Affiliation: New York University School of Medicine
- Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3Miguel Perez-Aso
1Department of Medicine, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
FASEB J 28:802-12. 2014..Our results indicate that cAMP is a concentration-dependent switch for collagen production via noncanonical, AKT-dependent, Smad2/3-independent signaling. These observations explain the paradoxical effects of cAMP on collagen expression...
- Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myelomaWenjie He
New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
FASEB J 27:3446-54. 2013..Furthermore, the effect of dipyridamole on osteoblast differentiation is diminished in both A2BR- and CD39-knockout mice. These results indicate that adenosine receptors may be useful targets for the treatment of MM-induced bone disease...
- Mechanistic aspects of inflammation and clinical management of inflammation in acute gouty arthritisBruce N Cronstein
NYU School of Medicine, New York, NY 10016, USA
J Clin Rheumatol 19:19-29. 2013..Results of ongoing trials of IL-1β antagonists will likely provide clarification of their potential role in the management of acute gouty arthritis...
- Pharmacological blockade of adenosine A2A receptors diminishes scarringMiguel Perez-Aso
Division of Translational Medicine, Department of Medicine, New York University School of Medicine, 550 First Ave, MSB255, New York, NY 10016, USA
FASEB J 26:4254-63. 2012..Taken together, our work strongly suggests that pharmacological A2AR blockade can be used to diminish scarring while improving the collagen composition and tensile strength of the healed wound...
- Regulation of foam cells by adenosineAllison B Reiss
Department of Medicine, Winthrop University Hospital, Mineola, NY, USA
Arterioscler Thromb Vasc Biol 32:879-86. 2012..This review focuses on the importance of extracellular adenosine acting at specific receptors as a regulatory mechanism to control the formation of foam cells under conditions of lipid loading...
- Adenosine in inflammatory joint diseasesE S L Chan
Department of Medicine, Divisions of Clinical Pharmacology and Rheumatology, New York University School of Medicine, New York, NY, USA
Purinergic Signal 3:145-52. 2007....
- How does methotrexate suppress inflammation?B Cronstein
NYU School of Medicine, New York, NY 10016, USA
Clin Exp Rheumatol 28:S21-3. 2010..Here we review the proposed mechanisms of action of methotrexate...
- The inflammatory process of gout and its treatmentBruce N Cronstein
Department of Medicine and Division of Clinical Pharmacology, New York University School of Medicine, New York, New York, USA
Arthritis Res Ther 8:S3. 2006..The third line of treatment is oral colchicine, which is highly effective when given early in an acute gouty attack, but it is poorly tolerated because of predictable gastrointestinal side effects...
- Metaanalysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicityMark C Fisher
New York University, Hospital for Joint Diseases, New York, NY 10003, USA
J Rheumatol 36:539-45. 2009..Because the results of small pharmacogenetic studies are often misleading, we undertook a metaanalysis of published studies to determine the role of polymorphisms in the therapeutic efficacy and toxicity of MTX...
- Methotrexate--how does it really work?Edwin S L Chan
Department of Medicine, New York University School of Medicine, 550 First Avenue, NBV16N1, New York, NY 10016, USA
Nat Rev Rheumatol 6:175-8. 2010..These activities contribute to the complex and multifaceted mechanisms that make methotrexate efficacious in the treatment of inflammatory disorders...
- Restraint stress fails to modulate cutaneous hypersensitivity responses in mice lacking the adenosine A1 receptorStephen J Oliver
Department of Medicine, New York University School of Medicine, NBV16N 1, 550 First Avenue, New York, NY, 10016, USA
Purinergic Signal 7:47-56. 2011..These results suggest that the adenosine A(1) receptor pathway plays a role in the process by which perceived psychological stress influences the contact hypersensitivity response...
- Pharmacogenetics in the rheumatic diseases, from prêt-à-porter to haute coutureBruce N Cronstein
Pathology and Pharmacology in the Division of Clinical Pharmacology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Nat Clin Pract Rheumatol 2:2-3. 2006
- Genetically based resistance to the antiinflammatory effects of methotrexate in the air-pouch model of acute inflammationDavid L Delano
New York University Medical Center, NY 10016, USA
Arthritis Rheum 52:2567-75. 2005..To determine whether genetic factors or the model itself is responsible for the poor response to MTX, we directly compared the responses of 4 inbred mouse strains to MTX in the air-pouch model of acute inflammation...
- Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritisBruce N Cronstein
Pathology and Pharmacology, Division of Clinical Pharmacology, Department of Medicine, NYU School of Medicine, 550 First Ave, New York, NY 10016, USA
Pharmacol Rev 57:163-72. 2005..These mechanisms of action and the role of methotrexate in the suppression of rheumatoid arthritis are reviewed...
