L A Devi

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Sequestration of the delta opioid receptor. Role of the C terminus in agonist-mediated internalization
    N Trapaidze
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 271:29279-85. 1996
  2. ncbi request reprint Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking
    L A Devi
    Dept of Pharmacology, New York University School of Medicine, New York, NY, USA
    Trends Pharmacol Sci 22:532-7. 2001
  3. pmc Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation
    B A Jordan
    Department of Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 98:343-8. 2001
  4. ncbi request reprint Defective prodynorphin processing in mice lacking prohormone convertase PC2
    Y Berman
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    J Neurochem 75:1763-70. 2000
  5. ncbi request reprint G-protein-coupled receptor dimerization: modulation of receptor function
    C D Rios
    Department of Pharmacology, New York University School of Medicine, MSB 408, 550 First Avenue, New York 10016, USA
    Pharmacol Ther 92:71-87. 2001
  6. ncbi request reprint G protein coupled receptor dimerization: implications in modulating receptor function
    I Gomes
    Department of Pharmacology, New York University School of Medicine, NY 10016, USA
    J Mol Med 79:226-42. 2001
  7. ncbi request reprint ProSAAS processing in mouse brain and pituitary
    N Mzhavia
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 276:6207-13. 2001
  8. ncbi request reprint Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice
    Y Berman
    Department of Pharmacology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 276:1466-73. 2001
  9. pmc Heterodimerization of mu and delta opioid receptors: A role in opiate synergy
    I Gomes
    Departments of Pharmacology and Anesthesiology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 20:RC110. 2000
  10. pmc Functional interactions between mu opioid and alpha 2A-adrenergic receptors
    B A Jordan
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, 19 84 Annenberg Building, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Pharmacol 64:1317-24. 2003

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Sequestration of the delta opioid receptor. Role of the C terminus in agonist-mediated internalization
    N Trapaidze
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 271:29279-85. 1996
    ....
  2. ncbi request reprint Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking
    L A Devi
    Dept of Pharmacology, New York University School of Medicine, New York, NY, USA
    Trends Pharmacol Sci 22:532-7. 2001
    ..In this article, the techniques used to study GPCR heterodimers, and the 'novel pharmacology' and functional implications resulting from heterodimerization will be discussed...
  3. pmc Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation
    B A Jordan
    Department of Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 98:343-8. 2001
    ..Taken together, these results provide direct evidence of heteromerization of GPCRs that couple to different types of G-proteins, which results in the modulation of receptor trafficking and signal transduction...
  4. ncbi request reprint Defective prodynorphin processing in mice lacking prohormone convertase PC2
    Y Berman
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    J Neurochem 75:1763-70. 2000
    ..Taken together, these results support a critical role for PC2 in the generation of Dyn peptides...
  5. ncbi request reprint G-protein-coupled receptor dimerization: modulation of receptor function
    C D Rios
    Department of Pharmacology, New York University School of Medicine, MSB 408, 550 First Avenue, New York 10016, USA
    Pharmacol Ther 92:71-87. 2001
    ..In addition, we discuss domains of the receptors that are thought to facilitate dimerization/oligomerization. Finally, we consider recent evidence for the subcellular localization of the dimer/oligomer assembly...
  6. ncbi request reprint G protein coupled receptor dimerization: implications in modulating receptor function
    I Gomes
    Department of Pharmacology, New York University School of Medicine, NY 10016, USA
    J Mol Med 79:226-42. 2001
    ..Thus dimerization appears to be a universal phenomenon that provides an additional mechanism for modulation of receptor function as well as cross-talk between G protein coupled receptors...
  7. ncbi request reprint ProSAAS processing in mouse brain and pituitary
    N Mzhavia
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 276:6207-13. 2001
    ..The observation that little SAAS and big LEN are the major forms of these peptides produced in mouse brain and pituitary raises the possibility that these peptides function as neurotransmitters or hormones...
  8. ncbi request reprint Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice
    Y Berman
    Department of Pharmacology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 276:1466-73. 2001
    ....
  9. pmc Heterodimerization of mu and delta opioid receptors: A role in opiate synergy
    I Gomes
    Departments of Pharmacology and Anesthesiology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 20:RC110. 2000
    ..Taken together, these studies show that heterodimers exhibit distinct ligand binding and signaling characteristics. These findings have important clinical ramifications and may provide new foundations for more effective therapies...
  10. pmc Functional interactions between mu opioid and alpha 2A-adrenergic receptors
    B A Jordan
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, 19 84 Annenberg Building, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Pharmacol 64:1317-24. 2003
    ..Taken together, these results suggest that physical associations between mu and alpha2A receptors could play a role in the functional interactions between these receptors...
  11. pmc G-protein-coupled receptor heterodimerization modulates receptor function
    B A Jordan
    Department of Pharmacology, New York University School of Medicine, New York 10016, USA
    Nature 399:697-700. 1999
    ..Furthermore, the kappa-delta heterodimer synergistically binds highly selective agonists and potentiates signal transduction. Thus, heterodimerization of these GPCRs represents a novel mechanism that modulates their function...
  12. ncbi request reprint Cloning, expression, and characterization of human metalloprotease 1: a novel member of the pitrilysin family of metalloendoproteases
    N Mzhavia
    Department of Pharmacology, New York University School of Medicine, NY 10016, USA
    DNA Cell Biol 18:369-80. 1999
    ..Taken together, these results suggest that hMP1 is a novel member of the metalloendoprotease superfamily with ubiquitous distribution that could play a broad role in general cellular regulation...
  13. ncbi request reprint The C-terminal region of proSAAS is a potent inhibitor of prohormone convertase 1
    Y Qian
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 275:23596-601. 2000
    ..High concentrations of the inhibitory peptide quantitatively release the bound PC1. Taken together, these data support the proposal that proSAAS functions as an endogenous inhibitor of PC1...
  14. ncbi request reprint Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing
    L D Fricker
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 20:639-48. 2000
    ..Purified proSAAS inhibits prohormone convertase 1 activity with an IC(50) of 590 nM but does not inhibit prohormone convertase 2. Taken together, proSAAS may represent an endogenous inhibitor of prohormone convertase 1...
  15. ncbi request reprint Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1
    A Basak
    Laboratories of Molecular Medicine and Diseases of Ageing Center, Loeb Health Research Institute, The Ottawa Hospital, Ottawa, Ontario K1Y 4K9, Canada
    J Biol Chem 276:32720-8. 2001
    ..Molecular modeling studies and circular dichroism analysis indicate an extended and poly-l-proline II type structural conformation for proSAAS-(235-244), the most potent PC1 inhibitor, a feature not present in poor PC1 inhibitors...
  16. pmc Identification of peptides from brain and pituitary of Cpe(fat)/Cpe(fat) mice
    F Y Che
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 98:9971-6. 2001
    ..In addition, the general technique of using affinity chromatography to isolate endogenous substrates from a mutant organism lacking an enzyme should be applicable to a wide range of enzyme-substrate systems...
  17. ncbi request reprint Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing
    L D Fricker
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 271:30619-24. 1996
    ..Furthermore, the increase in levels of high molecular weight enkephalin peptides in the Cpefat/Cpefat mouse suggests that CPE is required for efficient peptide processing by the endopeptidases...