Yu Chen

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. ncbi request reprint A prospective study of arm circumference and risk of death in Bangladesh
    Yu Chen
    Departments of Population Health and Environmental Medicine, New York University School of Medicine, New York, USA, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York City, USA, Leon H Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, USA, Columbia University Arsenic Research Project, Dhaka, Bangladesh, Departments of Health Studies, Medicine and Human Genetics and Comprehensive Cancer Center, The University of Chicago, Chicago, IL, USA and Department of Biostatistics, Mailman School of Public Health, Columbia University, New York City, USA
    Int J Epidemiol 43:1187-96. 2014
  2. pmc A prospective study of tobacco smoking and mortality in Bangladesh
    Fen Wu
    Department of Population Health, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 8:e58516. 2013
  3. pmc Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort study
    Yu Chen
    Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
    BMJ 342:d2431. 2011
  4. pmc Arsenic exposure from drinking water, arsenic methylation capacity, and carotid intima-media thickness in Bangladesh
    Yu Chen
    Departments of Population Health and Environmental Medicine, School of Medicine, New York University, 650 First Avenue, Room 510, New York, NY 10016, USA
    Am J Epidemiol 178:372-81. 2013
  5. pmc Association between Helicobacter pylori and mortality in the NHANES III study
    Yu Chen
    Department of Population Health, New York University School of Medicine, New York, NY 10016, USA
    Gut 62:1262-9. 2013
  6. pmc A prospective study of arsenic exposure, arsenic methylation capacity, and risk of cardiovascular disease in Bangladesh
    Yu Chen
    Department of Population Health, New York University School of Medicine, New York, New York 10016, USA
    Environ Health Perspect 121:832-8. 2013
  7. pmc Prospective investigation of major dietary patterns and risk of cardiovascular mortality in Bangladesh
    Yu Chen
    Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
    Int J Cardiol 167:1495-501. 2013
  8. pmc Arsenic exposure from drinking water and QT-interval prolongation: results from the Health Effects of Arsenic Longitudinal Study
    Yu Chen
    Department of Population Health, New York University School of Medicine, New York University, New York, New York 10016 USA
    Environ Health Perspect 121:427-32, 432e1-7. 2013
  9. pmc Association between gastric Helicobacter pylori colonization and glycated hemoglobin levels
    Yu Chen
    Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
    J Infect Dis 205:1195-202. 2012
  10. pmc Endogenous hormones and coronary heart disease in postmenopausal women
    Yu Chen
    Division of Epidemiology, Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016 3240, United States
    Atherosclerosis 216:414-9. 2011

Collaborators

Detail Information

Publications95

  1. ncbi request reprint A prospective study of arm circumference and risk of death in Bangladesh
    Yu Chen
    Departments of Population Health and Environmental Medicine, New York University School of Medicine, New York, USA, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York City, USA, Leon H Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, USA, Columbia University Arsenic Research Project, Dhaka, Bangladesh, Departments of Health Studies, Medicine and Human Genetics and Comprehensive Cancer Center, The University of Chicago, Chicago, IL, USA and Department of Biostatistics, Mailman School of Public Health, Columbia University, New York City, USA
    Int J Epidemiol 43:1187-96. 2014
    ..Epidemiological studies have observed protective effects of mid-upper arm circumference (MUAC) against all-cause mortality mostly in Western populations. However, evidence on cause-specific mortality is limited...
  2. pmc A prospective study of tobacco smoking and mortality in Bangladesh
    Fen Wu
    Department of Population Health, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 8:e58516. 2013
    ..Limited data are available on smoking-related mortality in low-income countries, where both chronic disease burden and prevalence of smoking are increasing...
  3. pmc Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort study
    Yu Chen
    Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
    BMJ 342:d2431. 2011
    ..To evaluate the association between arsenic exposure and mortality from cardiovascular disease and to assess whether cigarette smoking influences the association...
  4. pmc Arsenic exposure from drinking water, arsenic methylation capacity, and carotid intima-media thickness in Bangladesh
    Yu Chen
    Departments of Population Health and Environmental Medicine, School of Medicine, New York University, 650 First Avenue, Room 510, New York, NY 10016, USA
    Am J Epidemiol 178:372-81. 2013
    ..Future prospective studies are needed to confirm the association between arsenic methylation capacity and atherosclerosis-related outcomes. ..
