Ralph Carmel

Summary

Affiliation: New York Presbyterian Hospital
Country: USA

Publications

  1. ncbi Mandatory fortification of the food supply with cobalamin: an idea whose time has not yet come
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY, 11215, USA
    J Inherit Metab Dis 34:67-73. 2011
  2. ncbi Diagnosis and management of clinical and subclinical cobalamin deficiencies: Why controversies persist in the age of sensitive metabolic testing
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY, USA Department of Medicine, Weill Cornell Medical College, New York, NY, USA Electronic address
    Biochimie 95:1047-55. 2013
  3. ncbi Subclinical cobalamin deficiency
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn and Weill Cornell Medical College, New York, New York, USA
    Curr Opin Gastroenterol 28:151-8. 2012
  4. ncbi Failures of cobalamin assays in pernicious anemia
    Ralph Carmel
    New York Methodist Hospital, Brooklyn, NY
    N Engl J Med 367:385-6. 2012
  5. ncbi The disappearance of cobalamin absorption testing: a critical diagnostic loss
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY 11215, USA
    J Nutr 137:2481-4. 2007
  6. ncbi How I treat cobalamin (vitamin B12) deficiency
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, and Weill Medical College, Cornell University, New York, NY 11215, USA
    Blood 112:2214-21. 2008
  7. ncbi Efficacy and safety of fortification and supplementation with vitamin B12: biochemical and physiological effects
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY, USA
    Food Nutr Bull 29:S177-87. 2008
  8. ncbi Nutritional anemias and the elderly
    Ralph Carmel
    Departments of Medicine, New York Methodist Hospital, 506 Sixth Street, Brooklyn, NY 11215, USA
    Semin Hematol 45:225-34. 2008
  9. ncbi Genomic mutations associated with mild and severe deficiencies of transcobalamin I (haptocorrin) that cause mildly and severely low serum cobalamin levels
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY 11215, USA
    Br J Haematol 147:386-91. 2009
  10. ncbi Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY 11215, USA
    Am J Clin Nutr 94:348S-358S. 2011

Research Grants

  1. SUBTLE DISTURBANCES OF COBALAMIN STATUS
    Ralph Carmel; Fiscal Year: 2007
  2. SUBTLE DISTURBANCES OF COBALAMIN STATUS
    Ralph Carmel; Fiscal Year: 2000

