E A Deitch

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi request reprint Resistance of the female, as opposed to the male, intestine to I/R-mediated injury is associated with increased resistance to gut-induced distant organ injury
    Edwin A Deitch
    Department of Surgery, New Jersey Medical School, UMDNJ, Newark, NJ 07103, USA
    Shock 29:78-83. 2008
  2. pmc Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats
    Danielle Doucet
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 5:e9421. 2010
  3. pmc Oxidative modification of the intestinal mucus layer is a critical but unrecognized component of trauma hemorrhagic shock-induced gut barrier failure
    Jordan E Fishman
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Am J Physiol Gastrointest Liver Physiol 304:G57-63. 2013
  4. pmc Gut-origin sepsis: evolution of a concept
    Edwin A Deitch
    New Jersey Medical School, Newark, NJ, USA
    Surgeon 10:350-6. 2012
  5. pmc Role of lipase-generated free fatty acids in converting mesenteric lymph from a noncytotoxic to a cytotoxic fluid
    Xiaofa Qin
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Am J Physiol Gastrointest Liver Physiol 303:G969-78. 2012
  6. pmc Neuroimmune perspectives in sepsis
    Luis Ulloa
    Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Avenue, PO Box 1709, Newark, NJ 07103, USA
    Crit Care 13:133. 2009
  7. ncbi request reprint Role of the gut lymphatic system in multiple organ failure
    E A Deitch
    Department of Surgery, New Jersey Medical School, Room G 506, 185 South Orange Avenue, Newark, NJ 07103, USA
    Curr Opin Crit Care 7:92-8. 2001
  8. doi request reprint Gut lymph and lymphatics: a source of factors leading to organ injury and dysfunction
    Edwin A Deitch
    Department of Surgery, University of Medicine and Dentistry New Jersey, Newark, New Jersey, USA
    Ann N Y Acad Sci 1207:E103-11. 2010
  9. ncbi request reprint Role of the gut in the development of injury- and shock induced SIRS and MODS: the gut-lymph hypothesis, a review
    Edwin A Deitch
    Department of Surgery, UMDNJ New Jersey Medical School, MSB G506, Newark, NJ 07103, USA
    Front Biosci 11:520-8. 2006
  10. pmc Hormonally active women tolerate shock-trauma better than do men: a prospective study of over 4000 trauma patients
    Edwin A Deitch
    Department of Surgery, New Jersey Medical School, Newark, New Jersey 07103, USA
    Ann Surg 246:447-53; discussion 453-5. 2007

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Resistance of the female, as opposed to the male, intestine to I/R-mediated injury is associated with increased resistance to gut-induced distant organ injury
    Edwin A Deitch
    Department of Surgery, New Jersey Medical School, UMDNJ, Newark, NJ 07103, USA
    Shock 29:78-83. 2008
    ..These results indicate that the resistance of proestrus female rats to gut injury and gut-induced distant organ injury is greater than that observed in male rats...
  2. pmc Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats
    Danielle Doucet
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 5:e9421. 2010
    ....
  3. pmc Oxidative modification of the intestinal mucus layer is a critical but unrecognized component of trauma hemorrhagic shock-induced gut barrier failure
    Jordan E Fishman
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Am J Physiol Gastrointest Liver Physiol 304:G57-63. 2013
    ..There was no change in RNI-induced changes to the mucus layer. These results support the hypothesis that trauma/hemorrhagic shock leads to mucus damage and gut dysfunction through the generation of free radical species...
  4. pmc Gut-origin sepsis: evolution of a concept
    Edwin A Deitch
    New Jersey Medical School, Newark, NJ, USA
    Surgeon 10:350-6. 2012
    ..These observations have resulted in the gut-lymph hypothesis of MODS...
  5. pmc Role of lipase-generated free fatty acids in converting mesenteric lymph from a noncytotoxic to a cytotoxic fluid
    Xiaofa Qin
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Am J Physiol Gastrointest Liver Physiol 303:G969-78. 2012
    ..In conclusion, this study suggests that lipase-generated FFAs are the key components resulting in the cytotoxicity of T/HS and SMAO mesenteric lymph...
  6. pmc Neuroimmune perspectives in sepsis
    Luis Ulloa
    Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Avenue, PO Box 1709, Newark, NJ 07103, USA
    Crit Care 13:133. 2009
    ..Since the nervous system is the principal regulator of the immune system, physiologic studies understanding the neuroimmune connections can provide major advantages to design novel therapeutic strategies for sepsis...
  7. ncbi request reprint Role of the gut lymphatic system in multiple organ failure
    E A Deitch
    Department of Surgery, New Jersey Medical School, Room G 506, 185 South Orange Avenue, Newark, NJ 07103, USA
    Curr Opin Crit Care 7:92-8. 2001
    ..Finally, it would help explain the discordant results between experimental and some clinical studies on the role of gut injury and loss of gut barrier function in the development of a systemic inflammatory state and distant organ injury...