  5. pmc Association between Helicobacter pylori and mortality in the NHANES III study
    Yu Chen
    Department of Population Health, New York University School of Medicine, New York, NY 10016, USA
    Gut 62:1262-9. 2013
    ..Thus, it is important to evaluate its influence on total and category-specific mortality...
  6. pmc A prospective study of arsenic exposure, arsenic methylation capacity, and risk of cardiovascular disease in Bangladesh
    Yu Chen
    Department of Population Health, New York University School of Medicine, New York, New York 10016, USA
    Environ Health Perspect 121:832-8. 2013
    ..Few prospective studies have evaluated the influence of arsenic methylation capacity on cardiovascular disease (CVD) risk...
  7. pmc Prospective investigation of major dietary patterns and risk of cardiovascular mortality in Bangladesh
    Yu Chen
    Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
    Int J Cardiol 167:1495-501. 2013
    ..However, no studies have applied this technique to a population outside of the developed world...
  8. pmc Arsenic exposure from drinking water and QT-interval prolongation: results from the Health Effects of Arsenic Longitudinal Study
    Yu Chen
    Department of Population Health, New York University School of Medicine, New York University, New York, New York 10016 USA
    Environ Health Perspect 121:427-32, 432e1-7. 2013
    ..Arsenic exposure from drinking water has been associated with heart disease; however, underlying mechanisms are uncertain...
  9. pmc Association between gastric Helicobacter pylori colonization and glycated hemoglobin levels
    Yu Chen
    Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
    J Infect Dis 205:1195-202. 2012
    ..Few studies have evaluated the potential influence of Helicobacter pylori on biomarkers for diabetes...
  10. pmc Endogenous hormones and coronary heart disease in postmenopausal women
    Yu Chen
    Division of Epidemiology, Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016 3240, United States
    Atherosclerosis 216:414-9. 2011
    ..These findings suggest that circulating estradiol and SHBG are not associated with CHD risk in postmenopausal women beyond what can be explained by the variation in hypertension status, BMI, and cholesterol...
  11. pmc Association between arsenic exposure from drinking water and proteinuria: results from the Health Effects of Arsenic Longitudinal Study
    Yu Chen
    Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
    Int J Epidemiol 40:828-35. 2011
    ..Proteinuria has been recognized as a marker for an increased risk of chronic renal disease. It is unclear whether arsenic (As) exposure from drinking water is associated with proteinuria...
  12. ncbi request reprint Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh
    Habibul Ahsan
    Departments of Epidemiology, Columbia University, USA
    Cancer Epidemiol Biomarkers Prev 16:1270-8. 2007
    ....
  13. pmc Association between arsenic exposure from drinking water and plasma levels of soluble cell adhesion molecules
    Yu Chen
    Departments of Environmental Medicine and Medicine, and New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    Environ Health Perspect 115:1415-20. 2007
    ..Epidemiologic studies of cardiovascular disease risk factors and appropriate biomarkers in populations exposed to a wide range of arsenic levels are a public health research priority...
  14. ncbi request reprint Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh
    Julia E Heck
    Department of Epidemiology, Mailman School of Public Health and Institute for Social and Economic Research and Policy, Columbia University, New York, NY, USA
    Am J Clin Nutr 85:1367-74. 2007
    ..Previous studies suggest that persons with more complete methylation, characterized as greater proportions of DMA and lesser proportions of MMA and InAs in urine, have a lower risk of adverse arsenic-related health outcomes...
  15. pmc Arsenic exposure at low-to-moderate levels and skin lesions, arsenic metabolism, neurological functions, and biomarkers for respiratory and cardiovascular diseases: review of recent findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in
    Yu Chen
    Departments of Environmental Medicine and Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY, USA
    Toxicol Appl Pharmacol 239:184-92. 2009
    ....
  16. ncbi request reprint Modification of risk of arsenic-induced skin lesions by sunlight exposure, smoking, and occupational exposures in Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Epidemiology 17:459-67. 2006
    ..The risk of skin lesions associated with arsenic exposure from drinking water in Bangladesh is considerably greater in men than in women...
  17. ncbi request reprint Silencing of glutathione S-transferase P1 by promoter hypermethylation and its relationship to environmental chemical carcinogens in hepatocellular carcinoma
    Yu Jing Zhang
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Cancer Lett 221:135-43. 2005
    ..The mechanism by which environmental exposures induce epigenetic changes in HCC needs further analysis...
