Anna Csiszar

Summary

Affiliation: New York Medical College
Country: USA

Publications

  1. pmc Resveratrol induces mitochondrial biogenesis in endothelial cells
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 297:H13-20. 2009
  2. ncbi request reprint Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition
    Anna Csiszar
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 291:H1694-9. 2006
  3. ncbi request reprint Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Aging Cell 6:783-97. 2007
  4. pmc Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Pathol 170:388-98. 2007
  5. pmc Inflammation and endothelial dysfunction during aging: role of NF-kappaB
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    J Appl Physiol (1985) 105:1333-41. 2008
  6. pmc Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 294:H2721-35. 2008
  7. pmc Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Am J Pathol 168:629-38. 2006
  8. ncbi request reprint Vascular aging in the longest-living rodent, the naked mole rat
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 293:H919-27. 2007
  9. pmc Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus
    Nazar Labinskyy
    Department of Physiology, New York Medical College, Valhalla, New York, USA
    Am J Physiol Heart Circ Physiol 296:H946-56. 2009
  10. pmc Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Mech Ageing Dev 130:518-27. 2009

Collaborators

Detail Information

Publications61

  1. pmc Resveratrol induces mitochondrial biogenesis in endothelial cells
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 297:H13-20. 2009
    ..Resveratrol induced mitochondrial biogenesis in the aortas of type 2 diabetic mice, suggesting the potential for new treatment approaches targeting endothelial mitochondria in metabolic diseases...
  2. ncbi request reprint Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition
    Anna Csiszar
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 291:H1694-9. 2006
    ..We propose that these anti-inflammatory actions of resveratrol are responsible, at least in part, for its cardioprotective effects...
  3. ncbi request reprint Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Aging Cell 6:783-97. 2007
    ..Thus, increased lifespan potential in P. leucopus is associated with a decreased cellular ROS generation and increased oxidative stress resistance, which accords with the prediction of the oxidative stress hypothesis of aging...
  4. pmc Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Pathol 170:388-98. 2007
    ..Thus, we propose that anti-TNF-alpha treatment exerts anti-aging vasculoprotective effects...
  5. pmc Inflammation and endothelial dysfunction during aging: role of NF-kappaB
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    J Appl Physiol (1985) 105:1333-41. 2008
    ..We also discuss the possibility that nucleophosmin (NPM or nuclear phosphoprotein B23), a known modulator of the cellular oxidative stress response, may also regulate NF-kappaB activity in endothelial cells...
  6. pmc Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 294:H2721-35. 2008
    ..The vasoprotective effects of resveratrol will likely contribute to its antiaging action in mammals and may be especially beneficial in pathophysiological conditions associated with accelerated vascular aging...
  7. pmc Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Am J Pathol 168:629-38. 2006
    ..Thus, the proinflammatory effects of BMP-2 may play a role in vascular pathophysiology...
  8. ncbi request reprint Vascular aging in the longest-living rodent, the naked mole rat
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 293:H919-27. 2007
    ..Thus long-living NMRs can maintain a youthful vascular function and cellular oxidant-antioxidant phenotype relatively longer and are better protected against aging-induced oxidative stress than shorter-living rats...
  9. pmc Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus
    Nazar Labinskyy
    Department of Physiology, New York Medical College, Valhalla, New York, USA
    Am J Physiol Heart Circ Physiol 296:H946-56. 2009
    ..leucopus is associated with decreased cellular ROS generation and increased resistance to prooxidant and proinflammatory effects of metabolic stress, which accord with predictions of the oxidative stress hypothesis of aging...
  10. pmc Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Mech Ageing Dev 130:518-27. 2009
    ..CR exerts anti-oxidant and anti-inflammatory vascular effects, which are likely mediated by circulating factors, in part, via a SIRT1-dependent pathway...
  11. pmc Oxidative-nitrosative stress in a rabbit pup model of germinal matrix hemorrhage: role of NAD(P)H oxidase
    Muhammad T Zia
    Pediatrics, Maria Fareri Children s Hospital at Westchester Medical Center, Valhalla, NY 10595, USA
    Stroke 40:2191-8. 2009
    ....
  12. pmc Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, New York, USA
    Am J Physiol Heart Circ Physiol 297:H1876-81. 2009
    ....
