Susan De Santi

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Hippocampal formation glucose metabolism and volume losses in MCI and AD
    S De Santi
    Department of Psychiatry, New York University School of Medicine, New York, NY, USA
    Neurobiol Aging 22:529-39. 2001
  2. pmc Robust and conventional neuropsychological norms: diagnosis and prediction of age-related cognitive decline
    Susan De Santi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neuropsychology 22:469-84. 2008
  3. pmc The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease
    Lidia Glodzik-Sobanska
    New York University School of Medicine, New York, NY 10016, United States
    Neurobiol Aging 30:672-81. 2009
  4. pmc Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders
    Lidia Glodzik
    Department of Psychiatry, New York University School of Medicine, Center of Excellence on Aging, Center for Brain Health, 145 East 32nd Street, 5th Floor, New York, NY 10016, USA
    Neurobiol Aging 32:2131-41. 2011
  5. pmc Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease
    Miroslaw Brys
    New York University School of Medicine, Center for Brain Health, NY 10016, USA
    J Alzheimers Dis 16:351-62. 2009
  6. pmc Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment
    Miroslaw Brys
    New York University School of Medicine, NY, USA
    Neurobiol Aging 30:682-90. 2009
  7. pmc Alzheimer's disease markers, hypertension, and gray matter damage in normal elderly
    Lidia Glodzik
    Center of Excellence on Aging, Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 33:1215-27. 2012
  8. pmc Oxidative stress and amyloid-beta pathology in normal individuals with a maternal history of Alzheimer's
    Lisa Mosconi
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Biol Psychiatry 68:913-21. 2010
  9. pmc FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 36:811-22. 2009
  10. pmc Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathology
    Lidia Glodzik
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, 145 East 32nd Street, 5th Floor, New York, NY10016, USA
    J Alzheimers Dis 18:509-13. 2009

Detail Information

Publications32

  1. ncbi request reprint Hippocampal formation glucose metabolism and volume losses in MCI and AD
    S De Santi
    Department of Psychiatry, New York University School of Medicine, New York, NY, USA
    Neurobiol Aging 22:529-39. 2001
    ..These cross-sectional data show that in MCI hippocampal formation changes exist without significant neocortical changes. Neocortical changes best characterize AD. In both MCI and AD, metabolism reductions exceed volume losses...
  2. pmc Robust and conventional neuropsychological norms: diagnosis and prediction of age-related cognitive decline
    Susan De Santi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neuropsychology 22:469-84. 2008
    ..These findings indicate that Robust norms improve identification of healthy individuals who will decline and may be useful for selecting at-risk participants for research studies and early interventions...
  3. pmc The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease
    Lidia Glodzik-Sobanska
    New York University School of Medicine, New York, NY 10016, United States
    Neurobiol Aging 30:672-81. 2009
    ..The data also suggest that T-tau changes are more age dependent than Abeta changes. The evidence that P-tau231 and IP are the earliest markers for the neuronal damage related to AD awaits longitudinal study...
  4. pmc Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders
    Lidia Glodzik
    Department of Psychiatry, New York University School of Medicine, Center of Excellence on Aging, Center for Brain Health, 145 East 32nd Street, 5th Floor, New York, NY 10016, USA
    Neurobiol Aging 32:2131-41. 2011
    ....
  5. pmc Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease
    Miroslaw Brys
    New York University School of Medicine, Center for Brain Health, NY 10016, USA
    J Alzheimers Dis 16:351-62. 2009
    ..05). These results provide support for including multiple modalities of biomarkers in the identification of memory clinic patients at increased risk for dementia...
  6. pmc Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment
    Miroslaw Brys
    New York University School of Medicine, NY, USA
    Neurobiol Aging 30:682-90. 2009
    ..To longitudinally evaluate five cerebrospinal fluid (CSF) biomarkers in the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD)...
  7. pmc Alzheimer's disease markers, hypertension, and gray matter damage in normal elderly
    Lidia Glodzik
    Center of Excellence on Aging, Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 33:1215-27. 2012
    ..In this presymptomatic stage when no cognitive impairment is present, AD biomarkers and HTN have additive effects on gray matter damage...