  18. pmc Association between arsenic exposure from drinking water and hematuria: results from the Health Effects of Arsenic Longitudinal Study
    Tyler R McClintock
    Department of Population Health, New York University School of Medicine, New York, NY, USA Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA Department of Urology, New York University School of Medicine, New York, NY, USA
    Toxicol Appl Pharmacol 276:21-7. 2014
    ..17 μg/l, respectively. These data indicate a positive association of As exposure with both prevalence and incidence of dipstick hematuria. This exposure effect appears modifiable by relatively short-term changes in drinking water As...
  19. pmc Association between arsenic exposure from drinking water and plasma levels of cardiovascular markers
    Fen Wu
    Department of Environmental Medicine, New York University School of Medicine, New York, USA
    Am J Epidemiol 175:1252-61. 2012
    ....
  20. ncbi request reprint Arsenic exposure from drinking water, dietary intakes of B vitamins and folate, and risk of high blood pressure in Bangladesh: a population-based, cross-sectional study
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Epidemiol 165:541-52. 2007
    ..Future research is needed to evaluate the effect of low-level arsenic exposure on specific cardiovascular outcomes...
  21. pmc A prospective study of arsenic exposure from drinking water and incidence of skin lesions in Bangladesh
    Maria Argos
    Department of Health Studies, The University of Chicago, Illinois 60637, USA
    Am J Epidemiol 174:185-94. 2011
    ..Chronic arsenic exposure from drinking water was associated with increased incidence of skin lesions, even at low levels of arsenic exposure (<100 μg/L)...
  22. pmc Dietary B vitamin intakes and urinary total arsenic concentration in the Health Effects of Arsenic Longitudinal Study (HEALS) cohort, Bangladesh
    Maria Argos
    Department of Health Studies, The University of Chicago, 5841 S Maryland Avenue, MC2007, Chicago, IL 60637, USA
    Eur J Nutr 49:473-81. 2010
    ..Dietary factors influencing the metabolism of ingested arsenic may potentially be important modifiers of the health effects of arsenic in this population...
  23. doi request reprint Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study Project
    Yu Chen
    Department of Environmental Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Carcinogenesis 29:766-71. 2008
    ..In conclusion, the findings suggest that the CYP17 variant C allele may increase breast cancer risk in conjunction with long-term HRT use and high BMI in postmenopausal women...
  24. pmc Dietary intake of methionine, cysteine, and protein and urinary arsenic excretion in Bangladesh
    Julia E Heck
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 117:99-104. 2009
    ..Once ingested, arsenic is metabolized via methylation and excreted in urine. Knowledge about nutritional factors affecting individual variation in methylation is limited...
  25. ncbi request reprint Nutritional influence on risk of high blood pressure in Bangladesh: a population-based cross-sectional study
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Clin Nutr 84:1224-32. 2006
    ..The nutritional determinants of hypertension in Bangladesh and other low-income countries are largely unknown...
  26. pmc A prospective study of blood selenium levels and the risk of arsenic-related premalignant skin lesions
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Cancer Epidemiol Biomarkers Prev 16:207-13. 2007
    ..The findings support the hypothesis that dietary selenium intake may reduce the incidence of arsenic-related premalignant skin lesions among populations exposed to arsenic exposure from drinking water...
  27. pmc Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study
    Maria Argos
    Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
    Lancet 376:252-8. 2010
    ..We therefore prospectively assessed whether chronic and recent changes in arsenic exposure are associated with all-cause and chronic-disease mortalities in a Bangladeshi population...
  28. ncbi request reprint Combined genetic assessment of transforming growth factor-beta signaling pathway variants may predict breast cancer risk
    Virginia G Kaklamani
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Northwestern University, 676 North St Clair Street, Chicago, IL 60611, USA
    Cancer Res 65:3454-61. 2005
    ..25-3.87). This is the first study assessing the TGF-beta signaling pathway through two common and functionally relevant TGFBR1 and TGFB1 variants. This approach may predict breast cancer risk in a large subset of the population...
  29. ncbi request reprint Blood arsenic as a biomarker of arsenic exposure: results from a prospective study
    Marni Hall
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University Medical Center, 60 Haven Avenue B1, New York, NY 10032, USA
    Toxicology 225:225-33. 2006
    ..This prospective study confirms the increased risk of skin lesions in relation to As concentrations in blood, urine and water and also establishes that BAs is a useful biomarker of As exposure in this study population...
  30. pmc Interaction between arsenic exposure from drinking water and genetic susceptibility in carotid intima-media thickness in Bangladesh
    Fen Wu
    Department of Population Health, New York University School of Medicine, New York, NY, USA Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
    Toxicol Appl Pharmacol 276:195-203. 2014
    ..Future replication studies in diverse populations are needed to confirm the findings. ..
