURVIVAL
    Emanuel Dicicco Bloom; Fiscal Year: 2009
    ..3) Define effects of anti-mitogenic signaling on cell fate of mitotic precursors in culture and in vivo using over-expression vectors. Thus, we may gain insight into fundamental processes generating cellular diversity. ..
  2. PACAP REGULATION OF NEUROGENESIS AND SURVIVAL
    Emanuel Dicicco Bloom; Fiscal Year: 2001
    ....