Sandra Demaria

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated
    Sandra Demaria
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    Int J Radiat Oncol Biol Phys 58:862-70. 2004
  2. ncbi request reprint Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer
    Sandra Demaria
    Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Clin Cancer Res 11:728-34. 2005
  3. pmc Combining radiotherapy and immunotherapy: a revived partnership
    Sandra Demaria
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Int J Radiat Oncol Biol Phys 63:655-66. 2005
  4. doi request reprint Effects of chemoradiation on tumor-host interactions: the immunologic side
    Silvia C Formenti
    J Clin Oncol 26:1562-3; author reply 1563. 2008
  5. ncbi request reprint Select forms of tumor cell apoptosis induce dendritic cell maturation
    Sandra Demaria
    MSB 563, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Leukoc Biol 77:361-8. 2005
  6. ncbi request reprint Sensors of ionizing radiation effects on the immunological microenvironment of cancer
    Sandra Demaria
    Department of Pathology, NYU Cancer Institute, New York University School of Medicine, New York 10016, USA
    Int J Radiat Biol 83:819-25. 2007
  7. pmc Radiotherapy enhances antitumor effect of anti-CD137 therapy in a mouse Glioma model
    Elizabeth W Newcomb
    Departments of Pathology, New York University School of Medicine and NYU Cancer Institute and Langone Medical Center, New York, New York 10016, USA
    Radiat Res 173:426-32. 2010
  8. pmc Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
    M Zahidunnabi Dewan
    Department of Pathology, New York University School of Medicine and New York University Langone Medical Center, New York, New York 10016, USA
    Clin Cancer Res 15:5379-88. 2009
  9. pmc Invariant natural killer T cells regulate breast cancer response to radiation and CTLA-4 blockade
    Karsten A Pilones
    Department of Pathology, New York University School of Medicine and NYU Langone Medical Center, New York, New York 10016, USA
    Clin Cancer Res 15:597-606. 2009
  10. pmc Synergy of topical toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancer
    M Zahidunnabi Dewan
    Department of Pathology, Radiology, Radiation Oncology, and Medicine, New York University School of Medicine, and NYU Langone Medical Center, New York, New York 10016, USA
    Clin Cancer Res 18:6668-78. 2012

