Pamela Cowin

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Cadherins and catenins in breast cancer
    Pamela Cowin
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Curr Opin Cell Biol 17:499-508. 2005
  2. pmc Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland
    A Imbert
    Department of Cell Biology, New York University Medical School, New York, New York 10016, USA
    J Cell Biol 153:555-68. 2001
  3. pmc Plakoglobin suppresses epithelial proliferation and hair growth in vivo
    E Charpentier
    Departments of Cell Biology and Dermatology, New York University Medical School, New York 10016, USA
    J Cell Biol 149:503-20. 2000
  4. ncbi request reprint Beta-catenin and cyclin D1: connecting development to breast cancer
    Tracey M Rowlands
    Departments of Cell Biology and Dermatology, New York University School of Medicine, New York, New York 10016, USA
    Cell Cycle 3:145-8. 2004
  5. ncbi request reprint Beta-catenin and Tcfs in mammary development and cancer
    Sarah Hatsell
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    J Mammary Gland Biol Neoplasia 8:145-58. 2003
  6. pmc MMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors
    Brigitte Teissedre
    Departments of Cell Biology and Dermatology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 4:e4537. 2009
  7. doi request reprint Plakoglobin is required for effective intermediate filament anchorage to desmosomes
    Devrim Acehan
    Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10012, USA
    J Invest Dermatol 128:2665-75. 2008
  8. ncbi request reprint The pattern of beta-catenin responsiveness within the mammary gland is regulated by progesterone receptor
    Minoti Hiremath
    Department of Cell Biology, NYU School of Medicine, MSB 618, 550 1st Avenue, New York, NY 10016, USA
    Development 134:3703-12. 2007
  9. pmc Choreographing metastasis to the tune of LTBP
    Anupama Chandramouli
    Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
    J Mammary Gland Biol Neoplasia 16:67-80. 2011
  10. pmc Key signaling nodes in mammary gland development and cancer: β-catenin
    Angela Incassati
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Breast Cancer Res 12:213. 2010

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Cadherins and catenins in breast cancer
    Pamela Cowin
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Curr Opin Cell Biol 17:499-508. 2005
    ..However, beta-catenin signaling is upregulated by numerous pathways in >50% of breast tumors and animal models suggest its oncogenic function in breast relates to its role in mammary progenitor cell expansion...
  2. pmc Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland
    A Imbert
    Department of Cell Biology, New York University Medical School, New York, New York 10016, USA
    J Cell Biol 153:555-68. 2001
    ..In particular, Delta N 89 beta-catenin has no effect on ductal side branching. This suggests that Wnt induction of ductal branching involves additional downstream effectors or modulators...
  3. pmc Plakoglobin suppresses epithelial proliferation and hair growth in vivo
    E Charpentier
    Departments of Cell Biology and Dermatology, New York University Medical School, New York 10016, USA
    J Cell Biol 149:503-20. 2000
    ..1994). The proliferative rate of the epidermal cells was reduced and apoptotic changes, which are associated with entry into the regressive phase of the hair follicle cycle (catagen), occurred earlier than usual...
  4. ncbi request reprint Beta-catenin and cyclin D1: connecting development to breast cancer
    Tracey M Rowlands
    Departments of Cell Biology and Dermatology, New York University School of Medicine, New York, New York 10016, USA
    Cell Cycle 3:145-8. 2004
    ..These proteins are employed at critical junctures involving cell fate decisions that we speculate require specific types of cell cycle to traverse...
  5. ncbi request reprint Beta-catenin and Tcfs in mammary development and cancer
    Sarah Hatsell
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    J Mammary Gland Biol Neoplasia 8:145-58. 2003
    ..Cyclin D1, however, is dispensable for tumor formation and the initiation of alveologenesis but is essential for later alveolar expansion...
  6. pmc MMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors
    Brigitte Teissedre
    Departments of Cell Biology and Dermatology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 4:e4537. 2009
    ..They further suggest that Hedgehog pathway activation maybe a critical component and useful indicator of breast tumors arising from unopposed Wnt1 ligand...
  7. doi request reprint Plakoglobin is required for effective intermediate filament anchorage to desmosomes
    Devrim Acehan
    Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10012, USA
    J Invest Dermatol 128:2665-75. 2008
    ....
