B Cronstein

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. pmc Adenosine receptors and fibrosis: a translational review
    Bruce N Cronstein
    Department of Medicine, Division of Translational Medicine, NYU School of Medicine 550 First Avenue, New York, NY 10016 USA
    F1000 Biol Rep 3:21. 2011
  2. pmc Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3
    Miguel Perez-Aso
    1Department of Medicine, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    FASEB J 28:802-12. 2014
  3. pmc Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma
    Wenjie He
    New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    FASEB J 27:3446-54. 2013
  4. pmc Mechanistic aspects of inflammation and clinical management of inflammation in acute gouty arthritis
    Bruce N Cronstein
    NYU School of Medicine, New York, NY 10016, USA
    J Clin Rheumatol 19:19-29. 2013
  5. pmc Pharmacological blockade of adenosine A2A receptors diminishes scarring
    Miguel Perez-Aso
    Division of Translational Medicine, Department of Medicine, New York University School of Medicine, 550 First Ave, MSB255, New York, NY 10016, USA
    FASEB J 26:4254-63. 2012
  6. pmc Regulation of foam cells by adenosine
    Allison B Reiss
    Department of Medicine, Winthrop University Hospital, Mineola, NY, USA
    Arterioscler Thromb Vasc Biol 32:879-86. 2012
  7. pmc Adenosine in inflammatory joint diseases
    E S L Chan
    Department of Medicine, Divisions of Clinical Pharmacology and Rheumatology, New York University School of Medicine, New York, NY, USA
    Purinergic Signal 3:145-52. 2007
  8. ncbi request reprint How does methotrexate suppress inflammation?
    B Cronstein
    NYU School of Medicine, New York, NY 10016, USA
    Clin Exp Rheumatol 28:S21-3. 2010
  9. pmc The inflammatory process of gout and its treatment
    Bruce N Cronstein
    Department of Medicine and Division of Clinical Pharmacology, New York University School of Medicine, New York, New York, USA
    Arthritis Res Ther 8:S3. 2006
  10. pmc Restraint stress fails to modulate cutaneous hypersensitivity responses in mice lacking the adenosine A1 receptor
    Stephen J Oliver
    Department of Medicine, New York University School of Medicine, NBV16N 1, 550 First Avenue, New York, NY, 10016, USA
    Purinergic Signal 7:47-56. 2011

