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Genomes and Genes | Anna CsiszarSummaryAffiliation: New York Medical College Country: USA Publications
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Publications
Resveratrol induces mitochondrial biogenesis in endothelial cellsAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 297:H13-20. 2009..Resveratrol induced mitochondrial biogenesis in the aortas of type 2 diabetic mice, suggesting the potential for new treatment approaches targeting endothelial mitochondria in metabolic diseases...
Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibitionAnna Csiszar
Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 291:H1694-9. 2006..We propose that these anti-inflammatory actions of resveratrol are responsible, at least in part, for its cardioprotective effects...- Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevityAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Aging Cell 6:783-97. 2007..Thus, increased lifespan potential in P. leucopus is associated with a decreased cellular ROS generation and increased oxidative stress resistance, which accords with the prediction of the oxidative stress hypothesis of aging... - Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in agingAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Pathol 170:388-98. 2007..Thus, we propose that anti-TNF-alpha treatment exerts anti-aging vasculoprotective effects... - Inflammation and endothelial dysfunction during aging: role of NF-kappaBAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
J Appl Physiol 105:1333-41. 2008..We also discuss the possibility that nucleophosmin (NPM or nuclear phosphoprotein B23), a known modulator of the cellular oxidative stress response, may also regulate NF-kappaB activity in endothelial cells... - Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterationsAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 294:H2721-35. 2008..The vasoprotective effects of resveratrol will likely contribute to its antiaging action in mammals and may be especially beneficial in pathophysiological conditions associated with accelerated vascular aging... - Bone morphogenetic protein-2 induces proinflammatory endothelial phenotypeAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Am J Pathol 168:629-38. 2006..Thus, the proinflammatory effects of BMP-2 may play a role in vascular pathophysiology... - Vascular aging in the longest-living rodent, the naked mole ratAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 293:H919-27. 2007..Thus long-living NMRs can maintain a youthful vascular function and cellular oxidant-antioxidant phenotype relatively longer and are better protected against aging-induced oxidative stress than shorter-living rats... - Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopusNazar Labinskyy
Department of Physiology, New York Medical College, Valhalla, New York, USA
Am J Physiol Heart Circ Physiol 296:H946-56. 2009..leucopus is associated with decreased cellular ROS generation and increased resistance to prooxidant and proinflammatory effects of metabolic stress, which accord with predictions of the oxidative stress hypothesis of aging... - Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1Anna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Mech Ageing Dev 130:518-27. 2009..CR exerts anti-oxidant and anti-inflammatory vascular effects, which are likely mediated by circulating factors, in part, via a SIRT1-dependent pathway... - Oxidative-nitrosative stress in a rabbit pup model of germinal matrix hemorrhage: role of NAD(P)H oxidaseMuhammad T Zia
Pediatrics, Maria Fareri Children s Hospital at Westchester Medical Center, Valhalla, NY 10595, USA
Stroke 40:2191-8. 2009.... - Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cellsZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, New York, USA
Am J Physiol Heart Circ Physiol 297:H1876-81. 2009.... - Chronic high pressure-induced arterial oxidative stress: involvement of protein kinase C-dependent NAD(P)H oxidase and local renin-angiotensin systemZoltan Ungvari
Department of Physiology, Basic Sciences Building, New York Medical College, Valhalla, NY 10595, USA
Am J Pathol 165:219-26. 2004.... - Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cellsAnna Csiszar
Dept of Physiology, New York Medical College, Valhalla, New York 10595, USA
Am J Physiol Heart Circ Physiol 295:H569-77. 2008..The vascular bed-specific endothelial effects of BMP-4 are likely to contribute to its differential pathophysiological role in the systemic and pulmonary circulation... 
Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged ratsZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 294:H2121-8. 2008..We posit that impaired mitochondrial biogenesis and downregulation of COX may contribute to the increased mitochondrial oxidative stress in aged endothelial cells...- Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf miceAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 295:H1882-94. 2008..Thus GH and IGF-I promote antioxidant phenotypic changes in the endothelial cells, whereas Ames dwarfism leads to vascular oxidative stress... - High pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidaseZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Circulation 108:1253-8. 2003.... - Comparison of endothelial function, O2-* and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and miceNazar Labinskyy
Dept. of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 291:H2698-704. 2006.... - Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressureAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Circulation 111:2364-72. 2005..We tested the hypothesis that BMP-2 expression in endothelial cells is governed by an H2O2 and nuclear factor (NF)-kappaBeta-dependent pathway that can be activated by both proinflammatory and mechanical stimuli... - Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteriesZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 293:H37-47. 2007..g., calorie restriction mimetics) will exert significant anti-inflammatory and vasoprotective effects... - Cigarette smoke-induced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activationZsuzsanna Orosz
Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 292:H130-9. 2007..NAD(P)H oxidase-derived H(2)O(2) activates NF-kappaB, leading to proinflammatory alterations in vascular phenotype, which likely promotes development of atherosclerosis, especially if other risk factors are also present... - Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthaseZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Arterioscler Thromb Vasc Biol 23:418-24. 2003..Thus, TNF-alpha induces a proinflammatory vascular phenotype in HHcy that potentially contributes to the development of coronary atherosclerosis... - Transcriptional basis for exercise limitation in male eNOS-knockout mice with age: heart failure and the fetal phenotypeCaroline Ojaimi
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 289:H1399-407. 2005..In conclusion, age- and genotype-related exercise limitations in maximal work performed and maximal running distance in male eNOS-KO mice indicated that fetal phenotype and age were related to onset of heart failure... - Effect of prenatal glucocorticoids on cerebral vasculature of the developing brainGovindaiah Vinukonda
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
Stroke 41:1766-73. 2010..Therefore, we asked whether glucocorticoid treatment would suppress angiogenesis and enhance periendothelial coverage by pericytes and glial fibrillary acidic protein-positive end feet in the germinal matrix microvasculature... - Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibitionGovindaiah Vinukonda
Department of Paediatrics, New York Medical College Westchester Medical Centre, Valhalla, NY 10595, USA
Brain 133:2264-80. 2010.... - Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in agingAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Physiol Genomics 17:21-30. 2004.... - Mechanosensitive production of reactive oxygen species in endothelial and smooth muscle cells: role in microvascular remodeling?Zoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, 10595, USA
Antioxid Redox Signal 8:1121-9. 2006.... - Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesityAttila Feher
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Cardiovasc Res 87:732-9. 2010..We investigated the role of Cav-1 in modulating BK(Ca) channel-mediated, endothelium-derived hyperpolarizing factor (EDHF)-dependent arteriolar dilation in normal condition and in an experimental model of obesity... - Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathwayAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Arterioscler Thromb Vasc Biol 27:776-82. 2007..Recent studies suggested that atheroprotective levels of shear stress control endothelial BMP-4 expression; however, the underlying mechanisms remained unknown... - The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approachFrancesco Addabbo
Department of Medicine, Renal Research Institute, Division of Nephrology, New York Medical College, Valhalla, NY 10595, USA
Am J Pathol 174:34-43. 2009..These findings may contribute to an early preclinical diagnosis of endothelial dysfunction... - Resveratrol increases vascular oxidative stress resistanceZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 292:H2417-24. 2007..We propose that the antioxidant and antiapoptotic effects of resveratrol, together with its previously described anti-inflammatory actions, are responsible, at least in part, for its cardioprotective effects... - Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasoneHongmin Xu
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
J Neurosci Res 86:1482-500. 2008..Because fibronectin provides structural stability to the blood vessels, its reduced expression in the germinal matrix may contribute to the fragility of germinal matrix vasculature and the propensity to hemorrhage in premature neonates... - Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar functionAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY, USA
Circ Res 90:1159-66. 2002..Thus, aging induces changes in the phenotype of coronary arterioles that could contribute to the development of oxidative stress, which impairs NO-mediated dilations... - Oxidative stress in vascular senescence: lessons from successfully aging speciesZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Front Biosci 13:5056-70. 2008.... - Premature death and age-related cardiac dysfunction in male eNOS-knockout miceWei Li
Department of Physiology, New York Medical College, Valhalla, NY, USA
J Mol Cell Cardiol 37:671-80. 2004..These results indicate that male (-/-) mice have a significantly shorter lifespan than (+/+) or female mice, and male (-/-) mice develop cardiac dysfunction with age... - Oxidative stress and accelerated vascular aging: implications for cigarette smokingAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Front Biosci 14:3128-44. 2009..The potential pathogenetic role of peroxynitrite formation, and downstream mechanisms including poly(ADP-ribose) polymerase (PARP) activation in cardiovascular complications in smokers are also discussed... - Aging-induced proinflammatory shift in cytokine expression profile in coronary arteriesAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