  8. doi request reprint Gut lymph and lymphatics: a source of factors leading to organ injury and dysfunction
    Edwin A Deitch
    Department of Surgery, University of Medicine and Dentistry New Jersey, Newark, New Jersey, USA
    Ann N Y Acad Sci 1207:E103-11. 2010
    ..Second, this hypothesis provides new pathophysiologic information, thereby providing a basis for novel therapies. Finally, by studying the composition of lymph, MODS-inducing factors can be isolated and identified...
  9. ncbi request reprint Role of the gut in the development of injury- and shock induced SIRS and MODS: the gut-lymph hypothesis, a review
    Edwin A Deitch
    Department of Surgery, UMDNJ New Jersey Medical School, MSB G506, Newark, NJ 07103, USA
    Front Biosci 11:520-8. 2006
    ....
  10. pmc Hormonally active women tolerate shock-trauma better than do men: a prospective study of over 4000 trauma patients
    Edwin A Deitch
    Department of Surgery, New Jersey Medical School, Newark, New Jersey 07103, USA
    Ann Surg 246:447-53; discussion 453-5. 2007
    ..To test the hypothesis that comparably injured women, especially those in the hormonally active age groups, would manifest a better preserved hemodynamic response and tissue perfusion after major trauma than do men...
  11. ncbi request reprint Trauma-shock-induced gut injury and the production of biologically active intestinal lymph is abrogated by castration in a large animal porcine model
    Edwin A Deitch
    Department of Surgery, MSB G 506, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Shock 30:135-41. 2008
    ..In summary, this large animal porcine study validates the notion that castration limits gut injury and the production of biologically active intestinal lymph after T/HS...
  12. ncbi request reprint Factors in intestinal lymph after shock increase neutrophil adhesion molecule expression and pulmonary leukosequestration
    Joseph M Caruso
    Department of Surgery, New Jersey Medical School, Newark, New Jersey 07101 1709, USA
    J Trauma 55:727-33. 2003
    ....
  13. pmc Anticoagulants influence the in vitro activity and composition of shock lymph but not its in vivo activity
    Edwin A Deitch
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Shock 36:177-83. 2011
    ....
  14. doi request reprint Organ blood flow and the central hemodynamic response are better preserved in female, as opposed to the male rats, after trauma-hemorrhagic shock
    Edwin A Deitch
    Department of Surgery, New Jersey Medical School UMDNJ, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Trauma 65:566-72. 2008
    ....
  15. ncbi request reprint The role of lymph factors in lung injury, bone marrow suppression, and endothelial cell dysfunction in a primate model of trauma-hemorrhagic shock
    Edwin A Deitch
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Shock 22:221-8. 2004
    ..Thus, in a primate model of T/HS, gut-derived factors carried in the lymph potentiates lung injury and endothelial dysfunction, and suppresses bone marrow progenitor cell growth...
  16. ncbi request reprint Prevention of multiple organ failure
    E A Deitch
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, USA
    Surg Clin North Am 79:1471-88. 1999
    ..Only then are physicians likely to begin to see a reduction in the mortality rate of patients with this complex and challenging condition...
  17. ncbi request reprint Surgical Infection Society presidential address: is the glass half full or half empty? Thoughts on the SIS and American surgery
    Edwin A Deitch
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07102 2714, USA
    Surg Infect (Larchmt) 7:5-14. 2006
  18. ncbi request reprint Intestinal bacterial overgrowth induces the production of biologically active intestinal lymph
    Edwin A Deitch
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, 07101 1709, USA
    J Trauma 56:105-10. 2004
    ..We therefore studied whether mesenteric lymph can injure endothelial cells and/or active PMNs in an intestinal bacterial overgrowth model where there is no gut injury (monoassociation)...
  19. ncbi request reprint Neutrophil activation is modulated by sex hormones after trauma-hemorrhagic shock and burn injuries
    Edwin A Deitch
    Department of Surgery, MSB G506, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
    Am J Physiol Heart Circ Physiol 291:H1456-65. 2006
    ..In conclusion, there is a striking sexual dimorphism in neutrophil responses after trauma, and these changes reflect both cellular resistance to activation as well as a less activating humoral environment...
  20. ncbi request reprint The immunomodulatory effects of damage control abdominal packing on local and systemic neutrophil activity
    J M Adams
    Department of Surgery, Division of Trauma, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Trauma 50:792-800. 2001
    ..Peritoneal mediator production after DCL may be ETX driven, and may contribute to systemic inflammatory response syndrome. DCL trades early hemostasis for later inflammation. This should be considered in planning management strategies...
  21. pmc Sulphasalazine inhibits macrophage activation: inhibitory effects on inducible nitric oxide synthase expression, interleukin-12 production and major histocompatibility complex II expression
    G Hasko
    Department of Surgery, UMD New Jersey Medical School, Newark, NJ 07103, USA
    Immunology 103:473-8. 2001
    ..Finally, sulphasalazine suppressed the IFN-gamma-induced expression of major histocompatibility complex class II. These results demonstrate that the M phi is an important target of the immunosuppressive effect of sulphasalazine...
