Research Topics
Species | F X CastellanosSummaryAffiliation: New York University Country: USA Publications
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Publications
[Syndrome of attention deficit with hyperactivity as the expression of an organic functional disorder]F X Castellanos
Child Study Center, NYU School of Medicine, New York, NY 10016, USA
Rev Neurol 35:1-11. 2002....
Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorderF Xavier Castellanos
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
JAMA 288:1740-8. 2002..Various anatomic brain abnormalities have been reported for attention-deficit/hyperactivity disorder (ADHD), with varying methods, small samples, cross-sectional designs, and without accounting for stimulant drug exposure...
A cooperative interaction between LPHN3 and 11q doubles the risk for ADHDM Jain
Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Mol Psychiatry 17:741-7. 2012....
A quantitative MRI study of the corpus callosum in children and adolescentsJ N Giedd
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1600, USA
Brain Res Dev Brain Res 91:274-80. 1996..These findings support anatomical studies indicating ongoing myelination of higher association areas throughout adolescence, but raise intriguing questions about anterior-posterior gradients of interhemispheric myelination...
Sexual dimorphism of the developing human brainJ N Giedd
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
Prog Neuropsychopharmacol Biol Psychiatry 21:1185-201. 1997..5. These sexually dimorphic patterns of brain development may be related to the observed sex differences in age of onset, prevalence, and symptomatology seen in nearly all neuropsychiatric disorders of childhood...
Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit/hyperactivity disorder: genetic and brain morphometric analysesF X Castellanos
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1600, USA
Mol Psychiatry 3:431-4. 1998..These data do not support the reported association between DRD4*7R and the behavioral or brain morphometric phenotype associated with ADHD...
Development of the human corpus callosum during childhood and adolescence: a longitudinal MRI studyJ N Giedd
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
Prog Neuropsychopharmacol Biol Psychiatry 23:571-88. 1999..7. The results of this longitudinal study, in addition to confirming and extending previous cross-sectional reports, provide an increasingly accurate yardstick from which to assess pathological development...
Quantitative brain magnetic resonance imaging in girls with attention-deficit/hyperactivity disorderF X Castellanos
Child Psychiatry Branch, National Institute of Mental Health, Bldg 10, Room 3N-202, 10 Center Dr-MSC 1600, Bethesda, MD 20892-1600, USA
Arch Gen Psychiatry 58:289-95. 2001..CONCLUSIONS: These results confirm previous findings for boys in the posterior-inferior lobules of the cerebellar vermis. The influence of the cerebellar vermis on prefrontal and striatal circuitry should be explored...
[The neuroanatomy of attention deficit/hyperactivity disorder]F X Castellanos
Institute of Pediatric Neuroscience, NYU Child Study Center, New York NY 10016 6404, USA
Rev Neurol 38:S131-6. 2004..Specific regional differences have been found in many studies in the basal ganglia with the most prominent differences being found in the cerebellum...
Double-blind, placebo-controlled study of single-dose amphetamine formulations in ADHDR S James
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
J Am Acad Child Adolesc Psychiatry 40:1268-76. 2001..CONCLUSIONS: Both immediate-release amphetamines demonstrated earlier onset of effects, but dextroamphetamine Spansules showed more sustained effects that were present on a wider range of measures...
Cerebrospinal fluid cytokines in pediatric neuropsychiatric diseaseB B Mittleman
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 159:2994-9. 1997..These data provide a rationale for immune-based strategies of study and therapeutics in childhood neuropsychiatric disease...
Imaging normal and abnormal brain development: new perspectives for child psychiatryJ L Rapoport
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892 1600, USA
Aust N Z J Psychiatry 35:272-81. 2001....
Brain imaging of attention deficit/hyperactivity disorderJ N Giedd
Child Psychiatry Branch, National Institute of Mental Health, Building 10, Room 4C110, 10 Center Drive, MSC 1367, Bethesda, MD 20892, USA
Ann N Y Acad Sci 931:33-49. 2001..Although not currently of diagnostic utility, further extension and refinement of these findings may offer hope for greater understanding of the core nature of ADHD and possible subtyping to inform treatment interventions...
A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medicationM Arcos-Burgos
National Human Genome Research Institute, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
Mol Psychiatry 15:1053-66. 2010..Linkage and replicated association of ADHD with a novel non-candidate gene (LPHN3) provide new insights into the genetics, neurobiology, and treatment of ADHD...