- Molecular action of methotrexate in inflammatory diseasesEdwin S L Chan
Division of Clinical Pharmacology, NYU School of Medicine, New York, NY 10016, USA
Arthritis Res 4:266-73. 2002..In confirmation of this mechanism of action, recent studies in both animals and patients suggest that adenosine-receptor antagonists, among which is caffeine, reverse or prevent the anti-inflammatory effects of methotrexate...
- Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritisHenghe Tian
Division of Endocrinology, Diabetes, and Metabolism, NYU Medical Center, New York, NY 10016, USA
Bull NYU Hosp Jt Dis 65:168-73. 2007..Toward that objective, the latest developments in the pharmacokinetics, mechanism of action, pharmacogenetics, and toxicity of methotrexate are herein discussed...
- Interleukin-6--a key mediator of systemic and local symptoms in rheumatoid arthritisBruce N Cronstein
NYU School of Medicine, New York University Medical Center, New York, New York 10016, USA
Bull NYU Hosp Jt Dis 65:S11-5. 2007..Current evidence thus strongly supports the association between IL-6 and RA symptoms and suggests that IL-6 blockade will be a useful therapeutic strategy for patients with this disease...
- Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68M Carmen Montesinos
New York University School of Medicine, New York, New York 10016, USA
Arthritis Rheum 48:240-7. 2003....
- Cyclooxygenase-2-selective inhibitors: translating pharmacology into clinical utilityBruce N Cronstein
Division of Clinical Pharmacology, New York University School of Medicine, New York 10016, USA
Cleve Clin J Med 69:SI13-9. 2002..The clinical relevance of COX-1 compared with COX-2 inhibition is discussed to provide a framework upon which clinicians can better appreciate current and future therapeutic applications of coxibs...
- Non-prostaglandin effects of aspirin III and salicylate: inhibition of integrin-dependent human neutrophil aggregation and inflammation in COX 2- and NF kappa B (P105)-knockout miceGerald Weissmann
Division of Rheumatology, Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
Adv Exp Med Biol 507:571-7. 2002..In contrast, glucocorticoid action depended on the p105...
- Adenosine receptors and wound healingBruce N Cronstein
Department of Pathology, New York University School of Medicine, New York, 10016, USA
ScientificWorldJournal 4:1-8. 2004..The effects of adenosine A2A receptors on the cells and tissues of healing wounds have only recently been explored. We review here the known effects of adenosine A2A receptor occupancy on the cells involved in wound healing...
- An interaction between genetic factors and gender determines the magnitude of the inflammatory response in the mouse air pouch model of acute inflammationDavid L Delano
New York University Medical Center, New York, New York 10016, USA
Inflammation 29:1-7. 2005..The loci identified by in silico mapping likely contain genes with differential roles in determining this phenotype between genders...
- Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosisEdwin S L Chan
Division of Clinical Pharmacology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Br J Pharmacol 148:1144-55. 2006..6. These results demonstrate that hepatic adenosine A(2A) receptors play an active role in the pathogenesis of hepatic fibrosis, and suggest a novel therapeutic target in the treatment and prevention of hepatic cirrhosis...
- Pharmacogenetics in the rheumatic diseasesBruce N Cronstein
Pathologyand Pharmacology at NYU School of Medicine, New York, New York, USA
Bull NYU Hosp Jt Dis 64:16-9. 2006....
- Adenosine A2A receptors play an active role in mouse bone marrow-derived mesenchymal stem cell developmentMajid Katebi
New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
J Leukoc Biol 85:438-44. 2009..05 for all; n=3). These findings indicate that adenosine and adenosine A(2A)R play a critical role in promoting the proliferation and differentiation of mouse BM-MSCs...
- Update on gout: pathophysiology and potential treatmentsAryeh M Abeles
Division of Rheumatology, Medical Arts and Research Building, 263 Farmington Avenue, Farmington, CT 06030, USA
Curr Pain Headache Rep 11:440-6. 2007..Finally, we provide an overview of the current approach to gout, as well as what treatments are on the horizon...
- Gout: forgotten therapy for a common diseaseBruce N Cronstein
Curr Rheumatol Rep 7:1-2. 2005
- Adenosine: an endogenous regulator of innate immunityGyorgy Hasko
Department of Surgery, UMD New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA
Trends Immunol 25:33-9. 2004..The effects of adenosine, acting at its receptors, on the functions of the cells that mediate innate immune responses, will be reviewed...
- The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5'-nucleotidase: findings in a study of ecto-5'-nucleotidase gene-deficient miceM Carmen Montesinos
University of Valencia, Valencia, Spain
Arthritis Rheum 56:1440-5. 2007....