  8. pmc Oxidative stress and amyloid-beta pathology in normal individuals with a maternal history of Alzheimer's
    Lisa Mosconi
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Biol Psychiatry 68:913-21. 2010
    ..With a panel of cerebrospinal fluid (CSF) markers, this study examined whether NL MH showed evidence for AD pathology compared with PH and NH...
  9. pmc FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 36:811-22. 2009
    ....
  10. pmc Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathology
    Lidia Glodzik
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, 145 East 32nd Street, 5th Floor, New York, NY10016, USA
    J Alzheimers Dis 18:509-13. 2009
    ..No treatment effects were seen among impaired individuals, suggesting that longer treatment time may be necessary to achieve biomarker effect in this group...
  11. pmc Framingham cardiovascular risk profile correlates with impaired hippocampal and cortical vasoreactivity to hypercapnia
    Lidia Glodzik
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    J Cereb Blood Flow Metab 31:671-9. 2011
    ..6, P=0.05). An elevated risk for vascular pathology is associated with a reduced response to hypercapnia in both hippocampal and cortical tissue. The VR(h) is more sensitive to vascular burden than either resting CBF or brain volume...
  12. pmc Hippocampal hypometabolism predicts cognitive decline from normal aging
    Lisa Mosconi
    New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 29:676-92. 2008
    ..This longitudinal study used FDG-PET imaging to predict and monitor cognitive decline from normal aging...
  13. pmc Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer's disease
    Lisa Mosconi
    New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 33:624.e1-9. 2012
    ..There were no associations between paternal age and metabolism in any group. Evidence for a maternally inherited, maternal age-related mechanism provides further insight on risk factors and genetic transmission in late-onset AD...
  14. ncbi request reprint The role of quantitative structural imaging in the early diagnosis of Alzheimer's disease
    Lidia Glodzik-Sobanska
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Neuroimaging Clin N Am 15:803-26, x. 2005
    ..The last section describes problems encountered in the differential diagnosis...
  15. pmc Structural brain changes in normal individuals with a maternal history of Alzheimer's
    Valentina Berti
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 32:2325.e17-26. 2011
    ..Our findings support the use of regional brain atrophy as a preclinical biomarker for LOAD among at-risk individuals...
  16. pmc Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Biol Psychiatry 63:609-18. 2008
    ....
  17. ncbi request reprint Early detection of Alzheimer's disease using neuroimaging
    Lisa Mosconi
    Center for Brain Health MHL 400, New York University School of Medicine, 560 1st Avenue, New York, NY 10016, USA
    Exp Gerontol 42:129-38. 2007
    ..Overall, these studies show that the use of imaging for the early detection of AD is successful even in the earlier stages of disease when clinical symptoms are not fully expressed and the regional brain damage may be limited...
  18. ncbi request reprint (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals improves detection of mild cognitive impairment and Alzheimer's disease
    Lisa Mosconi
    New York University School of Medicine, New York, New York 10016, USA
    J Nucl Med 48:1129-34. 2007
    ..We tested whether an (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals ("normals," or NLs) would improve diagnosis of AD and mild cognitive impairment (MCI)...
  19. pmc Surgery and brain atrophy in cognitively normal elderly subjects and subjects diagnosed with mild cognitive impairment
    Richard P Kline
    Department of Anesthesiology, New York University Langone Medical Center, New York, New York 10016, USA
    Anesthesiology 116:603-12. 2012
    ..Using magnetic resonance imaging data from the Alzheimer's Disease Neuroimaging Initiative, we tested the hypothesis that surgery would impact brain parameters associated with progression of dementia...
  20. pmc Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 104:19067-72. 2007
    ..No CMRglc differences were found between FHp and FH(-) subjects. This study shows a relationship between reduced CMRglc in AD-vulnerable brain regions and a maternal family history of AD in cognitively normal individuals...