Collaborators

Detail Information

Publications31

  1. pmc Adenosine receptors and fibrosis: a translational review
    Bruce N Cronstein
    Department of Medicine, Division of Translational Medicine, NYU School of Medicine 550 First Avenue, New York, NY 10016 USA
    F1000 Biol Rep 3:21. 2011
    ..Accordingly, adenosine may be a good target for therapies that prevent fibrosis of the lungs, liver, and skin...
  2. pmc Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3
    Miguel Perez-Aso
    1Department of Medicine, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    FASEB J 28:802-12. 2014
    ..Our results indicate that cAMP is a concentration-dependent switch for collagen production via noncanonical, AKT-dependent, Smad2/3-independent signaling. These observations explain the paradoxical effects of cAMP on collagen expression...
  3. pmc Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma
    Wenjie He
    New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    FASEB J 27:3446-54. 2013
    ..Furthermore, the effect of dipyridamole on osteoblast differentiation is diminished in both A2BR- and CD39-knockout mice. These results indicate that adenosine receptors may be useful targets for the treatment of MM-induced bone disease...
  4. pmc Mechanistic aspects of inflammation and clinical management of inflammation in acute gouty arthritis
    Bruce N Cronstein
    NYU School of Medicine, New York, NY 10016, USA
    J Clin Rheumatol 19:19-29. 2013
    ..Results of ongoing trials of IL-1β antagonists will likely provide clarification of their potential role in the management of acute gouty arthritis...
  5. pmc Pharmacological blockade of adenosine A2A receptors diminishes scarring
    Miguel Perez-Aso
    Division of Translational Medicine, Department of Medicine, New York University School of Medicine, 550 First Ave, MSB255, New York, NY 10016, USA
    FASEB J 26:4254-63. 2012
    ..Taken together, our work strongly suggests that pharmacological A2AR blockade can be used to diminish scarring while improving the collagen composition and tensile strength of the healed wound...
  6. pmc Regulation of foam cells by adenosine
    Allison B Reiss
    Department of Medicine, Winthrop University Hospital, Mineola, NY, USA
    Arterioscler Thromb Vasc Biol 32:879-86. 2012
    ..This review focuses on the importance of extracellular adenosine acting at specific receptors as a regulatory mechanism to control the formation of foam cells under conditions of lipid loading...
  7. pmc Adenosine in inflammatory joint diseases
    E S L Chan
    Department of Medicine, Divisions of Clinical Pharmacology and Rheumatology, New York University School of Medicine, New York, NY, USA
    Purinergic Signal 3:145-52. 2007
    ....
  8. ncbi request reprint How does methotrexate suppress inflammation?
    B Cronstein
    NYU School of Medicine, New York, NY 10016, USA
    Clin Exp Rheumatol 28:S21-3. 2010
    ..Here we review the proposed mechanisms of action of methotrexate...
  9. pmc The inflammatory process of gout and its treatment
    Bruce N Cronstein
    Department of Medicine and Division of Clinical Pharmacology, New York University School of Medicine, New York, New York, USA
    Arthritis Res Ther 8:S3. 2006
    ..The third line of treatment is oral colchicine, which is highly effective when given early in an acute gouty attack, but it is poorly tolerated because of predictable gastrointestinal side effects...
  10. pmc Restraint stress fails to modulate cutaneous hypersensitivity responses in mice lacking the adenosine A1 receptor
    Stephen J Oliver
    Department of Medicine, New York University School of Medicine, NBV16N 1, 550 First Avenue, New York, NY, 10016, USA
    Purinergic Signal 7:47-56. 2011
    ..These results suggest that the adenosine A(1) receptor pathway plays a role in the process by which perceived psychological stress influences the contact hypersensitivity response...
  11. pmc Metaanalysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity
    Mark C Fisher
    New York University, Hospital for Joint Diseases, New York, NY 10003, USA
    J Rheumatol 36:539-45. 2009
    ..Because the results of small pharmacogenetic studies are often misleading, we undertook a metaanalysis of published studies to determine the role of polymorphisms in the therapeutic efficacy and toxicity of MTX...
  12. doi request reprint Methotrexate--how does it really work?
    Edwin S L Chan
    Department of Medicine, New York University School of Medicine, 550 First Avenue, NBV16N1, New York, NY 10016, USA
    Nat Rev Rheumatol 6:175-8. 2010
    ..These activities contribute to the complex and multifaceted mechanisms that make methotrexate efficacious in the treatment of inflammatory disorders...
  13. ncbi request reprint Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis
    Henghe Tian
    Division of Endocrinology, Diabetes, and Metabolism, NYU Medical Center, New York, NY 10016, USA
    Bull NYU Hosp Jt Dis 65:168-73. 2007
    ..Toward that objective, the latest developments in the pharmacokinetics, mechanism of action, pharmacogenetics, and toxicity of methotrexate are herein discussed...
  14. pmc Molecular action of methotrexate in inflammatory diseases
    Edwin S L Chan
    Division of Clinical Pharmacology, NYU School of Medicine, New York, NY 10016, USA
    Arthritis Res 4:266-73. 2002
    ..In confirmation of this mechanism of action, recent studies in both animals and patients suggest that adenosine-receptor antagonists, among which is caffeine, reverse or prevent the anti-inflammatory effects of methotrexate...
  15. ncbi request reprint Pharmacogenetics in the rheumatic diseases, from prêt-à-porter to haute couture