Collaborators

Detail Information

Publications24

  1. ncbi Mandatory fortification of the food supply with cobalamin: an idea whose time has not yet come
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY, 11215, USA
    J Inherit Metab Dis 34:67-73. 2011
    ..Extensive work, especially randomized clinical trials, must be done before mandatory dietary intervention on a national scale can be justified...
  2. ncbi Diagnosis and management of clinical and subclinical cobalamin deficiencies: Why controversies persist in the age of sensitive metabolic testing
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY, USA Department of Medicine, Weill Cornell Medical College, New York, NY, USA Electronic address
    Biochimie 95:1047-55. 2013
    ....
  3. ncbi Subclinical cobalamin deficiency
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn and Weill Cornell Medical College, New York, New York, USA
    Curr Opin Gastroenterol 28:151-8. 2012
    ..This review focuses on recent developments and controversies in the diagnosis, consequences, and management of subclinical cobalamin deficiency (SCCD), which affects many elderly persons...
  4. ncbi Failures of cobalamin assays in pernicious anemia
    Ralph Carmel
    New York Methodist Hospital, Brooklyn, NY
    N Engl J Med 367:385-6. 2012
    ..The manufacturers need to solve the problem of interference of the assay by antibodies to intrinsic factor...
  5. ncbi The disappearance of cobalamin absorption testing: a critical diagnostic loss
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY 11215, USA
    J Nutr 137:2481-4. 2007
  6. ncbi How I treat cobalamin (vitamin B12) deficiency
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, and Weill Medical College, Cornell University, New York, NY 11215, USA
    Blood 112:2214-21. 2008
    ....
  7. ncbi Efficacy and safety of fortification and supplementation with vitamin B12: biochemical and physiological effects
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY, USA
    Food Nutr Bull 29:S177-87. 2008
    ....
  8. ncbi Nutritional anemias and the elderly
    Ralph Carmel
    Departments of Medicine, New York Methodist Hospital, 506 Sixth Street, Brooklyn, NY 11215, USA
    Semin Hematol 45:225-34. 2008
    ..Nutritional anemias usually feature abnormal MCV, whereas the predominant anemias in the aged, especially the anemias of chronic disease/chronic inflammation (ACD/ACI), of renal failure, and of unknown causes, are typically normocytic...
  9. ncbi Genomic mutations associated with mild and severe deficiencies of transcobalamin I (haptocorrin) that cause mildly and severely low serum cobalamin levels
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY 11215, USA
    Br J Haematol 147:386-91. 2009
    ..They also add new approaches to studying mild and severe TC I deficiency and to reducing confusion of its low cobalamin levels with those of cobalamin deficiency and its often dramatically different prognosis and management...
  10. ncbi Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY 11215, USA
    Am J Clin Nutr 94:348S-358S. 2011
    ..Much work remains to be done...
  11. ncbi High serum cobalamin levels in the clinical setting--clinical associations and holo-transcobalamin changes
    R Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY 11215, USA
    Clin Lab Haematol 23:365-71. 2001
    ..The much better known association of high cobalamin levels with leucocytic disorders is rare, and no association was seen with liver disease...
  12. ncbi Diagnosis and management of clinical and subclinical cobalamin deficiency: advances and controversies
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY 11215, USA
    Curr Hematol Rep 5:23-33. 2006
    ..Reassessment of diagnostic and management approaches, including improving our ability to diagnose cobalamin malabsorption, is required...
  13. ncbi Mild transcobalamin I (haptocorrin) deficiency and low serum cobalamin concentrations
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, 506 Sixth Street, Brooklyn, NY 11215, USA
    Clin Chem 49:1367-74. 2003
    ..Low cobalamin concentrations are common, but their causes are often unknown. Transcobalamin I/haptocorrin (TC I/HC) deficiency, viewed as a rare cause, has not been examined systematically in patients with unexplained low serum cobalamin...
  14. ncbi Hyperhomocysteinemia and cobalamin deficiency in young Asian Indians in the United States
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, 506 Sixth Street, Brooklyn, NY 11215, USA
    Am J Hematol 70:107-14. 2002
    ..This public health problem is amenable to prevention and treatment in this growing segment of the U.S. population. It was, parenthetically, noteworthy that many of the affected subjects were young physician trainees...
  15. ncbi Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY, USA
    Blood 101:3302-8. 2003
    ..The origin of the folate differences is unclear and possibly varied. Low AdoMet and GSH levels were independent predictors of anemia...
  16. ncbi Mild hyperhomocysteinemia in adult patients with sickle cell disease: a common finding unrelated to folate and cobalamin status
    Meekoo Dhar
    Department of Medicine, New York Methodist Hospital, Brooklyn, New York 11215, USA
    Am J Hematol 76:114-20. 2004
    ..If reducing tHcy becomes advisable, then interventions other than folate therapy will be needed...
  17. ncbi Pernicious anemia with neuropsychiatric dysfunction in a patient with sickle cell anemia treated with folate supplementation
    Meekoo Dhar
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY 11215, USA
    N Engl J Med 348:2204-7. 2003
  18. ncbi Influence of cobalamin deficiency compared with that of cobalamin absorption on serum holo-transcobalamin II
    Xinke Chen
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY 11215, USA
    Am J Clin Nutr 81:110-4. 2005
    ..Serum holo-TC II cannot be used clinically to diagnose cobalamin malabsorption because of overlap with normal values. The influences on holo-TC II are complex and require careful analysis...
  19. ncbi Alcohol abuse: an important cause of severe hyperhomocysteinemia
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY 11215, USA
    Nutr Rev 60:215-21. 2002
    ..Both patients had severe neurologic symptoms as well as macrocytic red blood cells, which, along with the high homocysteine levels, were misattributed to cobalamin deficiency, in one case despite serum cobalamin levels that were normal...
  20. ncbi Haptocorrin (transcobalamin I) and cobalamin deficiencies
    Ralph Carmel
    Clin Chem 53:367-8; author reply 368-9. 2007
  21. ncbi Measuring and interpreting holo-transcobalamin (holo-transcobalamin II)
    Ralph Carmel
    Clin Chem 48:407-9. 2002
  22. ncbi Gene polymorphisms associated with diminished activity of 5,10-methylenetetrahydrofolate reductase do not explain the clinical manifestations of cobalamin deficiency
    Ralph Carmel
    Br J Haematol 120:907-9. 2003
  23. ncbi Mean corpuscular volume and other concerns in the study of vitamin B-12 deficiency: epidemiology with pathophysiology
    Ralph Carmel
    Am J Clin Nutr 87:1962-3; author reply 1963-4. 2008
  24. ncbi Is testing for clinical cobalamin deficiency truly unreliable?
    Ralph Carmel
    Blood 106:1136-8; author reply 1137-8. 2005

Research Grants9

  1. SUBTLE DISTURBANCES OF COBALAMIN STATUS
    Ralph Carmel; Fiscal Year: 2007
    ....
  2. SUBTLE DISTURBANCES OF COBALAMIN STATUS
    Ralph Carmel; Fiscal Year: 2000
    ..The mechanisms whereby H. pylori produces food-cobalamin malabsorption will be examined. In addition to the insights to be obtained, it is anticipated that a practical treatment for this common disorder will be established. ..