G Diamond

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells
    G Diamond
    Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Infect Immun 68:113-9. 2000
  2. pmc Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D(3)
    Sunghan Yim
    Department of Oral Biology, UMDNJ New Jersey Dental School, 185 South Orange Ave, Newark, NJ 07103, USA
    J Cyst Fibros 6:403-10. 2007
  3. pmc One of two human lactoferrin variants exhibits increased antibacterial and transcriptional activation activities and is associated with localized juvenile periodontitis
    Kabilan Velliyagounder
    Department of Oral Biology, New Jersey Dental School, Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Infect Immun 71:6141-7. 2003
  4. pmc Activity of an antimicrobial peptide mimetic against planktonic and biofilm cultures of oral pathogens
    Nicholas Beckloff
    Department of Oral Biology, UMDNJ New Jersey Dental School, 185 South Orange Ave, Newark, NJ 07103, USA
    Antimicrob Agents Chemother 51:4125-32. 2007
  5. pmc The roles of antimicrobial peptides in innate host defense
    Gill Diamond
    Department of Oral Biology, UMDNJ New Jersey Dental School, Newark, NJ 07101, USA
    Curr Pharm Des 15:2377-92. 2009
  6. pmc Beta-defensins: what are they really doing in the oral cavity?
    G Diamond
    Department of Oral Biology, UMDNJ New Jersey Dental School, Newark, NJ 07101, USA
    Oral Dis 17:628-35. 2011
  7. ncbi The innate immune response of the respiratory epithelium
    G Diamond
    Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ New Jersey Medical School, Newark 07103, USA
    Immunol Rev 173:27-38. 2000
  8. pmc Host defense peptides in the oral cavity and the lung: similarities and differences
    G Diamond
    Department of Oral Biology, UMDNJ New Jersey Dental School, 185 South Orange Ave, Newark 07103, NJ 07101, USA
    J Dent Res 87:915-27. 2008
  9. pmc Activity of antimicrobial peptide mimetics in the oral cavity: II. Activity against periopathogenic biofilms and anti-inflammatory activity
    J Hua
    Department of Oral Biology, UMDNJ New Jersey Dental School, Newark, NJ 07103, USA
    Mol Oral Microbiol 25:426-32. 2010
  10. ncbi Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder
    A M Cole
    Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ New Jersey Medical School and Graduate School of Biomedical Sciences, Newark, New Jersey 07103, USA
    J Biol Chem 272:12008-13. 1997

