Mony J de Leon

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease
    Lidia Glodzik-Sobanska
    New York University School of Medicine, New York, NY 10016, United States
    Neurobiol Aging 30:672-81. 2009
  2. pmc Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/poitron-emission tomography (FDG/PET)
    M J de Leon
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 98:10966-71. 2001
  3. ncbi request reprint Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment
    M J de Leon
    Department of Psychiatry, New York University School of Medicine New York, Center for Brain Health of the Silberstein Institute, NY 10016, USA
    Neurobiol Aging 27:394-401. 2006
  4. ncbi request reprint Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment
    M J de Leon
    Centre for Brain Health, Department of Psychiatry, New York University School of Medicine, NY 10016, USA
    Neurosci Lett 333:183-6. 2002
  5. ncbi request reprint Imaging and CSF studies in the preclinical diagnosis of Alzheimer's disease
    M J de Leon
    Center for Brain Health, NYU School of Medicine, Department of Psychiatry, 560 First Ave, New York 10016, USA
    Ann N Y Acad Sci 1097:114-45. 2007
  6. pmc Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment
    Miroslaw Brys
    New York University School of Medicine, NY, USA
    Neurobiol Aging 30:682-90. 2009
  7. pmc Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders
    Lidia Glodzik
    Department of Psychiatry, New York University School of Medicine, Center of Excellence on Aging, Center for Brain Health, 145 East 32nd Street, 5th Floor, New York, NY 10016, USA
    Neurobiol Aging 32:2131-41. 2011
  8. pmc Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathology
    Lidia Glodzik
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, 145 East 32nd Street, 5th Floor, New York, NY10016, USA
    J Alzheimers Dis 18:509-13. 2009
  9. pmc Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease
    Miroslaw Brys
    New York University School of Medicine, Center for Brain Health, NY 10016, USA
    J Alzheimers Dis 16:351-62. 2009
  10. pmc Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 34:22-34. 2013

Research Grants

Collaborators

Detail Information

Publications62

  1. pmc The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease
    Lidia Glodzik-Sobanska
    New York University School of Medicine, New York, NY 10016, United States
    Neurobiol Aging 30:672-81. 2009
    ..The data also suggest that T-tau changes are more age dependent than Abeta changes. The evidence that P-tau231 and IP are the earliest markers for the neuronal damage related to AD awaits longitudinal study...
  2. pmc Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/poitron-emission tomography (FDG/PET)
    M J de Leon
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 98:10966-71. 2001
    ..Further study is required to estimate individual risks and to determine the physiologic basis for METglu changes detected while cognition is normal...
  3. ncbi request reprint Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment
    M J de Leon
    Department of Psychiatry, New York University School of Medicine New York, Center for Brain Health of the Silberstein Institute, NY 10016, USA
    Neurobiol Aging 27:394-401. 2006
    ..These results demonstrate that CSF biomarkers for AD contribute to the characterization of MCI...
  4. ncbi request reprint Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment
    M J de Leon
    Centre for Brain Health, Department of Psychiatry, New York University School of Medicine, NY 10016, USA
    Neurosci Lett 333:183-6. 2002
    ..Longitudinally, only after adjusting for the ventricular volume and only for Ptau231, were increases seen in MCI. Further studies are warranted on mechanisms of tau clearance and on using imaging to interpret CSF studies...
  5. ncbi request reprint Imaging and CSF studies in the preclinical diagnosis of Alzheimer's disease
    M J de Leon
    Center for Brain Health, NYU School of Medicine, Department of Psychiatry, 560 First Ave, New York 10016, USA
    Ann N Y Acad Sci 1097:114-45. 2007
    ..Moreover, selected combinations of imaging and CSF biomarkers measures are of importance in monitoring the course of AD and thus relevant to evaluating clinical trials...
  6. pmc Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment
    Miroslaw Brys
    New York University School of Medicine, NY, USA
    Neurobiol Aging 30:682-90. 2009
    ..To longitudinally evaluate five cerebrospinal fluid (CSF) biomarkers in the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD)...