  22. ncbi request reprint Role of interleukin 8 in the genesis of acute respiratory distress syndrome through an effect on neutrophil apoptosis
    E R Goodman
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark 07103, USA
    Arch Surg 133:1234-9. 1998
    ..To evaluate the role of interleukin 8 (IL-8) in the regulation of neutrophil (PMN) apoptosis in normal plasma and plasma from patients with early, fulminant acute respiratory distress syndrome (ARDS)...
  23. ncbi request reprint Injury-enhanced calcium mobilization in circulating rat neutrophils models human PMN responses
    Z Fekete
    Department of Surgery, UMD-New Jersey Medical School, Newark 07103, USA
    Shock 16:15-20. 2001
    ..PMN thus activated act quite similar to human PMN in terms of GPC receptor-mediated calcium mobilization. Trauma enhances rat PMN responses to GPC agonists at least in part by loading cell calcium stores...
  24. ncbi request reprint Hemorrhagic shock induced up-regulation of P-selectin expression is mediated by factors in mesenteric lymph and blunted by mesenteric lymph duct interruption
    C A Adams
    Department of Surgery, UMD-New Jersey Medical School, Newark, New Jersey 07103, USA
    J Trauma 51:625-31; discussion 631-2. 2001
    ....
  25. ncbi request reprint Chemokine stimulation of human neutrophil [Ca2+]i signaling in biologic environments
    C J Hauser
    Department of Surgery, UMD New Jersey Medical School, Newark 70103, USA
    Shock 10:324-8. 1998
    ..GRO-alpha may act as a priming agent, with IL-8 activating PMN functions requiring high [Ca2+]i. This cross-cooperation is probably terminated by IL-8 regulation of GRO-alpha activity at the C-X-C chemokine receptor 2...
  26. ncbi request reprint Hematopoietic failure after hemorrhagic shock is mediated partially through mesenteric lymph
    D J Anjaria
    Department of Surgery, UMDNJ-New Jersey Medical School, Newark, NJ, USA
    Crit Care Med 29:1780-5. 2001
    ..This suppression appears mediated through mesenteric lymph as the effect is abrogated by mesenteric lymph duct ligation. These data clearly demonstrate a link between the gut and bone marrow failure after hemorrhagic shock..
  27. ncbi request reprint Augmented IL-10 production and redox-dependent signaling pathways in glucose-6-phosphate dehydrogenase-deficient mouse peritoneal macrophages
    Jeanette Wilmanski
    Graduate School of Biomedical Sciences, UMDNJ New Jersey Medical School, Newark, 07103, USA
    J Leukoc Biol 78:85-94. 2005
    ..Alterations in signaling pathways and associated changes in cytokine production may play a role in modulating the inflammatory responses following bacterial or malarial infections in G6PD deficiency...
  28. doi request reprint Mesenteric lymph duct ligation attenuates lung injury and neutrophil activation after intraperitoneal injection of endotoxin in rats
    Anthony C Watkins
    Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA
    J Trauma 64:126-30. 2008
    ..Since endotoxemia is also associated with gut injury, we tested the hypothesis that mesenteric lymph contributes to the lung injury seen in endotoxemia and that the ligation of the mesenteric lymph duct will attenuate this injury...
  29. ncbi request reprint A time course study of the protective effect of mesenteric lymph duct ligation on hemorrhagic shock-induced pulmonary injury and the toxic effects of lymph from shocked rats on endothelial cell monolayer permeability
    E A Deitch
    Department of Surgery, UMDNJ-New Jersey Medical School, Newark 07103-2714, USA
    Surgery 129:39-47. 2001
    ....
  30. ncbi request reprint Attenuated monocyte IL-10 production in glucose-6-phosphate dehydrogenase-deficient trauma patients
    Amy M Liese
    Department of Cell Biology and Injury Sciences, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA
    Shock 18:18-23. 2002
    ..An attenuated IL-10 production may be a contributing mechanism in the previously observed augmented inflammatory response in severely injured G6PD-deficient compared with non-deficient trauma patients...
  31. ncbi request reprint Major trauma enhances store-operated calcium influx in human neutrophils
    C J Hauser
    Department of Surgery, UMD New Jersey Medical School, Newark 07103, USA
    J Trauma 48:592-7; discussion 597-8. 2000
    ..We studied [Ca2+]i mobilization by chemotaxins and how trauma impacts the calcium entry mechanisms used by chemotaxins...
  32. ncbi request reprint Mesenteric lymph from rats subjected to trauma-hemorrhagic shock are injurious to rat pulmonary microvascular endothelial cells as well as human umbilical vein endothelial cells
    E A Deitch
    Department of Surgery, UMDNJ-New Jersey Medical School, Newark 07103, USA
    Shock 16:290-3. 2001
    ..Additionally, these studies support the emerging concept that gut-induced distant organ injury is mediated by factors contained in mesenteric lymph...