Functional connectivity of human striatum: a resting state FMRI studyA Di Martino
Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY 10016, USA
Cereb Cortex 18:2735-47. 2008..This approach holds promise for studying basal ganglia dysfunction in clinical disorders...
Association of the dopamine receptor D4 (DRD4) gene 7-repeat allele with children with attention-deficit/hyperactivity disorder (ADHD): an updateM C Gornick
Child Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892 1600, USA
Am J Med Genet B Neuropsychiatr Genet 144:379-82. 2007..This provides further evidence of the role of the DRD4 7-repeat allele in the etiology of ADHD and suggests that this allele may be associated with a more benign form of the disorder...
Altered performance on an ocular fixation task in attention-deficit/hyperactivity disorderT D Gould
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Biol Psychiatry 50:633-5. 2001....
Pedigree disequilibrium test (PDT) replicates association and linkage between DRD4 and ADHD in multigenerational and extended pedigrees from a genetic isolateM Arcos-Burgos
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 1852, USA
Mol Psychiatry 9:252-9. 2004..These results provide further evidence for the association of ADHD to genetic variation in or near to DRD4 and replicate the previously reported association between ADHD and the 7R allele...
Attention-deficit/hyperactivity disorder (ADHD): feasibility of linkage analysis in a genetic isolate using extended and multigenerational pedigreesM Arcos-Burgos
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Clin Genet 61:335-43. 2002....
Spontaneous attentional fluctuations in impaired states and pathological conditions: a neurobiological hypothesisEdmund J S Sonuga-Barke
Developmental Brain and Behaviour Unit, School of Psychology, University of Southampton, Southampton, UK
Neurosci Biobehav Rev 31:977-86. 2007..Finally, we explore the putative role of default-mode interference as a cause of performance variability in attention deficit/hyperactivity disorder...
Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesisJames M Swanson
Department of Pediatrics, University of California, Irvine, CA 92612, USA
Neuropsychol Rev 17:39-59. 2007....
Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with attention-deficit/hyperactivity disorderPhilip Shaw
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1500, USA
Arch Gen Psychiatry 63:540-9. 2006..Data from a previous prospective study of lobar volumes in children with attention-deficit/hyperactivity disorder (ADHD) are reexamined using a measure of cortical thickness...
Monozygotic twins discordant for attention-deficit/hyperactivity disorder: ascertainment and clinical characteristicsWendy S Sharp
Child Psychology Branch of the NIMH, USA
J Am Acad Child Adolesc Psychiatry 42:93-7. 2003..Despite these differences, affected twins were phenotypically comparable with affected singletons. Thus MZ twins discordant for ADHD, while rare, can inform research on the etiology and pathophysiology of this disorder...
Distinct neural mechanisms of risk and ambiguity: a meta-analysis of decision-makingAmy L Krain
New York University Child Study Center, New York University School of Medicine, 215 Lexington Avenue, New York, NY 10016, USA
Neuroimage 32:477-84. 2006..These findings provide evidence for the dissociation of neural circuits underlying risky and ambiguous decision-making, reflecting differential involvement of affective "hot" and cognitive "cool" processes...
Characterizing cognition in ADHD: beyond executive dysfunctionF Xavier Castellanos
Institute for Pediatric Neuroscience, NYU Child Study Center, 215 Lexington Avenue, New York, NY 10016, USA
Trends Cogn Sci 10:117-23. 2006..Such a reconceptualization provides a means to transcend the limits of current models of executive dysfunction in ADHD and suggests a plan for future research on cognition grounded in neurophysiological and developmental considerations...
Mapping the functional connectivity of anterior cingulate cortexDaniel S Margulies
The Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, 215 Lexington Avenue, 14th Floor, New York, NY 10016, USA
Neuroimage 37:579-88. 2007..We discuss the implications of our work for understanding ACC function and potential applications to clinical populations...
A functional magnetic resonance imaging investigation of uncertainty in adolescents with anxiety disordersAmy L Krain
New York University Child Study Center, New York University School of Medicine, New York, NY 10016, USA
Biol Psychiatry 63:563-8. 2008..As such, the present study examines the relationship between IU and neural responses to uncertainty in anxious adolescents...
Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorderF Xavier Castellanos
Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, New York University Child Study Center, New York, NY 10016, USA
Biol Psychiatry 63:332-7. 2008....
A randomized, double-blind, placebo-controlled trial of metoclopramide for the treatment of Tourette's disorderRob Nicolson
Department of Psychiatry, The University of Western Ontario, London, Ontario, Canada
J Am Acad Child Adolesc Psychiatry 44:640-6. 2005..The purpose of this study was to examine the efficacy and safety of metoclopramide in the treatment of children and adolescents with tic disorders...