  7. pmc Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders
    Lidia Glodzik
    Department of Psychiatry, New York University School of Medicine, Center of Excellence on Aging, Center for Brain Health, 145 East 32nd Street, 5th Floor, New York, NY 10016, USA
    Neurobiol Aging 32:2131-41. 2011
    ....
  8. pmc Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathology
    Lidia Glodzik
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, 145 East 32nd Street, 5th Floor, New York, NY10016, USA
    J Alzheimers Dis 18:509-13. 2009
    ..No treatment effects were seen among impaired individuals, suggesting that longer treatment time may be necessary to achieve biomarker effect in this group...
  9. pmc Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease
    Miroslaw Brys
    New York University School of Medicine, Center for Brain Health, NY 10016, USA
    J Alzheimers Dis 16:351-62. 2009
    ..05). These results provide support for including multiple modalities of biomarkers in the identification of memory clinic patients at increased risk for dementia...
  10. pmc Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 34:22-34. 2013
    ..NH and ≥ 71% for MH vs. PH, with relative risk = 1.9-5.1 (p values < 0.005). NL individuals with AD-affected mothers show co-occurring Aβ increases and hypometabolism in AD-vulnerable regions, suggesting an increased risk for AD...
  11. pmc Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Biol Psychiatry 63:609-18. 2008
    ....
  12. pmc Alzheimer's disease markers, hypertension, and gray matter damage in normal elderly
    Lidia Glodzik
    Center of Excellence on Aging, Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 33:1215-27. 2012
    ..In this presymptomatic stage when no cognitive impairment is present, AD biomarkers and HTN have additive effects on gray matter damage...
  13. pmc FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 36:811-22. 2009
    ....
  14. pmc Oxidative stress and amyloid-beta pathology in normal individuals with a maternal history of Alzheimer's
    Lisa Mosconi
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Biol Psychiatry 68:913-21. 2010
    ..With a panel of cerebrospinal fluid (CSF) markers, this study examined whether NL MH showed evidence for AD pathology compared with PH and NH...
  15. pmc Framingham cardiovascular risk profile correlates with impaired hippocampal and cortical vasoreactivity to hypercapnia
    Lidia Glodzik
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    J Cereb Blood Flow Metab 31:671-9. 2011
    ..6, P=0.05). An elevated risk for vascular pathology is associated with a reduced response to hypercapnia in both hippocampal and cortical tissue. The VR(h) is more sensitive to vascular burden than either resting CBF or brain volume...
  16. pmc Hippocampal hypometabolism predicts cognitive decline from normal aging
    Lisa Mosconi
    New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 29:676-92. 2008
    ..This longitudinal study used FDG-PET imaging to predict and monitor cognitive decline from normal aging...
  17. pmc Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer's disease
    Lisa Mosconi
    New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 33:624.e1-9. 2012
    ..There were no associations between paternal age and metabolism in any group. Evidence for a maternally inherited, maternal age-related mechanism provides further insight on risk factors and genetic transmission in late-onset AD...
  18. pmc Robust and conventional neuropsychological norms: diagnosis and prediction of age-related cognitive decline
    Susan De Santi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neuropsychology 22:469-84. 2008
    ..These findings indicate that Robust norms improve identification of healthy individuals who will decline and may be useful for selecting at-risk participants for research studies and early interventions...
  19. ncbi request reprint Early detection of Alzheimer's disease using neuroimaging
    Lisa Mosconi
    Center for Brain Health MHL 400, New York University School of Medicine, 560 1st Avenue, New York, NY 10016, USA
    Exp Gerontol 42:129-38. 2007
    ..Overall, these studies show that the use of imaging for the early detection of AD is successful even in the earlier stages of disease when clinical symptoms are not fully expressed and the regional brain damage may be limited...
  20. pmc Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer's
    Lisa Mosconi
    New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 107:5949-54. 2010
    ..Present findings may motivate further research on familial transmission and parent-of-origin effects in LOAD...
  21. pmc Structural brain changes in normal individuals with a maternal history of Alzheimer's
    Valentina Berti
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 32:2325.e17-26. 2011
    ..Our findings support the use of regional brain atrophy as a preclinical biomarker for LOAD among at-risk individuals...