  13. pmc Chronic high pressure-induced arterial oxidative stress: involvement of protein kinase C-dependent NAD(P)H oxidase and local renin-angiotensin system
    Zoltan Ungvari
    Department of Physiology, Basic Sciences Building, New York Medical College, Valhalla, NY 10595, USA
    Am J Pathol 165:219-26. 2004
    ....
  14. pmc Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells
    Anna Csiszar
    Dept of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Heart Circ Physiol 295:H569-77. 2008
    ..The vascular bed-specific endothelial effects of BMP-4 are likely to contribute to its differential pathophysiological role in the systemic and pulmonary circulation...
  15. doi request reprint Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 294:H2121-8. 2008
    ..We posit that impaired mitochondrial biogenesis and downregulation of COX may contribute to the increased mitochondrial oxidative stress in aged endothelial cells...
  16. pmc Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 295:H1882-94. 2008
    ..Thus GH and IGF-I promote antioxidant phenotypic changes in the endothelial cells, whereas Ames dwarfism leads to vascular oxidative stress...
  17. ncbi request reprint High pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidase
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Circulation 108:1253-8. 2003
    ..Thus, we tested the hypothesis that high intraluminal pressure (Pi) itself, by activating vascular oxidases, elicits increased superoxide (O2*-) production interfering with flow-induced dilation...
  18. ncbi request reprint Comparison of endothelial function, O2-* and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice
    Nazar Labinskyy
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 291:H2698-704. 2006
    ....
  19. ncbi request reprint Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Circulation 111:2364-72. 2005
    ..We tested the hypothesis that BMP-2 expression in endothelial cells is governed by an H2O2 and nuclear factor (NF)-kappaBeta-dependent pathway that can be activated by both proinflammatory and mechanical stimuli...
  20. ncbi request reprint Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 293:H37-47. 2007
    ..g., calorie restriction mimetics) will exert significant anti-inflammatory and vasoprotective effects...
  21. ncbi request reprint Cigarette smoke-induced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activation
    Zsuzsanna Orosz
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 292:H130-9. 2007
    ..NAD(P)H oxidase-derived H(2)O(2) activates NF-kappaB, leading to proinflammatory alterations in vascular phenotype, which likely promotes development of atherosclerosis, especially if other risk factors are also present...
  22. ncbi request reprint Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Arterioscler Thromb Vasc Biol 23:418-24. 2003
    ....
  23. ncbi request reprint Transcriptional basis for exercise limitation in male eNOS-knockout mice with age: heart failure and the fetal phenotype
    Caroline Ojaimi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 289:H1399-407. 2005
    ..In conclusion, age- and genotype-related exercise limitations in maximal work performed and maximal running distance in male eNOS-KO mice indicated that fetal phenotype and age were related to onset of heart failure...
  24. pmc Effect of prenatal glucocorticoids on cerebral vasculature of the developing brain
    Govindaiah Vinukonda
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
    Stroke 41:1766-73. 2010
    ..Therefore, we asked whether glucocorticoid treatment would suppress angiogenesis and enhance periendothelial coverage by pericytes and glial fibrillary acidic protein-positive end feet in the germinal matrix microvasculature...
  25. pmc Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibition
    Govindaiah Vinukonda
    Department of Paediatrics, New York Medical College Westchester Medical Centre, Valhalla, NY 10595, USA
    Brain 133:2264-80. 2010
    ....
  26. ncbi request reprint Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Physiol Genomics 17:21-30. 2004
    ....
  27. ncbi request reprint Mechanosensitive production of reactive oxygen species in endothelial and smooth muscle cells: role in microvascular remodeling?
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, 10595, USA
    Antioxid Redox Signal 8:1121-9. 2006
    ....
  28. ncbi request reprint Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasone
    Hongmin Xu
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    J Neurosci Res 86:1482-500. 2008
    ..Because fibronectin provides structural stability to the blood vessels, its reduced expression in the germinal matrix may contribute to the fragility of germinal matrix vasculature and the propensity to hemorrhage in premature neonates...
  29. pmc Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesity
    Attila Feher
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Cardiovasc Res 87:732-9. 2010