Competition between functional brain networks mediates behavioral variabilityA M Clare Kelly
The Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY 10016, USA
Neuroimage 39:527-37. 2008..We discuss the implications of these findings for our understanding of the behavioral significance of spontaneous brain activity, in both healthy and clinical populations...
Network homogeneity reveals decreased integrity of default-mode network in ADHDLucina Q Uddin
The Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, New York University Child Study Center, New York, NY 10016, USA
J Neurosci Methods 169:249-54. 2008..Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations...
Residual functional connectivity in the split-brain revealed with resting-state functional MRILucina Q Uddin
New York University Child Study Center, New York, NY 10016, USA
Neuroreport 19:703-9. 2008..Such continued interhemispheric interaction suggests that, at least in part, cortical networks in the brain can be coordinated by subcortical mechanisms...
Cerebellar neurotransmission in attention-deficit/hyperactivity disorder: does dopamine neurotransmission occur in the cerebellar vermis?Paul E A Glaser
Department of Psychiatry, University of Kentucky Chandler Medical Center, Lexington, 40536, USA
J Neurosci Methods 151:62-7. 2006..The presence of DAT may therefore allow for enhanced regulation of NE and not regulation of released DA...
Temporal and probabilistic discounting of rewards in children and adolescents: effects of age and ADHD symptomsAnouk Scheres
Psychology Department, University of Arizona, Tucson, 85721, USA
Neuropsychologia 44:2092-103. 2006..The decrease in TD as observed in adolescents compared to children may be related to developmental changes in the (dorsolateral) prefrontal cortex. Future research needs to investigate these possibilities...
Recent advances in structural and functional brain imaging studies of attention-deficit/hyperactivity disorderA M Clare Kelly
Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY 10016, USA
Curr Psychiatry Rep 9:401-7. 2007..These developments allow us to conclude that neuroimaging studies of ADHD will increasingly inform our understanding of the neuronal substrates of ADHD...
Varieties of attention-deficit/hyperactivity disorder-related intra-individual variabilityF Xavier Castellanos
Institute for Pediatric Neuroscience, New York University, Child Study Center, NYU School of Medicine, New York, New York 10016, USA
Biol Psychiatry 57:1416-23. 2005..These results highlight the importance of retaining time-series data and quantitatively examining intra-subject measures of variability as a putative endophenotype for ADHD...
Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypesF Xavier Castellanos
New York University Child Study Center, 577 First Avenue, CSC 204, New York, New York 10016-6404, USA
Nat Rev Neurosci 3:617-28. 2002
Proceed, with caution: SPECT cerebral blood flow studies of children and adolescents with attention deficit hyperactivity disorderF Xavier Castellanos
NYU Child Study Center, New York, New York 10016, USA
J Nucl Med 43:1630-3. 2002
Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorderF Xavier Castellanos
Child Psychiatry Branch, National Institute of Mental Health NIH, Bethesda, MD, USA
Am J Psychiatry 160:1693-6. 2003..To examine brain-behavior relationships in attention deficit hyperactivity disorder (ADHD), the authors obtained magnetic resonance imaging (MRI) scans of monozygotic twins discordant for ADHD...
The ipsilateral silent period in boys with attention-deficit/hyperactivity disorderMarjorie A Garvey
Pediatric Movement Disorders Unit, Human Motor Control Section, MNB, NINDS, National Institutes of Health, Bethesda, MD 20892, USA
Clin Neurophysiol 116:1889-96. 2005..Characterize maturation of transcallosal inhibition (ipsilateral silent period [iSP]) in attention deficit/hyperactivity disorder (ADHD) using transcranial magnetic stimulation (TMS)...
Shifting-related brain magnetic activity in attention-deficit/hyperactivity disorderFernando Mulas
Valencian Institute of Pediatric Neurology, Valencia, Spain
Biol Psychiatry 59:373-9. 2006..CONCLUSIONS: These preliminary data support theories of frontal dysfunction in ADHD but also suggest that deficits in higher-level functions might be secondary to disruptions in earlier limbic processes...
Neurologic examination abnormalities in children with bipolar disorder or attention-deficit/hyperactivity disorderDaniel P Dickstein
National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, 10 Center Drive MSC 1255, Building 10 Room 4N208, Bethesda MD 20892 1255, USA
Biol Psychiatry 58:517-24. 2005..To move beyond diagnosis toward unique pathophysiology, we evaluated both ADHD and BPD children for neurologic examination abnormalities (NEAs) in comparison with normal control (NC) children...