    Bruce N Cronstein
    Pathology and Pharmacology in the Division of Clinical Pharmacology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nat Clin Pract Rheumatol 2:2-3. 2006
  16. ncbi request reprint Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis
    Bruce N Cronstein
    Pathology and Pharmacology, Division of Clinical Pharmacology, Department of Medicine, NYU School of Medicine, 550 First Ave, New York, NY 10016, USA
    Pharmacol Rev 57:163-72. 2005
    ..These mechanisms of action and the role of methotrexate in the suppression of rheumatoid arthritis are reviewed...
  17. pmc Genetically based resistance to the antiinflammatory effects of methotrexate in the air-pouch model of acute inflammation
    David L Delano
    New York University Medical Center, NY 10016, USA
    Arthritis Rheum 52:2567-75. 2005
    ..To determine whether genetic factors or the model itself is responsible for the poor response to MTX, we directly compared the responses of 4 inbred mouse strains to MTX in the air-pouch model of acute inflammation...
  18. ncbi request reprint Cyclooxygenase-2-selective inhibitors: translating pharmacology into clinical utility
    Bruce N Cronstein
    Division of Clinical Pharmacology, New York University School of Medicine, New York 10016, USA
    Cleve Clin J Med 69:SI13-9. 2002
    ..The clinical relevance of COX-1 compared with COX-2 inhibition is discussed to provide a framework upon which clinicians can better appreciate current and future therapeutic applications of coxibs...
  19. ncbi request reprint Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68
    M Carmen Montesinos
    New York University School of Medicine, New York, New York 10016, USA
    Arthritis Rheum 48:240-7. 2003
    ....
  20. ncbi request reprint Interleukin-6--a key mediator of systemic and local symptoms in rheumatoid arthritis
    Bruce N Cronstein
    NYU School of Medicine, New York University Medical Center, New York, New York 10016, USA
    Bull NYU Hosp Jt Dis 65:S11-5. 2007
    ..Current evidence thus strongly supports the association between IL-6 and RA symptoms and suggests that IL-6 blockade will be a useful therapeutic strategy for patients with this disease...
  21. ncbi request reprint Non-prostaglandin effects of aspirin III and salicylate: inhibition of integrin-dependent human neutrophil aggregation and inflammation in COX 2- and NF kappa B (P105)-knockout mice
    Gerald Weissmann
    Division of Rheumatology, Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
    Adv Exp Med Biol 507:571-7. 2002
    ..In contrast, glucocorticoid action depended on the p105...
  22. ncbi request reprint Adenosine receptors and wound healing
    Bruce N Cronstein
    Department of Pathology, New York University School of Medicine, New York, 10016, USA
    ScientificWorldJournal 4:1-8. 2004
    ..The effects of adenosine A2A receptors on the cells and tissues of healing wounds have only recently been explored. We review here the known effects of adenosine A2A receptor occupancy on the cells involved in wound healing...
  23. ncbi request reprint An interaction between genetic factors and gender determines the magnitude of the inflammatory response in the mouse air pouch model of acute inflammation
    David L Delano
    New York University Medical Center, New York, New York 10016, USA
    Inflammation 29:1-7. 2005
    ..The loci identified by in silico mapping likely contain genes with differential roles in determining this phenotype between genders...
  24. pmc Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis
    Edwin S L Chan
    Division of Clinical Pharmacology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Br J Pharmacol 148:1144-55. 2006
    ..6. These results demonstrate that hepatic adenosine A(2A) receptors play an active role in the pathogenesis of hepatic fibrosis, and suggest a novel therapeutic target in the treatment and prevention of hepatic cirrhosis...
  25. ncbi request reprint Pharmacogenetics in the rheumatic diseases
    Bruce N Cronstein
    Pathologyand Pharmacology at NYU School of Medicine, New York, New York, USA
    Bull NYU Hosp Jt Dis 64:16-9. 2006
    ....
  26. pmc Adenosine A2A receptors play an active role in mouse bone marrow-derived mesenchymal stem cell development
    Majid Katebi
    New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Leukoc Biol 85:438-44. 2009
    ..05 for all; n=3). These findings indicate that adenosine and adenosine A(2A)R play a critical role in promoting the proliferation and differentiation of mouse BM-MSCs...
  27. ncbi request reprint Update on gout: pathophysiology and potential treatments
    Aryeh M Abeles
    Division of Rheumatology, Medical Arts and Research Building, 263 Farmington Avenue, Farmington, CT 06030, USA
    Curr Pain Headache Rep 11:440-6. 2007
    ..Finally, we provide an overview of the current approach to gout, as well as what treatments are on the horizon...
  28. ncbi request reprint Gout: forgotten therapy for a common disease
    Bruce N Cronstein
    Curr Rheumatol Rep 7:1-2. 2005
  29. ncbi request reprint Adenosine: an endogenous regulator of innate immunity
    Gyorgy Hasko
    Department of Surgery, UMD New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA
    Trends Immunol 25:33-9. 2004
    ..The effects of adenosine, acting at its receptors, on the functions of the cells that mediate innate immune responses, will be reviewed...
  30. ncbi request reprint The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5'-nucleotidase: findings in a study of ecto-5'-nucleotidase gene-deficient mice
    M Carmen Montesinos
    University of Valencia, Valencia, Spain
    Arthritis Rheum 56:1440-5. 2007
    ....