  8. ncbi request reprint The pattern of beta-catenin responsiveness within the mammary gland is regulated by progesterone receptor
    Minoti Hiremath
    Department of Cell Biology, NYU School of Medicine, MSB 618, 550 1st Avenue, New York, NY 10016, USA
    Development 134:3703-12. 2007
    ..Once activated by beta-catenin, responding cells switch on an alveolar differentiation program that is indistinguishable from that observed in pregnancy and is curtailed by PR signaling...
  9. pmc Choreographing metastasis to the tune of LTBP
    Anupama Chandramouli
    Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
    J Mammary Gland Biol Neoplasia 16:67-80. 2011
    ..LTBP may promote metastasis by providing the bridge between structural and signaling components of the epithelial to mesenchymal transition (EMT)...
  10. pmc Key signaling nodes in mammary gland development and cancer: β-catenin
    Angela Incassati
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Breast Cancer Res 12:213. 2010
    ..The present review will discuss β-catenin as a central transducer of numerous signaling pathways and its role in mammary development and breast cancer...
  11. pmc Molecular mechanisms guiding embryonic mammary gland development
    Pamela Cowin
    Departments of Cell Biology and Dermatology, New York University School of Medicine, New York, NY 10016, USA
    Cold Spring Harb Perspect Biol 2:a003251. 2010
    ..We also discuss the potential relevance of embryonic breast development to the pathophysiology of breast cancer and highlight questions for future research...
  12. pmc A systematic screen for micro-RNAs regulating the canonical Wnt pathway
    Roman Anton
    Cancer Institute Department of Pharmacology, New York University Langone Medical Center, New York University, New York, New York, United States of America
    PLoS ONE 6:e26257. 2011
    ..In summary, these findings suggest the potential use of Wnt-modulating miRs as diagnostic and therapeutic tools in Wnt-dependent diseases, such as cancer...
  13. pmc Links between transforming growth factor-beta and canonical Wnt signaling yield new insights into breast cancer susceptibility, suppression and tumor heterogeneity
    Angela Incassati
    Department of Cell Biology, New York University School of Medicine, NY, USA
    Breast Cancer Res 11:103. 2009
    ..These findings reveal a novel intersection of two tumor suppressors with a potent oncogenic pathway and highlight the need for further study on the role played by canonical Wnt signaling in breast cancer susceptibility and subtype...
  14. ncbi request reprint Untangling desmosomal knots with electron tomography
    Wanzhong He
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Science 302:109-13. 2003
    ..This flexibility suggests a novel mechanism for generating both cis and trans interactions and for propagating these adhesive interactions along the junction...
  15. pmc Bone morphogenetic protein signaling regulates postnatal hair follicle differentiation and cycling
    Udayan Guha
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Pathol 165:729-40. 2004
    ..BMPs likely promote a hair follicle-type differentiation pathway of keratinocytes while suppressing the sebaceous differentiation pathway of skin epithelium...
  16. ncbi request reprint Gli3-mediated repression of Hedgehog targets is required for normal mammary development
    Sarah J Hatsell
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 133:3661-70. 2006
    ..Thus, positive Hedgehog signaling is absent throughout mammary development, distinguishing the mammary gland from other epidermal appendages, such as hair follicles, which require Hedgehog pathway activity...
  17. pmc Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia
    Tracey M Rowlands
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 100:11400-5. 2003
    ..Thus, alveologenesis is a two-step process, and cyclin D1 activity during late alveologenesis cannot be replaced by the activity of other beta-catenin target genes that successfully drive proliferation at earlier stages...
  18. doi request reprint Distinct function of androgen receptor coactivator ARA70α and ARA70β in mammary gland development, and in breast cancer
    Xinyu Wu
    Department of Pathology, New York University School of Medicine, 423 E 23rd Street, Room6139 N, New York, NY 10010, USA
    Breast Cancer Res Treat 128:391-400. 2011
    ..Significantly, decreased ARA70α expression is associated with increased tendency of breast cancer metastasis. In summary, ARA70α and ARA70β have distinct effects in mammary gland development and in the progression of breast cancer...