Research Topics

Genomes and Genes


Edwin S L Chan


Affiliation: New York University
Country: USA


  1. Chan E, Zhang H, Fernandez P, Edelman S, Pillinger M, Ragolia L, et al. Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk. Arthritis Res Ther. 2007;9:R4 pubmed
    ..NS398-treated THP-1 macrophages show greater vulnerability to form foam cells. Increased cardiovascular risk with COX inhibition may be ascribed at least in part to altered cholesterol metabolism...
  2. Fernandez P, Perez Aso M, Smith G, Wilder T, Trzaska S, Chiriboga L, et al. Extracellular generation of adenosine by the ectonucleotidases CD39 and CD73 promotes dermal fibrosis. Am J Pathol. 2013;183:1740-1746 pubmed publisher
    ..We suggest that biochemical or biological inhibitors of CD39 and/or CD73 may hold promise in the treatment of dermal fibrosis in diseases such as scleroderma. ..