  33. ncbi request reprint Gut-lymph hypothesis of systemic inflammatory response syndrome/multiple-organ dysfunction syndrome: validating studies in a porcine model
    Maheswari Senthil
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    J Trauma 60:958-65; discussion 965-7. 2006
    ..A porcine model was chosen because the pig and human cardiovascular and gastrointestinal physiology are similar...
  34. ncbi request reprint A study of the biologic activity of trauma-hemorrhagic shock mesenteric lymph over time and the relative role of cytokines
    Marson T Davidson
    Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, 07103, USA
    Surgery 136:32-41. 2004
    ..Thus the goal of this study was to characterize the biologic activity of T/HS lymph collected at various times during and after shock...
  35. ncbi request reprint Trauma-hemorrhage-induced neutrophil priming is prevented by mesenteric lymph duct ligation
    Charles A Adams
    Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Shock 18:513-7. 2002
    ..Shock-induced gut lymph priming enhances PMN responses to many important chemoattractants, most notably the chemokines, and mesenteric lymph duct division effectively reverses such priming to priming levels seen in trauma without shock...
  36. ncbi request reprint The female intestine is more resistant than the male intestine to gut injury and inflammation when subjected to conditions associated with shock states
    Hiroshi Homma
    Department of Surgery, MSB G506, UMDNJ, New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103 2714, USA
    Am J Physiol Gastrointest Liver Physiol 288:G466-72. 2005
    ....
  37. ncbi request reprint PAF-mediated Ca2+ influx in human neutrophils occurs via store-operated mechanisms
    C J Hauser
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark 07103, USA
    J Leukoc Biol 69:63-8. 2001
    ..Therefore, we studied the role of SOCI in human PMN responses to the proinflammatory ligand PAF. PMN [Ca2+]i was studied by spectrofluorometry with and without external calcium. We studied the effects o..
  38. ncbi request reprint Priming of neutrophil [Ca2+]i signaling and oxidative burst by human fracture fluids
    C J Hauser
    Department of Surgery, UMD New Jersey Medical School, Newark 07103, USA
    J Trauma 47:854-8. 1999
    ..We hypothesize that small amounts of FF entering the circulation could exaggerate PMN [Ca2+]i and RB responses, potentially increasing the risk of adult respiratory distress syndrome...
  39. ncbi request reprint Early trauma polymorphonuclear neutrophil responses to chemokines are associated with development of sepsis, pneumonia, and organ failure
    J M Adams
    Department of Surgery, Division of Trauma, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Trauma 51:452-6; discussion 456-7. 2001
    ..Early responses of PMN CXC receptors to injury may influence the clinical course of trauma patients...
  40. ncbi request reprint Factors larger than 100 kd in post-hemorrhagic shock mesenteric lymph are toxic for endothelial cells
    C A Adams
    Department of Surgery, UMD-New Jersey Medical School, Newark, NJ 07103, USA
    Surgery 129:351-63. 2001
    ....
  41. ncbi request reprint Sex hormones modulate distant organ injury in both a trauma/hemorrhagic shock model and a burn model
    Preya Ananthakrishnan
    Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Surgery 137:56-65. 2005
    ....
  42. ncbi request reprint Trauma-hemorrhagic shock mesenteric lymph from rat contains a modified form of albumin that is implicated in endothelial cell toxicity
    Vicki L Kaiser
    Department of Surgery, New Jersey Medical School, Newark, New Jersey
    Shock 23:417-25. 2005
    ..Further investigations are needed to determine the type of RSA modification and the identity of the lipid factors and their role in MODS...
  43. ncbi request reprint Hypertonic saline resuscitation limits neutrophil activation after trauma-hemorrhagic shock
    Edwin A Deitch
    Department of Surgery, UMDNJ, New Jersey Medical School, Newark, New Jersey 07103, USA
    Shock 19:328-33. 2003
    ....
  44. ncbi request reprint Serine proteases are involved in the pathogenesis of trauma-hemorrhagic shock-induced gut and lung injury
    Edwin A Deitch
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Shock 19:452-6. 2003
    ....
  45. pmc Albumin protects against gut-induced lung injury in vitro and in vivo
    Adena J Osband
    Department of Surgery, New Jersey Medical School, Newark, NJ 07101 1709, USA
    Ann Surg 240:331-9. 2004
    ....
  46. ncbi request reprint Amiloride moderates increased gut permeability and diminishes mesenteric lymph-mediated priming of neutrophils in trauma/hemorrhagic shock
    Naohiko Fujiyoshi
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103 1709, USA
    Surgery 140:810-7. 2006
    ..This study investigates whether the protective effect of amiloride against T/HS-induced lung injury was associated with decreased lymph toxicity and gut permeability...
  47. ncbi request reprint Sex hormones affect bone marrow dysfunction after trauma and hemorrhagic shock
    Ziad C Sifri
    Division of Trauma, Department of Surgery, New Jersey Medical School, Newark, NJ, USA
    Crit Care Med 35:864-9. 2007
    ..Therefore, the present study examines the effects of sex hormones on post-T/HS BM dysfunction by measuring clonogenic growth of BM progenitors in castrated male rats and in ovariectomized and proestrus female rats...