  21. ncbi request reprint Subjective memory complaints: presence, severity and future outcome in normal older subjects
    Lidia Glodzik-Sobanska
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Dement Geriatr Cogn Disord 24:177-84. 2007
    ..Subjective memory complaint (SMC) in normal individuals may predict future cognitive decline. The goal of this study was to examine whether the probability of decline increases with growing intensity of complaint...
  22. ncbi request reprint Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's disease
    Lisa Mosconi
    Center for Brain Health, MHL 400, Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 34:1467-79. 2007
    ....
  23. pmc An entorhinal cortex sulcal pattern is associated with Alzheimer's disease
    Jiong Zhan
    Department of Psychiatry, New York University School of Medicine, New York 10016, USA
    Hum Brain Mapp 30:874-82. 2009
    ..We classified the lateral EC sulcal boundary as either a rhinal or collateral pattern and tested the hypotheses that the rhinal pattern was (1) more common in AD and (2) associated with a smaller EC size...
  24. ncbi request reprint Visual rating of medial temporal lobe metabolism in mild cognitive impairment and Alzheimer's disease using FDG-PET
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 33:210-21. 2006
    ..This study was designed to examine the utility of visual inspection of medial temporal lobe (MTL) metabolism in the diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease (AD) using FDG-PET scans...
  25. pmc Memantine decreases hippocampal glutamate levels: a magnetic resonance spectroscopy study
    Lidia Glodzik
    Center for Brain Health, Department of Psychiatry, New York University New York, NY 10016, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:1005-12. 2008
    ..Treatment with memantine decreased Glu/Cr (creatine) ratio in the left hippocampal region. Memantine reduced hippocampal glutamate levels, which may be consistent with its anti-excitotoxic property...
  26. pmc Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer's
    Lisa Mosconi
    New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 107:5949-54. 2010
    ..Present findings may motivate further research on familial transmission and parent-of-origin effects in LOAD...
  27. pmc Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    J Alzheimers Dis 20:843-54. 2010
    ..We then briefly review brain Abeta PET imaging studies in AD and discuss the potential of combining symptoms-sensitive FDG-PET measures with pathology-specific Abeta-PET to improve the early detection of AD...
  28. ncbi request reprint Magnetic resonance and PET studies in the early diagnosis of Alzheimer's disease
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, Center for Brain Health, 560 First Avenue, NY 10016, USA
    Expert Rev Neurother 4:831-49. 2004
    ..It is concluded that there is considerable promise for an early and specific diagnosis for Alzheimer's disease by combining information from imaging and biomarker modalities...
  29. pmc Does mild cognitive impairment increase the risk of developing postoperative cognitive dysfunction?
    Alex Bekker
    Department of Anesthesiology, New York University Medical Center, New York, NY, USA
    Am J Surg 199:782-8. 2010
    ..We sought to determine whether patients with mild cognitive impairment (MCI) would have an accelerated progression of dementia postoperatively when compared with the patients without MCI...
  30. ncbi request reprint Absence of hippocampal volume differences in survivors of the Nazi Holocaust with and without posttraumatic stress disorder
    Julia A Golier
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Psychiatry Res 139:53-64. 2005
    ..Larger temporal lobe volumes may be associated with early traumatization and survival or may reflect some other characteristic of Holocaust survivors...
  31. ncbi request reprint Regional brain atrophy rate predicts future cognitive decline: 6-year longitudinal MR imaging study of normal aging
    Henry Rusinek
    Department of Radiology, New York University School of Medicine, Bellevue C and D Bldg, Room D120, 550 First Ave, New York, NY 10016, USA
    Radiology 229:691-6. 2003
    ..To determine if medial temporal lobe (MTL) atrophy rate, assessed by using an automated procedure over the initial time interval of a 6-year, three-time-point longitudinal study, is predictive of future memory decline...
  32. ncbi request reprint Imaging is superior to cognitive testing for early diagnosis of Alzheimer's disease
    Edward Zamrini
    Department of Neurology, 454 Sparks Center, 1720 7th Avenue South, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neurobiol Aging 25:685-91. 2004
    ..Neuroimaging can provide objective measures of preclinical disease state and, when measured serially, rate of change. Such information can be used in prevention trials...