Research Topics
Genomes and Genes
| M V ChaoSummaryAffiliation: New York University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Trophic factors: An evolutionary cul-de-sac or door into higher neuronal function?M V Chao
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology and Physiology and Neuroscience, New York University School of Medicine, New York, NY 10016, USA
J Neurosci Res 59:353-5. 2000..The widening scope of neurotrophin action will require more physiological, genomic, and integrative approaches to understand fully the mechanisms by which survival factors can mediate so many diverse effects...- Neurotrophins: to cleave or not to cleaveMoses V Chao
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Neuron 33:9-12. 2002.... - Neurotrophins and their receptors: a convergence point for many signalling pathwaysMoses V Chao
Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Nat Rev Neurosci 4:299-309. 2003 - Dependence receptors: what is the mechanism?Moses V Chao
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Sci STKE 2003:PE38. 2003..The signaling mechanisms that account for this type of receptor activity are unknown. Several theories behind how dependence receptors may trigger cell death are described... - Neurotrophin signalling in health and diseaseMoses V Chao
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
Clin Sci (Lond) 110:167-73. 2006..In this review, we consider the signalling pathways activated by neurotrophins in both health and disease states... - Neurotrophin survival signaling mechanismsMoses V Chao
Physiology and Neuroscience, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
J Alzheimers Dis 6:S7-11. 2004 - A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2G Khursigara
Weill Medical College of Cornell University, New York, New York 10021, USA
J Neurosci 21:5854-63. 2001..These results indicate that adaptor proteins like RIP2 can provide a bifunctional switch for cell survival or cell death decisions mediated by the p75 neurotrophin receptor... - p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawalJ Zezula
Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
EMBO Rep 2:27-34. 2001.... - The uniqueness of being a neurotrophin receptorF S Lee
Weill Medical College of Cornell University Medical College, New York, New York 10021, USA
Curr Opin Neurobiol 11:281-6. 2001..Studies indicate a great deal of neurotrophin signaling specificity may stem from ligand-receptor selectivity and intracellular protein recruitment... - An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptorsH Kong
Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York, USA
J Neurosci 21:176-85. 2001.... - Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motorH Yano
Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, Departments of Cell Biology, New York, New York 10016, USA
J Neurosci 21:RC125. 2001..The association of Trk receptors with components of cytoplasmic dynein suggests that transport of neurotrophins during vesicular trafficking may occur through a direct interaction of the Trk receptor with the dynein motor machinery... - Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranesRithwick Rajagopal
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
J Neurosci 24:6650-8. 2004..These results indicate that there are alternative modes of activating Trk receptor tyrosine kinases in the absence of neurotrophin binding at the cell surface and that receptor signaling may occur and persist inside of neuronal cells... - Changes in cyclin-dependent kinase 2 and p27kip1 accompany glial cell differentiation of central glia-4 cellsR Tikoo
Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021, USA
J Biol Chem 272:442-7. 1997..Taken together, these results suggest that the inhibitory action of p27 upon cyclin E-CDK2 may prevent entry of cells into the S phase and regulate the progression of CG-4 cells toward an astrocytic lineage... - A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signalingRithwick Rajagopal
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology and Physiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Mol Cell Neurosci 33:36-46. 2006..These results indicate that Fyn is activated by GPCR stimulation and is responsible for transactivation of Trk receptors on intracellular membranes... - The cytoplasmic and transmembrane domains of the p75 and Trk A receptors regulate high affinity binding to nerve growth factorD Esposito
Division of Hematology, Weill Medical College of Cornell University, New York, New York 10021, USA
J Biol Chem 276:32687-95. 2001..These results indicate that the transmembrane and cytoplasmic domains of Trk A and p75 are responsible for high affinity site formation and suggest that p75 alters the conformation of Trk A to generate high affinity NGF binding... - Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factorA Chittka