  48. pmc Mesenteric lymph duct ligation prevents trauma/hemorrhage shock-induced cardiac contractile dysfunction
    Justin T Sambol
    Dept of Surgery, Univ of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Appl Physiol (1985) 106:57-65. 2009
    ..In conclusion, gut-derived factors carried in mesenteric lymph are responsible for acute T/HS-induced cardiac dysfunction...
  49. ncbi request reprint Calcium entry inhibition during resuscitation from shock attenuates inflammatory lung injury
    Cindy Lee
    Department of Surgery, Division of Trauma, New Jersey Medical School, Newark, New Jersey, USA
    Shock 30:29-35. 2008
    ..Ca2+ entry inhibition is a candidate therapy for management of lung injury after shock...
  50. ncbi request reprint Entry of gut lymph into the circulation primes rat neutrophil respiratory burst in hemorrhagic shock
    J M Adams
    Department of Surgery, Division of Trauma, UMDNJ-New Jersey Medical School, Newark, NJ, USA
    Crit Care Med 29:2194-8. 2001
    ..Mesenteric lymph is both necessary and sufficient to prime PMN after T/HS in the rat, and it primes PMN in part by enhancing [Ca2+]i responses to G-protein coupled chemoattractants. Mesenteric lymph mediates postshock PMN dysfunction...
  51. pmc Trauma inhibits erythroid burst-forming unit and granulocyte-monocyte colony-forming unit growth through the production of TGF-beta1 by bone marrow stroma
    J C Wu
    Department of Surgery, Section of Trauma, UMDNJ-New Jersey Medical School, Newark, New Jersey, USA
    Ann Surg 234:224-32. 2001
    ..This inhibition is mediated through the interaction of trauma plasma with bone marrow stroma. TGF-beta1 production by bone marrow stroma appears to plays an important role in the early but not late bone marrow suppression after injury...
  52. ncbi request reprint cDNA microarray analysis reveals a nuclear factor-kappaB-independent regulation of macrophage function by adenosine
    Zoltán H Németh
    Department of Surgery, University of Medicine and Dentistry New Jersey Medical School, Newark, NJ 07103, USA
    J Pharmacol Exp Ther 306:1042-9. 2003
    ..Together, our results suggest that the anti-inflammatory effects of adenosine are independent of NF-kappaB...
  53. pmc Pancreatic duct ligation reduces lung injury following trauma and hemorrhagic shock
    David B Cohen
    Department of Surgery, University of Medicine, and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Ann Surg 240:885-91. 2004
    ..This hypothesis was tested by examining the effect of PDL on T/HS-induced intestinal injury, lung injury, and RBC deformability...
  54. ncbi request reprint Store-operated calcium channel inhibition attenuates neutrophil function and postshock acute lung injury
    Cindy Lee
    Department of Surgery, Division of Trauma, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    J Trauma 59:56-63; discussion 63. 2005
    ..We hypothesized that SOCE inhibition might suppress postshock PMN activation, lessening lung injury without compromising cardiovascular performance...
  55. ncbi request reprint Lithium induces NF-kappa B activation and interleukin-8 production in human intestinal epithelial cells
    Zoltán H Németh
    Department of Surgery, UMD New Jersey Medical School, Newark, New Jersey 07103, USA
    J Biol Chem 277:7713-9. 2002
    ..These results demonstrate that lithium stimulates inflammatory gene expression via NF-kappa B and MAP kinase activation...
  56. ncbi request reprint Hemorrhagic shock induces endothelial cell apoptosis, which is mediated by factors contained in mesenteric lymph
    Qi Lu
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Crit Care Med 32:2464-70. 2004
    ....
  57. ncbi request reprint Mesenteric lymph duct ligation prevents shock-induced RBC deformability and shape changes
    Sergey B Zaets
    Department of Surgery, VA New Jersey Healthcare System, East Orange, New Jersey, USA
    J Surg Res 109:51-6. 2003
    ..We hypothesize that RBC injury is caused in part by gut injury and is mediated by gut-derived factors carried in the intestinal lymph...
  58. ncbi request reprint Trauma-hemorrhagic shock-induced up-regulation of endothelial cell adhesion molecules is blunted by mesenteric lymph duct ligation
    Da Zhong Xu
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Crit Care Med 32:760-5. 2004
    ....
  59. ncbi request reprint The influence of the type of resuscitation fluid on gut injury and distant organ injury in a rat model of trauma/hemorrhagic shock
    Dennis Vega
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    J Trauma 65:409-14; discussion 414-5. 2008
    ..Thus, we tested the effects of three commonly used resuscitation strategies on trauma-shock-induced gut and lung injury, as well as neutrophil activation and red blood cell (RBC) function...