  31. pmc Association between body mass index and cardiovascular disease mortality in east Asians and south Asians: pooled analysis of prospective data from the Asia Cohort Consortium
    Yu Chen
    Department of Population Health, New York University School of Medicine, New York, NY, USA
    BMJ 347:f5446. 2013
    ..To evaluate the association between body mass index and mortality from overall cardiovascular disease and specific subtypes of cardiovascular disease in east and south Asians...
  32. pmc Socioeconomic status and risk for arsenic-related skin lesions in Bangladesh
    Maria Argos
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Public Health 97:825-31. 2007
    ..In this study, we explored the association between socioeconomic status and arsenic toxicity...
  33. pmc Protective effects of B vitamins and antioxidants on the risk of arsenic-related skin lesions in Bangladesh
    Lydia B Zablotska
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 116:1056-62. 2008
    ..The mitigating effects of diet on arsenic-related premalignant skin lesions are largely unknown...
  34. ncbi request reprint Protein and amino acid intakes in a rural area of Bangladesh
    Julia E Heck
    Department of Epidemiology, Columbia University, New York, USA
    Food Nutr Bull 31:206-13. 2010
    ..Few studies have described protein and amino acid intakes in rural Bangladesh, a country with considerable undernutrition...
  35. pmc Intakes of several nutrients are associated with incidence of arsenic-related keratotic skin lesions in Bangladesh
    Stephanie Melkonian
    Department of Health Studies, The University of Chicago, Chicago, IL, USA
    J Nutr 142:2128-34. 2012
    ..Understanding differential susceptibility to skin lesion incidence based on nutrient intake will help researchers develop targeted interventions to prevent health consequences of arsenic poisoning in Bangladesh and beyond...
  36. pmc Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Breast Cancer Res 7:R71-81. 2005
    ....
  37. ncbi request reprint Arsenic exposure from drinking-water and carotid artery intima-medial thickness in healthy young adults in Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, 10032, USA
    J Health Popul Nutr 24:253-7. 2006
    ....
  38. pmc ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss
    Yu Chen
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Med 19:1023-9. 2013
    ..We propose that ETS factors cause prostate-specific transformation by altering the AR cistrome, priming the prostate epithelium to respond to aberrant upstream signals such as PTEN loss. ..
  39. pmc Prevalence of arsenic exposure from drinking water and awareness of its health risks in a Bangladeshi population: results from a large population-based study
    Faruque Parvez
    Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 114:355-9. 2006
    ..Increasing knowledge of the health consequences of As may be an important element in facilitating remediation...
  40. pmc Arsenic exposure and impaired lung function. Findings from a large population-based prospective cohort study
    Faruque Parvez
    1 Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York
    Am J Respir Crit Care Med 188:813-9. 2013
    ..Limited evidence for the deleterious effects on lung function exists among individuals exposed to a high dose of arsenic...
  41. pmc Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh
    Mary V Gamble
    Departments of Environmental Health Sciences, Columbia University, New York, NY, USA
    Am J Clin Nutr 84:1093-101. 2006
    ..Consequently, folate nutritional status may influence arsenic methylation and toxicity...
  42. ncbi request reprint Aflatoxin B1 and polycyclic aromatic hydrocarbon adducts, p53 mutations and p16 methylation in liver tissue and plasma of hepatocellular carcinoma patients
    Yu Jing Zhang
    Department of Environmental Health Science, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Int J Cancer 119:985-91. 2006
    ..These data suggest that genetic, epigenetic and environmental exposure biomarkers in plasma may help in estimating the risk for the development of HCC...
  43. pmc ARN-509: a novel antiandrogen for prostate cancer treatment
    Nicola J Clegg
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Res 72:1494-503. 2012
    ..Our findings offer preclinical proof of principle for ARN-509 as a promising therapeutic in both castration-sensitive and castration-resistant forms of prostate cancer...
  44. ncbi request reprint Variants in estrogen metabolism and biosynthesis genes and urinary estrogen metabolites in women with a family history of breast cancer
    Heather Greenlee
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, 7th Floor, New York, NY 10032, USA
    Breast Cancer Res Treat 102:111-7. 2007
    ....
