Kenneth D Carr

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Rewarding and locomotor-activating effects of direct dopamine receptor agonists are augmented by chronic food restriction in rats
    K D Carr
    Millhauser Laboratories, Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Psychopharmacology (Berl) 154:420-8. 2001
  2. pmc Effects of the MEK inhibitor, SL-327, on rewarding, motor- and cellular-activating effects of D-amphetamine and SKF-82958, and their augmentation by food restriction in rat
    Kenneth D Carr
    Department of Psychiatry, School of Medicine, New York University, 550 First Avenue, New York, NY 10016, USA
    Psychopharmacology (Berl) 201:495-506. 2009
  3. pmc Reward-potentiating effects of D-1 dopamine receptor agonist and AMPAR GluR1 antagonist in nucleus accumbens shell and their modulation by food restriction
    Kenneth D Carr
    Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Psychopharmacology (Berl) 202:731-43. 2009
  4. ncbi request reprint Evidence of increased dopamine receptor signaling in food-restricted rats
    K D Carr
    Department of Psychiatry, Millhauser Laboratories, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Neuroscience 119:1157-67. 2003
  5. ncbi request reprint Effects of the D(3) dopamine receptor antagonist, U99194A, on brain stimulation and d-amphetamine reward, motor activity, and c-fos expression in ad libitum fed and food-restricted rats
    K D Carr
    Department of Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Psychopharmacology (Berl) 163:76-84. 2002
  6. ncbi request reprint Augmentation of drug reward by chronic food restriction: behavioral evidence and underlying mechanisms
    Kenneth D Carr
    Department of Psychiatry, Millhauser Laboratories, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    Physiol Behav 76:353-64. 2002
  7. ncbi request reprint Chronic food restriction: enhancing effects on drug reward and striatal cell signaling
    Kenneth D Carr
    Departments of Psychiatry and Pharmacology, Millhauser Laboratories, New York University School of Medicine, New York, NY 10016, USA
    Physiol Behav 91:459-72. 2007
  8. ncbi request reprint Comparison of basal and D-1 dopamine receptor agonist-stimulated neuropeptide gene expression in caudate-putamen and nucleus accumbens of ad libitum fed and food-restricted rats
    Sandra L Haberny
    Department of Pharmacology, Millhauser Laboratories, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Brain Res Mol Brain Res 141:121-7. 2005
  9. pmc The adenosine A2A receptor agonist, CGS-21680, blocks excessive rearing, acquisition of wheel running, and increases nucleus accumbens CREB phosphorylation in chronically food-restricted rats
    Soledad Cabeza de Vaca
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Brain Res 1142:100-9. 2007
  10. pmc Effects of protein kinase A inhibitor and activator on rewarding effects of SKF-82958 microinjected into nucleus accumbens shell of ad libitum fed and food-restricted rats
    Soledad Cabeza de Vaca
    Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Psychopharmacology (Berl) 221:589-99. 2012

Research Grants

  1. CNS Mechanisms that Modulate Reward
    KENNETH CARR; Fiscal Year: 2007
  2. OPIOID MECHANISMS THAT FACILITATE REWARD
    KENNETH CARR; Fiscal Year: 2006
  3. CNS OPIOID MECHANISMS THAT MODULATE REWARD AND AVERSION
    KENNETH CARR; Fiscal Year: 2002
  4. CNS Mechanisms that Modulate Reward
    Kenneth D Carr; Fiscal Year: 2010