  60. ncbi request reprint Pancreatic duct ligation abrogates the trauma hemorrhage-induced gut barrier failure and the subsequent production of biologically active intestinal lymph
    Francis J Caputo
    Department of Surgery, New Jersey Medical School, Newark, New Jersey 07013, USA
    Shock 28:441-6. 2007
    ..Thus, it seems that intraluminal pancreatic proteases are necessary for the T/HS-induced gut injury and the production of bioactive mesenteric lymph...
  61. ncbi request reprint Mesenteric lymph duct ligation decreases red blood cell alterations caused by acute pancreatitis
    Tamara L Berezina
    University of Medicine and Dentistry of New Jersey New Jersey Medical School, MSB, Room G 507, 185 S Orange Ave, Newark, NJ 07103, USA
    Am J Surg 190:800-4. 2005
    ..The mechanisms by which AP induces RBC injury are unknown. The purpose of this study was to test the hypothesis that factors carried in the mesenteric lymph after an attack of AP significantly contribute to the RBC injury observed in AP...
  62. ncbi request reprint Intravenous injection of trauma-hemorrhagic shock mesenteric lymph causes lung injury that is dependent upon activation of the inducible nitric oxide synthase pathway
    Maheswari Senthil
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Ann Surg 246:822-30. 2007
    ....
  63. ncbi request reprint Small volume resuscitation with hypertonic saline is more effective in ameliorating trauma-hemorrhagic shock-induced lung injury, neutrophil activation and red blood cell dysfunction than pancreatitic protease inhibition
    Hiroshi Homma
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103 1709, USA
    J Trauma 59:266-72. 2005
    ..The two strategies were small volume resuscitation with hypertonic saline (HTS) and intraluminal inhibition of pancreatic proteases with the serine protease inhibitor nafamostat...
  64. pmc Recombinant factor XIII diminishes multiple organ dysfunction in rats caused by gut ischemia-reperfusion injury
    Sergey B Zaets
    Novo Nordisk US, North Brunswick, New Jersey, USA
    Shock 31:621-6. 2009
    ..Thus, administration of rFXIII diminishes SMAO-induced multiple organ dysfunction in rats, presumably by preservation of endothelial barrier function and the limitation of polymorphonuclear leukocyte activation...
  65. ncbi request reprint Attenuation of shock-induced acute lung injury by sphingosine kinase inhibition
    Cindy Lee
    Department of Surgery, Division of Trauma, University of Medicine and Dentistry of New Jersey Medical School, Newark, New Jersey, USA
    J Trauma 57:955-60. 2004
    ..We therefore hypothesized that inhibition of SK might inhibit PMN activation and thus ameliorate lung injury after trauma and hemorrhagic shock (T/HS)...
  66. ncbi request reprint Gut injury and gut-induced lung injury after trauma hemorrhagic shock is gender and estrus cycle specific in the rat
    Joseph M Caruso
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, 07103, USA
    J Trauma 55:531-9. 2003
    ..The purpose of this study was to test the hypothesis that trauma-hemorrhagic shock (T/HS)-induced gut and lung injury is modulated by gender and the stage of the estrus cycle at the time of injury...
  67. ncbi request reprint Sexual dimorphism in the activation of neutrophils by shock mesenteric lymph
    John M Adams
    Department of Surgery, Division of Trauma, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Surg Infect (Larchmt) 4:37-44. 2003
    ..Female gender and the proestrous state (PE) may confer protection against lung injury after T/HS. We therefore studied the dependence of T/HS-induced PMN priming on gender and stage of estrous...
  68. pmc Elimination of C5aR prevents intestinal mucosal damage and attenuates neutrophil infiltration in local and remote organs
    Da Zhong Xu
    Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA
    Shock 31:493-9. 2009
    ..Blocking C5aR may be considered as a potential therapeutic intervention for I/R injury...
  69. ncbi request reprint The female gender protects against pulmonary injury after trauma hemorrhagic shock
    J M Caruso
    Department of Surgery, New Jersey Medical School, Newark, New Jersey 07103, USA
    Surg Infect (Larchmt) 2:231-40. 2001
    ..During the diestrus stage of the menstrual cycle when gonadal hormone levels are lowest, the rats are more sensitive to T/HS-induced lung injury, indicating that gonadal hormones modulate T/HS-induced lung injury...
  70. ncbi request reprint Increased incidence of sepsis and altered monocyte functions in severely injured type A- glucose-6-phosphate dehydrogenase-deficient African American trauma patients
    Z Spolarics
    Department of Anatomy Cell Biology, New Jersey Medical School, Newark, NJ, USA
    Crit Care Med 29:728-36. 2001
    ....
  71. ncbi request reprint Role of granulocyte-macrophage colony-stimulating factor and its receptor in the genesis of acute respiratory distress syndrome through an effect on neutrophil apoptosis
    E R Goodman
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, USA
    Arch Surg 134:1049-54. 1999
    ....
  72. ncbi request reprint Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanisms
    G Hasko
    Inotek Corp, Beverly, Massachusetts 01915, USA
    FASEB J 14:2065-74. 2000
    ..In summary, adenosine inhibits IL-12 production via various adenosine receptors. These results support the notion that adenosine-based therapies might be useful in certain autoimmune and/or inflammatory diseases...
