Edwin S L Chan

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. doi request reprint Methotrexate--how does it really work?
    Edwin S L Chan
    Department of Medicine, New York University School of Medicine, 550 First Avenue, NBV16N1, New York, NY 10016, USA
    Nat Rev Rheumatol 6:175-8. 2010
  2. pmc Plasma from systemic lupus patients compromises cholesterol homeostasis: a potential mechanism linking autoimmunity to atherosclerotic cardiovascular disease
    Allison B Reiss
    Department of Medicine, Vascular Biology Institute, Division of Rheumatology, Allergy and Immunology, Winthrop University Hospital, 222 Station Plaza, North, Suite 502, Mineola, NY 11501, USA
    Rheumatol Int 30:591-8. 2010
  3. doi request reprint Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis
    Zhongsheng Peng
    Department of Medicine, Division of Clinical Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    FASEB J 22:2263-72. 2008
  4. pmc Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine
    Patricia Fernandez
    Department of Medicine, New York University School of Medicine, NewYork, New York 10016, USA
    Am J Pathol 172:1675-82. 2008
  5. doi request reprint Ecto-5'-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis
    Zhongsheng Peng
    Department of Medicine, Division of Clinical Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Nucleosides Nucleotides Nucleic Acids 27:821-4. 2008
  6. doi request reprint Adenosine A2A receptor blockade or deletion diminishes fibrocyte accumulation in the skin in a murine model of scleroderma, bleomycin-induced fibrosis
    Majid Katebi
    Division of Clinical Pharmacology, Department of Medicine, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    Inflammation 31:299-303. 2008
  7. pmc Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis
    Edwin S L Chan
    Division of Clinical Pharmacology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Br J Pharmacol 148:1144-55. 2006
  8. pmc Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk
    Edwin S L Chan
    Division of Clinical Pharmacology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Arthritis Res Ther 9:R4. 2007
  9. doi request reprint Extracellular generation of adenosine by the ectonucleotidases CD39 and CD73 promotes dermal fibrosis
    Patricia Fernandez
    Departments of Medicine and Dermatology, New York University School of Medicine, New York, New York
    Am J Pathol 183:1740-6. 2013
  10. ncbi request reprint Adenosine A2A receptor occupancy stimulates collagen expression by hepatic stellate cells via pathways involving protein kinase A, Src, and extracellular signal-regulated kinases 1/2 signaling cascade or p38 mitogen-activated protein kinase signaling path
    Jiantu Che
    Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mol Pharmacol 72:1626-36. 2007