Research Grants

Collaborators

Detail Information

Publications25

  1. pmc Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells
    G Diamond
    Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Infect Immun 68:113-9. 2000
    ..Together, these observations indicate that a strategy for the induction of peptide-based antimicrobial innate immunity is conserved among evolutionarily diverse organisms...
  2. pmc Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D(3)
    Sunghan Yim
    Department of Oral Biology, UMDNJ New Jersey Dental School, 185 South Orange Ave, Newark, NJ 07103, USA
    J Cyst Fibros 6:403-10. 2007
    ..Furthermore, serum levels of vitamin D are often deficient in cystic fibrosis (CF) patients...
  3. pmc One of two human lactoferrin variants exhibits increased antibacterial and transcriptional activation activities and is associated with localized juvenile periodontitis
    Kabilan Velliyagounder
    Department of Oral Biology, New Jersey Dental School, Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Infect Immun 71:6141-7. 2003
    ..Our findings suggest that these two lactoferrin variants are functionally different and that these differences may contribute to the pathogenesis of localized juvenile periodontitis...
  4. pmc Activity of an antimicrobial peptide mimetic against planktonic and biofilm cultures of oral pathogens
    Nicholas Beckloff
    Department of Oral Biology, UMDNJ New Jersey Dental School, 185 South Orange Ave, Newark, NJ 07103, USA
    Antimicrob Agents Chemother 51:4125-32. 2007
    ..We conclude that mPE and similar molecules display great potential for development as therapeutic antimicrobials...
  5. pmc The roles of antimicrobial peptides in innate host defense
    Gill Diamond
    Department of Oral Biology, UMDNJ New Jersey Dental School, Newark, NJ 07101, USA
    Curr Pharm Des 15:2377-92. 2009
    ..These peptides represent not only an important component of innate host defense against microbial colonization and a link between innate and adaptive immunity, but also form a foundation for the development of new therapeutic agents...
  6. pmc Beta-defensins: what are they really doing in the oral cavity?
    G Diamond
    Department of Oral Biology, UMDNJ New Jersey Dental School, Newark, NJ 07101, USA
    Oral Dis 17:628-35. 2011
    ..Together, the in vitro, in vivo and human studies suggest that these peptides are important in the biology of the oral cavity; exactly how is still subject to speculation...
  7. ncbi The innate immune response of the respiratory epithelium
    G Diamond
    Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ New Jersey Medical School, Newark 07103, USA
    Immunol Rev 173:27-38. 2000
    ..This can lead to increased susceptibility to airway infections...
  8. pmc Host defense peptides in the oral cavity and the lung: similarities and differences
    G Diamond
    Department of Oral Biology, UMDNJ New Jersey Dental School, 185 South Orange Ave, Newark 07103, NJ 07101, USA
    J Dent Res 87:915-27. 2008
    ..In this review, we examine the differences and similarities between host defense peptides in the oral cavity and the airway, to gain a better understanding of their contributions to immunity...
  9. pmc Activity of antimicrobial peptide mimetics in the oral cavity: II. Activity against periopathogenic biofilms and anti-inflammatory activity
    J Hua
    Department of Oral Biology, UMDNJ New Jersey Dental School, Newark, NJ 07103, USA
    Mol Oral Microbiol 25:426-32. 2010
    ....
  10. ncbi Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder
    A M Cole
    Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ New Jersey Medical School and Graduate School of Biomedical Sciences, Newark, New Jersey 07103, USA
    J Biol Chem 272:12008-13. 1997
    ..Immunohistochemistry locates pleurocidin in the epithelial mucous cells of flounder skin. Pleurocidin represents a novel antimicrobial peptide found in fish and may play a role in innate host defense...
  11. ncbi Antimicrobial peptides in the airway
    D M Laube
    Department of Oral Biology, UMDNJ New Jersey Dental School, Newark 07101, USA
    Curr Top Microbiol Immunol 306:153-82. 2006
    ..Research into the modulation of peptide gene expression in animal models, as well as the optimization of peptide-based therapeutics shows promise for the treatment and prevention of airway infectious diseases...
  12. pmc Induction of a rat enteric defensin gene by hemorrhagic shock
    M R Condon
    Department of Veterans Affairs Medical Center, East Orange, New Jersey, USA
    Infect Immun 67:4787-93. 1999
    ..This is the first study to show that enteric defensins are inducible following injury. We suggest that enteric defensins may contribute to the complex and integrated barrier function of the intestinal mucosal surface...
  13. ncbi Detection of HBD1 peptide in peripheral blood mononuclear cell subpopulations by intracellular flow cytometry
    Lisa K Ryan
    Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA
    Peptides 24:1785-94. 2003
    ..This response was limited to monocytes when ultrapure LPS was used, and was inhibited in PDC by chloroquine treatment...
  14. ncbi Differential regulation of innate immune response genes in gingival epithelial cells stimulated with Aggregatibacter actinomycetemcomitans