  73. ncbi request reprint Effect of trauma-hemorrhagic shock on red blood cell deformability and shape
    Sergey B Zaets
    Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    Shock 19:268-73. 2003
    ..Additionally, a direct relationship appears to exist between the magnitude of the physiologic insult and the degree of RBC damage...
  74. ncbi request reprint Adenosine: a potential mediator of immunosuppression in multiple organ failure
    Gyorgy Hasko
    Department of Surgery, University of Medicine and Dentistry, New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA
    Curr Opin Pharmacol 2:440-4. 2002
    ..A deeper understanding of the role of adenosine in multiple organ failure may facilitate the development of adenosine-based therapeutic strategies...
  75. ncbi request reprint Isolated traumatic brain injury: age is an independent predictor of mortality and early outcome
    Anne C Mosenthal
    Department of Surgery, New Jersey Medical School, Newark, New Jersey 07103, USA
    J Trauma 52:907-11. 2002
    ..The purpose of this study was to investigate the role of age in the mortality and early outcome from isolated TBI...
  76. doi request reprint Endotoxemia down-regulates bone marrow lymphopoiesis but stimulates myelopoiesis: the effect of G6PD deficiency
    Rachna Chandra
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Leukoc Biol 83:1541-50. 2008
    ..LPS-induced down-regulation of B cell production contributes to the generalized lymphopenia and lymphocyte dysfunction observed following nonspecific immune challenges...
  77. ncbi request reprint Gender differences in glucose variability after severe trauma
    Alicia M Mohr
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Am Surg 76:896-902. 2010
    ..In females, mortality cannot be predicted based on BG levels or BG variability. These data have significant implications for gender-related differences in postinjury management...
  78. pmc Female X-chromosome mosaicism for gp91phox expression diversifies leukocyte responses during endotoxemia
    Rachna Chandra
    Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA
    Crit Care Med 38:2003-10. 2010
    ..This is in contrast with the conditions in males who carry exclusively the maternal X chromosome...
  79. pmc HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury
    Rena Feinman
    UMDNJ New Jersey Medical School, Dept of Surgery, Newark, 07103, USA
    Am J Physiol Gastrointest Liver Physiol 299:G833-43. 2010
    ..Consequently, these results provide unique information on the initiating events in trauma-hemorrhagic shock-induced ALI and MODS as well as potential therapeutic insights...
  80. doi request reprint Mesenteric lymph duct ligation improves survival in a lethal shock model
    Chirag D Badami
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Shock 30:680-5. 2008
    ..Nonetheless, in conclusion, these studies support the hypothesis that factors carried in the mesenteric lymph significantly contribute to the development of irreversible shock after SAO...
  81. ncbi request reprint Depressed interleukin-12-producing activity by monocytes correlates with adverse clinical course and a shift toward Th2-type lymphocyte pattern in severely injured male trauma patients
    Zoltan Spolarics
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA
    Crit Care Med 31:1722-9. 2003
    ....
  82. ncbi request reprint Cellular mechanisms of burn-related changes in contractility and its prevention by mesenteric lymph ligation
    Kentaro Kawai
    Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Am J Physiol Heart Circ Physiol 292:H2475-84. 2007
    ..These findings also provide strong evidence that mesenteric lymph is involved in the onset of burn-related cardiomyocyte dysfunction...
  83. ncbi request reprint Female sex hormones protect red blood cells from damage after trauma-hemorrhagic shock
    Sergey B Zaets
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Surg Infect (Larchmt) 5:51-9. 2004
    ..However, it is unclear whether female or male sex hormones can influence the severity of these alterations...
  84. ncbi request reprint Red blood cell dysfunction in septic glucose-6-phosphate dehydrogenase-deficient mice
    Zoltan Spolarics
    Dept of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Ave, MSB G 626, Newark, NJ 07103, USA
    Am J Physiol Heart Circ Physiol 286:H2118-26. 2004
    ....
  85. pmc Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism
    Zoltán H Németh
    Department of Surgery, University of Medicine and Dentistry of New Jersey UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 175:8260-70. 2005
    ..Collectively, these studies identify a novel pathway in which activation of a G protein-coupled receptor augments translation of an anti-inflammatory gene...
  86. pmc Bone marrow failure following severe injury in humans
    David H Livingston
    Departments of Surgery, University Hospital E 245, 150 Bergen Street, Newark, NJ 07103, USA
    Ann Surg 238:748-53. 2003
    ....
  87. pmc Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis
    Zoltán H Németh
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Immunol 176:5616-26. 2006
    ..Similar to observations with A(2A)R KO mice, an A(2A)R antagonist increased survival even when administered in a delayed fashion. These studies demonstrate that A(2A)R blockade may be useful in the treatment of infection and sepsis...