  22. pmc Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease
    Yi Li
    New York University School of Medicine, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 35:2169-81. 2008
    ....
  23. pmc An entorhinal cortex sulcal pattern is associated with Alzheimer's disease
    Jiong Zhan
    Department of Psychiatry, New York University School of Medicine, New York 10016, USA
    Hum Brain Mapp 30:874-82. 2009
    ..We classified the lateral EC sulcal boundary as either a rhinal or collateral pattern and tested the hypotheses that the rhinal pattern was (1) more common in AD and (2) associated with a smaller EC size...
  24. ncbi request reprint Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's disease
    Lisa Mosconi
    Center for Brain Health, MHL 400, Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 34:1467-79. 2007
    ....
  25. pmc Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias
    Lisa Mosconi
    Center for Brain Health, New York University School of Medicine, New York, New York 10016, USA
    J Nucl Med 49:390-8. 2008
    ....
  26. pmc Combining early markers strongly predicts conversion from mild cognitive impairment to Alzheimer's disease
    Davangere P Devanand
    Division of Geriatric Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Biol Psychiatry 64:871-9. 2008
    ..The utility of combining early markers to predict conversion from mild cognitive impairment (MCI) to Alzheimer's Disease (AD) remains uncertain...
  27. ncbi request reprint (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals improves detection of mild cognitive impairment and Alzheimer's disease
    Lisa Mosconi
    New York University School of Medicine, New York, New York 10016, USA
    J Nucl Med 48:1129-34. 2007
    ..We tested whether an (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals ("normals," or NLs) would improve diagnosis of AD and mild cognitive impairment (MCI)...
  28. pmc TNF-alpha and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects
    Angela R Kamer
    New York University, College of Dentistry, Department of Periodontology and Implant Dentistry, New York, NY 10010, USA
    J Neuroimmunol 216:92-7. 2009
    ..This study shows that TNF-alpha and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis...
  29. ncbi request reprint The role of quantitative structural imaging in the early diagnosis of Alzheimer's disease
    Lidia Glodzik-Sobanska
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Neuroimaging Clin N Am 15:803-26, x. 2005
    ..The last section describes problems encountered in the differential diagnosis...
  30. pmc Surgery and brain atrophy in cognitively normal elderly subjects and subjects diagnosed with mild cognitive impairment
    Richard P Kline
    Department of Anesthesiology, New York University Langone Medical Center, New York, New York 10016, USA
    Anesthesiology 116:603-12. 2012
    ..Using magnetic resonance imaging data from the Alzheimer's Disease Neuroimaging Initiative, we tested the hypothesis that surgery would impact brain parameters associated with progression of dementia...
  31. pmc Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 104:19067-72. 2007
    ..No CMRglc differences were found between FHp and FH(-) subjects. This study shows a relationship between reduced CMRglc in AD-vulnerable brain regions and a maternal family history of AD in cognitively normal individuals...
  32. ncbi request reprint Visual rating of medial temporal lobe metabolism in mild cognitive impairment and Alzheimer's disease using FDG-PET
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 33:210-21. 2006
    ..This study was designed to examine the utility of visual inspection of medial temporal lobe (MTL) metabolism in the diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease (AD) using FDG-PET scans...
  33. pmc Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    J Alzheimers Dis 20:843-54. 2010
    ..We then briefly review brain Abeta PET imaging studies in AD and discuss the potential of combining symptoms-sensitive FDG-PET measures with pathology-specific Abeta-PET to improve the early detection of AD...
  34. doi request reprint Inflammation and Alzheimer's disease: possible role of periodontal diseases
    Angela R Kamer
    Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York, NY, USA
    Alzheimers Dement 4:242-50. 2008
    ..Because chronic periodontitis is a treatable infection, it might be a readily modifiable risk factor for AD...