    D M Laube
    Department of Oral Biology, UMDNJ New Jersey Dental School, Newark, NJ 07103, USA
    J Periodontal Res 43:116-23. 2008
    ..We hypothesized that gingival epithelial cell-derived innate immune mediators triggered in response to A. actinomycetemcomitans infection may play an important role in increased susceptibility to infection...
  15. ncbi Natures antibiotics: the potential of antimicrobial peptides as new drugs
    G Diamond
    UMDNJ - New Jersey Medical School, Newark, NJ, USA
    Biologist (London) 48:209-12. 2001
    ..Research into these peptides not only give us an insight into how we naturally prevent infections, but can also provide us with new drugs to treat the ever-increasing danger of infections caused by antibiotic-resistant bacteria...
  16. pmc Activity of antimicrobial peptide mimetics in the oral cavity: I. Activity against biofilms of Candida albicans
    J Hua
    Department of Oral Biology, UMDNJ New Jersey Dental School, Newark, NJ 07103, USA
    Mol Oral Microbiol 25:418-25. 2010
    ..Our results demonstrate the proof-of principle for the use of these compounds as anti-Candida agents, and their further testing is warranted as novel anti-Candida therapies...
  17. pmc In vivo beta-defensin gene expression in rat gingival epithelium in response to Actinobacillus actinomycetemcomitans infection
    A R Kurland
    Department of Oral Biology, UMDNJ New Jersey Dental School, Newark, NJ 07101, USA
    J Periodontal Res 41:567-72. 2006
    ..Therefore, the aim of this study was to investigate the expression of innate immune mediators in the rat gingival epithelium...
  18. pmc Measuring antimicrobial peptide activity on epithelial surfaces in cell culture
    Gill Diamond
    Department of Oral Biology, UMDNJ New Jersey Dental School, Newark, NJ, USA
    Methods Mol Biol 618:371-82. 2010
    ..Thus, a relatively inexpensive in vitro model can be used to evaluate the role of antimicrobial peptides in mucosal epithelium...
  19. pmc Suppression of NF-kappaB-mediated beta-defensin gene expression in the mammalian airway by the Bordetella type III secretion system
    Diana Legarda
    Department of Oral Biology, UMDNJ New Jersey Dental School, Newark, NJ, USA
    Cell Microbiol 7:489-97. 2005
    ..These results suggest a mechanism for bacterial evasion of the innate immune response in the airway, which could allow for the observed persistent colonization of this pathogen...
  20. pmc Vitamin D-mediated induction of innate immunity in gingival epithelial cells
    Laura McMahon
    Department of Oral Biology, UMDNJ New Jersey Dental School, Newark, NJ 07101, USA
    Infect Immun 79:2250-6. 2011
    ..This study is the first to demonstrate the effect of vitamin D on antibacterial defense of oral epithelial cells, suggesting that vitamin D(3) could be utilized to enhance the innate immune defense in the oral cavity...
  21. ncbi Computational analysis suggests beta-defensins are processed to mature peptides by signal peptidase
    Nicholas Beckloff
    Department of Oral Biology, UMDNJ New Jersey Dental School, Newark, NJ 07101, USA
    Protein Pept Lett 15:536-40. 2008
    ..This supports the extensive transcriptional control of beta-defensin expression compared with other AMP genes...
  22. pmc Inhibition of beta-defensin gene expression in airway epithelial cells by low doses of residual oil fly ash is mediated by vanadium
    Marcia E Klein-Patel
    Department of Oral Biology, UMDNJ New Jersey Dental School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Toxicol Sci 92:115-25. 2006
    ....
  23. pmc Coordinated expression of tracheal antimicrobial peptide and inflammatory-response elements in the lungs of neonatal calves with acute bacterial pneumonia
    Jessica M Caverly
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011 1250, USA
    Infect Immun 71:2950-5. 2003
    ..This work suggests that the coordinated expression of beta-defensin and inflammatory elements occurs during bacterial pneumonia...
  24. pmc Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions
    Edith Porter
    Department of Biological Sciences, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, USA
    Infect Immun 73:4823-33. 2005
    ....
  25. pmc Human {beta}-defensin 2 is expressed and associated with Mycobacterium tuberculosis during infection of human alveolar epithelial cells
    Bruno Rivas-Santiago
    Department of Microbiology, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
    Infect Immun 73:4505-11. 2005
    ..As HBD-2 has been shown to control growth of M. tuberculosis and has chemotactic activity, our results suggest that HBD-2 induction by M. tuberculosis may have a role in the pathogenesis of human tuberculosis...

Research Grants10

  1. Host-Pathogen Interactions in the Mammalian Airway
    Gill Diamond; Fiscal Year: 2006
    ..This would include strategies to modulate the endogenous antimicrobial peptide expression to prevent serious bacterial infections. ..
  2. Bacteria-host cell interactions in periodontal disease
    Gill Diamond; Fiscal Year: 2005
    ..The result from this study will allow us to develop novel strategies to prevent attachment and colonization of disease-causing bacteria. ..