Cell Biology Program, Weill Graduate School of Cornell University Medical College, New York, NY 10021, USA
Proc Natl Acad Sci U S A 96:10705-10. 1999..A direct correlation between nuclear expression of SC-1 with the loss of BrdUrd incorporation was observed. These results imply that SC-1 may be involved in events associated with growth arrest... - Activation of Trk neurotrophin receptors in the absence of neurotrophinsF S Lee
Department of Psychiatry, Weill Medical College of Cornell University Medical College, New York, NY 10021, USA
Proc Natl Acad Sci U S A 98:3555-60. 2001.... - Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiationR M Wolf
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Neurobiol 49:62-78. 2001.... - Neurotrophins: the biological paradox of survival factors eliciting apoptosisP Casaccia-Bonnefil
Molecular Neurobiology Program, Skirball Institute, 540 First Avenue, New York, USA 10016, USA
Cell Death Differ 5:357-64. 1998..In the absence of TrkA receptors, p75 can generate, in only specific cell populations, a death signal. Here we discuss the unique features and implications of this unusual signal transduction system... - Promoting neurotrophic effects by GPCR ligandsFreddy Jeanneteau
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, NY 10016, USA
Novartis Found Symp 276:181-9; discussion 189-92, 233-7, 275-81. 2006..If small-molecule GPCR ligands can ameliorate neuronal cell loss through Trk, transactivation may offer a new strategy for promoting trophic effects during neurodegeneration... - Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylationJuan Carlos Arevalo
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, NY 10016, USA
J Biol Chem 281:1001-7. 2006..Therefore, Trk receptor signaling involves an inducible switch mechanism through an unconventional substrate that distinguishes neurotrophin action from other growth factor receptors... - Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killingHiroko Yano
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
J Neurosci 29:14790-802. 2009..Together, these results raise the intriguing possibility that dysregulation of proneurotrophin processing/release by innervated targets can be deleterious to the neurons projecting to these sites... - Mechanisms of neurotrophin receptor signallingN Zampieri
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Biochem Soc Trans 34:607-11. 2006..Cleavage of p75 may represent a general mechanism for transmitting signals as an independent receptor and as a co-receptor for other signalling systems... - MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowthMarco Domeniconi
Biology Department, Hunter College, City University of New York, 695 Park Avenue, New York, New York 10021, USA
Neuron 46:849-55. 2005.... - A novel p75 neurotrophin receptor-related protein, NRH2, regulates nerve growth factor binding to the TrkA receptorSimon S Murray
Skirball Institute of Bimolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
J Neurosci 24:2742-9. 2004..Coexpression of NRH2 with TrkA receptors resulted in the formation of high-affinity binding sites for NGF. These results indicate that a transmembrane protein related to p75NTR is capable of modulating Trk receptor binding properties... - Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domainsNiccolo Zampieri
Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
J Biol Chem 280:14563-71. 2005..Mass spectrometric analysis confirmed the cleavage can occur with a truncated p75(NTR) displaying only 15 extracellular amino acids in the stalk region... - BDNF-mediated neurotransmission relies upon a myosin VI motor complexHiroko Yano
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
Nat Neurosci 9:1009-18. 2006..Together, these results define an important role for the Myo6-GIPC1 motor complex in presynaptic function and in BDNF-TrkB-mediated synaptic plasticity... - Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptorKwang Mook Jung
Department of Pathology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Biol Chem 278:42161-9. 2003.... - Structural biology. The p75 NGF receptor exposedNiccolo Zampieri
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Science 304:833-4. 2004 - JNK-interacting protein 1 promotes Akt1 activationAlbert H Kim
Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
J Biol Chem 278:29830-6. 2003..This study also indicates that JIP1 expression can exert signaling effects independent of JNK activity... - Akt1 regulates a JNK scaffold during excitotoxic apoptosisAlbert H Kim
Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Neuron 35:697-709. 2002..Overexpression of Akt1 mutants that bind JIP1 reduced excitotoxic apoptosis. These results suggest that Akt1 binding to JIP1 acts as a regulatory gate preventing JNK activation, which is released under conditions of excitotoxic injury... - Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discriminationKevin G Bath
Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10065, USA
J Neurosci 28:2383-93. 2008..Through these observations, we have identified novel links between genetic variant BDNF and adult neurogenesis in vivo, which may contribute to significant impairments in olfactory function... - Ankyrin Repeat-rich Membrane Spanning/Kidins220 protein regulates dendritic branching and spine stability in vivoSynphen H Wu
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
Dev Neurobiol 69:547-57. 2009..Taken together, these data suggest that ARMS/Kidins220 is important for the growth of dendritic arbors and spine stability during an activity- and BDNF-dependent period of development... - The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampusIpe Ninan
Department of Psychiatry and Neurobiology Program, Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
J Neurosci 30:8866-70. 2010..Thus, these results show that the BDNF Val66Met polymorphism has a direct effect on NMDA receptor transmission, which may account for changes in synaptic plasticity in the hippocampus... - Stable isotopic labeling by amino acids in cultured primary neurons: application to brain-derived neurotrophic factor-dependent phosphotyrosine-associated signalingDaniel S Spellman
Department of Pharmacology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Mol Cell Proteomics 7:1067-76. 2008..These results demonstrate that the combination of primary neuronal cell culture and SILAC can be a powerful tool for the study of the proteomes of neuronal molecular and cellular dynamics... - Telomerase and oligodendrocyte differentiationG L Caporaso
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
J Neurobiol 49:224-34. 2001..These data suggest a possible role for telomerase during normal growth and differentiation of oligodendrocytes that may be relevant to the mechanism of myelination in the CNS... - Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1A H Kim
Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Mol Cell Biol 21:893-901. 2001..These results provide the first direct link between Akt and the family of stress-activated kinases... - Axonal growth: where neurotrophins meet WntsJuan Carlos Arevalo
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016 USA
Curr Opin Cell Biol 17:112-5. 2005..Therefore, components of the Wnt signaling pathway are downstream of trophic factors, providing new insights into cytoskeletal regulatory events during axonal growth... - Pro-NGF secreted by astrocytes promotes motor neuron cell deathMarco Domeniconi
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Mol Cell Neurosci 34:271-9. 2007..These results are consistent with a role for activated astrocytes and pro-NGF in the induction of motor neuron death and suggest a possible therapeutic target for the treatment of motor neuron disease... - Localization of BDNF mRNA with the Huntington's disease protein in rat brainBin Ma
Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
Mol Neurodegener 5:22. 2010..In dendrites, Htt co-localizes with components of neuronal granules and mRNAs, indicating that it might play a role in post-transcriptional processing/transport of dendritic mRNAs... - Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitinationJuan Carlos Arevalo
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology, and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
Neuron 50:549-59. 2006..Our results indicate that Trk neurotrophin receptors are differentially regulated by ubiquitination to modulate the survival of neurons... - The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branchingFreddy Jeanneteau
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York, New York, USA
Nat Neurosci 13:1373-9. 2010..Our results identify a signaling mechanism that regulates axonal branching and provide a framework for studying the molecular mechanisms of innervation and axonal remodeling under normal and pathological conditions... - Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effectFreddy Jeanneteau
Molecular Neurobiology Program, Department of Cell Biology, Physiology, Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Proc Natl Acad Sci U S A 105:4862-7. 2008..The ability of GCs to promote Trk receptor activity represents a molecular mechanism that integrates the actions of GCs and neurotrophins... - Spongiform pathology in mouse CNS lacking 'neuropathy target esterase' and cellular prion proteinJack Rosenbluth