  35. pmc Memantine decreases hippocampal glutamate levels: a magnetic resonance spectroscopy study
    Lidia Glodzik
    Center for Brain Health, Department of Psychiatry, New York University New York, NY 10016, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:1005-12. 2008
    ..Treatment with memantine decreased Glu/Cr (creatine) ratio in the left hippocampal region. Memantine reduced hippocampal glutamate levels, which may be consistent with its anti-excitotoxic property...
  36. pmc Anteroposterior hippocampal metabolic heterogeneity: three-dimensional multivoxel proton 1H MR spectroscopic imaging--initial findings
    Kevin G King
    Department of Radiology, Center for Brain Health, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    Radiology 249:242-50. 2008
    ..To quantify proton magnetic resonance (MR) spectroscopy-detectable metabolite concentrations along anteroposterior axis of hippocampus in healthy young and elderly subjects...
  37. ncbi request reprint Subjective memory complaints: presence, severity and future outcome in normal older subjects
    Lidia Glodzik-Sobanska
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Dement Geriatr Cogn Disord 24:177-84. 2007
    ..Subjective memory complaint (SMC) in normal individuals may predict future cognitive decline. The goal of this study was to examine whether the probability of decline increases with growing intensity of complaint...
  38. ncbi request reprint Mild cognitive impairment (MCI): a historical perspective
    Barry Reisberg
    Aging and Dementia Research Center, New York University School of Medicine, New York 10016, USA
    Int Psychogeriatr 20:18-31. 2008
    ..Nevertheless, longitudinal and other studies indicate essential compatibility between GDS stage 3 MCI and Petersen's MCI duration and outcomes...
  39. pmc Hippocampal blood flow in normal aging measured with arterial spin labeling at 3T
    Henry Rusinek
    Department of Radiology, New York University School of Medicine, New York, New York, USA
    Magn Reson Med 65:128-37. 2011
    ..6 mL/(100 g min) or 5.4%. The 3T true fast imaging in steady precession arterial spin labeling method offers a HBF measurement strategy that combines good spatial resolution, sensitivity, and minimal image distortions...
  40. ncbi request reprint Magnetic resonance and PET studies in the early diagnosis of Alzheimer's disease
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, Center for Brain Health, 560 First Avenue, NY 10016, USA
    Expert Rev Neurother 4:831-49. 2004
    ..It is concluded that there is considerable promise for an early and specific diagnosis for Alzheimer's disease by combining information from imaging and biomarker modalities...
  41. pmc Does mild cognitive impairment increase the risk of developing postoperative cognitive dysfunction?
    Alex Bekker
    Department of Anesthesiology, New York University Medical Center, New York, NY, USA
    Am J Surg 199:782-8. 2010
    ..We sought to determine whether patients with mild cognitive impairment (MCI) would have an accelerated progression of dementia postoperatively when compared with the patients without MCI...
  42. doi request reprint The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's disease
    Barry Reisberg
    Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY, USA
    Alzheimers Dement 4:S98-S108. 2008
    ..Subjective cognitive impairment (SCI) has been a common, but poorly understood condition, frequently occurring in older persons...
  43. ncbi request reprint Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, New York, USA
    J Nucl Med 47:1778-86. 2006
    ....
  44. ncbi request reprint Salivary cortisol day profiles in elderly with mild cognitive impairment
    Oliver T Wolf
    Center for Brain Health, Neuroimaging Laboratory, New York University School of Medicine, 560 First Avenue, NY, New York 10016, USA
    Psychoneuroendocrinology 27:777-89. 2002
    ..Whether cortisol levels, in conjunction with other factors, such as hippocampal volume, will lead to improved prediction of future decline to AD in participants with MCI remains to be established in longitudinal studies...
  45. ncbi request reprint Regional brain atrophy rate predicts future cognitive decline: 6-year longitudinal MR imaging study of normal aging
    Henry Rusinek
    Department of Radiology, New York University School of Medicine, Bellevue C and D Bldg, Room D120, 550 First Ave, New York, NY 10016, USA
    Radiology 229:691-6. 2003
    ..To determine if medial temporal lobe (MTL) atrophy rate, assessed by using an automated procedure over the initial time interval of a 6-year, three-time-point longitudinal study, is predictive of future memory decline...