Research Grants

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated
    Sandra Demaria
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    Int J Radiat Oncol Biol Phys 58:862-70. 2004
    ..We therefore tested the hypothesis that the abscopal effect elicited by radiation is immune mediated. This was directly tested by enhancing the number of available dendritic cells using the growth factor Flt3-Ligand (Flt3-L)...
  2. ncbi request reprint Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer
    Sandra Demaria
    Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Clin Cancer Res 11:728-34. 2005
    ..Here we tested the hypothesis that the combination of RT to the primary tumor with CTLA-4 blockade can elicit antitumor immunity inhibiting the metastases...
  3. pmc Combining radiotherapy and immunotherapy: a revived partnership
    Sandra Demaria
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Int J Radiat Oncol Biol Phys 63:655-66. 2005
    ..In addition, the experimental evidence supporting the contention that RT can be used as a tool to induce antitumor immunity is discussed, and a new approach to radioimmunotherapy of cancer is proposed...
  4. doi request reprint Effects of chemoradiation on tumor-host interactions: the immunologic side
    Silvia C Formenti
    J Clin Oncol 26:1562-3; author reply 1563. 2008
  5. ncbi request reprint Select forms of tumor cell apoptosis induce dendritic cell maturation
    Sandra Demaria
    MSB 563, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Leukoc Biol 77:361-8. 2005
    ..These data have important implications for the effects of chemotherapy on antitumor immunity in solid and hematologic malignancies...
  6. ncbi request reprint Sensors of ionizing radiation effects on the immunological microenvironment of cancer
    Sandra Demaria
    Department of Pathology, NYU Cancer Institute, New York University School of Medicine, New York 10016, USA
    Int J Radiat Biol 83:819-25. 2007
    ..We will briefly review some of the recently emerged evidence that irradiation of the tumor and its microenvironment can induce essential molecular signals required for an effective response of the immune system to the tumor...
  7. pmc Radiotherapy enhances antitumor effect of anti-CD137 therapy in a mouse Glioma model
    Elizabeth W Newcomb
    Departments of Pathology, New York University School of Medicine and NYU Cancer Institute and Langone Medical Center, New York, New York 10016, USA
    Radiat Res 173:426-32. 2010
    ..In view of the finding that radiation enhanced the antitumor effect of anti-CD137 therapy, this approach should be studied further for clinical translation...
  8. pmc Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
    M Zahidunnabi Dewan
    Department of Pathology, New York University School of Medicine and New York University Langone Medical Center, New York, New York 10016, USA
    Clin Cancer Res 15:5379-88. 2009
    ..This study tested the hypothesis that the type of dose fractionation regimen determines the ability of radiotherapy to synergize with anti-CTLA-4 antibody...
  9. pmc Invariant natural killer T cells regulate breast cancer response to radiation and CTLA-4 blockade
    Karsten A Pilones
    Department of Pathology, New York University School of Medicine and NYU Langone Medical Center, New York, New York 10016, USA
    Clin Cancer Res 15:597-606. 2009
    ..Here we tested the hypothesis that invariant natural killer T (iNKT) cells, a subset with unique regulatory functions, can regulate the response to radiotherapy and CTLA-4 blockade...
  10. pmc Synergy of topical toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancer
    M Zahidunnabi Dewan
    Department of Pathology, Radiology, Radiation Oncology, and Medicine, New York University School of Medicine, and NYU Langone Medical Center, New York, New York 10016, USA
    Clin Cancer Res 18:6668-78. 2012
    ..This study tested the hypothesis that topical Toll-like receptor (TLR) 7 agonist imiquimod promotes antitumor immunity and synergizes with other treatments in a model of skin-involving breast cancer...
  11. pmc Up-regulation of the pro-inflammatory chemokine CXCL16 is a common response of tumor cells to ionizing radiation
    Satoko Matsumura
    Departments of Pathology, New York University School of Medicine and NYU Langone Medical Center, New York, New York 10016, USA
    Radiat Res 173:418-25. 2010
    ..Overall, our data indicate that up-regulation of CXCL16 is a common response of tumor cells to radiation, and they have important implications for the use of local radiotherapy in combination with immunotherapy...
  12. pmc Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects
    Maria Grazia Ruocco
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    J Clin Invest 122:3718-30. 2012
    ..These results demonstrate that anti-CTLA-4 mAb therapy induces motility of TIL and that NKG2D ligation offsets this effect to enhance TILs arrest and antitumor activity...
  13. pmc Topical TLR7 agonist imiquimod can induce immune-mediated rejection of skin metastases in patients with breast cancer
    Sylvia Adams
    Departments of Medicine, New York University School of Medicine, New York, New York 10016, USA
    Clin Cancer Res 18:6748-57. 2012
    ..Here we tested the hypothesis that topical imiquimod stimulates local antitumor immunity and induces the regression of breast cancer skin metastases...
  14. ncbi request reprint The combination of ionizing radiation and peripheral vaccination produces long-term survival of mice bearing established invasive GL261 gliomas
    Elizabeth W Newcomb
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Clin Cancer Res 12:4730-7. 2006