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Rewarding and locomotor-activating effects of direct dopamine receptor agonists are augmented by chronic food restriction in rats
    K D Carr
    Millhauser Laboratories, Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Psychopharmacology (Berl) 154:420-8. 2001
    ..It is not known whether behavioral effects of selective, direct DA receptor agonists are also subject to the augmenting effect of food restriction...
  2. pmc Effects of the MEK inhibitor, SL-327, on rewarding, motor- and cellular-activating effects of D-amphetamine and SKF-82958, and their augmentation by food restriction in rat
    Kenneth D Carr
    Department of Psychiatry, School of Medicine, New York University, 550 First Avenue, New York, NY 10016, USA
    Psychopharmacology (Berl) 201:495-506. 2009
    ..While a role has been established for ERK signaling in drug-mediated associative learning, it is not clear whether ERK regulates unconditioned behavioral effects of abused drugs...
  3. pmc Reward-potentiating effects of D-1 dopamine receptor agonist and AMPAR GluR1 antagonist in nucleus accumbens shell and their modulation by food restriction
    Kenneth D Carr
    Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Psychopharmacology (Berl) 202:731-43. 2009
    ..The neuroanatomical site(s) of key neuroadaptations may include nucleus accumbens (NAc) where changes in D-1 dopamine (DA) receptor-mediated cell signaling and gene expression have been documented...
  4. ncbi request reprint Evidence of increased dopamine receptor signaling in food-restricted rats
    K D Carr
    Department of Psychiatry, Millhauser Laboratories, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Neuroscience 119:1157-67. 2003
    ..The signaling pathways mediating these augmented responses remain to be fully elucidated...
  5. ncbi request reprint Effects of the D(3) dopamine receptor antagonist, U99194A, on brain stimulation and d-amphetamine reward, motor activity, and c-fos expression in ad libitum fed and food-restricted rats
    K D Carr
    Department of Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Psychopharmacology (Berl) 163:76-84. 2002
    ..However, the locations of the D(3) receptors that regulate behavior, and the range of behavioral functions regulated, are not clear...
  6. ncbi request reprint Augmentation of drug reward by chronic food restriction: behavioral evidence and underlying mechanisms
    Kenneth D Carr
    Department of Psychiatry, Millhauser Laboratories, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    Physiol Behav 76:353-64. 2002
    ....
  7. ncbi request reprint Chronic food restriction: enhancing effects on drug reward and striatal cell signaling
    Kenneth D Carr
    Departments of Psychiatry and Pharmacology, Millhauser Laboratories, New York University School of Medicine, New York, NY 10016, USA
    Physiol Behav 91:459-72. 2007
    ....
  8. ncbi request reprint Comparison of basal and D-1 dopamine receptor agonist-stimulated neuropeptide gene expression in caudate-putamen and nucleus accumbens of ad libitum fed and food-restricted rats
    Sandra L Haberny
    Department of Pharmacology, Millhauser Laboratories, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Brain Res Mol Brain Res 141:121-7. 2005
    ....
  9. pmc The adenosine A2A receptor agonist, CGS-21680, blocks excessive rearing, acquisition of wheel running, and increases nucleus accumbens CREB phosphorylation in chronically food-restricted rats
    Soledad Cabeza de Vaca
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Brain Res 1142:100-9. 2007
    ..Medications targeting the A(2A) receptor may have utility in the treatment of maladaptive behaviors associated with FR, including substance abuse and compulsive exercise...
  10. pmc Effects of protein kinase A inhibitor and activator on rewarding effects of SKF-82958 microinjected into nucleus accumbens shell of ad libitum fed and food-restricted rats
    Soledad Cabeza de Vaca
    Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Psychopharmacology (Berl) 221:589-99. 2012
    ..The D-1 receptor is positively coupled to adenylyl cyclase and activates protein kinase A (PKA)...
  11. ncbi request reprint A progressive ratio schedule of self-stimulation testing in rats reveals profound augmentation of d-amphetamine reward by food restriction but no effect of a "sensitizing" regimen of d-amphetamine
    Soledad Cabeza de Vaca
    Department of Psychiatry Millhauser Laboratories, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Psychopharmacology (Berl) 175:106-13. 2004
    ....
  12. ncbi request reprint Effects of central leptin infusion on the reward-potentiating effect of D-amphetamine
    Joy Hao
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Brain Res 1087:123-33. 2006
    ..Together, results of this study support the importance of weight loss, but not leptin, in the enhancement of drug reward sensitivity...
  13. pmc Synthesis, protein levels, activity, and phosphorylation state of tyrosine hydroxylase in mesoaccumbens and nigrostriatal dopamine pathways of chronically food-restricted rats
    Yan Pan
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Brain Res 1122:135-42. 2006
    ..According to this scheme, the previously observed upregulation of striatal cell signaling and transcriptional responses to DA receptor agonist administration may include compensatory neuroadaptations...
  14. pmc SKF-83566, a D1-dopamine receptor antagonist, inhibits the dopamine transporter