Department of Physiology and Neuroscience, New York University School of Medicine, PHB 833, 550 First Avenue, New York, NY 10016, USA
Neurobiol Dis 35:433-7. 2009..We conclude that spongiform pathology in conditional NTE knockout mice is not mediated by PrPc, and that tubulovesicular inclusions can be seen in spongiform encephalopathy of other etiologies and are not pathognomonic of prion disease... - Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning proteinMi Sook Chang
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York, USA
J Neurosci Res 78:186-92. 2004..These findings thus suggest that Kidins220/ARMS plays an important role in regulating interactions between Trk and p75 neurotrophin receptors... - Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptidesFrancis S Lee
Department of Psychiatry, Weill Medical College, Cornell University, New York, New York 10021, USA
J Biol Chem 277:9096-102. 2002..This ability may explain several neuroprotective actions of PACAP upon neuronal populations after injury, nerve lesion, or neurotrophin deprivation... - Biochemical characterization of intracellular membranes bearing Trk neurotrophin receptorsHiroko Yano
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Neurochem Res 30:767-77. 2005..Taken together, these biochemical approaches allowed separation of distinct Trk-bearing membrane pools, which may be involved in different functions of neurotrophin receptor signaling and trafficking... - Telomerase activity in the subventricular zone of adult miceGregg L Caporaso
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Mol Cell Neurosci 23:693-702. 2003..We conclude that telomerase is active in neural precursor cells of the adult mouse and suggest that its regulation is an important parameter for cellular proliferation to occur in the mammalian brain... - Mechanisms of neurotrophin receptor vesicular transportHiroko Yano
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
J Neurobiol 58:244-57. 2004..In particular, the molecules that may direct Trk receptor trafficking in the axon will be discussed. Finally, potential mechanisms by which receptor-containing vesicles link to molecular cytoskeletal motors will be presented... - Mesenchymal and neuronal cell expression of the p75 neurotrophin receptor gene occur by different mechanismsL J Huber
Department of Cell Biology, Cornell University Medical College, New York, New York 10021
Dev Biol 167:227-38. 1995.... - Kainate receptors expressed by a subpopulation of developing nociceptors rapidly switch from high to low Ca2+ permeabilityC J Lee
Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA
J Neurosci 21:4572-81. 2001..Thereafter, the receptors may serve a new function that does not require Ca(2+) permeability... - Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiationP Casaccia-Bonnefil
Molecular Neurobiology, Skirball Institute for Biomolecular Medicine at NYU Medical Center, New York, NY 10016, USA nyu edu
Development 126:4027-37. 1999.... - Transactivation of Trk receptors in spinal motor neuronsMarco Domeniconi
Department of Biological Sciences, Hunter College, City University of New York, New York, NY, USA
Histol Histopathol 25:1207-13. 2010..We propose in this review to exploit transactivation to improve the survival of motor neurons in a transgenic mouse model of ALS and for other neurodegenerative diseases, such as Alzheimer's and Huntington's disease... - Distinctive features of Trk neurotrophin receptor transactivation by G protein-coupled receptorsFrancis S Lee
Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
Cytokine Growth Factor Rev 13:11-7. 2002..This article will discuss potential mechanisms by which adenosine can activate trophic responses through Trk tyrosine kinase receptors... - A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning proteinJuan Carlos Arevalo
Molecular Neurobiology Program, Departments of Cell Biology, Physiology and Neuroscience, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
EMBO J 23:2358-68. 2004..These findings suggest that ARMS acts as a major and neuronal-specific platform for prolonged MAP kinase signaling by neurotrophins... - Association of the Abl tyrosine kinase with the Trk nerve growth factor receptorH Yano
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
J Neurosci Res 59:356-64. 2000..These results suggest that c-Abl may be recruited to the NGF receptor complex and be involved in regulating specific phosphorylation events that occur during neuronal differentiation... - Nuclear localization of the p75 neurotrophin receptor intracellular domainChristopher N Parkhurst
Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