    ..We investigated the role of Cav-1 in modulating BK(Ca) channel-mediated, endothelium-derived hyperpolarizing factor (EDHF)-dependent arteriolar dilation in normal condition and in an experimental model of obesity...
  30. pmc The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach
    Francesco Addabbo
    Department of Medicine, Renal Research Institute, Division of Nephrology, New York Medical College, Valhalla, NY 10595, USA
    Am J Pathol 174:34-43. 2009
    ..These findings may contribute to an early preclinical diagnosis of endothelial dysfunction...
  31. ncbi request reprint Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathway
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Arterioscler Thromb Vasc Biol 27:776-82. 2007
    ..Recent studies suggested that atheroprotective levels of shear stress control endothelial BMP-4 expression; however, the underlying mechanisms remained unknown...
  32. ncbi request reprint Resveratrol increases vascular oxidative stress resistance
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 292:H2417-24. 2007
    ..We propose that the antioxidant and antiapoptotic effects of resveratrol, together with its previously described anti-inflammatory actions, are responsible, at least in part, for its cardioprotective effects...
  33. ncbi request reprint Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY, USA
    Circ Res 90:1159-66. 2002
    ..Thus, aging induces changes in the phenotype of coronary arterioles that could contribute to the development of oxidative stress, which impairs NO-mediated dilations...
  34. ncbi request reprint Oxidative stress in vascular senescence: lessons from successfully aging species
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Front Biosci 13:5056-70. 2008
    ....
  35. ncbi request reprint Premature death and age-related cardiac dysfunction in male eNOS-knockout mice
    Wei Li
    Department of Physiology, New York Medical College, Valhalla, NY, USA
    J Mol Cell Cardiol 37:671-80. 2004
    ..These results indicate that male (-/-) mice have a significantly shorter lifespan than (+/+) or female mice, and male (-/-) mice develop cardiac dysfunction with age...
  36. pmc Oxidative stress and accelerated vascular aging: implications for cigarette smoking
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Front Biosci (Landmark Ed) 14:3128-44. 2009
    ..The potential pathogenetic role of peroxynitrite formation, and downstream mechanisms including poly(ADP-ribose) polymerase (PARP) activation in cardiovascular complications in smokers are also discussed...
  37. ncbi request reprint Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    FASEB J 17:1183-5. 2003
    ..Thus, a proinflammatory shift in the profile of vascular cytokine expression may contribute to the aging-induced phenotypic changes in coronary arteries, promoting the development of ischemic heart disease in the elderly...
  38. ncbi request reprint Paucity of pericytes in germinal matrix vasculature of premature infants
    Alex Braun
    Department of Pathology, New York Medical College, Westchester Medical Center, Valhalla, New York 10595, USA
    J Neurosci 27:12012-24. 2007
    ..Hence, a paucity of pericytes in the GM vasculature may contribute to its propensity to hemorrhage, and a lower expression of TGF-beta1 could be a basis of reduced pericyte density in its vasculature...
  39. pmc Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen
    Nazar Labinskyy
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Curr Med Chem 13:989-96. 2006
    ..This review focuses on the role of oxidative stress and inflammation in cardiovascular dysfunction in aging, and on emerging anti-aging therapeutic strategies offered by resveratrol and other polyphenol compounds...
  40. pmc Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, 10595, USA
    Curr Vasc Pharmacol 3:285-91. 2005
    ....
  41. ncbi request reprint Different roles of PKC and MAP kinases in arteriolar constrictions to pressure and agonists
    Michael P Massett
    Department of Physiology, New York Medical College, Valhalla 10595, USA
    Am J Physiol Heart Circ Physiol 283:H2282-7. 2002
    ....
  42. ncbi request reprint Vascular inflammation in aging
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla 10595, USA
    Herz 29:733-40. 2004
    ....
  43. ncbi request reprint Angiogenic inhibition reduces germinal matrix hemorrhage
    Praveen Ballabh
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    Nat Med 13:477-85. 2007
    ..Thus, by suppressing germinal matrix angiogenesis, prenatal celecoxib or ZD6474 treatment may be able to reduce both the incidence and severity of GMH in susceptible premature infants...
  44. pmc Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, NY, 10595, USA
    Age (Dordr) 30:121-33. 2008
    ..leucopus cells toward oxidative stress-induced apoptosis. The link between these three pathways and species longevity is discussed...
  45. ncbi request reprint Altered mitochondrial energy metabolism may play a role in vascular aging
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Med Hypotheses 67:904-8. 2006