  45. doi request reprint Arsenic exposure and anemia in Bangladesh: a population-based study
    Julia E Heck
    Department of Epidemiology, Mailman School of Public Health, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Occup Environ Med 50:80-7. 2008
    ..The purpose of this study was to examine the association between arsenic exposure and anemia, based on blood hemoglobin concentration...
  46. ncbi request reprint A CYP19 (aromatase) polymorphism is associated with increased premenopausal breast cancer risk
    Kathryn E Talbott
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA
    Breast Cancer Res Treat 111:481-7. 2008
    ..The finding supports the potential role of variation in estrogen biosynthesis genes in premenopausal breast cancer risk...
  47. pmc Reduction in urinary arsenic levels in response to arsenic mitigation efforts in Araihazar, Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 115:917-23. 2007
    ..There is a need to identify and evaluate an effective mitigation program for arsenic exposure from drinking water in Bangladesh...
  48. ncbi request reprint Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal Study
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Am J Epidemiol 163:1138-48. 2006
    ..53, 5.44), and 5.39 (95% CI: 3.69, 7.86), respectively. The effect seemed to be influenced by gender, age, and body mass index. These findings provide information that should be considered in future research and policy decisions...
  49. pmc A population-based prospective study of energy-providing nutrients in relation to all-cause cancer mortality and cancers of digestive organs mortality
    Maria Argos
    Department of Health Studies, The University of Chicago, Chicago, IL
    Int J Cancer 133:2422-8. 2013
    ..Novel findings from this prospective study show protein is an important risk factor or proxy to an important risk factor for cancer mortality especially from digestive organ cancers in Bangladesh...
  50. pmc A prospective study of respiratory symptoms associated with chronic arsenic exposure in Bangladesh: findings from the Health Effects of Arsenic Longitudinal Study (HEALS)
    Faruque Parvez
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
    Thorax 65:528-33. 2010
    ..A total of 7.31, 9.95 and 2.03% of the 11 746 participants completing 4 years of active follow-up reported having a chronic cough, breathing problem or blood in their sputum, respectively, as assessed by trained physicians...
  51. ncbi request reprint Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columfbia University, Room 720G, 722 West 168th Street, New York, NY 10032, USA
    Cancer Lett 201:57-65. 2003
    ..Our findings, although based on small numbers, suggest that the oxidative stress genes MPO and CAT may influence the risk of arsenic-induced premalignant hyperkeratotic skin lesions...
  52. ncbi request reprint Uremia attenuates growth hormone-stimulated insulin-like growth factor-1 expression, a process worsened by inflammation
    Yu Chen
    Department of Medicine, Stanford University, Stanford, California, USA
    Kidney Int 78:89-95. 2010
    ..Thus, our findings indicate that hepatic resistance to GH-induced IGF-1 expression in uremia arises due to defects in STAT5b phosphorylation and its impaired binding to DNA, processes further aggravated by inflammation...
  53. pmc A prospective study of body mass index and mortality in Bangladesh
    Brandon L Pierce
    Department of Health Studies, The University of Chicago, Chicago, IL 60637, USA
    Int J Epidemiol 39:1037-45. 2010
    ..However, this relationship is not well characterized in Bangladesh, where the BMI distribution is shifted towards lower values...
  54. ncbi request reprint Successful implantation of intravenously administered stem cells correlates with severity of inflammation in murine myocarditis
    Sohail Malek
    Charles A Dana Research Institute and the Harvard Thorndike Laboratories of Beth Israel Deaconess Medical Center, The Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02135, USA
    Pflugers Arch 452:268-75. 2006
    ..We conclude that factors released from myocardium during inflammation are important for enhancing the homing, migration, and implantation of systemically infused stem cells...
  55. pmc Endotoxin-induced growth hormone resistance in skeletal muscle
    Yu Chen
    Department of Medicine, Stanford University, Stanford, California 94305, USA
    Endocrinology 150:3620-6. 2009
    ....
  56. pmc Do placental genes affect maternal breast cancer? Association between offspring's CGB5 and CSH1 gene variants and maternal breast cancer risk
    Yu Chen
    Department of Environmental Medicine, New York University Cancer Institute, New York University School of Medicine, New York, NY, USA
    Cancer Res 68:9729-34. 2008
    ..90; 95% CI, 0.53-1.51; P for interaction=0.04). The findings suggest that placental CGB5 genotype may be predictive of maternal post-pregnancy breast cancer risk among women who give birth early in life...