Collaborators

Detail Information

Publications18

  1. doi request reprint Methotrexate--how does it really work?
    Edwin S L Chan
    Department of Medicine, New York University School of Medicine, 550 First Avenue, NBV16N1, New York, NY 10016, USA
    Nat Rev Rheumatol 6:175-8. 2010
    ..These activities contribute to the complex and multifaceted mechanisms that make methotrexate efficacious in the treatment of inflammatory disorders...
  2. pmc Plasma from systemic lupus patients compromises cholesterol homeostasis: a potential mechanism linking autoimmunity to atherosclerotic cardiovascular disease
    Allison B Reiss
    Department of Medicine, Vascular Biology Institute, Division of Rheumatology, Allergy and Immunology, Winthrop University Hospital, 222 Station Plaza, North, Suite 502, Mineola, NY 11501, USA
    Rheumatol Int 30:591-8. 2010
    ..001). Impaired cholesterol homeostasis in SLE provides further evidence of immune involvement in atherogenesis. Strategies to inhibit or reverse arterial cholesterol accumulation may benefit SLE patients...
  3. doi request reprint Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis
    Zhongsheng Peng
    Department of Medicine, Division of Clinical Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    FASEB J 22:2263-72. 2008
    ....
  4. pmc Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine
    Patricia Fernandez
    Department of Medicine, New York University School of Medicine, NewYork, New York 10016, USA
    Am J Pathol 172:1675-82. 2008
    ..These data confirm a fibrogenic role for adenosine in the skin and reveal A(2A) receptor antagonists as novel therapeutic agents for the modulation of dermal fibrotic disorders...
  5. doi request reprint Ecto-5'-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis
    Zhongsheng Peng
    Department of Medicine, Division of Clinical Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Nucleosides Nucleotides Nucleic Acids 27:821-4. 2008
    ....
  6. doi request reprint Adenosine A2A receptor blockade or deletion diminishes fibrocyte accumulation in the skin in a murine model of scleroderma, bleomycin-induced fibrosis
    Majid Katebi
    Division of Clinical Pharmacology, Department of Medicine, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    Inflammation 31:299-303. 2008
    ..Moreover, these results provide further evidence that adenosine A(2A) receptors may represent a new target for the treatment of such fibrosing diseases as scleroderma or nephrogenic fibrosing dermopathy...
  7. pmc Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis
    Edwin S L Chan
    Division of Clinical Pharmacology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Br J Pharmacol 148:1144-55. 2006
    ..6. These results demonstrate that hepatic adenosine A(2A) receptors play an active role in the pathogenesis of hepatic fibrosis, and suggest a novel therapeutic target in the treatment and prevention of hepatic cirrhosis...
  8. pmc Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk
    Edwin S L Chan
    Division of Clinical Pharmacology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Arthritis Res Ther 9:R4. 2007
    ..NS398-treated THP-1 macrophages show greater vulnerability to form foam cells. Increased cardiovascular risk with COX inhibition may be ascribed at least in part to altered cholesterol metabolism...
  9. doi request reprint Extracellular generation of adenosine by the ectonucleotidases CD39 and CD73 promotes dermal fibrosis
    Patricia Fernandez
    Departments of Medicine and Dermatology, New York University School of Medicine, New York, New York
    Am J Pathol 183:1740-6. 2013
    ..We suggest that biochemical or biological inhibitors of CD39 and/or CD73 may hold promise in the treatment of dermal fibrosis in diseases such as scleroderma...
  10. ncbi request reprint Adenosine A2A receptor occupancy stimulates collagen expression by hepatic stellate cells via pathways involving protein kinase A, Src, and extracellular signal-regulated kinases 1/2 signaling cascade or p38 mitogen-activated protein kinase signaling path
    Jiantu Che
    Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mol Pharmacol 72:1626-36. 2007
    ....
  11. doi request reprint Enhanced CD36 scavenger receptor expression in THP-1 human monocytes in the presence of lupus plasma: linking autoimmunity and atherosclerosis
    Allison B Reiss
    Vascular Biology Institute, Department of Medicine, Winthrop University Hospital, 222 Station Plaza, North, Suite 502, Mineola, NY 11501, USA
    Exp Biol Med (Maywood) 234:354-60. 2009
    ..CD36 may provide a novel therapeutic target in the treatment of ASCVD in SLE patients...
  12. doi request reprint Disruption of cholesterol efflux by coxib medications and inflammatory processes: link to increased cardiovascular risk
    Allison B Reiss
    Vascular Biology Institute, Department of Medicine, Winthrop University Hospital, Mineola, NY, and Department of Medicine, NYU School of Medicine, New York, NY, USA
    J Investig Med 57:695-702. 2009
    ..We explore the relationship between suppression of reverse cholesterol transport and harmful cardiac effects of coxibs...
  13. ncbi request reprint Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer's disease
    Allison B Reiss
    Department of Medicine, New York University School of Medicine, New Bellevue 16N1, 550 First Avenue, New York, NY 10016, USA
    Neurobiol Aging 25:977-89. 2004
    ..The reduction in stroke and AD risk in patients treated with cholesterol-lowering statins is also discussed...
  14. pmc Adenosine in fibrosis
    Edwin S L Chan
    Clinical and Translational Science Institute, NYU School of Medicine, 550 First Ave, New York, NY 10016, USA
    Mod Rheumatol 20:114-22. 2010
    ..An understanding of these processes may shed new light on potential therapeutic options in diseases such as scleroderma where tissue fibrosis features prominently...
  15. pmc Molecular pathogenesis of skin fibrosis: insight from animal models
    Gideon P Smith
    New York University School of Medicine, 550 First Avenue, NBV 16N1, New York, NY 10016, USA
    Curr Rheumatol Rep 12:26-33. 2010
    ..This article summarizes recent progress in the understanding of the molecular pathogenesis of skin fibrosis in SSc from different animal models, both its initiation and its maintenance phases...
  16. pmc Molecular action of methotrexate in inflammatory diseases
    Edwin S L Chan
    Division of Clinical Pharmacology, NYU School of Medicine, New York, NY 10016, USA
    Arthritis Res 4:266-73. 2002
    ..In confirmation of this mechanism of action, recent studies in both animals and patients suggest that adenosine-receptor antagonists, among which is caffeine, reverse or prevent the anti-inflammatory effects of methotrexate...
  17. ncbi request reprint Adenosine A2A receptor occupancy stimulates expression of proteins involved in reverse cholesterol transport and inhibits foam cell formation in macrophages
    Allison B Reiss
    Department of Medicine, New York University School of Medicine, New York, NY, USA
    J Leukoc Biol 76:727-34. 2004
    ..These findings suggest a novel approach to the development of agents that prevent progression of atherosclerosis...
  18. pmc Methotrexate in atherogenesis and cholesterol metabolism
    Eric Coomes
    Department of Medicine, Division of Translational Medicine, New York University School of Medicine, NBV 16N1, 550 First Avenue, New York, NY 10016, USA
    Cholesterol 2011:503028. 2011
    ..Elucidating underlying cardiovascular mechanisms of these drugs provides a framework for developing novel cardioprotective anti-inflammatory medications, such as selective A(2A) receptor agonists...