    ....
  46. pmc Bone morphogenetic protein inhibition promotes neurological recovery after intraventricular hemorrhage
    Krishna Dummula
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    J Neurosci 31:12068-82. 2011
    ..Hence, BMP inhibition might enhance neurological recovery in premature infants with IVH...
  47. doi request reprint Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathy
    Martino Pepe
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 106:1893-903. 2010
    ..Vascular endothelial growth factor (VEGF)-B selectively binds VEGF receptor (VEGFR)-1, a receptor that does not mediate angiogenesis, and is emerging as a major cytoprotective factor...
  48. pmc Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, USA
    Circ Res 102:519-28. 2008
    ....
  49. ncbi request reprint The pattern of cytokine gene expression in human colorectal carcinoma
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, USA
    Pathol Oncol Res 10:109-16. 2004
    ..It is likely that multiple interactions between pro- and anti-inflammatory cytokines regulate tumor growth and the functional activity of tumor-infiltrating lymphocytes...
  50. ncbi request reprint Increases in endothelial Ca(2+) activate K(Ca) channels and elicit EDHF-type arteriolar dilation via gap junctions
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Heart Circ Physiol 282:H1760-7. 2002
    ....
  51. pmc Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease
    Anna Csiszar
    Reynolds Oklahoma Center on Aging, Department of Physiology, Oklahoma City, USA
    Ann N Y Acad Sci 1215:117-22. 2011
    ....
  52. pmc Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expression
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, New York, USA
    Antioxid Redox Signal 11:1683-97. 2009
    ..This review considers how hemodynamic forces regulate BMP-2/4 expression and explores the role of mechanosensitive generation of reactive oxygen species by NAD(P)H oxidases in the control of BMP signaling...
  53. ncbi request reprint Synergistic effects of vascular IL-17 and TNFalpha may promote coronary artery disease
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Med Hypotheses 63:696-8. 2004
    ..We propose that increased vascular IL-17 and TNFalpha levels can act synergistically to create a pro-inflammatory microenvironment promoting the development of atherosclerotic vascular disease...
  54. ncbi request reprint Cyclosporin A does not block exercise-induced cardiac hypertrophy
    Tess Hainsey
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Med Sci Sports Exerc 34:1249-54. 2002
    ..It is unclear what impact CsA may have on the myocardial response to exercise, a physiological model of overload...
  55. pmc Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
    Kevin J Pearson
    Laboratories of Experimental Gerontology, Clinical Investigation, and Immunology and Research Resources Branch, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 105:2325-30. 2008
    ..However, CR extended lifespan and increased insulin sensitivity similarly in KO and WT mice. These findings identify a molecular pathway that dissociates the prolongevity and anticarcinogenic effects of CR...
  56. pmc Endothelial dysfunction and vascular inflammation in type 2 diabetes: interaction of AGE/RAGE and TNF-alpha signaling
    Anna Csiszar
    Am J Physiol Heart Circ Physiol 295:H475-6. 2008
  57. pmc Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
    Kevin J Pearson
    Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Cell Metab 8:157-68. 2008
    ..Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife...
  58. pmc Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia: morphological and functional evidence for increased peroxynitrite formation
    Zoltan Ungvari
    Department of Pathophysiology, Semmelweis University, Budapest, Hungary
    Am J Pathol 161:145-53. 2002
    ..The reduced bioavailability of NO impairs flow-induced dilations of coronary arteries, which may contribute to the development of coronary atherosclerosis and ischemic heart disease...
  59. pmc CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion
    Mohanraj Rajesh
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
    Am J Physiol Heart Circ Physiol 293:H2210-8. 2007
    ....
  60. ncbi request reprint Inhibition of NAD(P)H oxidase attenuates aggregation of platelets from high-risk cardiac patients with aspirin resistance
    Gyorgyi Stef
    State Hospital for Cardiology, Balatonfured 8230, Hungary
    Pharmacol Rep 59:428-36. 2007
    ....
  61. ncbi request reprint Resveratrol inhibits aggregation of platelets from high-risk cardiac patients with aspirin resistance
    Gyorgyi Stef
    State Hospital for Cardiology, Balatonfured, Hungary
    J Cardiovasc Pharmacol 48:1-5. 2006
    ..Collectively, resveratrol effectively inhibited collagen- and epinephrine-induced aggregation of platelets from ASA-R patients, which may contribute to its cardioprotective effects in high-risk cardiac patients...