  57. ncbi request reprint A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh
    Wendy J Verret
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    J Occup Environ Med 47:1026-35. 2005
    ..We sought to determine whether supplementation of vitamin E (alpha-tocopherol), selenium (L-selenomethionine), or their combination improves arsenical skin lesions...
  58. pmc Serum taurine and risk of coronary heart disease: a prospective, nested case-control study
    Oktawia P Wójcik
    Department of Environmental Medicine, New York University School of Medicine, 650 First Avenue, 5th Floor, New York, NY 10016 3240, USA
    Eur J Nutr 52:169-78. 2013
    ..Taurine (2-aminoethanesulfonic acid), a molecule obtained from diet, is involved in bile acid conjugation, blood pressure regulation, anti-oxidation and anti-inflammation. We performed the first prospective study of taurine and CHD risk...
  59. pmc Association between selected oral pathogens and gastric precancerous lesions
    Christian R Salazar
    Department of Epidemiology and Health Promotion, New York University College of Dentistry, New York, NY, USA
    PLoS ONE 8:e51604. 2013
    ..03-0.06). Among individuals with periodontal disease, high levels of colonization of periodontal pathogens are associated with an increased risk of gastric precancerous lesions...
  60. pmc Arsenic exposure from drinking water and dyspnoea risk in Araihazar, Bangladesh: a population-based study
    Gene R Pesola
    Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Harlem Hospital, Columbia University, New York, NY 10037, USA
    Eur Respir J 39:1076-83. 2012
    ..This study suggests that mandated well water testing for arsenic with reduction in exposure may significantly reduce diseases that manifest as dyspnoea, usually cardiac or pulmonary...
  61. pmc Association between body-mass index and risk of death in more than 1 million Asians
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
    N Engl J Med 364:719-29. 2011
    ..Most studies that have evaluated the association between the body-mass index (BMI) and the risks of death from any cause and from specific causes have been conducted in populations of European origin...
  62. pmc Body mass index and diabetes in Asia: a cross-sectional pooled analysis of 900,000 individuals in the Asia cohort consortium
    Paolo Boffetta
    Mount Sinai School of Medicine, The Tisch Cancer Institute, New York, New York, United States of America
    PLoS ONE 6:e19930. 2011
    ..The shape of the association of overweight and obesity with diabetes risk and its overall impact have not been adequately studied in Asia...
  63. pmc Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh
    Faruque Parvez
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    Environ Health Perspect 116:190-5. 2008
    ..The association with nonmalignant respiratory illnesses has not been well established because the assessments of respiratory symptoms may be influenced by recall bias or interviewer bias because participants had visible skin lesions...
  64. pmc No association between arsenic exposure from drinking water and diabetes mellitus: a cross-sectional study in Bangladesh
    Yu Chen
    Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA
    Environ Health Perspect 118:1299-305. 2010
    ..The long-term effects of arsenic exposure from drinking water at levels < 300 microg/L and the risk of diabetes mellitus remains a controversial topic...
  65. ncbi request reprint Health Effects of Arsenic Longitudinal Study (HEALS): description of a multidisciplinary epidemiologic investigation
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Expo Sci Environ Epidemiol 16:191-205. 2006
    ..HEALS is a valuable resource for examining novel research questions on the health effects of As exposure...
  66. pmc Arsenic exposure in Latin America: biomarkers, risk assessments and related health effects
    Tyler R McClintock
    New York University School of Medicine, New York University, New York, NY, USA
    Sci Total Environ 429:76-91. 2012
    ..Targeted future studies will not only yield a better understanding of the public health impact of As in Latin America populations, but also allow for effective and timely mitigation efforts...
  67. pmc Burden of total and cause-specific mortality related to tobacco smoking among adults aged ≥ 45 years in Asia: a pooled analysis of 21 cohorts
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee, United States of America Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS Med 11:e1001631. 2014
    ..Tobacco smoking is a major risk factor for many diseases. We sought to quantify the burden of tobacco-smoking-related deaths in Asia, in parts of which men's smoking prevalence is among the world's highest...
  68. ncbi request reprint Validity of a food-frequency questionnaire for a large prospective cohort study in Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA
    Br J Nutr 92:851-9. 2004
    ..To our knowledge, the present study is the first to document the validity of a FFQ with the use of 7 d FD in a Bangladeshi population...
  69. pmc Genetic variants in hormone-related genes and risk of breast cancer
    Tess Clendenen
    Department of Population Health, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 8:e69367. 2013
    ..Our results suggest that these genetic variants do not have a strong effect on breast cancer risk. ..