FASEB J 17:1183-5. 2003..Thus, a proinflammatory shift in the profile of vascular cytokine expression may contribute to the aging-induced phenotypic changes in coronary arteries, promoting the development of ischemic heart disease in the elderly... - Paucity of pericytes in germinal matrix vasculature of premature infantsAlex Braun
Department of Pathology, New York Medical College, Westchester Medical Center, Valhalla, New York 10595, USA
J Neurosci 27:12012-24. 2007..Hence, a paucity of pericytes in the GM vasculature may contribute to its propensity to hemorrhage, and a lower expression of TGF-beta1 could be a basis of reduced pericyte density in its vasculature... - Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogenNazar Labinskyy
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Curr Med Chem 13:989-96. 2006..This review focuses on the role of oxidative stress and inflammation in cardiovascular dysfunction in aging, and on emerging anti-aging therapeutic strategies offered by resveratrol and other polyphenol compounds... - Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with agingAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, 10595, USA
Curr Vasc Pharmacol 3:285-91. 2005.... - Different roles of PKC and MAP kinases in arteriolar constrictions to pressure and agonistsMichael P Massett
Department of Physiology, New York Medical College, Valhalla 10595, USA
Am J Physiol Heart Circ Physiol 283:H2282-7. 2002.... - Vascular inflammation in agingZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla 10595, USA
Herz 29:733-40. 2004.... - Angiogenic inhibition reduces germinal matrix hemorrhagePraveen Ballabh
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
Nat Med 13:477-85. 2007..Thus, by suppressing germinal matrix angiogenesis, prenatal celecoxib or ZD6474 treatment may be able to reduce both the incidence and severity of GMH in susceptible premature infants... - Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiencyZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY, 10595, USA
Age (Dordr) 30:121-33. 2008..leucopus cells toward oxidative stress-induced apoptosis. The link between these three pathways and species longevity is discussed... - Altered mitochondrial energy metabolism may play a role in vascular agingAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Med Hypotheses 67:904-8. 2006.... - Bone morphogenetic protein inhibition promotes neurological recovery after intraventricular hemorrhageKrishna Dummula
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
J Neurosci 31:12068-82. 2011..Hence, BMP inhibition might enhance neurological recovery in premature infants with IVH... - Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathyMartino Pepe
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Circ Res 106:1893-903. 2010..Vascular endothelial growth factor (VEGF)-B selectively binds VEGF receptor (VEGFR)-1, a receptor that does not mediate angiogenesis, and is emerging as a major cytoprotective factor... - Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular agingZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, USA
Circ Res 102:519-28. 2008.... - The pattern of cytokine gene expression in human colorectal carcinomaAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, USA
Pathol Oncol Res 10:109-16. 2004..It is likely that multiple interactions between pro- and anti-inflammatory cytokines regulate tumor growth and the functional activity of tumor-infiltrating lymphocytes... - Increases in endothelial Ca(2+) activate K(Ca) channels and elicit EDHF-type arteriolar dilation via gap junctionsZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Am J Physiol Heart Circ Physiol 282:H1760-7. 2002.... - Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular diseaseAnna Csiszar
Reynolds Oklahoma Center on Aging, Department of Physiology, Oklahoma City, USA
Ann N Y Acad Sci 1215:117-22. 2011.... - Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expressionAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, New York, USA
Antioxid Redox Signal 11:1683-97. 2009..This review considers how hemodynamic forces regulate BMP-2/4 expression and explores the role of mechanosensitive generation of reactive oxygen species by NAD(P)H oxidases in the control of BMP signaling... - Synergistic effects of vascular IL-17 and TNFalpha may promote coronary artery diseaseAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Med Hypotheses 63:696-8. 2004..We propose that increased vascular IL-17 and TNFalpha levels can act synergistically to create a pro-inflammatory microenvironment promoting the development of atherosclerotic vascular disease... - Cyclosporin A does not block exercise-induced cardiac hypertrophyTess Hainsey
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Med Sci Sports Exerc 34:1249-54. 2002..Whether this phenotype shift contributes to the lowered exercise capacity found in transplant patients remains to be determined... - Nrf2 mediates cancer protection but not prolongevity induced by caloric restrictionKevin J Pearson
Laboratories of Experimental Gerontology, Clinical Investigation, and Immunology and Research Resources Branch, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 105:2325-30. 2008..However, CR extended lifespan and increased insulin sensitivity similarly in KO and WT mice. These findings identify a molecular pathway that dissociates the prolongevity and anticarcinogenic effects of CR... - Endothelial dysfunction and vascular inflammation in type 2 diabetes: interaction of AGE/RAGE and TNF-alpha signalingAnna Csiszar
Am J Physiol Heart Circ Physiol 295:H475-6. 2008 - Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life spanKevin J Pearson
Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Cell Metab 8:157-68. 2008..Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife... - Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia: morphological and functional evidence for increased peroxynitrite formationZoltan Ungvari
Department of Pathophysiology, Semmelweis University, Budapest, Hungary
Am J Pathol 161:145-53. 2002..The reduced bioavailability of NO impairs flow-induced dilations of coronary arteries, which may contribute to the development of coronary atherosclerosis and ischemic heart disease... - CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesionMohanraj Rajesh
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
Am J Physiol Heart Circ Physiol 293:H2210-8. 2007.... - Inhibition of NAD(P)H oxidase attenuates aggregation of platelets from high-risk cardiac patients with aspirin resistanceGyorgyi Stef
State Hospital for Cardiology, Balatonfured 8230, Hungary
Pharmacol Rep 59:428-36. 2007.... - Resveratrol inhibits aggregation of platelets from high-risk cardiac patients with aspirin resistanceGyorgyi Stef
State Hospital for Cardiology, Balatonfured, Hungary
J Cardiovasc Pharmacol 48:1-5. 2006..Collectively, resveratrol effectively inhibited collagen- and epinephrine-induced aggregation of platelets from ASA-R patients, which may contribute to its cardioprotective effects in high-risk cardiac patients...