J Biol Chem 285:5361-8. 2010..Expression of the p75 ICD resulted in modulation of gene expression from this locus. These results suggest that the p75 ICD generated by gamma-secretase cleavage is capable of modulating transcriptional events in the nucleus... - The tyrosine kinase Fyn determines the localization of TrkB receptors in lipid raftsDaniela B Pereira
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
J Neurosci 27:4859-69. 2007..These results indicate that the lipid raft localization of TrkB receptors is regulated by Fyn and represents an important factor in determining the outcome of BDNF signaling in neurons... - Role of transverse bands in maintaining paranodal structure and axolemmal domain organization in myelinated nerve fibers: effect on longevity in dysmyelinated mutant miceAmanda J Mierzwa
Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
J Comp Neurol 518:2841-53. 2010.... - Neuregulin-1 type III determines the ensheathment fate of axonsCarla Taveggia
Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Neuron 47:681-94. 2005..These results indicate that levels of NRG1 type III, independent of axon diameter, provide a key instructive signal that determines the ensheathment fate of axons... - Retrograde transport reduxMoses V Chao
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Neuron 39:1-2. 2003..Unraveling the exact mechanisms that account for retrograde transport of neurotrophins and their receptors will reveal the cellular requirements for propagating trophic signals over long distances... - Morphological differentiation of oligodendrocytes requires activation of Fyn tyrosine kinaseD J Osterhout
Molecular Neurobiology Program, Skirball Institute, New York University Medical Center, New York 10016, USA
J Cell Biol 145:1209-18. 1999..These findings strongly suggest that activation of Fyn is an essential signaling component for the morphological differentiation of oligodendrocytes... - The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutationsA K Vaishnaw
Hospital for Special Surgery, Cornell University Medical College, New York, New York 10021, USA
J Clin Invest 103:355-63. 1999..These observations were consistent with differing mechanisms of action and modes of inheritance of ICD and ECD mutations, suggesting that individuals with an ECD mutation may require additional defect(s) for expression of CSS... - Association of the p75 neurotrophin receptor with TRAF6G Khursigara
Molecular Neurobiology Program, Skirball Institute, New York University Medical Center, 540 New York, New York 10016, USA
J Biol Chem 274:2597-600. 1999..These results indicate that TRAF6 can potentially function as a signal transducer for NGF actions through the p75 receptor... - Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1P Casaccia-Bonnefil
Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York 10021, USA
Genes Dev 11:2335-46. 1997..Together these data indicate a role for p27 during the decision to withdraw from the cell cycle in the oligodendrocyte lineage... - Dopamine D1 receptor-induced signaling through TrkB receptors in striatal neuronsYuriko Iwakura
Molecular Neurobiology Program, Kimmel Center at Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
J Biol Chem 283:15799-806. 2008..These results indicate that stimulation of dopamine D1 receptors can be coupled to the neurotrophin receptor signaling to mediate the effects of dopamine upon striatal neurons... - Neurotrophins, synaptic plasticity and dementiaOttavio Arancio
Department of Pathology and Taub Institute, Columbia University College of Physicians and Surgeons, 630 W168th Street, New York, NY 10032, USA
Curr Opin Neurobiol 17:325-30. 2007..This review highlights several recent findings that suggest trophic factors and APP use similar pathways to control neuronal activity... - The ARMS/Kidins220 scaffold protein modulates synaptic transmissionJuan Carlos Arevalo
Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Mol Cell Neurosci 45:92-100. 2010..These results provide evidence that modulation of ARMS/Kidins220 levels can regulate basal synaptic strength in a specific manner in hippocampal neurons... - Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegenerationKaterina Akassoglou
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Proc Natl Acad Sci U S A 101:5075-80. 2004..Thus, these results identify a physiological role for NTE in the nervous system and indicate that a loss-of-function mechanism may contribute to neurodegenerative diseases characterized by vacuolation and neuronal loss... - Nerve growth factor production by lymphocytesL Santambrogio
Department of Pathology, New York University School of Medicine, NY 10016
J Immunol 153:4488-95. 1994..We conclude that lymphocytes synthesize and secrete NGF either as a para-autocrine factor acting on the immune system itself, or as a factor for the maintenance of peripheral neurons... - A role for huntington disease protein in dendritic RNA granulesJeffrey N Savas
Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
J Biol Chem 285:13142-53. 2010..When tethered to a reporter construct, Htt down-regulated reporter gene expression in a manner dependent on Ago2, suggesting that Htt may function to repress translation of mRNAs during transport in neuronal granules... - The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin EAlexandra Chittka
Institute for Clinical Neurobiology, University of Wurzburg, Wurzburg, Germany
J Cell Biol 164:985-96. 2004..The zinc finger domains are also necessary to direct SC1's nuclear localization. Lastly, SC1 represses the promoter of a promitotic gene, cyclin E, suggesting a mechanism for how growth arrest is regulated by SC1... - Lack of the cell-cycle inhibitor p27Kip1 results in selective increase of transit-amplifying cells for adult neurogenesisFiona Doetsch
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 22:2255-64. 2002..We conclude that cell-cycle regulation of SVZ adult progenitors is remarkably cell-type specific, with p27Kip1 being a key regulator of the cell division of the transit-amplifying progenitors... - Annexin II light chain regulates sensory neuron-specific sodium channel expressionKenji Okuse
Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
Nature 417:653-6. 2002..Because direct association with p11 is required for functional expression of Na(V)1.8, disrupting this interaction may be a useful new approach to downregulating Na(V)1.8 and effecting analgesia... - TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domainSoledad Urra
Department of Physiology, Center for Cellular Regulation and Pathology Joaquin V Luco, Faculty of Biological Sciences, Pontificia Universidad Catolica, Alameda 340, Santiago 8320000, Chile
J Biol Chem 282:7606-15. 2007..Moreover, we show similar structural requirements for gamma-secretase processing of p75 and amyloid precursor protein-derived CTFs. Thus, NGF-induced endocytosis regulates both signaling and proteolytic processing of p75... - Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neuronsRajappa S Kenchappa
Department of Biochemistry and Center for Molecular Neuroscience, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
Neuron 50:219-32. 2006..These results indicate that p75-mediated apoptosis requires gamma-secretase dependent release of its ICD, which facilitates nuclear translocation of NRIF... - Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brainTomi Rantamäki
Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland
Neuropsychopharmacology 32:2152-62. 2007..In conclusion, our data suggest that rapid activation of the TrkB neurotrophin receptor and PLCgamma1 signaling is a common mechanism for all antidepressant drugs... - Developmental and activity-dependent regulation of ARMS/Kidins220 in cultured rat hippocampal neuronsRosa Y Cortés
Department of Cell Biology and Neuroscience, Rutgers University, Nelson Laboratories, Piscataway, New Jersey
Dev Neurobiol 67:1687-98. 2007..We find that ARMS/Kidins220 may function in neuronal development as an indicator and potentially as a homeostatic regulator of overall synaptic strength in hippocampal neurons... - Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkBStefan Wiese
Institute for Clinical Neurobiology, University of Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
Proc Natl Acad Sci U S A 104:17210-5. 2007.... - Prevention of apoptotic but not necrotic cell death following neuronal injury by neurotrophins signaling through the tyrosine kinase receptorDong H Kim
Department of Neurosurgery, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosurg 100:79-87. 2004..The goal of this study was to determine the effect of neurotrophin treatment on each of these processes following injury and to characterize the receptor(s) required... - p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathwayBenjamin D Sachs
Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
J Cell Biol 177:1119-32. 2007..Our results reveal a novel pathogenic mechanism by which p75(NTR) regulates degradation of cAMP and perpetuates scar formation after injury... - Motors, adaptors, and receptors: key elements of neuronal transportGiampietro Schiavo
Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, United Kingdom
J Neurobiol 58:161-3. 2004 - {alpha}-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent mannerShuo Luo
Department of Biochemistry, Molecular Neuroscience Center and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
J Cell Biol 169:813-24. 2005..Altogether, our findings suggest that ARMS may play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EphA4...