  70. ncbi request reprint A prospective study of variability in systolic blood pressure and mortality in a rural Bangladeshi population cohort
    Lital Yinon
    Departments of Population Health and Environmental Medicine, New York University School of Medicine, New York, NY, USA
    Prev Med 57:807-12. 2013
    ..However, most of these were in populations with pre-existing cardiovascular diseases (CVD) and studies in general population are lacking...
  71. ncbi request reprint DNA repair gene XPD and susceptibility to arsenic-induced hyperkeratosis
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, Room 18 129, 622 West 168th Street, New York, NY 10032, USA
    Toxicol Lett 143:123-31. 2003
    ..Future larger studies are needed to confirm this novel finding and investigate how combinations of different candidate genes and/or other host and environmental factors may influence the risk of arsenic induced skin and other cancers...
  72. pmc Betel quid chewing in rural Bangladesh: prevalence, predictors and relationship to blood pressure
    Julia E Heck
    Department of Epidemiology, University of California, Los Angeles, CA, USA
    Int J Epidemiol 41:462-71. 2012
    ..The purpose of our study was to examine the prevalence and predictors of betel quid chewing in a rural area of Bangladesh, and determine its effects on body mass index (BMI) and blood pressure...
  73. pmc Temporal reproducibility of taurine measurements in frozen serum of healthy postmenopausal women
    Oktawia P Wójcik
    Department of Environmental Medicine, New York University School of Medicine, 650 First Avenue, 5th Floor, New York, NY 10016 3240, USA
    Br J Nutr 104:629-32. 2010
    ..The CV was 7 %. These results indicate that the mean of two or more annual measurements of serum taurine is a sufficiently reliable measure of long-term serum levels that can be used in epidemiological studies...
  74. pmc Helicobacter pylori colonization is inversely associated with childhood asthma
    Yu Chen
    Department of Environmental Medicine, School of Medicine, New York University, New York, New York 10016, USA
    J Infect Dis 198:553-60. 2008
    ..Asthma, a serious health problem worldwide, is becoming more common. Colonization with Helicobacter pylori, a major human indigenous (commensal) microbe, during early life may be relevant to the risk of childhood asthma...
  75. pmc Association between anthropometric measures of obesity and subclinical atherosclerosis in Bangladesh
    Wenzhen Ge
    Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
    Atherosclerosis 232:234-41. 2014
    ..However, their relationships with subclinical atherosclerosis are unclear. Studies in normal-weight populations, especially in Asian countries where leanness is prevalent, are lacking...
  76. pmc Association between oral health and gastric precancerous lesions
    Christian R Salazar
    Department of Epidemiology and Health Promotion, New York University College of Dentistry, New York, NY 10003, USA
    Carcinogenesis 33:399-403. 2012
    ..7%)], independent of potential confounders. Our findings demonstrate that specific oral health conditions and behaviors such as gingival bleeding and tooth flossing are associated with gastric precancerous lesions...
  77. pmc Does Helicobacter pylori protect against asthma and allergy?
    Martin J Blaser
    Department of Medicine, New York University School of Medicine, 550 First Avenue OBV A606, New York, NY 10016, USA
    Gut 57:561-7. 2008
  78. ncbi request reprint Determinants of oral health care utilization among diverse groups of immigrants in New York City
    Gustavo D Cruz
    Department of Epidemiology and Health Promotion, College of Dentistry, New York University, 250 Park Avenue South, New York, N Y 10003 1402, USA
    J Am Dent Assoc 141:871-8. 2010
    ..Few studies have examined utilization of oral health care services among immigrants. The authors examined the determinants of utilization of oral health care among a diverse group of immigrants in New York City...
  79. pmc Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
    Brett S Carver
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer Cell 19:575-86. 2011
    ....
  80. ncbi request reprint A family-based genetic association study of variants in estrogen-metabolism genes COMT and CYP1B1 and breast cancer risk
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Breast Cancer Res Treat 85:121-31. 2004
    ....
  81. pmc ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours
    Ping Chi
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nature 467:849-53. 2010
    ..It also represents a novel mechanism of oncogenic transcription factor activation...
  82. pmc Cancer burden from arsenic in drinking water in Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th Street, New York, NY 10032, USA
    Am J Public Health 94:741-4. 2004
    ..Results indicated at least a doubling of lifetime mortality risk from liver, bladder, and lung cancers (229.6 vs 103.5 per 100 000 population) in Bangladesh owing to arsenic in drinking water...