    ..Here, we tested the hypothesis that whole-brain radiotherapy (WBRT) up-regulates MHC-I expression on GL261 tumors and enhances the effectiveness of immunotherapy...
  15. pmc TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo
    Fanny Bouquet
    Department of Radiation Oncology, New York University School of Medicine, New York, New York 10016, USA
    Clin Cancer Res 17:6754-65. 2011
    ..To determine whether inhibition of TGFβ signaling prior to irradiation sensitizes human and murine cancer cells in vitro and in vivo...
  16. pmc Systemic effects of local radiotherapy
    Silvia C Formenti
    Department of Radiation Oncology, NYU Langone Medical Center and NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Lancet Oncol 10:718-26. 2009
    ..Local radiation also triggers systemic effects that can be used in combination with immunotherapy to induce responses outside the radiation field...
  17. pmc Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells
    Satoko Matsumura
    Department of Pathology, New York University School of Medicine, New York, USA
    J Immunol 181:3099-107. 2008
    ..The ability of IR to convert tumors into "inflamed" peripheral tissues could be exploited to overcome obstacles at the effector phase of the antitumor immune response and improve the therapeutic efficacy of immunotherapy...
  18. pmc Expression of cancer testis antigens in human BRCA-associated breast cancers: potential targets for immunoprevention?
    Sylvia Adams
    New York University Cancer Institute, New York University School of Medicine, 462 First Avenue, New York, NY 10016, USA
    Cancer Immunol Immunother 60:999-1007. 2011
    ..The objective of this study was to examine the expression of CT antigens and their frequency in BRCA-associated breast cancers...
  19. pmc Combining radiotherapy and cancer immunotherapy: a paradigm shift
    Silvia C Formenti
    Department of Radiation Oncology, New York University School of Medicine, 160 E 34th St, New York, NY 10016, USA
    J Natl Cancer Inst 105:256-65. 2013
    ..Moreover, we discuss some of the current challenges to translate this knowledge to the clinic as more trials testing radiation with different immunotherapies are proposed...
  20. ncbi request reprint Downregulation of major histocompatibility complex antigens in invading glioma cells: stealth invasion of the brain
    David Zagzag
    Microvascular and Molecular Neuro Oncology Laboratory, New York University School of Medicine, New York, NY, USA
    Lab Invest 85:328-41. 2005
    ..These results suggest that the very process of tumor invasion is associated with decreased expression of MHC antigens allowing glioma cells to invade the surrounding brain in a 'stealth'-like manner...
  21. pmc Invariant NKT cells as novel targets for immunotherapy in solid tumors
    Karsten A Pilones
    Department of Pathology, NYU School of Medicine, 550 First Avenue, MSB 521, New York, NY 10016, USA
    Clin Dev Immunol 2012:720803. 2012
    ..Increased understanding of the signals that determine the function of NKT cells in cancer will be essential to improve current strategies for NKT-cell-based immunotherapeutic approaches...
  22. doi request reprint Defining the role of the immune system in cancer treatment: highlights from the Immunochemotherapy Conference
    Sandra Demaria
    Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Expert Rev Anticancer Ther 11:841-3. 2011
    ..The emerging evidence that was presented in support of this new concept will be summarized in this article...
  23. doi request reprint The numbers of FoxP3+ lymphocytes in sentinel lymph nodes of breast cancer patients correlate with primary tumor size but not nodal status
    Raavi Gupta
    Department of Pathology, New York University of Medicine, USA
    Cancer Invest 29:419-25. 2011
    ..These results suggest the presence of an immune suppressive environment in SLNs of larger tumors...
  24. pmc Local control by radiotherapy: is that all there is?
    Silvia C Formenti
    Department of Radiation Oncology, New York University School of Medicine and NYU Cancer Institute, 160 East 34th Street, New York, NY 10016, USA
    Breast Cancer Res 10:215. 2008
    ....
  25. pmc Cancer and inflammation: promise for biologic therapy
    Sandra Demaria
    Department of Pathology, New York University School of Medicine, New York, NY, USA
    J Immunother 33:335-51. 2010
    ....
  26. pmc Radiation as an immunological adjuvant: current evidence on dose and fractionation
    Sandra Demaria
    Department of Pathology, New York University School of Medicine, NYU Langone Medical Center New York, NY, USA
    Front Oncol 2:153. 2012
    ..We critically review the available in vitro and in vivo data on this subject and discuss the potential impact of fractionation on the ability of radiation to synergize with immunotherapy...

Research Grants5

  1. Local Radiation as an Adjuvant for Immunotherapy
    Sandra Demaria; Fiscal Year: 2007
    ..Overall, these studies will provide the pre-clinical data necessary for testing this novel therapeutic strategy in future clinical trials. ..
  2. Local Radiation as an Adjuvant for Immunotherapy
    Sandra Demaria; Fiscal Year: 2010
    ..Overall, these studies will provide the pre-clinical data necessary for testing this novel therapeutic strategy in future clinical trials. ..
  3. TUMOR APOPTOSIS AS MAJOR DETERMINANT OF IMMUNOGENICITY
    Sandra Demaria; Fiscal Year: 2006
    ..These studies will provide the basis for further pre-clinical and clinical studies testing whether levels of apoptosis promoting anti-tumor immunity can be induced by chemotherapy and irradiation. ..