  46. ncbi request reprint Absence of hippocampal volume differences in survivors of the Nazi Holocaust with and without posttraumatic stress disorder
    Julia A Golier
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Psychiatry Res 139:53-64. 2005
    ..Larger temporal lobe volumes may be associated with early traumatization and survival or may reflect some other characteristic of Holocaust survivors...
  47. pmc Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Ann N Y Acad Sci 1147:180-95. 2008
    ..The present paper reviews findings that implicate hypometabolism and oxidative stress as crucial players in the initiation and progression of synaptic pathology in AD...
  48. pmc Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly
    Antonio Convit
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 100:2019-22. 2003
    ..This observation may bring to light a mechanism for aging brain injury that may have substantial medical impact, given the large number of elderly individuals with impaired glucose metabolism...
  49. pmc Current Challenges for the Early Detection of Alzheimer's Disease: Brain Imaging and CSF Studies
    Rachel Mistur
    Department of Psychiatry, New York University School of Medicine, New York, NY, USA
    J Clin Neurol 5:153-66. 2009
    ..Finally, we will discuss the potential to combine different PET tracers and CSF markers of pathology to improve the early detection of AD...
  50. pmc A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice
    Einar M Sigurdsson
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 29:836-47. 2008
    ..3) Smaller, earlier plaques require contrast ligand for MRI visualization. Our ligand when combined with VBA may be useful for following therapeutic approaches targeting amyloid in transgenic mouse models...
  51. pmc Cerebrovascular reactivity to carbon dioxide in Alzheimer's disease
    Lidia Glodzik
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    J Alzheimers Dis 35:427-40. 2013
    ..Thus, CVRCO2 may be an attractive means to detect an early vascular dysfunction in subjects at risk...
  52. ncbi request reprint Alzheimer's disease and peripheral infections: the possible contribution from periodontal infections, model and hypothesis
    Angela R Kamer
    Department of Periodontics and Implant Dentistry and Basic Sciences, NYU College of Dentistry, New York, NY 10010, USA
    J Alzheimers Dis 13:437-49. 2008
    ..Since periodontitis is a treatable condition, it may be a readily modifiable risk factor for AD...
  53. ncbi request reprint Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer's disease
    Allison B Reiss
    Department of Medicine, New York University School of Medicine, New Bellevue 16N1, 550 First Avenue, New York, NY 10016, USA
    Neurobiol Aging 25:977-89. 2004
    ..The reduction in stroke and AD risk in patients treated with cholesterol-lowering statins is also discussed...
  54. ncbi request reprint Basal hypothalamo-pituitary-adrenal axis activity and corticotropin feedback in young and older men: relationships to magnetic resonance imaging-derived hippocampus and cingulate gyrus volumes
    Oliver T Wolf
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Neuroendocrinology 75:241-9. 2002
    ..It remains possible that age-associated changes in fast feedback may be related to changes to other brain sites, such as hypothalamus or pituitary...
  55. ncbi request reprint Changes in brain functional homogeneity in subjects with Alzheimer's disease
    Nora D Volkow
    Medical Department, Bldg 490, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Psychiatry Res 114:39-50. 2002
    ..The enhanced CV in precuneus, despite its marked reductions in metabolism, suggests that increases in regional homogeneity in parietal and temporal cortices are not a mere reflection of the decrement in metabolism...
  56. ncbi request reprint Hippocampal atrophy disrupts transfer generalization in nondemented elderly
    Catherine E Myers
    Department of Psychology, Rutgers University, Newark, New Jersey 07102, USA
    J Geriatr Psychiatry Neurol 15:82-90. 2002
    ..These preliminary results suggest that even very mild degrees of hippocampal atrophy may be associated with subtle behavioral impairments...
  57. ncbi request reprint Seeing what Alzheimer saw
    Mony J de Leon
    Nat Med 13:129-31. 2007
  58. ncbi request reprint Alzheimer's disease
    Kaj Blennow
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgren s University Hospital, Molndal, Sweden
    Lancet 368:387-403. 2006
    ..This seminar reviews the key aspects of the disease, including epidemiology, genetics, pathogenesis, diagnosis, and treatment, as well as recent developments and controversies...