  83. pmc NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores
    Stephanie A Stehman
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    J Cell Biol 178:583-94. 2007
    ..Together, these results identify a common function for NudE and NudEL in mitotic progression and identify an alternative mechanism for dynein recruitment to and regulation at kinetochores...
  84. pmc Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target
    Yu Chen
    Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Lancet Oncol 10:981-91. 2009
    ..Both agents are undergoing phase 3 testing. Here, we review the basic science and clinical development of these and other agents...
  85. ncbi request reprint Inverse associations of Helicobacter pylori with asthma and allergy
    Yu Chen
    Department of Environmental Medicine, New York University School of Medicine, New York, USA
    Arch Intern Med 167:821-7. 2007
    ..Acquisition of Helicobacter pylori, which predominantly occurs before age 10 years, may reduce risks of asthma and allergy...
  86. ncbi request reprint Inflammatory bowel disease in patients with celiac disease
    Alice Yang
    Department of Medicine, Pathology and Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Inflamm Bowel Dis 11:528-32. 2005
    ..We therefore studied the occurrence of these conditions in a cohort of patients with celiac disease seen at a referral center...
  87. doi request reprint The association of immigration and acculturation attributes with oral health among immigrants in New York City
    Gustavo D Cruz
    New York University College of Dentistry, Department of Epidemiology and Health Promotion, 250 Park Avenue South, Sixth Floor, New York, NY 10003, USA
    Am J Public Health 99:S474-80. 2009
    ..We examined associations between immigration and acculturation attributes and oral disease among immigrants...
  88. pmc The potential protective effects of taurine on coronary heart disease
    Oktawia P Wójcik
    Department of Environmental Medicine, New York University School of Medicine, 650 FirstAvenue, New York, NY 10016, USA
    Atherosclerosis 208:19-25. 2010
    ..We also discuss shortcomings of the human studies that need to be addressed in the future. The identification of taurine as a preventive factor for CHD may be of great public health importance...
  89. pmc Quantitation of major human cutaneous bacterial and fungal populations
    Zhan Gao
    Department of Medicine, New York University Langone Medical Center, New York, New York 10016, USA
    J Clin Microbiol 48:3575-81. 2010
    ..These results provide the first quantitation of the site and host specificities of major bacterial and fungal populations in human skin and present simple methods for their assessment in studies of disease...
  90. ncbi request reprint Prostate cancer in 2011: Hitting old targets better and identifying new targets
    Yu Chen
    Human Oncology and Pathogenesis Program and Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Nat Rev Clin Oncol 9:70-2. 2012
    ..These outcomes contrasted with the heightened controversy generated by the recommendation against PSA screening and other early detection strategies...
  91. ncbi request reprint Mixer/Bon and FoxH1/Sur have overlapping and divergent roles in Nodal signaling and mesendoderm induction
    Prabhat S Kunwar
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 130:5589-99. 2003
    ....
  92. pmc LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages
    Jin Wu Tsai
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Cell Biol 170:935-45. 2005
    ..Finally, axonal growth also ceased. These results identify multiple distinct and novel roles for LIS1 in nucleokinesis and process dynamics and suggest that nuclear position controls neural progenitor cell division...
  93. ncbi request reprint Collagen synthesis is not altered in women with stress urinary incontinence
    Yu Chen
    The Research Institute, The North Shore Long Island Jewish Health System, New Hyde Park, New York, USA
    Neurourol Urodyn 23:367-73. 2004
    ....
  94. pmc Inference for causal interactions for continuous exposures under dichotomization
    Tyler J VanderWeele
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, Massachusetts 02115, USA
    Biometrics 67:1414-21. 2011
    ..The results in this article are applied to a study of the interactive effects between smoking and arsenic exposure from well water in producing skin lesions...
  95. pmc Development of a second-generation antiandrogen for treatment of advanced prostate cancer
    Chris Tran
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Science 324:787-90. 2009
    ..These compounds thus appear to be promising candidates for treatment of advanced prostate cancer...

Research Grants2

  1. Genetic Susceptibilty to Cardiovascular Effects of Arsenic Exposure
    Yu Chen; Fiscal Year: 2010
    ..The findings may also improve risk assessment of health effects of arsenic exposure. ..
  2. Genetic Susceptibilty to Cardiovascular Effects of Arsenic Exposure
    Yu Chen; Fiscal Year: 2009
    ..The findings may also improve risk assessment of health effects of arsenic exposure. ..