    Melissa A Stouffer
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    J Neurochem 118:714-20. 2011
    ..More positively, however, SKF-83566 might be a candidate to attenuate cocaine effects in vivo because of the greater potency of this drug at the cocaine versus DA binding site of the DAT...
  15. pmc Effects of food restriction and sucrose intake on synaptic delivery of AMPA receptors in nucleus accumbens
    Xing Xiang Peng
    Department of Psychiatry, New York University School of Medicine, New York 10016, USA
    Synapse 65:1024-31. 2011
    ....
  16. pmc Food restriction increases acquisition, persistence and drug prime-induced expression of a cocaine-conditioned place preference in rats
    Danielle Zheng
    Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Pharmacol Biochem Behav 100:538-44. 2012
    ..In so far as CPP models Pavlovian conditioning that contributes to addiction, these results suggest the importance of diet and the physiology of energy balance as modulatory factors...
  17. pmc Effects of the group I metabotropic glutamate receptor agonist, DHPG, and injection stress on striatal cell signaling in food-restricted and ad libitum fed rats
    Yan Pan
    Department of Psychiatry, Millhauser Laboratories, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    BMC Neurosci 5:50. 2004
    ..The purpose of the present study was to evaluate whether chronic food restriction increases striatal MAP kinase signaling in response to the group I mGluR agonist, DHPG...
  18. pmc Enhanced cocaine-conditioned place preference and associated brain regional levels of BDNF, p-ERK1/2 and p-Ser845-GluA1 in food-restricted rats
    Shan Liu
    Department of Psychiatry, New York University School of Medicine, USA
    Brain Res 1400:31-41. 2011
    ..The one effect observed exclusively in cocaine-treated FR rats was increased p-Ser845-GluA1 in nucleus accumbens. These findings suggest a number of avenues for continuing investigation with potential translational significance...
  19. ncbi request reprint Striatal cell signaling in chronically food-restricted rats under basal conditions and in response to brief handling
    Yan Pan
    Department of Psychiatry, Millhauser Laboratories, room HN607, New York University School of Medicine, 550 First Avenue, NY 10016, USA
    Neurosci Lett 393:243-8. 2006
    ....
  20. pmc Sucrose ingestion induces rapid AMPA receptor trafficking
    David S Tukey
    Department of Biochemistry and Molecular Pharmacology, New York, New York 10016, and Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 33:6123-32. 2013
    ..Trafficking is stimulated by a chemosensory pathway that is not dependent on the caloric value of sucrose...
  21. pmc Effects of time of feeding on psychostimulant reward, conditioned place preference, metabolic hormone levels, and nucleus accumbens biochemical measures in food-restricted rats
    Danielle Zheng
    Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, Alexandria Center for Life Sciences, 450 East 29th Street, New York, NY, 10016, USA
    Psychopharmacology (Berl) 227:307-20. 2013
    ..When there is a single daily meal, circadian rhythms are correspondingly entrained, and pre- and postprandial periods are accompanied by different circulating levels of metabolic hormones that modulate brain dopamine function...
  22. pmc Food scarcity, neuroadaptations, and the pathogenic potential of dieting in an unnatural ecology: binge eating and drug abuse
    Kenneth D Carr
    Department of Psychiatry, Millhauser Laboratories, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    Physiol Behav 104:162-7. 2011
    ..Possible mechanistic underpinnings of increased drug reward magnitude, drug-seeking, and binge intake of sucrose in food-restricted animal subjects are discussed and possible implications for human weight-loss dieting are considered...
  23. ncbi request reprint Chronic food restriction and dopamine transporter function in rat striatum
    Juan Zhen
    Department of Psychiatry, Millhauser Labs, New York University, New York, NY 10016, USA
    Brain Res 1082:98-101. 2006
    ..These results point to factors other than DAT density or affinity underlying the sensitized response to psychostimulants in food restriction...
  24. ncbi request reprint Role of alpha(1)-adrenoceptors of the locus coeruleus in self-stimulation of the medial forebrain bundle
    Yan Lin
    Department of Psychiatry, New York University School of Medicine, New York University Medical Center, New York, NY 10016, USA
    Neuropsychopharmacology 32:835-41. 2007
    ..It is concluded that LC alpha(1)-adrenoceptors are involved both in reward/motivational processes and operant response elaboration which are postulated to work together to facilitate goal attainment...
  25. ncbi request reprint The melanocortin receptor agonist MTII augments the rewarding effect of amphetamine in ad-libitum-fed and food-restricted rats
    Soledad Cabeza de Vaca
    Millhauser Laboratories, Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Psychopharmacology (Berl) 161:77-85. 2002
    ....

Research Grants16

  1. CNS Mechanisms that Modulate Reward
    KENNETH CARR; Fiscal Year: 2007
    ....
  2. OPIOID MECHANISMS THAT FACILITATE REWARD
    KENNETH CARR; Fiscal Year: 2006
    ..abstract_text> ..
  3. CNS OPIOID MECHANISMS THAT MODULATE REWARD AND AVERSION
    KENNETH CARR; Fiscal Year: 2002
    ....
  4. CNS Mechanisms that Modulate Reward
    Kenneth D Carr; Fiscal Year: 2010
    ....