  59. ncbi request reprint Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's disease
    Richard A Frank
    Pharmacia Corporation, Mailstop 134, Peapack, NJ 07977, USA
    Neurobiol Aging 24:521-36. 2003
  60. ncbi request reprint Biomarkers for the early diagnosis of Alzheimer's disease
    Mony J de Leon
    Lancet Neurol 5:198-9. 2006
  61. ncbi request reprint Subjective memory complaints in aging are associated with elevated cortisol levels
    Oliver T Wolf
    Institute for Experimental Psychology, University of Duesseldorf, Germany
    Neurobiol Aging 26:1357-63. 2005
    ..Differences in personality traits or in stress susceptibility might underlie the present findings. Future studies of memory complaints should take a comprehensive approach including relevant endocrine parameters...
  62. ncbi request reprint MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease
    Joseph A Helpern
    Nathan S Kline Institute, Orangeburg, New York 10962, USA
    Magn Reson Med 51:794-8. 2004
    ..No differences in T(1) values or proton density were detected between any groups of mice. These results indicate that T(2) may be a sensitive marker of abnormalities in this transgenic mouse model of AD...

Research Grants38

  1. PREDICTORS OF COGNITIVE DECLINE IN NORMAL AGING
    Mony de Leon; Fiscal Year: 2007
    ..There are ample numbers of volunteer subjects and patients available. There is adequate statistical power for testing the hypotheses. ..
  2. CLINICAL CORRELATES OF LONGITUDINAL PET CHANGES IN AD
    Mony de Leon; Fiscal Year: 2006
    ..We have strong preliminary evidence in support of our hypotheses and all the facilities are in place. ..
  3. Imaging and the Aging Brain
    Mony de Leon; Fiscal Year: 2006
    ..In vivo imaging of molecules,2. Cells and networks throughout the lifespan;3. Imaging and physiology of aging; 4. Translational applications; 5. and Technologies at the forefront of imaging. ..
  4. Biomarkers in Early Alzheimer's Disease
    Mony de Leon; Fiscal Year: 2007
    ..Ample numbers of subjects are available, and we already completed the proposed three evaluations on 8 eligible NL subjects. There is adequate statistical power for testing the hypotheses. ..
  5. CLINICAL CORRELATES OF LONGITUDINAL PET CHANGES IN AD
    Mony de Leon; Fiscal Year: 2009
    ..This project will test the hypothesis that validated biological markers for neurofibrillary tangle and amyloid plaque pathology contribute to FDG-PET in predicting future cognitive decline in cognitively normal subjects. ..
  6. CLINICAL CORRELATES OF LONGITUDINAL PET CHANGES IN AD
    Mony J de Leon; Fiscal Year: 2010
    ..This project will test the hypothesis that validated biological markers for neurofibrillary tangle and amyloid plaque pathology contribute to FDG-PET in predicting future cognitive decline in cognitively normal subjects. ..
  7. PREDICTORS OF COGNITIVE DECLINE IN NORMAL AGING
    Mony de Leon; Fiscal Year: 2009
    ..There are ample numbers of volunteer subjects and patients available. There is adequate statistical power for testing the hypotheses. ..
  8. MRI Progression Markers of Cognitive Decline in the Elderly
    Henry Rusinek; Fiscal Year: 2010
    ....
  9. CLINICAL CORRELATES OF LONGITUDINAL PET CHANGES IN AD
    Mony de Leon; Fiscal Year: 2000
    ..Early detection of AD will facilitate testing treatments under conditions of less brain damage. ..
  10. PREDICTORS OF COGNITIVE DECLINE IN NORMAL AGING
    Mony de Leon; Fiscal Year: 2002
    ..Over 36 months, all subjects will receive 3 cognitive evaluations and 2 MRI scans. The results will improve our knowledge of the progression of brain changes underlying memory decline in aging. ..
  11. Biomarkers in Early Alzheimer's Disease (AD).
    Henry Rusinek; Fiscal Year: 2010
    ....