  88. ncbi request reprint Dual effects of mesenteric lymph isolated from rats with burn injury on contractile function in rat ventricular myocytes
    Atsuko Yatani
    Dept of Cell Biology and Molecular Medicine, UMDNJ New Jersey Medical School, PO Box 1709, MSB G 609, Newark, NJ 07101 1709, USA
    Am J Physiol Heart Circ Physiol 290:H778-85. 2006
    ..These burn lymph-induced changes in cardiac myocyte Ca2+ handling can contribute to burn-induced contractile dysfunction and ultimately to heart failure...
  89. ncbi request reprint Persistent HIF-1alpha activation in gut ischemia/reperfusion injury: potential role of bacteria and lipopolysaccharide
    Jadd Koury
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Shock 22:270-7. 2004
    ..aeruginosa or lipopolysaccharide...
  90. ncbi request reprint Albumin peptide: a molecular marker for trauma/hemorrhagic-shock in rat mesenteric lymph
    Vicki L Kaiser
    Department of Surgery, UMD New Jersey Medical School, P O Box 1709, Newark, NJ 07101, USA
    Peptides 26:2491-9. 2005
    ..We therefore propose that the significant increase in the albumin peptide is a marker for post-T/HS lymph-induced endothelial cell toxicity...
  91. pmc Mast cell stabilization improves survival by preventing apoptosis in sepsis
    Laura Ramos
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, Center of Immunity and Infection, Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 185:709-16. 2010
    ..Our study provides the first evidence that MCs have major immunological implications regulating cell death in sepsis and represent a pharmacological target for infectious disorders in a clinically realistic time frame...
  92. ncbi request reprint Inhibition of the Na(+)/H(+) antiporter suppresses IL-12 p40 production by mouse macrophages
    Z H Nemeth
    Department of Surgery, UMD New Jersey Medical School, Newark, NJ 07103, USA
    Biochim Biophys Acta 1539:233-42. 2001
    ..In summary, the production of IL-12 p40 requires a functional Na(+)/H(+) antiporter...
  93. ncbi request reprint Hypoxia combined with Escherichia coli produces irreversible gut mucosal injury characterized by increased intestinal cytokine production and DNA degradation
    J Ding
    Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA
    Shock 16:189-95. 2001
    ....
  94. ncbi request reprint Morphologic changes of red blood cells during hemorrhagic shock replicate changes of aging
    T L Berezina
    Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103-2714, USA
    Shock 15:467-70. 2001
    ..These changes in RBC size and shape may be due to the effects of shock-induced oxidative stress...
  95. ncbi request reprint Bacterial translocation is inhibited in inducible nitric oxide synthase knockout mice after endotoxin challenge but not in a model of bacterial overgrowth
    S Mishima
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, USA
    Arch Surg 132:1190-5. 1997
    ..Studies have shown that nitric oxide (NO) and NO synthase (NOS) inhibitors injure and protect organs after endotoxin (lipopolysaccharide [LPS]) challenge...
  96. ncbi request reprint Bacterial translocation or lymphatic drainage of toxic products from the gut: what is important in human beings?
    Edwin A Deitch
    Department of Surgery, New Jersey Medical School, Newark, NJ 07103, USA
    Surgery 131:241-4. 2002
  97. ncbi request reprint Molecular signatures of trauma-hemorrhagic shock-induced lung injury: hemorrhage- and injury-associated genes
    Rena Feinman
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
    Shock 28:360-8. 2007
    ..Our model system provided a unique opportunity to distinguish the molecular changes associated with T/HS-induced acute lung injury from the systemic molecular response to T/HS...
  98. pmc Shaping of monocyte and macrophage function by adenosine receptors
    Gyorgy Hasko
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Pharmacol Ther 113:264-75. 2007
    ..A deeper insight into the regulation of monocyte and macrophage function by adenosine receptors should assist in developing new therapies for inflammatory diseases...
  99. ncbi request reprint Mesenteric lymph from rats with thermal injury prolongs the action potential and increases Ca2+ transient in rat ventricular myocytes
    Atsuko Yatani
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07101 1709, USA
    Shock 20:458-64. 2003
    ..The electrophysiological changes are similar to those that occur during compensated cardiac hypertrophy, suggesting a common mechanistic link between burn lymph- and hypertrophy-induced cardiac dysfunction...
  100. ncbi request reprint Influence of gut microflora on mesenteric lymph cytokine production in rats with hemorrhagic shock
    Weidun Guo
    Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    J Trauma 52:1178-85; disciussion 1185. 2002
    ..The aim of the present study was to test the hypothesis that the resident gut microflora play a role in modulating gut cytokine production under normal circumstances and in response to tissue injury with or without hemorrhagic shock...
  101. ncbi request reprint Shock mesenteric lymph-induced rat polymorphonuclear neutrophil activation and endothelial cell injury is mediated by aqueous factors
    Saraswati D Dayal
    Department of Surgery, New Jersey Medical School, Newark, New Jersey 07103, USA
    J Trauma 52:1048-55; discussion 1055. 2002
    ..The involved mediators, however, are unknown. We studied the ability of aqueous (AQ) and lipid (LIP) extracts of rat T/HS ML to activate PMNs and injure ECs...