Children, stress, and context: integrating basic, clinical, and experimental prevention researchLaurie Miller Brotman
New York University Child Study Center, NY 10016, USA
Child Dev 74:1053-7. 2003....
Differential effects of amphetamine isomers on dopamine release in the rat striatum and nucleus accumbens corePaul E A Glaser
Department of Psychiatry, University of Kentucky, 306 Davis Mills Bldg, Lexington, KY 40536, USA
Psychopharmacology (Berl) 178:250-8. 2005....
Attention-deficit/hyperactivity disorder in a population isolate: linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11Mauricio Arcos-Burgos
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-3717, USA
Am J Hum Genet 75:998-1014. 2004..The concordance between results from different analytical methods of linkage and the replication of data between two independent studies suggest that these loci truly harbor ADHD susceptibility genes...
Functional neuroimaging of social cognition in pervasive developmental disorders: a brief reviewAdriana Di Martino
New York University Child Study Center, 577 First Avenue, New York, NY 10016, USA
Ann N Y Acad Sci 1008:256-60. 2003..Future studies should extend these important initial results to younger and more severely affected subjects...
Latent class subtyping of attention-deficit/hyperactivity disorder and comorbid conditionsMaria T Acosta
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 3717, USA
J Am Acad Child Adolesc Psychiatry 47:797-807. 2008..The aim of this study was to perform LCA in a sample of 1,010 individuals from a nationwide recruitment of unilineal nuclear families with at least one child with ADHD and another child either affected or clearly unaffected...
Attention-deficit/hyperactivity disorder and comorbidities in 18 Paisa Colombian multigenerational familiesJuan D Palacio
Neurosciences Group, University of Antioquia, , Colombia
J Am Acad Child Adolesc Psychiatry 43:1506-15. 2004..This pattern of comorbidity, as well as the large dense pedigrees of the sample, suggests that it will be particularly useful for molecular genetic studies that are currently under way...
Molecular genetic studies of ADHD: 1991 to 2004Aaron J Bobb
Child Psychiatry Branch, NIMH, NIH, 10 Center Drive, Bethesda, MD 20892, USA
Am J Med Genet B Neuropsychiatr Genet 132:109-25. 2005..All candidate gene approaches continue to face the problem of relatively low power, given modest odds ratios for even the best replicated genes...
Support for association between ADHD and two candidate genes: NET1 and DRD1Aaron J Bobb
Child Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892 1600, USA
Am J Med Genet B Neuropsychiatr Genet 134:67-72. 2005..Because family-based and case-control methods gave divergent results, both should be used in genetic studies of ADHD...
Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorderPhilip Shaw
Child Psychiatry Branch, Room 3N202, Bldg 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 64:921-31. 2007..Attention-deficit/hyperactivity disorder (ADHD) is one of the most heritable neuropsychiatric disorders, and a polymorphism within the dopamine D4 receptor (DRD4) gene has been frequently implicated in its pathogenesis...
Cytogenetic abnormalities in attention-deficit/hyperactivity disorderTheresa M Bastain
Child Psychiatry Branch of the NIMH, USA
J Am Acad Child Adolesc Psychiatry 41:806-10. 2002....
Attention-deficit/hyperactivity disorder and comorbid disruptive behavior disorders: evidence of pleiotropy and new susceptibility lociMahim Jain
Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 3717, USA
Biol Psychiatry 61:1329-39. 2007..Attention-deficit/hyperactivity disorder (ADHD) comorbid with oppositional defiant disorder (ODD) or conduct disorder (CD) and substance abuse/dependence seems to represent a specific subset within the phenotypic ADHD spectrum...
Brain development and ADHDAmy L Krain
Institute for Pediatric Neuroscience, NYU Child Study Center, 215 Lexington Avenue, New York, NY 10016, USA
Clin Psychol Rev 26:433-44. 2006..Differences in gray and white matter have also been examined. The ultimate goal of this research is to determine the underlying neurophysiology of ADHD and how specific phenotypes may be related to alterations in brain structure...
Functional MRI in pediatric neurobehavioral disordersMichael Seyffert
Institute for Pediatric Neuroscience, New York University Child Study Center, New York New York 10016, USA
Int Rev Neurobiol 67:239-84. 2005
Towards a neuroscience of attention-deficit/hyperactivity disorder: fractionating the phenotypeF Xavier Castellanos
J Neurosci Methods 151:1-4. 2006
